This gene encodes a protein with a glyoxalase domain. [provided by RefSeq, Sep 2011] See more...

Aliases for GLOD5 Gene

Aliases for GLOD5 Gene

  • Glyoxalase Domain Containing 5 2 3 5
  • Glyoxalase Domain-Containing Protein 5 3 4
  • GLOD5 5

External Ids for GLOD5 Gene

Previous GeneCards Identifiers for GLOD5 Gene

  • GC0XP048509
  • GC0XP048620
  • GC0XP046281

Summaries for GLOD5 Gene

Entrez Gene Summary for GLOD5 Gene

  • This gene encodes a protein with a glyoxalase domain. [provided by RefSeq, Sep 2011]

GeneCards Summary for GLOD5 Gene

GLOD5 (Glyoxalase Domain Containing 5) is a Protein Coding gene. An important paralog of this gene is MCEE.

Additional gene information for GLOD5 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GLOD5 Gene

Genomics for GLOD5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GLOD5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GLOD5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GLOD5

Top Transcription factor binding sites by QIAGEN in the GLOD5 gene promoter:
  • AML1a
  • c-Rel
  • PPAR-gamma2
  • Sp1
  • SRF
  • SRF (504 AA)

Genomic Locations for GLOD5 Gene

Genomic Locations for GLOD5 Gene
12,077 bases
Plus strand
11,911 bases
Plus strand

Genomic View for GLOD5 Gene

Genes around GLOD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLOD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLOD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLOD5 Gene

Proteins for GLOD5 Gene

  • Protein details for GLOD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glyoxalase domain-containing protein 5
    Protein Accession:

    Protein attributes for GLOD5 Gene

    160 amino acids
    Molecular mass:
    18322 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GLOD5 Gene

neXtProt entry for GLOD5 Gene

Post-translational modifications for GLOD5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GLOD5 Gene

No data available for DME Specific Peptides for GLOD5 Gene

Domains & Families for GLOD5 Gene

Gene Families for GLOD5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GLOD5 Gene

Suggested Antigen Peptide Sequences for GLOD5 Gene

GenScript: Design optimal peptide antigens:
  • Glyoxalase domain-containing protein 5 (GLOD5_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glyoxalase I family.
  • Belongs to the glyoxalase I family.
genes like me logo Genes that share domains with GLOD5: view

Function for GLOD5 Gene

Phenotypes From GWAS Catalog for GLOD5 Gene

genes like me logo Genes that share phenotypes with GLOD5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GLOD5

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GLOD5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GLOD5 Gene

Localization for GLOD5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLOD5 gene
Compartment Confidence
mitochondrion 2
cytosol 2
nucleus 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GLOD5 Gene

Pathways & Interactions for GLOD5 Gene

PathCards logo

SuperPathways for GLOD5 Gene

No Data Available

Interacting Proteins for GLOD5 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000302552 A6NK44-GLOD5_HUMAN for GLOD5 Gene via STRING IID

Gene Ontology (GO) - Biological Process for GLOD5 Gene


No data available for Pathways by source and SIGNOR curated interactions for GLOD5 Gene

Drugs & Compounds for GLOD5 Gene

No Compound Related Data Available

Transcripts for GLOD5 Gene

mRNA/cDNA for GLOD5 Gene

3 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GLOD5

Alternative Splicing Database (ASD) splice patterns (SP) for GLOD5 Gene

No ASD Table

Relevant External Links for GLOD5 Gene

GeneLoc Exon Structure for

Expression for GLOD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GLOD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GLOD5 Gene

This gene is overexpressed in Kidney - Cortex (x14.6), Colon - Transverse (x10.9), Liver (x7.7), and Small Intestine - Terminal Ileum (x7.1).

Protein differential expression in normal tissues from HIPED for GLOD5 Gene

This gene is overexpressed in Rectum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GLOD5 Gene

Protein tissue co-expression partners for GLOD5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GLOD5

SOURCE GeneReport for Unigene cluster for GLOD5 Gene:

genes like me logo Genes that share expression patterns with GLOD5: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLOD5 Gene

Orthologs for GLOD5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GLOD5 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia GLOD5 30 31
  • 89.79 (n)
(Bos Taurus)
Mammalia GLOD5 30
  • 88.53 (n)
(Rattus norvegicus)
Mammalia Glod5 30
  • 84.23 (n)
(Mus musculus)
Mammalia Glod5 30 17 31
  • 82.66 (n)
(Ornithorhynchus anatinus)
Mammalia GLOD5 31
  • 66 (a)
(Monodelphis domestica)
Mammalia GLOD5 31
  • 55 (a)
(Gallus gallus)
Aves GLOD5 30 31
  • 69.81 (n)
(Anolis carolinensis)
Reptilia GLOD5 31
  • 64 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia glod5 30
  • 62.01 (n)
(Danio rerio)
Actinopterygii zgc:112315 30
  • 66.14 (n)
GLOD5 31
  • 56 (a)
Species where no ortholog for GLOD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GLOD5 Gene

Gene Tree for GLOD5 (if available)
Gene Tree for GLOD5 (if available)
Evolutionary constrained regions (ECRs) for GLOD5: view image

Paralogs for GLOD5 Gene

Paralogs for GLOD5 Gene

genes like me logo Genes that share paralogs with GLOD5: view

Variants for GLOD5 Gene

Additional dbSNP identifiers (rs#s) for GLOD5 Gene

Structural Variations from Database of Genomic Variants (DGV) for GLOD5 Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV gain+loss 17666407
esv3576862 CNV gain 25503493
nsv528292 CNV gain 19592680

Variation tolerance for GLOD5 Gene

Residual Variation Intolerance Score: 92.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.22; 52.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GLOD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GLOD5 Gene

Disorders for GLOD5 Gene

No disorders were found for GLOD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLOD5 Gene

Publications for GLOD5 Gene

  1. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3
  2. A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. (PMID: 19377476) Tarpey PS … Stratton MR (Nature genetics 2009) 3
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for GLOD5 Gene

Sources for GLOD5 Gene