The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq, Jul 2008] See more...

Aliases for GLO1 Gene

Aliases for GLO1 Gene

  • Glyoxalase I 2 3 4 5
  • S-D-Lactoylglutathione Methylglyoxal Lyase 3 4
  • Glyoxalase Domain Containing 1 2 3
  • Lactoylglutathione Lyase 3 4
  • Ketone-Aldehyde Mutase 3 4
  • Methylglyoxalase 3 4
  • Aldoketomutase 3 4
  • EC 4.4.1.5 4 50
  • GLOD1 2 3
  • Glx I 3 4
  • Epididymis Secretory Protein Li 74 3
  • Lactoyl Glutathione Lyase 3
  • HEL-S-74 3
  • GLYI 3
  • GLO1 5

External Ids for GLO1 Gene

Previous GeneCards Identifiers for GLO1 Gene

  • GC06M038645
  • GC06M038690
  • GC06M038751
  • GC06M038361
  • GC06M038643
  • GC06M038981
  • GC06M039800
  • GC06M039976
  • GC06M041312
  • GC06M038784
  • GC06M038837
  • GC06M042239
  • GC06M043499

Summaries for GLO1 Gene

Entrez Gene Summary for GLO1 Gene

  • The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq, Jul 2008]

GeneCards Summary for GLO1 Gene

GLO1 (Glyoxalase I) is a Protein Coding gene. Diseases associated with GLO1 include Triosephosphate Isomerase Deficiency and Hyperglycemia. Among its related pathways are Metabolism and Pyruvate metabolism and Citric Acid (TCA) cycle. Gene Ontology (GO) annotations related to this gene include lactoylglutathione lyase activity. An important paralog of this gene is GLOD4.

UniProtKB/Swiss-Prot Summary for GLO1 Gene

  • Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis.

Gene Wiki entry for GLO1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GLO1 Gene

Genomics for GLO1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GLO1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J038701 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 269.5 +1.0 1037 3.4 SP1 ZNF207 ZNF600 SIX5 JUND ZNF592 POLR2A ATF3 ZSCAN16 YY1 GLO1 HSALNG0049886 ANKRD18EP BTBD9 piR-36575-061
GH06J038754 Enhancer 0.8 Ensembl ENCODE 23.4 -52.6 -52604 1.8 ATF2 JUND ZNF217 CTBP1 PRDM6 SMARCE1 DPF2 NFIB JUN PKNOX1 GLO1 DNAH8 HSALNG0049892 RF00017-5020 ZRF1PS GLP1R
GH06J038638 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 9.3 +63.3 63328 3.2 ZNF207 MYC ZNF600 ZNF580 ATF2 POLR2A ZIC2 ZBTB10 KLF7 NR2C1 BTBD9 HSALNG0049877 HSALNG0049878 LOC105375044 lnc-DNAH8-2 DNAH8 GLO1 RF00017-5015 ZFAND3
GH06J038673 Enhancer 0.9 Ensembl ENCODE 21.1 +29.2 29244 1.4 ZNF600 ZBTB33 BHLHE40 SPI1 SP1 GLIS1 ZNF18 ZFP69B MEIS2 HDAC1 HSALNG0049884 piR-35672-046 GLO1 BTBD9 RF00017-5018 lnc-DNAH8-2
GH06J038676 Enhancer 0.7 Ensembl ENCODE 22.2 +26.0 25996 3.1 ZNF639 CCAR2 SUPT5H ZNF366 HLF SPI1 ZNF512 ETV6 PRDM1 HSALNG0049884 GLO1 BTBD9 HSALNG0049885 lnc-DNAH8-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GLO1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GLO1

Top Transcription factor binding sites by QIAGEN in the GLO1 gene promoter:
  • AREB6
  • C/EBPalpha
  • FOXO4
  • GR
  • GR-alpha
  • HNF-3beta
  • Ik-2
  • p53
  • STAT1
  • STAT3

Genomic Locations for GLO1 Gene

Latest Assembly
chr6:38,675,925-38,703,145
(GRCh38/hg38)
Size:
27,221 bases
Orientation:
Minus strand

Previous Assembly
chr6:38,643,701-38,670,921
(GRCh37/hg19 by Entrez Gene)
Size:
27,221 bases
Orientation:
Minus strand

chr6:38,643,701-38,670,917
(GRCh37/hg19 by Ensembl)
Size:
27,217 bases
Orientation:
Minus strand

Genomic View for GLO1 Gene

Genes around GLO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLO1 Gene

Proteins for GLO1 Gene

  • Protein details for GLO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04760-LGUL_HUMAN
    Recommended name:
    Lactoylglutathione lyase
    Protein Accession:
    Q04760
    Secondary Accessions:
    • B2R6P7
    • B4DDV0
    • P78375
    • Q59EL0
    • Q5TZW3
    • Q96FC0
    • Q96J41

    Protein attributes for GLO1 Gene

    Size:
    184 amino acids
    Molecular mass:
    20778 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=BAD93038.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GLO1 Gene

    Alternative splice isoforms for GLO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLO1 Gene

Selected DME Specific Peptides for GLO1 Gene

Q04760:
  • FVKKPDDGKMKG
  • MKFSLYFLAYEDKNDIPK
  • RFEELGV
  • KSLDFYTRVLG
  • ELTHNWGT
  • YHNGNSDPRGFGHIGI
  • PDGYWIE

Post-translational modifications for GLO1 Gene

  • Glutathionylation at Cys-139 inhibits enzyme activity.
  • Phosphorylated at Thr-107 in the presence of CaMK2. However, this is a consensus site for phosphorylation by CK2 so phosphorylation may be mediated by CK2 rather than CaMK2. Phosphorylation is induced by TNF and suppresses the TNF-induced transcriptional activity of NF-kappa-B.
  • Exists in a nitric oxide (NO)-modified form. The exact nature of the modification is unknown, but it suppresses the TNF-induced transcriptional activity of NF-kappa-B.
  • Ubiquitination at Lys44, Lys140, and Lys148
  • Modification sites at PhosphoSitePlus

Other Protein References for GLO1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GLO1 Gene

Gene Families for GLO1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for GLO1 Gene

InterPro:
Blocks:
  • Glyoxalase/Bleomycin resistance protein/dioxygenase domain
  • Glyoxalase I
  • Glyoxalase/extradiol ring-cleavage dioxygenase

Suggested Antigen Peptide Sequences for GLO1 Gene

GenScript: Design optimal peptide antigens:
  • S-D-lactoylglutathione methylglyoxal lyase (LGUL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q04760

UniProtKB/Swiss-Prot:

LGUL_HUMAN :
  • Belongs to the glyoxalase I family.
Family:
  • Belongs to the glyoxalase I family.
genes like me logo Genes that share domains with GLO1: view

Function for GLO1 Gene

Molecular function for GLO1 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(R)-S-lactoylglutathione = glutathione + methylglyoxal; Xref=Rhea:RHEA:19069, ChEBI:CHEBI:17158, ChEBI:CHEBI:57474, ChEBI:CHEBI:57925; EC=4.4.1.5; Evidence={ECO:0000269|PubMed:23122816, ECO:0000269|PubMed:9705294};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.3 mM for methylglyoxal/glutathione (native form) {ECO:0000269|PubMed:20454679}; KM=0.7 mM for methylglyoxal/glutathione (reduced form) {ECO:0000269|PubMed:20454679}; Vmax=0.335 umol/min/mg enzyme with methylglyoxal/glutathione as substrate (native form) {ECO:0000269|PubMed:20454679}; Vmax=0.7 umol/min/mg enzyme with methylglyoxal/glutathione as substrate (reduced form) {ECO:0000269|PubMed:20454679}; Note=Reduction of GLO1 was carried out by incubation with 20 mM betamercaptoethanol prior to kinetic analysis.;
UniProtKB/Swiss-Prot EnzymeRegulation:
Regulated by oxidation of Cys-139 in response to the redox state of the cell. Results in the alternative formation of cystine or glutathione-bound cysteine, the latter modification leading to reduced enzyme activity.
GENATLAS Biochemistry:
glyoxalase I

Enzyme Numbers (IUBMB) for GLO1 Gene

Phenotypes From GWAS Catalog for GLO1 Gene

Gene Ontology (GO) - Molecular Function for GLO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004462 lactoylglutathione lyase activity TAS,IDA 9705294
GO:0005515 protein binding IPI 32296183
GO:0008270 zinc ion binding IEA,IDA 9705294
GO:0016829 lyase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GLO1: view
genes like me logo Genes that share phenotypes with GLO1: view

Animal Models for GLO1 Gene

MGI Knock Outs for GLO1:
  • Glo1 Glo1<tm1a(KOMP)Mbp>
  • Glo1 Glo1<tm1a(KOMP)Wtsi>

Animal Models for research

  • Taconic Biosciences Mouse Models for GLO1

miRNA for GLO1 Gene

miRTarBase miRNAs that target GLO1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GLO1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GLO1 Gene

Localization for GLO1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLO1 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
extracellular 4
mitochondrion 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GLO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm TAS 16130169
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with GLO1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GLO1 Gene

Pathways & Interactions for GLO1 Gene

genes like me logo Genes that share pathways with GLO1: view

Pathways by source for GLO1 Gene

UniProtKB/Swiss-Prot Q04760-LGUL_HUMAN

  • Pathway: Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.

Gene Ontology (GO) - Biological Process for GLO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006090 pyruvate metabolic process TAS --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0006749 glutathione metabolic process IEA --
GO:0009438 methylglyoxal metabolic process IEA --
genes like me logo Genes that share ontologies with GLO1: view

No data available for SIGNOR curated interactions for GLO1 Gene

Drugs & Compounds for GLO1 Gene

(39) Drugs for GLO1 Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved, Investigational Nutra Target 0
Indomethacin Approved, Investigational Pharma Target, inhibitor Cox inhibitor 154
S-Hexylglutathione Experimental Pharma Target 0
Mercaptoethanol Experimental Pharma Target 0
methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoate Experimental Pharma Target 0

(26) Additional Compounds for GLO1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
S-Lactoylglutathione
  • S-D-Lactoylglutathione
  • (R)-S-Lactoylglutathione
  • D-Lactoylglutathione
  • delta-Lactoylglutathione
  • N-(N-L-gamma-Glutamyl-S-(2-hydroxy-1-oxopropyl)-L-cysteinyl)-glycine
25138-66-3

(1) ApexBio Compounds for GLO1 Gene

Compound Action Cas Number
Glyoxalase I inhibitor Glyoxalase I inhibitor 221174-33-0
genes like me logo Genes that share compounds with GLO1: view

Drug products for research

Transcripts for GLO1 Gene

mRNA/cDNA for GLO1 Gene

1 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GLO1

Alternative Splicing Database (ASD) splice patterns (SP) for GLO1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: -
SP3: - - - -
SP4:

Relevant External Links for GLO1 Gene

GeneLoc Exon Structure for
GLO1

Expression for GLO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GLO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GLO1 Gene

This gene is overexpressed in Bone (20.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GLO1 Gene



Protein tissue co-expression partners for GLO1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GLO1

SOURCE GeneReport for Unigene cluster for GLO1 Gene:

Hs.268849

Evidence on tissue expression from TISSUES for GLO1 Gene

  • Nervous system(5)
  • Intestine(4.8)
  • Liver(4.7)
  • Eye(4.7)
  • Blood(4.7)
  • Skin(4)
  • Kidney(3.7)
  • Lung(3.7)
  • Heart(2.8)
  • Muscle(2.6)
  • Pancreas(2.3)
  • Adrenal gland(2.1)
  • Spleen(2.1)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with GLO1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLO1 Gene

Orthologs for GLO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GLO1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GLO1 29 30
  • 99.09 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GLO1 29 30
  • 91.67 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GLO1 29 30
  • 90.76 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia GLO1 30
  • 84 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Glo1 29 16 30
  • 82.43 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Glo1 29
  • 82.25 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia GLO1 30
  • 77 (a)
OneToOne
Chicken
(Gallus gallus)
Aves GLO1 29 30
  • 82.31 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GLO1 30
  • 84 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia glo1 29
  • 70.15 (n)
Str.7707 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.5524 29
Zebrafish
(Danio rerio)
Actinopterygii glo1 29 29 30
  • 69.16 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG1707 29 30 31
  • 60.82 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012071 29
  • 55.43 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GLO1 29 30 32
  • 56.25 (n)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F06226g 29
  • 55.64 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ADR286C 29
  • 52.31 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT1G08110 29
  • 61.18 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.865 29
Soybean
(Glycine max)
eudicotyledons Gma.4045 29
Rice
(Oryza sativa)
Liliopsida Os05g0295800 29
  • 63.57 (n)
Os.11010 29
Barley
(Hordeum vulgare)
Liliopsida Hv.11411 29
Corn
(Zea mays)
Liliopsida Zm.16759 29
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes glo1 29
  • 58.02 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU04815 29
  • 53.7 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.11135 29
Species where no ortholog for GLO1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GLO1 Gene

ENSEMBL:
Gene Tree for GLO1 (if available)
TreeFam:
Gene Tree for GLO1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GLO1: view image
Alliance of Genome Resources:
Additional Orthologs for GLO1

Paralogs for GLO1 Gene

Paralogs for GLO1 Gene

genes like me logo Genes that share paralogs with GLO1: view

Variants for GLO1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for GLO1 Gene

LGUL_HUMAN-Q04760
Exists in three separable isoforms which originate from two alleles in the genome. These correspond to two homodimers and one heterodimer composed of two subunits showing different electrophoretic properties.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GLO1 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs201361403 Likely Benign: not provided 38,682,106(-) C/T
NM_006708.3(GLO1):c.377-5G>A
INTRON
rs4746 Uncertain Significance: Autism 1 38,682,852(-) T/Gp.Glu111Ala
NM_006708.3(GLO1):c.332A>C (p.Glu111Ala)
MISSENSE
rs17855424 -- p.Cys19Tyr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GLO1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GLO1 Gene

Variant ID Type Subtype PubMed ID
esv2759421 CNV gain+loss 17122850
esv3608747 CNV loss 21293372
nsv1015689 CNV gain 25217958
nsv428144 CNV gain 18775914
nsv507326 OTHER sequence alteration 20534489
nsv830642 CNV loss 17160897

Variation tolerance for GLO1 Gene

Residual Variation Intolerance Score: 26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.48; 88.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GLO1 Gene

Human Gene Mutation Database (HGMD)
GLO1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLO1
Leiden Open Variation Database (LOVD)
GLO1

SNP Genotyping and Copy Number Assays for research

Disorders for GLO1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for GLO1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
triosephosphate isomerase deficiency
  • tpid
hyperglycemia
restless legs syndrome
  • wed
autism
  • autistic disorder
mood disorder
  • episodic mood disorder
- elite association - COSMIC cancer census association via MalaCards
Search GLO1 in MalaCards View complete list of genes associated with diseases

Genatlas disease for GLO1 Gene

glyoxalase I deficiency

Additional Disease Information for GLO1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with GLO1: view

No data available for UniProtKB/Swiss-Prot for GLO1 Gene

Publications for GLO1 Gene

  1. Human glyoxalase I. cDNA cloning, expression, and sequence similarity to glyoxalase I from Pseudomonas putida. (PMID: 7684374) Kim NS … Kato S (The Journal of biological chemistry 1993) 2 3 4 22
  2. Posttranslational modification of human glyoxalase 1 indicates redox-dependent regulation. (PMID: 20454679) Birkenmeier G … Birkemeyer C (PloS one 2010) 3 4 22
  3. Polymorphisms in glyoxalase 1 gene are not associated with vascular complications: the Hoorn and CoDAM studies. (PMID: 19412133) Engelen L … Schalkwijk CG (Journal of hypertension 2009) 3 22 40
  4. CYP17, GSTP1, PON1 and GLO1 gene polymorphisms as risk factors for breast cancer: an Italian case-control study. (PMID: 19379515) Antognelli C … Rulli A (BMC cancer 2009) 3 22 40
  5. Lack of evidence to support the glyoxalase 1 gene (GLO1) as a risk gene of autism in Han Chinese patients from Taiwan. (PMID: 18721844) Wu YY … Chen CH (Progress in neuro-psychopharmacology & biological psychiatry 2008) 3 22 40

Products for GLO1 Gene

Sources for GLO1 Gene