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Aliases for GLP1R Gene

Aliases for GLP1R Gene

  • Glucagon Like Peptide 1 Receptor 2 3 5
  • Glucagon-Like Peptide 1 Receptor 2 3
  • GLP-1 Receptor 3 4
  • GLP-1-R 3 4
  • GLP-1R 3 4
  • Seven Transmembrane Helix Receptor 3
  • GLP1 Receptor 3
  • GLP-1 3

External Ids for GLP1R Gene

Previous GeneCards Identifiers for GLP1R Gene

  • GC06P039018
  • GC06P039063
  • GC06P039124
  • GC06P038734

Summaries for GLP1R Gene

Entrez Gene Summary for GLP1R Gene

  • This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]

GeneCards Summary for GLP1R Gene

GLP1R (Glucagon Like Peptide 1 Receptor) is a Protein Coding gene. Diseases associated with GLP1R include Insulinoma and Fasting Hypoglycemia. Among its related pathways are Presynaptic function of Kainate receptors and Metabolism. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and glucagon receptor activity. An important paralog of this gene is GCGR.

UniProtKB/Swiss-Prot for GLP1R Gene

  • G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).

Tocris Summary for GLP1R Gene

  • Glucagon-like peptide 1 (GLP-1) receptors are members of the glucagon receptor family that also includes glucagon, GLP-2, secretin, GHRH and GIP receptors. GLP-1 receptors are found both centrally and peripherally. GLP-1 receptors mediate the effects of the incretin axis.

Gene Wiki entry for GLP1R Gene

Additional gene information for GLP1R Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLP1R Gene

Genomics for GLP1R Gene

GeneHancer (GH) Regulatory Elements for GLP1R Gene

Promoters and enhancers for GLP1R Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J039048 Promoter/Enhancer 0.9 EPDnew dbSUPER 650.7 0.0 -19 0.1 POLR2A CTBP2 ETS1 GLP1R LOC100128655
GH06J039114 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10 +66.3 66294 2.1 HDGF PKNOX1 CLOCK MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 GC06M039604 GC06M039606 GC06M039607 GC06M039609 GC06M039628 PIR34348 SAYSD1 PIR35108 PIR44528 KCNK17
GH06J039101 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.9 +53.3 53342 1.1 CTCF PKNOX1 ATF1 RB1 ZFP64 RAD21 ZNF335 CTBP1 ZBTB48 VEZF1 GC06M039605 PIR34726 SAYSD1 GLP1R KCNK17 KCNK5 LOC105375046 GC06M039634
GH06J039082 Enhancer 0.5 dbSUPER 22.9 +34.5 34505 1.9 ZFHX2 RFX1 GLIS1 ZKSCAN8 KLF9 EGR2 GLP1R SAYSD1 DAAM2 LOC105375046 PIR34726 GC06M039605
GH06J039093 Enhancer 0.8 FANTOM5 dbSUPER 12.5 +44.6 44632 0 FOXA2 NFIA RXRA REST RAD21 FOXA1 SP1 JUND ATF3 HNF4A GLP1R SAYSD1 GC06M039605 PIR34726 LOC105375046
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GLP1R on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GLP1R gene promoter:
  • MEF-2A
  • aMEF-2
  • Chx10
  • TBP
  • RORalpha2
  • AML1a
  • CP2
  • Pax-5
  • Olf-1
  • Pax-6

Genomic Locations for GLP1R Gene

Genomic Locations for GLP1R Gene
chr6:39,048,781-39,091,303
(GRCh38/hg38)
Size:
42,523 bases
Orientation:
Plus strand
chr6:39,016,557-39,055,520
(GRCh37/hg19)
Size:
38,964 bases
Orientation:
Plus strand

Genomic View for GLP1R Gene

Genes around GLP1R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLP1R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLP1R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLP1R Gene

Proteins for GLP1R Gene

  • Protein details for GLP1R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43220-GLP1R_HUMAN
    Recommended name:
    Glucagon-like peptide 1 receptor
    Protein Accession:
    P43220
    Secondary Accessions:
    • Q2M229
    • Q99669

    Protein attributes for GLP1R Gene

    Size:
    463 amino acids
    Molecular mass:
    53026 Da
    Quaternary structure:
    • May form homodimers and heterodimers with GIPR.

    Three dimensional structures from OCA and Proteopedia for GLP1R Gene

neXtProt entry for GLP1R Gene

Post-translational modifications for GLP1R Gene

  • N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.
  • Glycosylation at isoforms=115, Asn82, and Asn63
  • Modification sites at PhosphoSitePlus

Other Protein References for GLP1R Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for GLP1R

No data available for DME Specific Peptides for GLP1R Gene

Domains & Families for GLP1R Gene

Gene Families for GLP1R Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for GLP1R Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P43220

UniProtKB/Swiss-Prot:

GLP1R_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family.
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with GLP1R: view

Function for GLP1R Gene

Molecular function for GLP1R Gene

UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).
UniProtKB/Swiss-Prot EnzymeRegulation:
The allosteric modulators NNC0640, PF-06372222 and MK-0893 inhibit the increase of intracellular cAMP levels in response to GLP-1.
GENATLAS Biochemistry:
glucagon-like peptide 1,receptor,G protein coupled receptor superfamily,mediating the insulinotropic effect of the incretin hormone GLP1,regulated by SP1 and SP3

Gene Ontology (GO) - Molecular Function for GLP1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 8405712
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004967 glucagon receptor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008528 G-protein coupled peptide receptor activity IEA --
genes like me logo Genes that share ontologies with GLP1R: view
genes like me logo Genes that share phenotypes with GLP1R: view

Animal Models for GLP1R Gene

MGI Knock Outs for GLP1R:

Animal Model Products

Clone Products

  • Addgene plasmids for GLP1R

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GLP1R Gene

Localization for GLP1R Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLP1R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLP1R gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GLP1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 28514449
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS 8405712
genes like me logo Genes that share ontologies with GLP1R: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GLP1R Gene

Pathways & Interactions for GLP1R Gene

genes like me logo Genes that share pathways with GLP1R: view

SIGNOR curated interactions for GLP1R Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GLP1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA 28514449
GO:0007190 activation of adenylate cyclase activity TAS 8405712
genes like me logo Genes that share ontologies with GLP1R: view

Drugs & Compounds for GLP1R Gene

(62) Drugs for GLP1R Gene - From: DrugBank, PharmGKB, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Liraglutide Approved Pharma Full agonist, Agonist, agonist, Target 347
Exenatide Approved, Investigational Pharma binder, Target, agonist 312
Albiglutide Approved Pharma activator, Target, agonist 0
Lixisenatide Approved Pharma Target, agonist 0
Sitagliptin Approved, Investigational Pharma 0

(15) Additional Compounds for GLP1R Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]exendin
[<sup>125</sup>I]GLP-1-(7-37)
Full agonist, Agonist
glucagon-like peptide-1-(7-37)
Full agonist, Agonist
GLP-1 (7-37)
106612-94-6
Oxyntomodulin (porcine, bovine)
62340-29-8

(5) Tocris Compounds for GLP1R Gene

Compound Action Cas Number
Exendin-4 Potent GLP-1 receptor agonist 141758-74-9
GLP-1 (7-37) Endogenous bioactive GLP-1 receptor ligand 106612-94-6
Glucagon-like peptide 1 (1-37) (human, rat) Endogenous pancreatic peptide 87805-34-3
Glucagon-like peptide 1 (7-36) amide (human, rat) Potent insulinotropic peptide 107444-51-9
Oxyntomodulin (porcine, bovine) Endogenous gut peptide; modulates feeding and metabolism 62340-29-8
genes like me logo Genes that share compounds with GLP1R: view

Transcripts for GLP1R Gene

mRNA/cDNA for GLP1R Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GLP1R Gene

Glucagon-like peptide 1 receptor:
Representative Sequences:

Clone Products

  • Addgene plasmids for GLP1R

Alternative Splicing Database (ASD) splice patterns (SP) for GLP1R Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c ^ 15
SP1: - -
SP2:
SP3: -
SP4: - - - -

Relevant External Links for GLP1R Gene

GeneLoc Exon Structure for
GLP1R
ECgene alternative splicing isoforms for
GLP1R

Expression for GLP1R Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GLP1R Gene

mRNA differential expression in normal tissues according to GTEx for GLP1R Gene

This gene is overexpressed in Pancreas (x18.8), Heart - Left Ventricle (x5.8), and Heart - Atrial Appendage (x5.7).

Protein differential expression in normal tissues from HIPED for GLP1R Gene

This gene is overexpressed in Platelet (32.1) and Fetal testis (31.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GLP1R Gene



Protein tissue co-expression partners for GLP1R Gene

NURSA nuclear receptor signaling pathways regulating expression of GLP1R Gene:

GLP1R

SOURCE GeneReport for Unigene cluster for GLP1R Gene:

Hs.389103

Evidence on tissue expression from TISSUES for GLP1R Gene

  • Pancreas(4.6)
  • Nervous system(2.2)
  • Blood(2.1)
  • Heart(2)
  • Intestine(2)
genes like me logo Genes that share expression patterns with GLP1R: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLP1R Gene

Orthologs for GLP1R Gene

This gene was present in the common ancestor of chordates.

Orthologs for GLP1R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLP1R 34 33
  • 98.7 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GLP1R 34 33
  • 89.95 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GLP1R 34 33
  • 88.86 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Glp1r 16 34 33
  • 87.19 (n)
rat
(Rattus norvegicus)
Mammalia Glp1r 33
  • 87.04 (n)
oppossum
(Monodelphis domestica)
Mammalia GLP1R 34
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GLP1R 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves GLP-1R 34
  • 76 (a)
OneToOne
GLP1R 33
  • 74.51 (n)
lizard
(Anolis carolinensis)
Reptilia GLP1R 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia glp1r 33
  • 73.2 (n)
Species where no ortholog for GLP1R was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GLP1R Gene

ENSEMBL:
Gene Tree for GLP1R (if available)
TreeFam:
Gene Tree for GLP1R (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GLP1R: view image

Paralogs for GLP1R Gene

Paralogs for GLP1R Gene

(12) SIMAP similar genes for GLP1R Gene using alignment to 1 proteins:

  • GLP1R_HUMAN
genes like me logo Genes that share paralogs with GLP1R: view

Variants for GLP1R Gene

Sequence variations from dbSNP and Humsavar for GLP1R Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000144199 -- 39,088,253(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000181238 -- 39,072,557(+) C/T intron_variant
rs1000184256 -- 39,049,340(+) C/G/T genic_upstream_transcript_variant, intron_variant
rs1000260493 -- 39,087,506(+) G/A 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000262617 -- 39,050,521(+) G/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GLP1R Gene

Variant ID Type Subtype PubMed ID
esv3608753 CNV loss 21293372
nsv1015689 CNV gain 25217958
nsv1027064 CNV gain 25217958
nsv1031922 CNV gain 25217958
nsv462919 CNV loss 19166990
nsv470815 CNV loss 18288195
nsv519907 CNV loss 19592680
nsv528286 CNV gain 19592680
nsv602963 CNV loss 21841781

Variation tolerance for GLP1R Gene

Residual Variation Intolerance Score: 72.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.08; 87.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GLP1R Gene

Human Gene Mutation Database (HGMD)
GLP1R
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLP1R

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLP1R Gene

Disorders for GLP1R Gene

MalaCards: The human disease database

(12) MalaCards diseases for GLP1R Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
insulinoma
  • islet cell tumor
fasting hypoglycemia
pneumatosis cystoides intestinalis
endocrine pancreas disease
  • disorder of endocrine pancreas
hyperglycemia
- elite association - COSMIC cancer census association via MalaCards
Search GLP1R in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GLP1R

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GLP1R: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GLP1R Gene

Publications for GLP1R Gene

  1. Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor. (PMID: 19861722) Underwood CR … Reedtz-Runge S (The Journal of biological chemistry 2010) 3 4 22 58
  2. Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain. (PMID: 18287102) Runge S … Rudolph R (The Journal of biological chemistry 2008) 3 4 22 58
  3. Five missense mutations in glucagon-like peptide 1 receptor gene in Japanese population. (PMID: 15364163) Tokuyama Y … Kanatsuka A (Diabetes research and clinical practice 2004) 3 22 44 58
  4. Signal transduction of the GLP-1-receptor cloned from a human insulinoma. (PMID: 7517895) van Eyll B … Göke B (FEBS letters 1994) 3 4 22 58
  5. Cloning and functional expression of a human glucagon-like peptide-1 receptor. (PMID: 8216285) Graziano MP … Strader CD (Biochemical and biophysical research communications 1993) 3 4 22 58

Products for GLP1R Gene

  • Addgene plasmids for GLP1R

Sources for GLP1R Gene

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