This gene encodes a G protein-coupled receptor that is closely related to the glucagon receptor and binds to glucagon-like peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal growth and increases villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. [provided by RefSeq, Dec 2014] See more...

Aliases for GLP2R Gene

Aliases for GLP2R Gene

  • Glucagon Like Peptide 2 Receptor 2 3 5
  • Glucagon-Like Peptide 2 Receptor 2 3 4
  • GLP-2 Receptor 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • GLP-2-R 4
  • GLP-2R 4

External Ids for GLP2R Gene

Previous GeneCards Identifiers for GLP2R Gene

  • GC17P010095
  • GC17P010844
  • GC17P009672
  • GC17P009929
  • GC17P009670

Summaries for GLP2R Gene

Entrez Gene Summary for GLP2R Gene

  • This gene encodes a G protein-coupled receptor that is closely related to the glucagon receptor and binds to glucagon-like peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal growth and increases villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. [provided by RefSeq, Dec 2014]

GeneCards Summary for GLP2R Gene

GLP2R (Glucagon Like Peptide 2 Receptor) is a Protein Coding gene. Diseases associated with GLP2R include Short Bowel Syndrome and Adenosquamous Gallbladder Carcinoma. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and glucagon receptor activity. An important paralog of this gene is GCGR.

UniProtKB/Swiss-Prot Summary for GLP2R Gene

  • This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Tocris Summary for GLP2R Gene

  • Glucagon-like peptide 2 (GLP-2) receptors are members of the glucagon receptor family that also includes glucagon, GLP-1, secretin, GHRH and GIP receptors. GLP-2 receptors are found in the CNS and the gastrointestinal system, with the highest expression levels in the jejunum.

Gene Wiki entry for GLP2R Gene

Additional gene information for GLP2R Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GLP2R Gene

Genomics for GLP2R Gene

GeneHancer (GH) Regulatory Elements for GLP2R Gene

Promoters and enhancers for GLP2R Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J009819 Enhancer 0.4 dbSUPER 506.6 -1.5 -1467 1.9 TRIM28 RBM25 JUND FOS ZNF394 GLP2R GSG1L2 ENSG00000278944
GH17J009825 Promoter 0.3 EPDnew 500.7 +3.7 3699 0.1 GLP2R lnc-GSG1L2-1 DHRS7C lnc-GSG1L2-2
GH17J009826 Promoter 0.3 EPDnew 500.7 +3.3 3303 0.1 GLP2R lnc-GSG1L2-1 lnc-GSG1L2-2
GH17J009835 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 8.2 +15.4 15421 4.5 TCF12 ZNF639 ZNF623 EP300 CTCF CTBP1 OSR2 ESRRA WT1 ZBTB17 MAGOH2P ADPRM DHRS7C GLP2R lnc-GSG1L2-1 lnc-GSG1L2-2
GH17J009225 Enhancer 1.4 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 5.2 -595.0 -595005 4.4 ZIC2 ZNF316 CTCF FOS NANOG TCF12 ZFHX2 STAT3 SUZ12 EBF1 PPIAP52 GLP2R NDEL1 NTN1 CFAP52 LOC105371532 piR-45035-083
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GLP2R on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GLP2R

Top Transcription factor binding sites by QIAGEN in the GLP2R gene promoter:
  • E47
  • GATA-2
  • Ik-3
  • Nkx6-1
  • Olf-1
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • Tal-1

Genomic Locations for GLP2R Gene

Genomic Locations for GLP2R Gene
chr17:9,822,206-9,892,104
(GRCh38/hg38)
Size:
69,899 bases
Orientation:
Plus strand
chr17:9,725,523-9,795,419
(GRCh37/hg19)
Size:
69,897 bases
Orientation:
Plus strand

Genomic View for GLP2R Gene

Genes around GLP2R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLP2R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLP2R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLP2R Gene

Proteins for GLP2R Gene

  • Protein details for GLP2R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95838-GLP2R_HUMAN
    Recommended name:
    Glucagon-like peptide 2 receptor
    Protein Accession:
    O95838
    Secondary Accessions:
    • Q4VAT3

    Protein attributes for GLP2R Gene

    Size:
    553 amino acids
    Molecular mass:
    63001 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GLP2R Gene

Post-translational modifications for GLP2R Gene

  • Glycosylation at Asn97, Asn113, Asn148, and Asn162
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GLP2R Gene

Domains & Families for GLP2R Gene

Gene Families for GLP2R Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for GLP2R Gene

Blocks:
  • G-protein coupled receptors family 2 (secretin-like)
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GLP2R Gene

GenScript: Design optimal peptide antigens:
  • Glucagon-like peptide 2 receptor (GLP2R_HUMAN)
  • GLP2R protein (Q4VAT1_HUMAN)
  • GLP2R protein (Q4VAT2_HUMAN)
  • GLP2R protein (Q4VAT4_HUMAN)
  • GLP2R protein (Q86XI5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95838

UniProtKB/Swiss-Prot:

GLP2R_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family.
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with GLP2R: view

Function for GLP2R Gene

Molecular function for GLP2R Gene

UniProtKB/Swiss-Prot Function:
This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
GENATLAS Biochemistry:
glucagon-like peptide 2 (intestinotrophic) receptor,expressed in the gut,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for GLP2R Gene

Gene Ontology (GO) - Molecular Function for GLP2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA,TAS 9990065
GO:0004967 glucagon receptor activity IBA 21873635
GO:0008528 G protein-coupled peptide receptor activity IBA 21873635
GO:0017046 peptide hormone binding IBA 21873635
genes like me logo Genes that share ontologies with GLP2R: view
genes like me logo Genes that share phenotypes with GLP2R: view

Animal Models for GLP2R Gene

MGI Knock Outs for GLP2R:

Animal Model Products

  • Taconic Biosciences Mouse Models for GLP2R

CRISPR Products

miRNA for GLP2R Gene

miRTarBase miRNAs that target GLP2R

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GLP2R

Clone Products

  • Addgene plasmids for GLP2R

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GLP2R Gene

Localization for GLP2R Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLP2R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLP2R gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GLP2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GLP2R: view

Pathways & Interactions for GLP2R Gene

genes like me logo Genes that share pathways with GLP2R: view

Pathways by source for GLP2R Gene

Gene Ontology (GO) - Biological Process for GLP2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS,IEA --
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway TAS,IEA --
GO:0008284 positive regulation of cell proliferation TAS 9990065
genes like me logo Genes that share ontologies with GLP2R: view

No data available for SIGNOR curated interactions for GLP2R Gene

Drugs & Compounds for GLP2R Gene

(9) Drugs for GLP2R Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Teduglutide Approved Pharma Target, agonist 33
Glucagon Approved Pharma Full agonist, Agonist, Target, agonist 617
GLP-2 (rat) Pharma Endogenous hormone; displays intestinotrophic activity 0
glucagon-like peptide 2 Pharma Full agonist, Agonist 0
glucagon-like peptide 2-(3-33) Pharma Partial agonist, Agonist 0

(1) Additional Compounds for GLP2R Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) Tocris Compounds for GLP2R Gene

Compound Action Cas Number
GLP-2 (human) Endogenous hormone; displays intestinotrophic activity 223460-79-5
GLP-2 (rat) Endogenous hormone; displays intestinotrophic activity 195262-56-7

(2) ApexBio Compounds for GLP2R Gene

Compound Action Cas Number
BIX 01294 G9a and GLP inhibitor 935693-62-2
GLP-2 (rat) 195262-56-7
genes like me logo Genes that share compounds with GLP2R: view

Drug Products

Transcripts for GLP2R Gene

mRNA/cDNA for GLP2R Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GLP2R

Clone Products

  • Addgene plasmids for GLP2R

Alternative Splicing Database (ASD) splice patterns (SP) for GLP2R Gene

No ASD Table

Relevant External Links for GLP2R Gene

GeneLoc Exon Structure for
GLP2R

Expression for GLP2R Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GLP2R Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GLP2R Gene

This gene is overexpressed in Bladder (x6.6), Colon - Sigmoid (x6.6), Small Intestine - Terminal Ileum (x4.8), and Adipose - Visceral (Omentum) (x4.4).

Protein differential expression in normal tissues from HIPED for GLP2R Gene

This gene is overexpressed in Placenta (28.3), Tlymphocyte (15.3), Bone marrow mesenchymal stem cell (10.3), Adipocyte (7.9), and Heart (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GLP2R Gene



Protein tissue co-expression partners for GLP2R Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GLP2R

SOURCE GeneReport for Unigene cluster for GLP2R Gene:

Hs.248202

Evidence on tissue expression from TISSUES for GLP2R Gene

  • Stomach(4.3)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with GLP2R: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLP2R Gene

Orthologs for GLP2R Gene

This gene was present in the common ancestor of chordates.

Orthologs for GLP2R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLP2R 31 30
  • 99.46 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Glp2r 17 31 30
  • 84.26 (n)
dog
(Canis familiaris)
Mammalia GLP2R 31 30
  • 84.04 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GLP2R 31 30
  • 82.82 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Glp2r 30
  • 82.73 (n)
oppossum
(Monodelphis domestica)
Mammalia GLP2R 31
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves GLP2R 31 30
  • 64.43 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GLP2R 31
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia glp2r 30
  • 61.32 (n)
zebrafish
(Danio rerio)
Actinopterygii GLP2R 31
  • 46 (a)
OneToOne
Species where no ortholog for GLP2R was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GLP2R Gene

ENSEMBL:
Gene Tree for GLP2R (if available)
TreeFam:
Gene Tree for GLP2R (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GLP2R: view image

Paralogs for GLP2R Gene

(13) SIMAP similar genes for GLP2R Gene using alignment to 8 proteins:

  • GLP2R_HUMAN
  • E9PC86_HUMAN
  • H0Y6C2_HUMAN
  • I3L0P5_HUMAN
  • Q4VAT1_HUMAN
  • Q4VAT2_HUMAN
  • Q4VAT4_HUMAN
  • Q86XI5_HUMAN
genes like me logo Genes that share paralogs with GLP2R: view

Variants for GLP2R Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GLP2R Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
734846 Benign: not provided 9,833,888(+) C/G MISSENSE_VARIANT
781254 Benign: not provided 9,826,128(+) A/T MISSENSE_VARIANT
781255 Benign: not provided 9,857,438(+) G/A SYNONYMOUS_VARIANT
781256 Benign: not provided 9,889,611(+) G/A MISSENSE_VARIANT
783771 Benign: not provided 9,836,384(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for GLP2R Gene

Structural Variations from Database of Genomic Variants (DGV) for GLP2R Gene

Variant ID Type Subtype PubMed ID
nsv1065401 CNV loss 25217958
nsv1976 CNV deletion 18451855
nsv473444 CNV novel sequence insertion 20440878
nsv833358 CNV gain 17160897
nsv833360 CNV loss 17160897
nsv833361 CNV gain 17160897
nsv978358 CNV duplication 23825009

Variation tolerance for GLP2R Gene

Residual Variation Intolerance Score: 57.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.19; 69.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GLP2R Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLP2R

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLP2R Gene

Disorders for GLP2R Gene

MalaCards: The human disease database

(3) MalaCards diseases for GLP2R Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
short bowel syndrome
  • acquired short bowel syndrome
adenosquamous gallbladder carcinoma
  • adenosquamous carcinoma of gallbladder
mucositis
  • inflammatory disease of mucous membrane
- elite association - COSMIC cancer census association via MalaCards
Search GLP2R in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GLP2R

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GLP2R: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GLP2R Gene

Publications for GLP2R Gene

  1. Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2. (PMID: 9990065) Munroe DG … Crivici A (Proceedings of the National Academy of Sciences of the United States of America 1999) 2 3 4 23 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 41 54
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54
  5. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro AP … Woodside DB (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 41 54

Products for GLP2R Gene

Sources for GLP2R Gene