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Aliases for GLOD4 Gene

Aliases for GLOD4 Gene

  • Glyoxalase Domain Containing 4 2 3 5
  • C17orf25 3 4
  • Glyoxalase Domain-Containing Protein 4 3
  • Chromosome 17 Open Reading Frame 25 2
  • CGI-150 3
  • HC71 3

External Ids for GLOD4 Gene

Previous HGNC Symbols for GLOD4 Gene

  • C17orf25

Previous GeneCards Identifiers for GLOD4 Gene

  • GC17M000610
  • GC17M000662
  • GC17M000675
  • GC17M000685
  • GC17M000698
  • GC17M000710

Summaries for GLOD4 Gene

GeneCards Summary for GLOD4 Gene

GLOD4 (Glyoxalase Domain Containing 4) is a Protein Coding gene.

Gene Wiki entry for GLOD4 Gene

Additional gene information for GLOD4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLOD4 Gene

Genomics for GLOD4 Gene

GeneHancer (GH) Regulatory Elements for GLOD4 Gene

Promoters and enhancers for GLOD4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J000781 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +1.1 1090 2.2 PKNOX1 CLOCK MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 MRM3 GLOD4 PRPF8 ENSG00000262228 GEMIN4 CRK MYO1C
GH17J000784 Enhancer 0.3 Ensembl 650.7 -1.1 -1111 0.2 ZBTB17 GLOD4 VPS53 MRM3 ENSG00000262434
GH17J000975 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 11 -195.0 -195034 6.7 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZNF121 GLIS2 ZNF213 ZNF143 DEK NXN PRPF8 WDR81 SMYD4 ENSG00000262920 GEMIN4 GLOD4 MRM3 ENSG00000262228 ENSG00000263017
GH17J000750 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.5 +31.1 31063 3.5 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B GEMIN4 DBIL5P VPS53 PIR42448 PRPF8 FAM57A MRM3 WDR81 GLOD4 ENSG00000262920
GH17J000713 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.3 +67.8 67834 3.2 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B VPS53 GC17P000714 GEMIN4 PRPF8 FAM57A ENSG00000262920 ENSG00000262228 DBIL5P TIMM22 GLOD4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GLOD4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GLOD4 gene promoter:
  • CUTL1
  • YY1
  • ARP-1
  • POU2F1a
  • POU2F1
  • C/EBPalpha
  • FOXO1
  • FOXO1a
  • NF-1

Genomic Locations for GLOD4 Gene

Genomic Locations for GLOD4 Gene
26,294 bases
Minus strand
25,245 bases
Minus strand

Genomic View for GLOD4 Gene

Genes around GLOD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLOD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLOD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLOD4 Gene

Proteins for GLOD4 Gene

  • Protein details for GLOD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glyoxalase domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • D3DTG9
    • D3DTH1
    • Q96B89
    • Q9H3J8
    • Q9HC37
    • Q9NVN1

    Protein attributes for GLOD4 Gene

    313 amino acids
    Molecular mass:
    34793 Da
    Quaternary structure:
    • Interacts with NUDT9.
    • Expression is decreased in hepatocellular carcinoma samples as compared to adjacent non-cancerous liver tissues from the same patients. Transfection in hepatocellular carcinoma cells and overexpression can inhibit the cell growth.

    Three dimensional structures from OCA and Proteopedia for GLOD4 Gene

    Alternative splice isoforms for GLOD4 Gene


neXtProt entry for GLOD4 Gene

Post-translational modifications for GLOD4 Gene

  • Ubiquitination at Lys30, isoforms=2239, and Lys139
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GLOD4 Gene

Domains & Families for GLOD4 Gene

Gene Families for GLOD4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GLOD4 Gene

Suggested Antigen Peptide Sequences for GLOD4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glyoxalase I family.
  • Belongs to the glyoxalase I family.
genes like me logo Genes that share domains with GLOD4: view

Function for GLOD4 Gene

Phenotypes From GWAS Catalog for GLOD4 Gene

Gene Ontology (GO) - Molecular Function for GLOD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with GLOD4: view
genes like me logo Genes that share phenotypes with GLOD4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GLOD4

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GLOD4 Gene

Localization for GLOD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLOD4 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLOD4 gene
Compartment Confidence
extracellular 5
mitochondrion 4
cytosol 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GLOD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with GLOD4: view

Pathways & Interactions for GLOD4 Gene

SuperPathways for GLOD4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GLOD4 Gene


No data available for Pathways by source and SIGNOR curated interactions for GLOD4 Gene

Drugs & Compounds for GLOD4 Gene

No Compound Related Data Available

Transcripts for GLOD4 Gene

Unigene Clusters for GLOD4 Gene

Glyoxalase domain containing 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLOD4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: - - - - -
SP2: -
SP3: - - -
SP4: -
SP6: - -

Relevant External Links for GLOD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GLOD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GLOD4 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GLOD4 Gene

Protein tissue co-expression partners for GLOD4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GLOD4 Gene:


SOURCE GeneReport for Unigene cluster for GLOD4 Gene:


mRNA Expression by UniProt/SwissProt for GLOD4 Gene:

Tissue specificity: Expressed in heart, brain, liver, kidney, pancreas and placenta. Not expressed in skeletal muscle and lung.

Evidence on tissue expression from TISSUES for GLOD4 Gene

  • Nervous system(4.8)
  • Liver(4.4)
genes like me logo Genes that share expression patterns with GLOD4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLOD4 Gene

Orthologs for GLOD4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GLOD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GLOD4 34 33
  • 99.33 (n)
(Canis familiaris)
Mammalia GLOD4 34 33
  • 91.72 (n)
(Mus musculus)
Mammalia Glod4 16 34 33
  • 88.7 (n)
(Rattus norvegicus)
Mammalia Glod4 33
  • 88.37 (n)
(Bos Taurus)
Mammalia GLOD4 34 33
  • 87.25 (n)
(Monodelphis domestica)
Mammalia GLOD4 34
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia GLOD4 34
  • 74 (a)
(Gallus gallus)
Aves GLOD4 34 33
  • 75.76 (n)
(Anolis carolinensis)
Reptilia GLOD4 34
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia glod4 33
  • 70.15 (n)
MGC76089 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.10609 33
(Danio rerio)
Actinopterygii glod4 34 33
  • 69.92 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1532 34 33
  • 57.21 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000367 33
  • 52.35 (n)
(Caenorhabditis elegans)
Secernentea glod-4 34 33
  • 55.28 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G67280 33
  • 45.64 (n)
(Oryza sativa)
Liliopsida Os05g0230900 33
  • 47.54 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 57 (a)
Species where no ortholog for GLOD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLOD4 Gene

Gene Tree for GLOD4 (if available)
Gene Tree for GLOD4 (if available)
Evolutionary constrained regions (ECRs) for GLOD4: view image

Paralogs for GLOD4 Gene

(1) SIMAP similar genes for GLOD4 Gene using alignment to 11 proteins:

  • B7Z403_HUMAN
  • I3L1F4_HUMAN
  • I3L1I0_HUMAN
  • I3L277_HUMAN
  • I3L2C2_HUMAN
  • I3L3G0_HUMAN
  • I3L3Q4_HUMAN
  • I3NI24_HUMAN
  • I3NI27_HUMAN
  • K7ENF2_HUMAN Pseudogenes for GLOD4 Gene

genes like me logo Genes that share paralogs with GLOD4: view

No data available for Paralogs for GLOD4 Gene

Variants for GLOD4 Gene

Sequence variations from dbSNP and Humsavar for GLOD4 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000062636 -- 759,579(-) G/A 3_prime_UTR_variant
rs1000116664 -- 765,274(-) C/A intron_variant
rs1000304722 -- 779,498(-) C/T intron_variant
rs1000387183 -- 782,045(-) T/G 5_prime_UTR_variant, intron_variant
rs1000635563 -- 780,861(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GLOD4 Gene

Variant ID Type Subtype PubMed ID
dgv3071n100 CNV gain 25217958
dgv3072n100 CNV gain 25217958
dgv3074n100 CNV gain 25217958
dgv3075n100 CNV loss 25217958
dgv393e201 CNV deletion 23290073
dgv5386n54 CNV gain 21841781
dgv5387n54 CNV loss 21841781
dgv5389n54 CNV gain 21841781
esv1080251 CNV deletion 17803354
esv2260949 CNV deletion 18987734
esv23272 CNV loss 19812545
esv2422420 CNV duplication 17116639
esv2670126 CNV deletion 23128226
esv2715352 CNV deletion 23290073
esv2715353 CNV deletion 23290073
esv2715354 CNV deletion 23290073
esv2715355 CNV deletion 23290073
esv2758673 CNV gain 17122850
esv3639625 CNV gain 21293372
esv3639638 CNV gain 21293372
esv3639639 CNV loss 21293372
esv3639641 CNV gain 21293372
esv3892944 CNV gain 25118596
nsv1057000 CNV gain 25217958
nsv1058033 CNV loss 25217958
nsv1060084 CNV gain 25217958
nsv1062294 CNV loss 25217958
nsv1063272 CNV gain 25217958
nsv1064955 CNV gain 25217958
nsv457631 CNV gain 19166990
nsv469891 CNV loss 16826518
nsv475648 CNV novel sequence insertion 20440878
nsv574091 CNV gain 21841781

Variation tolerance for GLOD4 Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.33; 53.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GLOD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLOD4 Gene

Disorders for GLOD4 Gene

Additional Disease Information for GLOD4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GLOD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLOD4 Gene

Publications for GLOD4 Gene

  1. Cloning and characterization of a novel gene (C17orf25) from the deletion region on chromosome 17p13.3 in hepatocelular carcinoma. (PMID: 11642406) Qin WX … Gu JR (Cell research 2001) 2 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Interaction of C17orf25 with ADP-ribose pyrophosphatase NUDT9 detected via yeast two-hybrid method. (PMID: 12897971) Zhang HT … Gong Y (Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica 2003) 3 4 58

Products for GLOD4 Gene

Sources for GLOD4 Gene

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