GLRA2 Gene (Protein Coding)

Glycine Receptor Alpha 2

GC0XP014529
GIFtS:
44
The glycine receptor consists of two subunits, alpha and beta, and acts as a pentamer. The protein encoded by this gene is an alpha subunit and can bind strychnine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010] See more...

Aliases for GLRA2 Gene

Aliases for GLRA2 Gene

  • Glycine Receptor Alpha 2 2 3 5
  • Glycine Receptor Subunit Alpha-2 3 4
  • Glycine Receptor, Alpha-2 Polypeptide 3
  • Glycine Receptor Alpha 2 Subunit 3
  • GLRA2 5
  • GLR 3

External Ids for GLRA2 Gene

Previous HGNC Symbols for GLRA2 Gene

  • GLR

Previous GeneCards Identifiers for GLRA2 Gene

  • GC0XP013992
  • GC0XP013373
  • GC0XP013749
  • GC0XP013909
  • GC0XP014307
  • GC0XP014457
  • GC0XP012306

Summaries for GLRA2 Gene

Entrez Gene Summary for GLRA2 Gene

  • The glycine receptor consists of two subunits, alpha and beta, and acts as a pentamer. The protein encoded by this gene is an alpha subunit and can bind strychnine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]

GeneCards Summary for GLRA2 Gene

GLRA2 (Glycine Receptor Alpha 2) is a Protein Coding gene. Diseases associated with GLRA2 include Epilepsy, Idiopathic Generalized 13 and Hyperekplexia. Among its related pathways are Ligand-gated ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include extracellular ligand-gated ion channel activity and extracellularly glycine-gated chloride channel activity. An important paralog of this gene is GLRA3.

UniProtKB/Swiss-Prot Summary for GLRA2 Gene

  • Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:15302677, PubMed:16144831, PubMed:23895467, PubMed:25445488). Channel opening is also triggered by taurine and beta-alanine (PubMed:15302677). Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Plays a role in cellular responses to ethanol (PubMed:23895467).

Tocris Summary for GLRA2 Gene

  • Glycine receptors (GlyR) are members of the cys-loop family of ligand-gated ion channels, responsible for mediating the inhibitory effects of glycine. They are widely distributed throughout the CNS, particularly within the hippocampus, spinal cord and brain stem.

Gene Wiki entry for GLRA2 Gene

Additional gene information for GLRA2 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GLRA2 Gene

Genomics for GLRA2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for GLRA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH0XJ014529 Promoter 1.1 EPDnew Ensembl 600.7 +0.0 2 1 CTCF REST RAD21 SMC3 YY1 EHMT2 ZNF654 SIN3A ZNF143 MIER2 GLRA2 LOC107985686 FANCB
GH0XJ014496 Enhancer 0.5 ENCODE 13.1 -32.1 -32057 1.1 PKNOX1 RELB RUNX3 ASH2L EBF1 ATF7 GLRA2 RF00994-1160 piR-55361-590 GEMIN8
GH0XJ014554 Enhancer 0.3 ENCODE 12.6 +25.1 25056 0.2 NR2F2 GLRA2 LOC107985686 FANCB
GH0XJ014673 Enhancer 0.9 Ensembl ENCODE 0.1 +144.4 144403 1.4 ZNF629 ZNF692 DPF2 JUND ZNF10 CEBPB RUNX3 CHD2 OSR2 JUN MOSPD2 piR-37972-711 piR-60146-198 GLRA2 FANCB
GH0XJ014409 Enhancer 0.6 Ensembl ENCODE 0.1 -119.8 -119760 1 RFX1 FOXA2 NFIB FOXA1 FOSL2 NFIA RF01045-152 piR-40110-706 GLRA2 GEMIN8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GLRA2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GLRA2

Top Transcription factor binding sites by QIAGEN in the GLRA2 gene promoter:
  • Arnt
  • Brachyury
  • E4BP4
  • FOXF2
  • HOXA5
  • Nkx2-5
  • SRY
  • TBP
  • TFIID
  • TGIF

Genomic Locations for GLRA2 Gene

Genomic Locations for GLRA2 Gene
chrX:14,529,298-14,731,812
(GRCh38/hg38)
Size:
202,515 bases
Orientation:
Plus strand
chrX:14,547,420-14,749,934
(GRCh37/hg19)
Size:
202,515 bases
Orientation:
Plus strand

Genomic View for GLRA2 Gene

Genes around GLRA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLRA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLRA2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GLRA2 Gene

Proteins for GLRA2 Gene

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  • Protein details for GLRA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23416-GLRA2_HUMAN
    Recommended name:
    Glycine receptor subunit alpha-2
    Protein Accession:
    P23416
    Secondary Accessions:
    • A8K0J6
    • B2R6I8
    • B7Z4F5
    • J3KQ59
    • Q53YX7
    • Q6ICQ0
    • Q99862

    Protein attributes for GLRA2 Gene

    Size:
    452 amino acids
    Molecular mass:
    52002 Da
    Quaternary structure:
    • Homopentamer (in vitro). Interacts with GLRB (PubMed:16144831). Heteropentamer composed of GLRA2 and GLRB. Both homopentamers and heteropentamers form functional ion channels, but their characteristics are subtly different (PubMed:15302677).
    Miscellaneous:
    • The alpha subunit binds strychnine.

    Alternative splice isoforms for GLRA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLRA2 Gene

Protein Expression for GLRA2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for GLRA2 Gene

  • Glycosylation at Asn103 and Asn72
  • Modification sites at PhosphoSitePlus

Other Protein References for GLRA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for GLRA2

No data available for DME Specific Peptides for GLRA2 Gene

Domains & Families for GLRA2 Gene

Gene Families for GLRA2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for GLRA2 Gene

InterPro:
Blocks:
  • Neurotransmitter-gated ion-channel
  • Gamma-aminobutyric acid A (GABAA) receptor signature
  • Glycine receptor alpha 2 subunit signature
ProtoNet:

Suggested Antigen Peptide Sequences for GLRA2 Gene

GenScript: Design optimal peptide antigens:
  • Glycine receptor subunit alpha-2 (GLRA2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P23416

UniProtKB/Swiss-Prot:

GLRA2_HUMAN :
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA2 sub-subfamily.
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA2 sub-subfamily.
genes like me logo Genes that share domains with GLRA2: view

Function for GLRA2 Gene

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Molecular function for GLRA2 Gene

UniProtKB/Swiss-Prot Function:
Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:15302677, PubMed:16144831, PubMed:23895467, PubMed:25445488). Channel opening is also triggered by taurine and beta-alanine (PubMed:15302677). Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Plays a role in cellular responses to ethanol (PubMed:23895467).
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: Note=For isoform Alpha-2* homopentamers, a concentration of about 66 uM glycine results in half-maximal channel conductance. For isoform Alpha-2B homopentamers, a concentration of about 34 uM glycine results in half-maximal channel conductance.;
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by strychnine (PubMed:2155780, PubMed:15302677). Inhibited by picrotoxin (PubMed:15302677). Channel activity is potentiated by 10-100 uM Zn(2+) (PubMed:15302677, PubMed:16144831, PubMed:23895467). Channel activity is marginally increased by 50 mM ethanol; it is strongly increased by a combination of 0.5 uM Zn(2+) and 50 mM ethanol (PubMed:23895467). Channel activity is inhibited by 100-1000 uM Zn(2+) (PubMed:15302677).
GENATLAS Biochemistry:
glycine receptor,alpha 2 subunit

Phenotypes From GWAS Catalog for GLRA2 Gene

Gene Ontology (GO) - Molecular Function for GLRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005216 ion channel activity IEA --
GO:0005230 extracellular ligand-gated ion channel activity IEA --
GO:0005254 contributes_to chloride channel activity IBA 21873635
GO:0016594 glycine binding IDA 2155780
genes like me logo Genes that share ontologies with GLRA2: view
genes like me logo Genes that share phenotypes with GLRA2: view

Animal Models for GLRA2 Gene

MGI Knock Outs for GLRA2:

Animal Model Products

  • Taconic Biosciences Mouse Models for GLRA2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GLRA2

Clone Products

  • Addgene plasmids for GLRA2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GLRA2 Gene

Localization for GLRA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLRA2 Gene

Cell junction, synapse, postsynaptic cell membrane. Multi-pass membrane protein. Cell junction, synapse. Cell membrane. Multi-pass membrane protein. Cell projection.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLRA2 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
golgi apparatus 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for GLRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA,IDA 2155780
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with GLRA2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GLRA2 Gene

Pathways & Interactions for GLRA2 Gene

genes like me logo Genes that share pathways with GLRA2: view

Pathways by source for GLRA2 Gene

1 KEGG pathway for GLRA2 Gene
1 GeneGo (Thomson Reuters) pathway for GLRA2 Gene
  • Neurophysiological process PGE2-induced pain processing

Gene Ontology (GO) - Biological Process for GLRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006821 chloride transport IEA --
GO:0007165 signal transduction IBA 21873635
GO:0007218 neuropeptide signaling pathway IBA,IDA 2155780
GO:0007268 chemical synaptic transmission TAS --
genes like me logo Genes that share ontologies with GLRA2: view

No data available for SIGNOR curated interactions for GLRA2 Gene

Drugs & Compounds for GLRA2 Gene

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  1. Drug

(31) Drugs for GLRA2 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanol Approved Pharma Target, agonist 3266
Lindane Approved, Withdrawn Pharma Target, antagonist 0
Glycine Approved, Vet_approved Nutra Agonist, Full agonist, Target, ligand 196
Colchicine Approved Pharma Antagonist, binder Tubulin Inhibitor 157
Tropisetron Approved, Investigational Pharma Antagonist, antagonist 27

(1) Additional Compounds for GLRA2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for GLRA2 Gene

Compound Action Cas Number
beta-Alanine Endogenous glycine agonist, more selective than taurine (Cat. No. 0209) 107-95-9
Hypotaurine Non-selective endogenous glycine receptor agonist 300-84-5
L-Alanine Glycine receptor agonist 56-41-7
L-Serine Weak endogenous glycine receptor agonist 56-45-1
Taurine Non-selective, endogenous glycine receptor partial agonist 107-35-7

(1) ApexBio Compounds for GLRA2 Gene

Compound Action Cas Number
Hypotaurine 300-84-5
genes like me logo Genes that share compounds with GLRA2: view

Drug Products

Transcripts for GLRA2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for GLRA2 Gene

4 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GLRA2

Clone Products

  • Addgene plasmids for GLRA2

Alternative Splicing Database (ASD) splice patterns (SP) for GLRA2 Gene

No ASD Table

Relevant External Links for GLRA2 Gene

GeneLoc Exon Structure for
GLRA2

Expression for GLRA2 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GLRA2 Gene

mRNA expression in normal human tissues for GLRA2 Gene
mRNA expression by BioGPS for GLRA2 GenemRNA expression by GTEx for GLRA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GLRA2 Gene

This gene is overexpressed in Brain - Hypothalamus (x10.5), Brain - Cerebellar Hemisphere (x8.0), Brain - Cerebellum (x6.7), Brain - Amygdala (x5.7), and Brain - Anterior cingulate cortex (BA24) (x4.0).

Protein differential expression in normal tissues from HIPED for GLRA2 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GLRA2 Gene



Protein tissue co-expression partners for GLRA2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GLRA2

SOURCE GeneReport for Unigene cluster for GLRA2 Gene:

Hs.2700

Evidence on tissue expression from TISSUES for GLRA2 Gene

  • Nervous system(4.9)
  • Kidney(3.5)
  • Eye(2.7)
  • Muscle(2.3)
genes like me logo Genes that share expression patterns with GLRA2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLRA2 Gene

Orthologs for GLRA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GLRA2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia GLRA2 30 31
  • 99.85 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia GLRA2 31
  • 97 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia GLRA2 30 31
  • 94.91 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Glra2 30
  • 93.22 (n)
Cow
(Bos Taurus)
 Mammalia GLRA2 30 31
  • 92.99 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Glra2 30 17 31
  • 92.85 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia GLRA2 31
  • 86 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves GLRA2 30 31
  • 85.55 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia GLRA2 31
  • 94 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia glra2 30
  • 80.74 (n)
Zebrafish
(Danio rerio)
 Actinopterygii glra2 30 31
  • 71.16 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta Rdl 32
  • 46 (a)
GluClalpha 32
  • 43 (a)
CG8916 32
  • 41 (a)
ort 32
  • 41 (a)
CG6927 32
  • 31 (a)
CG7589 32
  • 31 (a)
CG11340 32
  • 30 (a)
Worm
(Caenorhabditis elegans)
 Secernentea glc-3 32
  • 45 (a)
avr-14 32
  • 40 (a)
glc-1 32
  • 39 (a)
T24D8.1 32
  • 38 (a)
F11H8.2 32
  • 37 (a)
glc-2 32
  • 37 (a)
C39B10.2 32
  • 37 (a)
gbr-5 32
  • 36 (a)
F55D10.5 32
  • 36 (a)
Y39A3B.2 32
  • 36 (a)
gbr-4 32
  • 34 (a)
glc-4 32
  • 32 (a)
gbr-6 32
  • 31 (a)
Y71D11A.5 32
  • 30 (a)
C53D6.3 32
  • 30 (a)
F58G6.4 32
  • 30 (a)
K10D6.1 32
  • 30 (a)
W10G11.16 32
  • 30 (a)
T20B12.9 32
  • 29 (a)
T27E9.9 32
  • 29 (a)
Y73F8A.2 32
  • 29 (a)
F09G2.5 32
  • 28 (a)
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 59 (a)
 OneToMany
Species where no ortholog for GLRA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GLRA2 Gene

ENSEMBL:
Gene Tree for GLRA2 (if available)
TreeFam:
Gene Tree for GLRA2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GLRA2: view image

Paralogs for GLRA2 Gene

Variants for GLRA2 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GLRA2 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
780683 Benign: not provided 14,730,215(+) C/T SYNONYMOUS_VARIANT
810508 Uncertain Significance: not provided 14,581,408(+) T/TAAGC INTRON_VARIANT
810509 Uncertain Significance: not provided 14,581,411(+) G/A INTRON_VARIANT
810510 Uncertain Significance: not provided 14,609,162(+) C/T MISSENSE_VARIANT
rs1555999184 Uncertain Significance: not provided 14,532,376(+) G/T INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for GLRA2 Gene

Structural Variations from Database of Genomic Variants (DGV) for GLRA2 Gene

Variant ID Type Subtype PubMed ID
dgv502n21 CNV gain 19592680
esv1737273 CNV insertion 17803354
esv27338 CNV loss 19812545
esv2739975 CNV deletion 23290073
esv2739976 CNV deletion 23290073
esv3397621 OTHER inversion 20981092
esv3435574 OTHER inversion 20981092
nsv507947 OTHER sequence alteration 20534489
nsv518002 CNV gain 19592680
nsv518062 CNV gain 19592680
nsv520933 CNV gain 19592680
nsv522625 CNV gain 19592680
nsv526475 CNV gain 19592680
nsv6810 CNV deletion 18451855
nsv6811 CNV insertion 18451855
nsv9934 CNV loss 18304495

Variation tolerance for GLRA2 Gene

Residual Variation Intolerance Score: 23.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GLRA2 Gene

Human Gene Mutation Database (HGMD)
GLRA2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLRA2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLRA2 Gene

Disorders for GLRA2 Gene

MalaCards: The human disease database

(10) MalaCards diseases for GLRA2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
epilepsy, idiopathic generalized 13
  • epilepsy, idiopathic generalized, susceptibility to, 13
hyperekplexia
  • startle disease, familial
high pressure neurological syndrome
glycine encephalopathy
  • gce
stiff-person syndrome
  • sps
- elite association - COSMIC cancer census association via MalaCards
Search GLRA2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GLRA2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with GLRA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GLRA2 Gene

Publications for GLRA2 Gene

  1. Structure of the human alpha 2 subunit gene of the glycine receptor--use of vectorette and Alu-exon PCR. (PMID: 8973915) Monani U … Burghes AH (Genome research 1996) 3 4 23
  2. Zinc-dependent modulation of α2- and α3-glycine receptor subunits by ethanol. (PMID: 23895467) McCracken LM … Harris RA (Alcoholism, clinical and experimental research 2013) 3 4
  3. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) Gratacòs M … Psychiatric Genetics Network Group (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 41
  4. Genetical genomic determinants of alcohol consumption in rats and humans. (PMID: 19874574) Tabakoff B … WHO/ISBRA Study on State and Trait Markers of Alcoholism (BMC biology 2009) 3 41
  5. Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors. (PMID: 16144831) Miller PS … Smart TG (The Journal of biological chemistry 2005) 3 4

ExternalLinks

View latest publications for GLRA2 gene in Mastermind

Products for GLRA2 Gene

  • Addgene plasmids for GLRA2

Sources for GLRA2 Gene