Aliases for GLP2R Gene
External Ids for GLP2R Gene
Previous GeneCards Identifiers for GLP2R Gene
This gene encodes a G protein-coupled receptor that is closely related to the glucagon receptor and binds to glucagon-like peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal growth and increases villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. [provided by RefSeq, Dec 2014]
GeneCards Summary for GLP2R Gene
GLP2R (Glucagon Like Peptide 2 Receptor) is a Protein Coding gene. Diseases associated with GLP2R include Short Bowel Syndrome and Adenosquamous Gallbladder Carcinoma. Among its related pathways are Signaling by GPCR and Presynaptic function of Kainate receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and glucagon receptor activity. An important paralog of this gene is SCTR.
UniProtKB/Swiss-Prot Summary for GLP2R Gene
This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Glucagon-like peptide 2 (GLP-2) receptors are members of the glucagon receptor family that also includes glucagon, GLP-1, secretin, GHRH and GIP receptors. GLP-2 receptors are found in the CNS and the gastrointestinal system, with the highest expression levels in the jejunum.