Aliases for GLIS1 Gene
External Ids for GLIS1 Gene
Previous GeneCards Identifiers for GLIS1 Gene
GLIS1 is a GLI (MIM 165220)-related Kruppel-like zinc finger protein that functions as an activator and repressor of transcription (Kim et al., 2002 [PubMed 12042312]).[supplied by OMIM, Mar 2008]
GeneCards Summary for GLIS1 Gene
GLIS1 (GLIS Family Zinc Finger 1) is a Protein Coding gene. Diseases associated with GLIS1 include Myoclonic Epilepsy Associated With Ragged-Red Fibers and Neonatal Diabetes Mellitus. Gene Ontology (GO) annotations related to this gene include RNA polymerase II regulatory region sequence-specific DNA binding and DNA-binding transcription repressor activity, RNA polymerase II-specific. An important paralog of this gene is GLIS3.
UniProtKB/Swiss-Prot Summary for GLIS1 Gene
Acts as both a repressor and activator of transcription (PubMed:21654807). Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity). By controlling the expression of genes involved in cell differentiation inhibits the lineage commitment of multipotent cells (PubMed:21654807). Prevents, for instance, the differentiation of multipotent mesenchymal cells into adipocyte and osteoblast (By similarity).