Aliases for GLO1 Gene
External Ids for GLO1 Gene
Previous GeneCards Identifiers for GLO1 Gene
The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq, Jul 2008]
GeneCards Summary for GLO1 Gene
GLO1 (Glyoxalase I) is a Protein Coding gene. Diseases associated with GLO1 include Triosephosphate Isomerase Deficiency and Hyperglycemia. Among its related pathways are Pyruvate metabolism and Citric Acid (TCA) cycle and Metabolism. Gene Ontology (GO) annotations related to this gene include lactoylglutathione lyase activity. An important paralog of this gene is GLOD4.
UniProtKB/Swiss-Prot Summary for GLO1 Gene
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis.