Aliases for GLRA4 Gene
External Ids for GLRA4 Gene
Previous GeneCards Identifiers for GLRA4 Gene
This gene encodes a glycine receptor and member of the ligand-gated ion channel family of proteins. The encoded protein is missing the fourth transmembrane region compared to related proteins in mouse and rat, and experimental data suggests that the human protein is functionally inactive. However, there is strong evidence to support transcription of this gene. As a result, RefSeq, in collaboration with Ensembl-GENCODE, has determined that this locus is best described as a transcribed pseudogene. [provided by RefSeq, Aug 2019]
GeneCards Summary for GLRA4 Gene
GLRA4 (Glycine Receptor Alpha 4 (Pseudogene)) is a Pseudogene. Diseases associated with GLRA4 include Hyperekplexia and Stiff-Person Syndrome. Among its related pathways are DAG and IP3 signaling and Ligand-gated ion channel transport. Gene Ontology (GO) annotations related to this gene include chloride channel activity and glycine binding. An important paralog of this gene is GLRA2.
Glycine receptors (GlyR) are members of the cys-loop family of ligand-gated ion channels, responsible for mediating the inhibitory effects of glycine. They are widely distributed throughout the CNS, particularly within the hippocampus, spinal cord and brain stem.