Aliases for GLRX5 Gene
External Ids for GLRX5 Gene
Previous HGNC Symbols for GLRX5 Gene
Previous GeneCards Identifiers for GLRX5 Gene
This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, May 2010]
GeneCards Summary for GLRX5 Gene
GLRX5 (Glutaredoxin 5) is a Protein Coding gene. Diseases associated with GLRX5 include Anemia, Sideroblastic, 3, Pyridoxine-Refractory and Spasticity, Childhood-Onset, With Hyperglycinemia. Among its related pathways are PAK Pathway. Gene Ontology (GO) annotations related to this gene include electron transfer activity and 2 iron, 2 sulfur cluster binding. An important paralog of this gene is GLRX3.
UniProtKB/Swiss-Prot Summary for GLRX5 Gene
Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (PubMed:20364084). Involved in protein lipoylation, acting in the pathway that provides an iron-sulfur cluster to lipoate synthase (PubMed:24334290). Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (PubMed:20364084). May protect cells against apoptosis due to reactive oxygen species and oxidative stress (By similarity).