This gene encodes a member of the cysteine-rich secretory protein, antigen 5, and pathogenesis-related 1 superfamily. Members of this family have roles in a variety of processes, including cancer and immune defense. This gene is located in a cluster with two related genes on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 20... See more...

Aliases for GLIPR1L2 Gene

Aliases for GLIPR1L2 Gene

  • GLIPR1 Like 2 2 3 5
  • GLI Pathogenesis Related 1 Like 2 2 3
  • GLIPR1-Like Protein 2 3 4
  • GLI Pathogenesis-Related 1 Like 2 2

External Ids for GLIPR1L2 Gene

Previous GeneCards Identifiers for GLIPR1L2 Gene

  • GC12P074072
  • GC12P075784
  • GC12P072834

Summaries for GLIPR1L2 Gene

Entrez Gene Summary for GLIPR1L2 Gene

  • This gene encodes a member of the cysteine-rich secretory protein, antigen 5, and pathogenesis-related 1 superfamily. Members of this family have roles in a variety of processes, including cancer and immune defense. This gene is located in a cluster with two related genes on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

GeneCards Summary for GLIPR1L2 Gene

GLIPR1L2 (GLIPR1 Like 2) is a Protein Coding gene. An important paralog of this gene is GLIPR1.

Additional gene information for GLIPR1L2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GLIPR1L2 Gene

Genomics for GLIPR1L2 Gene

GeneHancer (GH) Regulatory Elements for GLIPR1L2 Gene

Promoters and enhancers for GLIPR1L2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J075388 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 579.6 -0.6 -589 3.9 RXRA ZNF217 CTCF SIN3A NRF1 TCF12 SP1 PHF8 JUND FOS GLIPR1L2 CAPS2 lnc-CAPS2-4 KRR1 GLIPR1 piR-39300-038
GH12J075477 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 73.5 +90.7 90692 7.5 ZBTB40 CTCF GTF2E2 FOS POLR2A REST TRIM22 CBFB ZNF384 TBP GLIPR1 GLIPR1L2 KRR1 GLIPR1L1 CAPS2 ENSG00000257497 piR-38716-036
GH12J075333 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 44.3 -56.4 -56399 1.5 ZNF217 CTCF TEAD4 ZIC2 ZBTB26 REST RAD21 CTBP1 SKI TRIM22 ENSG00000273987 GLIPR1L1 GLIPR1L2 piR-41876-002 lnc-CAPS2-4 CAPS2
GH12J075444 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 65.1 +54.8 54793 4.9 EP300 JUND FOS FOSL2 MAFK SPI1 NFE2 PRDM1 RARA BHLHE40 GLIPR1L2 KRR1 GLIPR1 ENSG00000257497 AY882290-001 piR-48369-039
GH12J075437 Enhancer 0.8 Ensembl ENCODE dbSUPER 76.1 +47.2 47227 1.4 CTCF RAD21 KLF1 ZNF644 GLIPR1L2 CAPS2 GLIPR1 piR-48369-039 AY882290-001
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GLIPR1L2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GLIPR1L2

Genomic Locations for GLIPR1L2 Gene

Genomic Locations for GLIPR1L2 Gene
41,619 bases
Plus strand
41,619 bases
Plus strand

Genomic View for GLIPR1L2 Gene

Genes around GLIPR1L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLIPR1L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLIPR1L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLIPR1L2 Gene

Proteins for GLIPR1L2 Gene

  • Protein details for GLIPR1L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GLIPR1-like protein 2
    Protein Accession:
    Secondary Accessions:
    • Q6MZS1
    • Q8N6N0
    • Q8NA43

    Protein attributes for GLIPR1L2 Gene

    344 amino acids
    Molecular mass:
    40179 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH16749.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAC04085.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=CAE45957.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GLIPR1L2 Gene

neXtProt entry for GLIPR1L2 Gene

Post-translational modifications for GLIPR1L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GLIPR1L2 Gene

Domains & Families for GLIPR1L2 Gene

Gene Families for GLIPR1L2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GLIPR1L2 Gene

  • Allergen V5/Tpx-1 related

Suggested Antigen Peptide Sequences for GLIPR1L2 Gene

GenScript: Design optimal peptide antigens:
  • GLIPR1-like protein 2 (GRPL2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CRISP family.
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with GLIPR1L2: view

Function for GLIPR1L2 Gene

Molecular function for GLIPR1L2 Gene

UniProtKB/Swiss-Prot Induction:
Up-regulated by doxycycline.

Phenotypes From GWAS Catalog for GLIPR1L2 Gene

genes like me logo Genes that share phenotypes with GLIPR1L2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GLIPR1L2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GLIPR1L2 Gene

Localization for GLIPR1L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLIPR1L2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLIPR1L2 gene
Compartment Confidence
extracellular 4
golgi apparatus 1
plasma membrane 0
peroxisome 0
cytosol 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GLIPR1L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GLIPR1L2: view

Pathways & Interactions for GLIPR1L2 Gene

PathCards logo

SuperPathways for GLIPR1L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GLIPR1L2 Gene


No data available for Pathways by source and SIGNOR curated interactions for GLIPR1L2 Gene

Drugs & Compounds for GLIPR1L2 Gene

No Compound Related Data Available

Transcripts for GLIPR1L2 Gene

mRNA/cDNA for GLIPR1L2 Gene

6 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLIPR1L2 Gene

No ASD Table

Relevant External Links for GLIPR1L2 Gene

GeneLoc Exon Structure for

Expression for GLIPR1L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GLIPR1L2 Gene

mRNA differential expression in normal tissues according to GTEx for GLIPR1L2 Gene

This gene is overexpressed in Testis (x11.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GLIPR1L2

SOURCE GeneReport for Unigene cluster for GLIPR1L2 Gene:


mRNA Expression by UniProt/SwissProt for GLIPR1L2 Gene:

Tissue specificity: Highly expressed in testis. Detected in prostate, kidney, bladder, lung and bone marrow.

Evidence on tissue expression from TISSUES for GLIPR1L2 Gene

  • Lymph node(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with GLIPR1L2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLIPR1L2 Gene

Orthologs for GLIPR1L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GLIPR1L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GLIPR1L2 31 30
  • 98.4 (n)
(Canis familiaris)
Mammalia GLIPR1L2 31 30
  • 80.6 (n)
(Rattus norvegicus)
Mammalia Glipr1l2 30
  • 73.93 (n)
(Mus musculus)
Mammalia Glipr1l2 17 31 30
  • 71.08 (n)
(Bos Taurus)
Mammalia GLIPR1L2 31
  • 66 (a)
(Monodelphis domestica)
Mammalia GLIPR1L2 31
  • 41 (a)
(Gallus gallus)
Aves -- 31
  • 42 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 39 (a)
-- 31
  • 39 (a)
-- 31
  • 37 (a)
(Danio rerio)
Actinopterygii CU694453.1 31
  • 36 (a)
glipr1b 31
  • 31 (a)
(Caenorhabditis elegans)
Secernentea scl-2 31
  • 24 (a)
scl-6 31
  • 23 (a)
scl-12 31
  • 23 (a)
scl-3 31
  • 23 (a)
scl-21 31
  • 23 (a)
scl-5 31
  • 22 (a)
scl-19 31
  • 22 (a)
scl-10 31
  • 22 (a)
scl-13 31
  • 22 (a)
scl-11 31
  • 22 (a)
scl-15 31
  • 21 (a)
scl-14 31
  • 21 (a)
scl-1 31
  • 21 (a)
scl-7 31
  • 21 (a)
scl-9 31
  • 21 (a)
scl-17 31
  • 20 (a)
scl-18 31
  • 20 (a)
scl-20 31
  • 20 (a)
scl-8 31
  • 20 (a)
Species where no ortholog for GLIPR1L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GLIPR1L2 Gene

Gene Tree for GLIPR1L2 (if available)
Gene Tree for GLIPR1L2 (if available)
Evolutionary constrained regions (ECRs) for GLIPR1L2: view image

Paralogs for GLIPR1L2 Gene

(2) SIMAP similar genes for GLIPR1L2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GLIPR1L2: view

Variants for GLIPR1L2 Gene

Additional dbSNP identifiers (rs#s) for GLIPR1L2 Gene

Variation tolerance for GLIPR1L2 Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GLIPR1L2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for GLIPR1L2 Gene

Disorders for GLIPR1L2 Gene

Additional Disease Information for GLIPR1L2

No disorders were found for GLIPR1L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLIPR1L2 Gene

Publications for GLIPR1L2 Gene

  1. Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster. (PMID: 16714093) Ren C … Thompson TC (Genomics 2006) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 54
  4. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for GLIPR1L2 Gene

Sources for GLIPR1L2 Gene