Aliases for GLMP Gene

Aliases for GLMP Gene

  • Glycosylated Lysosomal Membrane Protein 2 3 4 5
  • Kidney Lysosomal Membrane Protein 2 3
  • Lysosomal Protein NCU-G1 3 4
  • C1orf85 3 4
  • NCU-G1 2 3
  • Chromosome 1 Open Reading Frame 85 2
  • Kidney Predominant Protein NCU-G1 3
  • MGC31963 2
  • GLMP 5

External Ids for GLMP Gene

Previous HGNC Symbols for GLMP Gene

  • C1orf85

Summaries for GLMP Gene

GeneCards Summary for GLMP Gene

GLMP (Glycosylated Lysosomal Membrane Protein) is a Protein Coding gene. Diseases associated with GLMP include Multilocular Clear Cell Renal Cell Carcinoma. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and nuclear receptor transcription coactivator activity.

Additional gene information for GLMP Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GLMP Gene

Genomics for GLMP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GLMP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GLMP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GLMP

Genomic Locations for GLMP Gene

Genomic Locations for GLMP Gene
5,601 bases
Minus strand
5,584 bases
Minus strand

Genomic View for GLMP Gene

Genes around GLMP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLMP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLMP Gene

Proteins for GLMP Gene

  • Protein details for GLMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glycosylated lysosomal membrane protein
    Protein Accession:
    Secondary Accessions:
    • A6NH16
    • B4DJN4
    • Q5SZX4
    • Q6UX96
    • Q8IV07
    • Q96F65

    Protein attributes for GLMP Gene

    406 amino acids
    Molecular mass:
    43864 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH11575.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GLMP Gene


neXtProt entry for GLMP Gene

Post-translational modifications for GLMP Gene

  • Highly N-glycosylated.
  • Glycosylation at Asn134, Asn65, Asn159, Asn187, and Asn230
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • GLMP_HUMAN (794)

No data available for DME Specific Peptides for GLMP Gene

Domains & Families for GLMP Gene

Gene Families for GLMP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GLMP Gene


Suggested Antigen Peptide Sequences for GLMP Gene

GenScript: Design optimal peptide antigens:
  • Lysosomal protein NCU-G1 (NCUG1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GLMP family.
  • Belongs to the GLMP family.
genes like me logo Genes that share domains with GLMP: view

Function for GLMP Gene

Molecular function for GLMP Gene

UniProtKB/Swiss-Prot Induction:
Transcription is activated by TFEB.

Phenotypes From GWAS Catalog for GLMP Gene

Gene Ontology (GO) - Molecular Function for GLMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IDA 18021396
GO:0003700 DNA-binding transcription factor activity IMP 18021396
GO:0044212 transcription regulatory region DNA binding IDA --
genes like me logo Genes that share ontologies with GLMP: view
genes like me logo Genes that share phenotypes with GLMP: view

Animal Models for GLMP Gene

MGI Knock Outs for GLMP:

Animal Model Products

  • Taconic Biosciences Mouse Models for GLMP

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GLMP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GLMP Gene

Localization for GLMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLMP Gene

Lysosome membrane. Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLMP gene
Compartment Confidence
lysosome 5
nucleus 4
cytosol 4
plasma membrane 3
extracellular 2
mitochondrion 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for GLMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18021396
GO:0005764 lysosome IBA,IDA 19556463
GO:0005765 lysosomal membrane IEA --
GO:0005829 cytosol IDA 18021396
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GLMP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GLMP Gene

Pathways & Interactions for GLMP Gene

PathCards logo

SuperPathways for GLMP Gene

No Data Available

Gene Ontology (GO) - Biological Process for GLMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045944 positive regulation of transcription by RNA polymerase II IMP 18021396
genes like me logo Genes that share ontologies with GLMP: view

No data available for Pathways by source and SIGNOR curated interactions for GLMP Gene

Drugs & Compounds for GLMP Gene

No Compound Related Data Available

Transcripts for GLMP Gene

mRNA/cDNA for GLMP Gene

15 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GLMP

Alternative Splicing Database (ASD) splice patterns (SP) for GLMP Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c
SP1: - -
SP2: - - -
SP3: - -
SP4: - - - - -
SP5: - - -

Relevant External Links for GLMP Gene

GeneLoc Exon Structure for

Expression for GLMP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GLMP Gene

Protein differential expression in normal tissues from HIPED for GLMP Gene

This gene is overexpressed in Amniocyte (38.3) and Liver (20.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GLMP Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GLMP

Evidence on tissue expression from TISSUES for GLMP Gene

  • Skin(4.5)
  • Spleen(4.3)
  • Nervous system(4.3)
  • Intestine(4.2)
  • Liver(2.3)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with GLMP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLMP Gene

Orthologs for GLMP Gene

This gene was present in the common ancestor of animals.

Orthologs for GLMP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C1H1orf85 30
  • 99.26 (n)
C1orf85 31
  • 99 (a)
(Bos Taurus)
Mammalia C3H1orf85 30
  • 86.14 (n)
C1orf85 31
  • 82 (a)
(Canis familiaris)
Mammalia C7H1orf85 30
  • 84.51 (n)
C1orf85 31
  • 79 (a)
(Mus musculus)
Mammalia 0610031J06Rik 30 31
  • 81.57 (n)
Glmp 17
(Rattus norvegicus)
Mammalia RGD1303130 30
  • 81.48 (n)
(Monodelphis domestica)
Mammalia C1orf85 31
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia C1orf85 31
  • 45 (a)
(Gallus gallus)
Aves LOC777136 30
  • 56.58 (n)
C1orf85 31
  • 43 (a)
(Anolis carolinensis)
Reptilia C1orf85 31
  • 41 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia c1orf85 30
  • 53.8 (n)
(Danio rerio)
Actinopterygii zgc:92308 30
  • 47.67 (n)
C19H1orf85 31
  • 33 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004431 30
  • 42.11 (n)
Species where no ortholog for GLMP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GLMP Gene

Gene Tree for GLMP (if available)
Gene Tree for GLMP (if available)
Evolutionary constrained regions (ECRs) for GLMP: view image

Paralogs for GLMP Gene

No data available for Paralogs for GLMP Gene

Variants for GLMP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GLMP Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
770493 Benign: not provided 156,293,154(-) G/C MISSENSE_VARIANT
rs10908495 - p.Ile223Val
rs10908496 - p.Pro203Ser
rs1570805 - p.Val94Ile

Additional dbSNP identifiers (rs#s) for GLMP Gene

Structural Variations from Database of Genomic Variants (DGV) for GLMP Gene

Variant ID Type Subtype PubMed ID
nsv509524 CNV insertion 20534489
nsv547968 CNV loss 21841781

Variation tolerance for GLMP Gene

Residual Variation Intolerance Score: 76.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.78; 93.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GLMP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLMP Gene

Disorders for GLMP Gene

MalaCards: The human disease database

(1) MalaCards diseases for GLMP Gene - From: DISEASES

Disorder Aliases PubMed IDs
multilocular clear cell renal cell carcinoma
  • cystadenocarcinoma of kidney
- elite association - COSMIC cancer census association via MalaCards
Search GLMP in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with GLMP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GLMP Gene

Publications for GLMP Gene

  1. NCU-G1 is a highly glycosylated integral membrane protein of the lysosome. (PMID: 19489740) Schieweck O … Lübke T (The Biochemical journal 2009) 2 3 23
  2. Human NCU-G1 can function as a transcription factor and as a nuclear receptor co-activator. (PMID: 18021396) Steffensen KR … Eskild W (BMC molecular biology 2007) 2 3 4
  3. The lysosomal transporter MFSD1 is essential for liver homeostasis and critically depends on its accessory subunit GLMP. (PMID: 31661432) Massa López D … Damme M (eLife 2019) 2 3
  4. A gene network regulating lysosomal biogenesis and function. (PMID: 19556463) Sardiello M … Ballabio A (Science (New York, N.Y.) 2009) 3 4
  5. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4

Products for GLMP Gene

Sources for GLMP Gene