Aliases for GLP2R Gene
External Ids for GLP2R Gene
Previous GeneCards Identifiers for GLP2R Gene
This gene encodes a G protein-coupled receptor that is closely related to the glucagon receptor and binds to glucagon-like peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal growth and increases villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. [provided by RefSeq, Dec 2014]
GeneCards Summary for GLP2R Gene
GLP2R (Glucagon Like Peptide 2 Receptor) is a Protein Coding gene. Diseases associated with GLP2R include Short Bowel Syndrome and Adenosquamous Gallbladder Carcinoma. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and glucagon receptor activity. An important paralog of this gene is GCGR.
UniProtKB/Swiss-Prot Summary for GLP2R Gene
This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Glucagon-like peptide 2 (GLP-2) receptors are members of the glucagon receptor family that also includes glucagon, GLP-1, secretin, GHRH and GIP receptors. GLP-2 receptors are found in the CNS and the gastrointestinal system, with the highest expression levels in the jejunum.