External Ids for GLRA4 Gene
Previous GeneCards Identifiers for GLRA4 Gene
This gene encodes a protein which has a neurotransmitter-gated ion-channel ligand binding domain. The encoded protein is very similar to a mouse protein which is a subunit of the retinal glycine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for GLRA4 Gene
GLRA4 (Glycine Receptor Alpha 4) is a Protein Coding gene. Diseases associated with GLRA4 include Pelizaeus-Merzbacher Disease. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and DAG and IP3 signaling. Gene Ontology (GO) annotations related to this gene include chloride channel activity and glycine binding. An important paralog of this gene is GLRA2.
UniProtKB/Swiss-Prot for GLRA4 Gene
Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents.
Glycine receptors (GlyR) are members of the cys-loop family of ligand-gated ion channels, responsible for mediating the inhibitory effects of glycine. They are widely distributed throughout the CNS, particularly within the hippocampus, spinal cord and brain stem.