Aliases for GLRX3 Gene
External Ids for GLRX3 Gene
Previous HGNC Symbols for GLRX3 Gene
Previous GeneCards Identifiers for GLRX3 Gene
This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
GeneCards Summary for GLRX3 Gene
GLRX3 (Glutaredoxin 3) is a Protein Coding gene. Diseases associated with GLRX3 include Multiple Mitochondrial Dysfunctions Syndrome 2 With Hyperglycinemia and Aceruloplasminemia. Gene Ontology (GO) annotations related to this gene include protein kinase C binding. An important paralog of this gene is GLRX5.
UniProtKB/Swiss-Prot Summary for GLRX3 Gene
Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation (PubMed:23615448). Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.