This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal... See more...

Aliases for GLIS3 Gene

Aliases for GLIS3 Gene

  • GLIS Family Zinc Finger 3 2 3 5
  • Zinc Finger Protein 515 2 3 4
  • Zinc Finger Protein GLIS3 3 4
  • GLI-Similar 3 3 4
  • ZNF515 3 4
  • Gli-Similar 3 2
  • OK/KNS-Cl.4 3
  • MGC33662 2
  • GLIS3 5
  • NDH 3

External Ids for GLIS3 Gene

Previous HGNC Symbols for GLIS3 Gene

  • ZNF515

Summaries for GLIS3 Gene

Entrez Gene Summary for GLIS3 Gene

  • This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only two have been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for GLIS3 Gene

GLIS3 (GLIS Family Zinc Finger 3) is a Protein Coding gene. Diseases associated with GLIS3 include Diabetes Mellitus, Neonatal, With Congenital Hypothyroidism and Congenital Hypothyroidism. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific. An important paralog of this gene is GLIS1.

UniProtKB/Swiss-Prot Summary for GLIS3 Gene

  • Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GLIS3 Gene

Genomics for GLIS3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GLIS3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J004291 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 272.8 +51.2 51174 12 JUND ATF2 CEBPA ATF3 ZNF10 BRCA1 POLR2A ZBTB10 YY1 CEBPB GLIS3 ENSG00000228322 HSALNG0069709 HSALNG0069710 MTND4P14 PLPP6 LOC107986989 HSALNG0069708 lnc-GLIS3-2 RFX3
GH09J004143 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 250.1 +201.9 201887 5.8 ZNF384 MAFK KDM1A FOS EP300 PRDM1 SP1 GLIS3 ENSG00000236724 RF00017-6832 lnc-RFX3-5 lnc-GLIS3-2 RFX3
GH09J004118 Promoter 0.7 EPDnew 250.1 +230.4 230387 0.1 CTCF SMC3 RAD21 MYC MAX ZNF143 XRCC5 GLIS3 lnc-RFX3-5 RF00017-6832 lnc-GLIS3-2 RFX3
GH09J004305 Enhancer 1.1 Ensembl ENCODE dbSUPER 19.6 +42.3 42291 2.2 ATF2 CEBPA ATF3 YY1 CEBPB FEZF1 HOMEZ FOXA2 KDM6A SMAD4 GLIS3 ENSG00000228322 HSALNG0069710 LOC107986989 piR-31534-666 lnc-GLIS3-2 RFX3
GH09J004303 Enhancer 0.7 ENCODE dbSUPER 19.7 +45.1 45108 0.1 ATF3 HNF4A RAD21 SP1 EGR1 YY1 RXRA EP300 GLIS3 LOC107986989 ENSG00000228322 HSALNG0069710 piR-31534-666 lnc-GLIS3-2 RFX3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GLIS3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GLIS3

Top Transcription factor binding sites by QIAGEN in the GLIS3 gene promoter:
  • CREB
  • GATA-6
  • Ik-3
  • NF-kappaB1
  • PPAR-gamma1
  • PPAR-gamma2
  • Roaz
  • SRY
  • YY1

Genomic Locations for GLIS3 Gene

Latest Assembly
chr9:3,824,127-4,348,392
(GRCh38/hg38)
Size:
524,266 bases
Orientation:
Minus strand

Previous Assembly
chr9:3,824,127-4,300,068
(GRCh37/hg19 by Entrez Gene)
Size:
475,942 bases
Orientation:
Minus strand

chr9:3,824,127-4,348,392
(GRCh37/hg19 by Ensembl)
Size:
524,266 bases
Orientation:
Minus strand

Genomic View for GLIS3 Gene

Genes around GLIS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLIS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLIS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLIS3 Gene

Proteins for GLIS3 Gene

  • Protein details for GLIS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEA6-GLIS3_HUMAN
    Recommended name:
    Zinc finger protein GLIS3
    Protein Accession:
    Q8NEA6
    Secondary Accessions:
    • B1AL19
    • Q1PHK5

    Protein attributes for GLIS3 Gene

    Size:
    775 amino acids
    Molecular mass:
    83636 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GLIS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLIS3 Gene

Post-translational modifications for GLIS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GLIS3 Gene

Domains & Families for GLIS3 Gene

Gene Families for GLIS3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for GLIS3 Gene

Suggested Antigen Peptide Sequences for GLIS3 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 515 (GLIS3_HUMAN)
  • GLIS family zinc finger 3 transcript variant TS22 (Q1PHI1_HUMAN)
  • GLIS family zinc finger 3 transcript variant TS21 (Q1PHI2_HUMAN)
  • GLIS family zinc finger 3 transcript variant TS20 (Q1PHI3_HUMAN)
  • GLIS family zinc finger 3 transcript variant TS13 (Q1PHJ0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NEA6

UniProtKB/Swiss-Prot:

GLIS3_HUMAN :
  • Belongs to the GLI C2H2-type zinc-finger protein family.
Family:
  • Belongs to the GLI C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with GLIS3: view

Function for GLIS3 Gene

Molecular function for GLIS3 Gene

UniProtKB/Swiss-Prot Function:
Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity).

Phenotypes From GWAS Catalog for GLIS3 Gene

Gene Ontology (GO) - Molecular Function for GLIS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with GLIS3: view
genes like me logo Genes that share phenotypes with GLIS3: view

Human Phenotype Ontology for GLIS3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for GLIS3 Gene

MGI Knock Outs for GLIS3:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GLIS3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GLIS3 Gene

Localization for GLIS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLIS3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLIS3 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2
golgi apparatus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GLIS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,ISS --
genes like me logo Genes that share ontologies with GLIS3: view

Pathways & Interactions for GLIS3 Gene

PathCards logo

SuperPathways for GLIS3 Gene

No Data Available

SIGNOR curated interactions for GLIS3 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for GLIS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II ISS --
GO:0006357 regulation of transcription by RNA polymerase II IEA,IBA 21873635
GO:0006366 transcription by RNA polymerase II ISS --
GO:0045944 positive regulation of transcription by RNA polymerase II ISS --
genes like me logo Genes that share ontologies with GLIS3: view

No data available for Pathways by source for GLIS3 Gene

Drugs & Compounds for GLIS3 Gene

No Compound Related Data Available

Transcripts for GLIS3 Gene

mRNA/cDNA for GLIS3 Gene

2 REFSEQ mRNAs :
41 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GLIS3

Alternative Splicing Database (ASD) splice patterns (SP) for GLIS3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2:
SP3:
SP4:

Relevant External Links for GLIS3 Gene

GeneLoc Exon Structure for
GLIS3

Expression for GLIS3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GLIS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GLIS3 Gene

This gene is overexpressed in Plasma (68.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GLIS3 Gene



Protein tissue co-expression partners for GLIS3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GLIS3

SOURCE GeneReport for Unigene cluster for GLIS3 Gene:

Hs.162125

mRNA Expression by UniProt/SwissProt for GLIS3 Gene:

Q8NEA6-GLIS3_HUMAN
Tissue specificity: In the adult, expressed at high levels in the kidney and at lower levels in the brain, skeletal muscle, pancreas, liver, lung, thymus and ovary.

Evidence on tissue expression from TISSUES for GLIS3 Gene

  • Thyroid gland(2.7)
  • Pancreas(2.7)
  • Nervous system(2.4)
  • Skin(2.2)
  • Kidney(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for GLIS3 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • urinary
Regions:
Head and neck:
  • brain
  • ear
  • eye
  • head
  • hypothalamus
  • mouth
  • neck
  • pituitary gland
  • thyroid
Thorax:
  • heart
  • lung
Abdomen:
  • abdominal wall
  • biliary tract
  • gallbladder
  • intestine
  • kidney
  • large intestine
  • liver
  • pancreas
  • small intestine
Pelvis:
  • uterus
General:
  • blood
  • blood vessel
  • coagulation system
  • peripheral nerve
  • peripheral nervous system
  • red blood cell
  • skin
genes like me logo Genes that share expression patterns with GLIS3: view

Primer products for research

No data available for mRNA differential expression in normal tissues for GLIS3 Gene

Orthologs for GLIS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GLIS3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GLIS3 29 30
  • 98.67 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GLIS3 29 30
  • 87.8 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GLIS3 29 30
  • 87.6 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Glis3 29 16 30
  • 84.34 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Glis3 29
  • 84.23 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia GLIS3 30
  • 81 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia GLIS3 30
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves GLIS3 29 30
  • 69.55 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GLIS3 30
  • 69 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia glis3 29
  • 68.49 (n)
Zebrafish
(Danio rerio)
Actinopterygii glis3 29 30
  • 60.63 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta lmd 30
  • 25 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea ztf-14 30
  • 25 (a)
ManyToMany
tra-1 30
  • 14 (a)
ManyToMany
Species where no ortholog for GLIS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GLIS3 Gene

ENSEMBL:
Gene Tree for GLIS3 (if available)
TreeFam:
Gene Tree for GLIS3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GLIS3: view image
Alliance of Genome Resources:
Additional Orthologs for GLIS3

Paralogs for GLIS3 Gene

Paralogs for GLIS3 Gene

(48) SIMAP similar genes for GLIS3 Gene using alignment to 13 proteins:

  • GLIS3_HUMAN
  • F8WEV9_HUMAN
  • Q1PHI1_HUMAN
  • Q1PHI2_HUMAN
  • Q1PHI3_HUMAN
  • Q1PHJ0_HUMAN
  • Q1PHJ1_HUMAN
  • Q1PHJ2_HUMAN
  • Q1PHJ7_HUMAN
  • Q1PHJ8_HUMAN
  • Q1PHK2_HUMAN
  • Q1PHK3_HUMAN
  • Q1PHK4_HUMAN
genes like me logo Genes that share paralogs with GLIS3: view

Variants for GLIS3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GLIS3 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
1030058 Uncertain Significance: Diabetes mellitus, neonatal, with congenital hypothyroidism 4,286,221(-) C/T
NM_001042413.2(GLIS3):c.205G>A (p.Ala69Thr)
MISSENSE
1030059 Uncertain Significance: Diabetes mellitus, neonatal, with congenital hypothyroidism 3,829,438(-) C/T
NM_001042413.2(GLIS3):c.2528G>A (p.Arg843Lys)
MISSENSE
1030060 Likely Pathogenic: Diabetes mellitus, neonatal, with congenital hypothyroidism 4,286,332(-) G/A
NM_001042413.2(GLIS3):c.94C>T (p.Arg32Ter)
NONSENSE
912686 Likely Benign: Diabetes mellitus, neonatal, with congenital hypothyroidism 3,825,083(-) G/A
NM_001042413.2(GLIS3):c.*3189C>T
THREE_PRIME_UTR
912687 Uncertain Significance: Diabetes mellitus, neonatal, with congenital hypothyroidism 3,825,135(-) G/A
NM_001042413.2(GLIS3):c.*3137C>T
THREE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GLIS3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GLIS3 Gene

Variant ID Type Subtype PubMed ID
dgv12479n54 CNV loss 21841781
dgv1433e214 CNV loss 21293372
dgv7379n100 CNV loss 25217958
dgv7380n100 CNV loss 25217958
esv2105371 CNV deletion 18987734
esv2218450 CNV deletion 18987734
esv22225 CNV loss 19812545
esv2423311 CNV insertion 19546169
esv2442988 CNV deletion 19546169
esv2657927 CNV deletion 23128226
esv2662838 CNV deletion 23128226
esv2666704 CNV deletion 23128226
esv2672805 CNV deletion 23128226
esv2673095 CNV deletion 23128226
esv2738148 CNV deletion 23290073
esv275424 CNV gain+loss 21479260
esv2759658 CNV loss 17122850
esv2762784 CNV loss 21179565
esv27658 CNV loss 19812545
esv3304383 CNV mobile element insertion 20981092
esv3308529 CNV mobile element insertion 20981092
esv3340916 CNV insertion 20981092
esv3372991 CNV insertion 20981092
esv3413495 CNV insertion 20981092
esv3544447 CNV deletion 23714750
esv3573085 CNV loss 25503493
esv3619320 CNV loss 21293372
esv3619322 CNV loss 21293372
esv3619324 CNV loss 21293372
esv3619326 CNV loss 21293372
esv3619328 CNV loss 21293372
esv3619329 CNV loss 21293372
esv3619330 CNV loss 21293372
esv3619332 CNV loss 21293372
esv3891528 CNV gain 25118596
nsv1016929 CNV gain 25217958
nsv1021184 CNV gain 25217958
nsv1023271 CNV gain 25217958
nsv1023363 CNV gain 25217958
nsv1028973 CNV loss 25217958
nsv1124396 CNV deletion 24896259
nsv416336 CNV deletion 16902084
nsv438089 CNV loss 16468122
nsv474878 CNV novel sequence insertion 20440878
nsv517705 CNV loss 19592680
nsv518476 CNV loss 19592680
nsv519359 CNV loss 19592680
nsv520350 CNV gain+loss 19592680
nsv524574 CNV gain 19592680
nsv528551 CNV loss 19592680
nsv613149 CNV loss 21841781
nsv613150 CNV loss 21841781
nsv613153 CNV loss 21841781
nsv613154 CNV loss 21841781
nsv613155 CNV loss 21841781
nsv613156 CNV loss 21841781
nsv6458 CNV insertion 18451855

Variation tolerance for GLIS3 Gene

Residual Variation Intolerance Score: 80.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.42; 71.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GLIS3 Gene

Human Gene Mutation Database (HGMD)
GLIS3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLIS3
Leiden Open Variation Database (LOVD)
GLIS3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLIS3 Gene

Disorders for GLIS3 Gene

MalaCards: The human disease database

(15) MalaCards diseases for GLIS3 Gene - From: OMI, CVR, GTR, ORP, COP, and GCD

Disorder Aliases PubMed IDs
diabetes mellitus, neonatal, with congenital hypothyroidism
  • ndh
congenital hypothyroidism
  • neonatal hypothyroidism
hypothyroidism
  • thyroid deficiency
neonatal diabetes
  • diabetes mellitus syndrome in newborn infant
primary angle-closure glaucoma
  • primary angle closure glaucoma
- elite association - COSMIC cancer census association via MalaCards
Search GLIS3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

GLIS3_HUMAN
  • Diabetes mellitus, neonatal, with congenital hypothyroidism (NDH) [MIM:610199]: A syndrome of neonatal diabetes syndrome associated with congenital hypothyroidism, congenital glaucoma, hepatic fibrosis and polycystic kidneys. {ECO:0000269 PubMed:16715098, ECO:0000269 PubMed:21139041}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for GLIS3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with GLIS3: view

No data available for Genatlas for GLIS3 Gene

Publications for GLIS3 Gene

  1. Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism. (PMID: 16715098) Senée V … Julier C (Nature genetics 2006) 3 4 72
  2. GLIS3, a novel member of the GLIS subfamily of Krüppel-like zinc finger proteins with repressor and activation functions. (PMID: 14500813) Kim YS … Jetten AM (Nucleic acids research 2003) 2 3 4
  3. Expanding the Clinical Spectrum Associated With GLIS3 Mutations. (PMID: 26259131) Dimitri P … De Franco E (The Journal of clinical endocrinology and metabolism 2015) 3 72
  4. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. (PMID: 22158537) Cho YS … Seielstad M (Nature genetics 2011) 3 40
  5. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. (PMID: 20081858) Dupuis J … Barroso I (Nature genetics 2010) 3 40

Products for GLIS3 Gene

Sources for GLIS3 Gene