Aliases for GLIPR2 Gene

Aliases for GLIPR2 Gene

  • GLI Pathogenesis Related 2 2 3 5
  • Golgi-Associated Plant Pathogenesis-Related Protein 1 3 4
  • Glioma Pathogenesis-Related Protein 2 3 4
  • Golgi-Associated PR-1 Protein 3 4
  • GliPR 2 3 4
  • C9orf19 3 4
  • GAPR-1 3 4
  • GAPR1 3 4
  • Chromosome 9 Open Reading Frame 19 2
  • GLI Pathogenesis-Related 2 2
  • 17kD Fetal Brain Protein 3

External Ids for GLIPR2 Gene

Previous HGNC Symbols for GLIPR2 Gene

  • C9orf19

Summaries for GLIPR2 Gene

GeneCards Summary for GLIPR2 Gene

GLIPR2 (GLI Pathogenesis Related 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity. An important paralog of this gene is PI15.

Additional gene information for GLIPR2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GLIPR2 Gene

Genomics for GLIPR2 Gene

GeneHancer (GH) Regulatory Elements for GLIPR2 Gene

Promoters and enhancers for GLIPR2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J036135 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 520.4 +4.6 4565 11 EP300 CTCF ZIC2 REST ZNF423 GABPA ZBTB26 MYC CTBP1 POLR2A GLIPR2 CCIN CLTA HMGB3P24 TMEM8B
GH09J036136 Enhancer 0.4 ENCODE dbSUPER 500.7 -1.3 -1277 0.2 KLF1 GLIPR2 piR-50437-656
GH09J036150 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 18.8 +16.4 16448 6 ZBTB40 EP300 SP1 RELA POLR2A ZBTB26 MXI1 RBM25 BCL11A NR2F2 GLIPR2 GNE HMGB3P24 OR2S2 TLN1 OR13J1 CCIN
GH09J036189 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.8 +55.5 55524 4.7 FOXK2 ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 TCF12 USF1 POLR2G CLTA lnc-GNE-3 GNE GLIPR2 piR-43105-660
GH09J035904 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.5 -227.7 -227690 8.7 ZNF217 CTCF TCF12 NCOR1 JUND FOS ZNF10 ZIC2 REST POLR2A SPAAR NONHSAG052133.2 HRCT1 TMEM8B OR13J1 FAM221B NDUFA5P4 ENSG00000227388 NPR2 OR2S1P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GLIPR2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GLIPR2

Top Transcription factor binding sites by QIAGEN in the GLIPR2 gene promoter:
  • AML1a
  • AREB6
  • CREB
  • deltaCREB
  • FOXJ2
  • FOXJ2 (long isoform)
  • GATA-1
  • NF-kappaB1
  • p53
  • RelA

Genomic Locations for GLIPR2 Gene

Genomic Locations for GLIPR2 Gene
27,378 bases
Plus strand
27,179 bases
Plus strand

Genomic View for GLIPR2 Gene

Genes around GLIPR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLIPR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLIPR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLIPR2 Gene

Proteins for GLIPR2 Gene

  • Protein details for GLIPR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Golgi-associated plant pathogenesis-related protein 1
    Protein Accession:
    Secondary Accessions:
    • Q5VZR1
    • Q8N2S6
    • Q8WWC9
    • Q8WX36

    Protein attributes for GLIPR2 Gene

    154 amino acids
    Molecular mass:
    17218 Da
    Quaternary structure:
    • Homodimer. Interacts with CAV1.

    Three dimensional structures from OCA and Proteopedia for GLIPR2 Gene

neXtProt entry for GLIPR2 Gene

Post-translational modifications for GLIPR2 Gene

  • Ubiquitination at Lys15 and Lys88
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for GLIPR2 Gene

Domains & Families for GLIPR2 Gene

Gene Families for GLIPR2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for GLIPR2 Gene

  • Allergen V5/Tpx-1 related

Suggested Antigen Peptide Sequences for GLIPR2 Gene

GenScript: Design optimal peptide antigens:
  • Chromosome 9 open reading frame 19, isoform CRA_a (D3DRP5_HUMAN)
  • Glioma pathogenesis-related protein 2 (GAPR1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CRISP family.
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with GLIPR2: view

Function for GLIPR2 Gene

Phenotypes From GWAS Catalog for GLIPR2 Gene

Gene Ontology (GO) - Molecular Function for GLIPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IDA 15123429
genes like me logo Genes that share ontologies with GLIPR2: view
genes like me logo Genes that share phenotypes with GLIPR2: view

Animal Model Products

CRISPR Products

miRNA for GLIPR2 Gene

miRTarBase miRNAs that target GLIPR2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GLIPR2 Gene

Localization for GLIPR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLIPR2 Gene

Golgi apparatus membrane; Lipid-anchor. Note=Binds lipid-enriched microdomains of Golgi membranes not only by ionic interactions but also through the myristate.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLIPR2 gene
Compartment Confidence
golgi apparatus 5
extracellular 4
cytoskeleton 2
nucleus 2
cytosol 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GLIPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IDA 11865038
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GLIPR2: view

Pathways & Interactions for GLIPR2 Gene

PathCards logo

SuperPathways for GLIPR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GLIPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010634 positive regulation of epithelial cell migration IDA 23516513
GO:0010718 positive regulation of epithelial to mesenchymal transition IDA 23516513
GO:0070374 positive regulation of ERK1 and ERK2 cascade IDA 23516513
genes like me logo Genes that share ontologies with GLIPR2: view

No data available for Pathways by source and SIGNOR curated interactions for GLIPR2 Gene

Drugs & Compounds for GLIPR2 Gene

(1) Drugs for GLIPR2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cysteinesulfonic Acid Experimental Pharma Target 0
genes like me logo Genes that share compounds with GLIPR2: view

Transcripts for GLIPR2 Gene

mRNA/cDNA for GLIPR2 Gene

19 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLIPR2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e
SP1: - -
SP2: - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - - - - - - - - - - -
SP8: -
SP9: - - - - - - - - -
SP10: - - - - - - - - - - -
SP11: - - - - - -
SP12: - - - - - - - - - - - - -
SP13: -

Relevant External Links for GLIPR2 Gene

GeneLoc Exon Structure for

Expression for GLIPR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GLIPR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GLIPR2 Gene

This gene is overexpressed in Whole Blood (x15.3).

Protein differential expression in normal tissues from HIPED for GLIPR2 Gene

This gene is overexpressed in Nasal epithelium (8.9) and Serum (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GLIPR2 Gene

Protein tissue co-expression partners for GLIPR2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GLIPR2

SOURCE GeneReport for Unigene cluster for GLIPR2 Gene:


mRNA Expression by UniProt/SwissProt for GLIPR2 Gene:

Tissue specificity: Highest expression in lung and peripheral leukocytes, and minor expression in liver and kidney.

Evidence on tissue expression from TISSUES for GLIPR2 Gene

  • Nervous system(4.8)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with GLIPR2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GLIPR2 Gene

Orthologs for GLIPR2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GLIPR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GLIPR2 31 30
  • 98.89 (n)
(Canis familiaris)
Mammalia GLIPR2 31 30
  • 91.78 (n)
(Bos Taurus)
Mammalia GLIPR2 31 30
  • 90.57 (n)
(Rattus norvegicus)
Mammalia Glipr2 30
  • 88.6 (n)
(Mus musculus)
Mammalia Glipr2 17 31 30
  • 88.16 (n)
(Ornithorhynchus anatinus)
Mammalia GLIPR2 31
  • 87 (a)
(Monodelphis domestica)
Mammalia GLIPR2 31
  • 20 (a)
(Gallus gallus)
Aves GLIPR2 31 30
  • 74.12 (n)
(Anolis carolinensis)
Reptilia GLIPR2 31
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia glipr2 30
  • 59.34 (n)
(Danio rerio)
Actinopterygii glipr2l 31 30
  • 68.65 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007584 30
  • 53.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG31482 31
  • 34 (a)
(Caenorhabditis elegans)
Secernentea F09B9.5 31
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRY1 31
  • 20 (a)
PRY2 31
  • 16 (a)
PRY3 33 31
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 27 (a)
Species where no ortholog for GLIPR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLIPR2 Gene

Gene Tree for GLIPR2 (if available)
Gene Tree for GLIPR2 (if available)
Evolutionary constrained regions (ECRs) for GLIPR2: view image

Paralogs for GLIPR2 Gene

(1) SIMAP similar genes for GLIPR2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GLIPR2: view

Variants for GLIPR2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GLIPR2 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type

Additional dbSNP identifiers (rs#s) for GLIPR2 Gene

Structural Variations from Database of Genomic Variants (DGV) for GLIPR2 Gene

Variant ID Type Subtype PubMed ID
esv34080 CNV loss 18971310
nsv1017711 CNV gain 25217958
nsv1125318 OTHER inversion 24896259
nsv519442 CNV loss 19592680
nsv527617 CNV gain 19592680
nsv528600 CNV loss 19592680
nsv831547 CNV loss 17160897

Variation tolerance for GLIPR2 Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GLIPR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLIPR2 Gene

Disorders for GLIPR2 Gene

Additional Disease Information for GLIPR2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GLIPR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLIPR2 Gene

Publications for GLIPR2 Gene

  1. Identification and characterization of a novel human plant pathogenesis-related protein that localizes to lipid-enriched microdomains in the Golgi complex. (PMID: 11865038) Eberle HB … Helms JB (Journal of cell science 2002) 2 3 4 23 54
  2. Cloning and characterization of a human novel gene C9orf19 encoding a conserved putative protein with an SCP-like extracellular protein domain. (PMID: 12137952) Eisenberg I … Mitrani-Rosenbaum S (Gene 2002) 2 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 54

Products for GLIPR2 Gene

Sources for GLIPR2 Gene