Aliases for GLIPR1L1 Gene

Aliases for GLIPR1L1 Gene

  • GLIPR1 Like 1 2 3 5
  • GLI Pathogenesis Related 1 Like 1 2 3
  • GLIPR1-Like Protein 1 3 4
  • GLI Pathogenesis-Related 1 Like 1 2
  • ALKN2972 3
  • PRO7434 3

External Ids for GLIPR1L1 Gene

Previous GeneCards Identifiers for GLIPR1L1 Gene

  • GC12P074016
  • GC12P075728
  • GC12P072777

Summaries for GLIPR1L1 Gene

GeneCards Summary for GLIPR1L1 Gene

GLIPR1L1 (GLIPR1 Like 1) is a Protein Coding gene. An important paralog of this gene is GLIPR1.

UniProtKB/Swiss-Prot Summary for GLIPR1L1 Gene

  • Plays a role in the binding between sperm and oocytes. Component of epididymosomes, one type of membranous microvesicules which mediate the transfer of lipids and proteins to spermatozoa plasma membrane during epididymal maturation. Also component of the CD9-positive microvesicules found in the cauda region.

Additional gene information for GLIPR1L1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GLIPR1L1 Gene

Genomics for GLIPR1L1 Gene

GeneHancer (GH) Regulatory Elements for GLIPR1L1 Gene

Promoters and enhancers for GLIPR1L1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J075333 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.0 32 1.5 ZNF217 CTCF TEAD4 ZIC2 ZBTB26 REST RAD21 CTBP1 SKI TRIM22 ENSG00000273987 GLIPR1L1 GLIPR1L2 piR-41876-002 lnc-CAPS2-4 CAPS2
GH12J075508 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.9 +176.1 176083 4.9 RXRA ZBTB40 ZNF217 EP300 SIN3A NRF1 MYC TCF12 POLR2G SP1 KRR1 ENSG00000257497 GLIPR1L2 GLIPR1L1 GLIPR1 CAPS2 PHLDA1 KCNC2
GH12J075366 Enhancer 0.3 ENCODE 68.8 +32.2 32248 1.3 BATF JUNB GLIPR1L1 ENSG00000257497 piR-39300-038 piR-41876-002 CAPS2 lnc-CAPS2-4
GH12J075477 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.8 +147.1 147123 7.5 ZBTB40 CTCF GTF2E2 FOS POLR2A REST TRIM22 CBFB ZNF384 TBP GLIPR1 GLIPR1L2 KRR1 GLIPR1L1 CAPS2 ENSG00000257497 piR-38716-036
GH12J075848 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 13.8 +517.1 517081 7.8 TCF12 MXI1 ZNF316 MAFF FOS FOSL2 MAFK POLR2A ZNF426 SPI1 PHLDA1 GLIPR1L1 CAPS2 ZDHHC17 KRR1 ENSG00000258091 LOC105369846 lnc-GLIPR1-7 ENSG00000258077
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GLIPR1L1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GLIPR1L1

Top Transcription factor binding sites by QIAGEN in the GLIPR1L1 gene promoter:
  • C/EBPalpha
  • CUTL1
  • Evi-1
  • Ik-2
  • LCR-F1
  • SRF
  • SRF (504 AA)
  • STAT3
  • STAT5B
  • ZID

Genomic Locations for GLIPR1L1 Gene

Genomic Locations for GLIPR1L1 Gene
chr12:75,334,639-75,370,560
(GRCh38/hg38)
Size:
35,922 bases
Orientation:
Plus strand
chr12:75,728,419-75,764,340
(GRCh37/hg19)
Size:
35,922 bases
Orientation:
Plus strand

Genomic View for GLIPR1L1 Gene

Genes around GLIPR1L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLIPR1L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLIPR1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLIPR1L1 Gene

Proteins for GLIPR1L1 Gene

  • Protein details for GLIPR1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWM5-GPRL1_HUMAN
    Recommended name:
    GLIPR1-like protein 1
    Protein Accession:
    Q6UWM5
    Secondary Accessions:
    • Q96L06

    Protein attributes for GLIPR1L1 Gene

    Size:
    242 amino acids
    Molecular mass:
    27151 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GLIPR1L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLIPR1L1 Gene

Post-translational modifications for GLIPR1L1 Gene

  • N-glycosylated. N-glycosylation decreases during the transit in the caput.
  • Glycosylation at Asn119
  • Modification sites at PhosphoSitePlus

Other Protein References for GLIPR1L1 Gene

No data available for DME Specific Peptides for GLIPR1L1 Gene

Domains & Families for GLIPR1L1 Gene

Gene Families for GLIPR1L1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for GLIPR1L1 Gene

Blocks:
  • Allergen V5/Tpx-1 related
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GLIPR1L1 Gene

GenScript: Design optimal peptide antigens:
  • GLIPR1-like protein 1 (GPRL1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6UWM5

UniProtKB/Swiss-Prot:

GPRL1_HUMAN :
  • Belongs to the CRISP family.
Family:
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with GLIPR1L1: view

Function for GLIPR1L1 Gene

Molecular function for GLIPR1L1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the binding between sperm and oocytes. Component of epididymosomes, one type of membranous microvesicules which mediate the transfer of lipids and proteins to spermatozoa plasma membrane during epididymal maturation. Also component of the CD9-positive microvesicules found in the cauda region.

Phenotypes From GWAS Catalog for GLIPR1L1 Gene

genes like me logo Genes that share phenotypes with GLIPR1L1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GLIPR1L1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GLIPR1L1 Gene

Localization for GLIPR1L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLIPR1L1 Gene

Cytoplasmic vesicle, secretory vesicle, acrosome. Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Note=Located in the connecting piece of elongated spermatids and sperm. Also located in the apical region of the sperm head after sperm capacitation. Located on sperm equatorial segment and neck. Associated with epididymosomes from the caput and cauda epididymis. {ECO:0000250 UniProtKB:Q32LB5, ECO:0000250 UniProtKB:Q9DAG6}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLIPR1L1 gene
Compartment Confidence
extracellular 4
plasma membrane 3
mitochondrion 0
cytosol 0

Gene Ontology (GO) - Cellular Components for GLIPR1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GLIPR1L1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GLIPR1L1 Gene

Pathways & Interactions for GLIPR1L1 Gene

PathCards logo

SuperPathways for GLIPR1L1 Gene

No Data Available

Interacting Proteins for GLIPR1L1 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 9)
STRING Interaction Network
Selected Interacting proteins: ENSP00000310770 Q6UWM5-GPRL1_HUMAN for GLIPR1L1 Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for GLIPR1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007338 single fertilization IEA --
genes like me logo Genes that share ontologies with GLIPR1L1: view

No data available for Pathways by source and SIGNOR curated interactions for GLIPR1L1 Gene

Drugs & Compounds for GLIPR1L1 Gene

No Compound Related Data Available

Transcripts for GLIPR1L1 Gene

mRNA/cDNA for GLIPR1L1 Gene

2 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLIPR1L1 Gene

No ASD Table

Relevant External Links for GLIPR1L1 Gene

GeneLoc Exon Structure for
GLIPR1L1

Expression for GLIPR1L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GLIPR1L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GLIPR1L1 Gene

This gene is overexpressed in Testis (x33.0).

Protein differential expression in normal tissues from HIPED for GLIPR1L1 Gene

This gene is overexpressed in Ovary (39.5) and Testis (29.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GLIPR1L1 Gene



Protein tissue co-expression partners for GLIPR1L1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GLIPR1L1

SOURCE GeneReport for Unigene cluster for GLIPR1L1 Gene:

Hs.567788

mRNA Expression by UniProt/SwissProt for GLIPR1L1 Gene:

Q6UWM5-GPRL1_HUMAN
Tissue specificity: Highly expressed in testis.
genes like me logo Genes that share expression patterns with GLIPR1L1: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLIPR1L1 Gene

Orthologs for GLIPR1L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GLIPR1L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLIPR1L1 31 30
  • 99.28 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GLIPR1L1 31 30
  • 70.98 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Glipr1l1 30
  • 64.9 (n)
mouse
(Mus musculus)
Mammalia Glipr1l3 17 30
  • 63.89 (n)
Glipr1l1 31
  • 46 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLIPR1L1 31
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GLIPR1L1 31
  • 49 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GLIPR1L1 31
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 31
  • 33 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 38 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
-- 31
  • 33 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia glipr1l1 30
  • 49.3 (n)
zebrafish
(Danio rerio)
Actinopterygii glipr1b 31
  • 32 (a)
ManyToMany
CU694453.1 31
  • 32 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea scl-1 31
  • 28 (a)
ManyToMany
scl-15 31
  • 26 (a)
ManyToMany
scl-14 31
  • 26 (a)
ManyToMany
scl-11 31
  • 26 (a)
ManyToMany
scl-2 31
  • 26 (a)
ManyToMany
scl-12 31
  • 26 (a)
ManyToMany
scl-13 31
  • 25 (a)
ManyToMany
scl-5 31
  • 25 (a)
ManyToMany
scl-9 31
  • 24 (a)
ManyToMany
scl-3 31
  • 24 (a)
ManyToMany
scl-20 31
  • 24 (a)
ManyToMany
scl-7 31
  • 24 (a)
ManyToMany
scl-8 31
  • 23 (a)
ManyToMany
scl-10 31
  • 23 (a)
ManyToMany
scl-6 31
  • 23 (a)
ManyToMany
scl-21 31
  • 23 (a)
ManyToMany
scl-18 31
  • 21 (a)
ManyToMany
scl-19 31
  • 21 (a)
ManyToMany
scl-17 31
  • 20 (a)
ManyToMany
Species where no ortholog for GLIPR1L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLIPR1L1 Gene

ENSEMBL:
Gene Tree for GLIPR1L1 (if available)
TreeFam:
Gene Tree for GLIPR1L1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GLIPR1L1: view image

Paralogs for GLIPR1L1 Gene

(6) SIMAP similar genes for GLIPR1L1 Gene using alignment to 2 proteins:

  • GPRL1_HUMAN
  • H0YIW6_HUMAN
genes like me logo Genes that share paralogs with GLIPR1L1: view

Variants for GLIPR1L1 Gene

Additional dbSNP identifiers (rs#s) for GLIPR1L1 Gene

Structural Variations from Database of Genomic Variants (DGV) for GLIPR1L1 Gene

Variant ID Type Subtype PubMed ID
dgv98n21 CNV gain 19592680
esv3630011 CNV gain 21293372
nsv1054059 CNV loss 25217958
nsv520316 CNV loss 19592680

Variation tolerance for GLIPR1L1 Gene

Residual Variation Intolerance Score: 59.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GLIPR1L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLIPR1L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GLIPR1L1 Gene

Disorders for GLIPR1L1 Gene

Additional Disease Information for GLIPR1L1

No disorders were found for GLIPR1L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLIPR1L1 Gene

Publications for GLIPR1L1 Gene

  1. Glioma pathogenesis-related 1-like 1 is testis enriched, dynamically modified, and redistributed during male germ cell maturation and has a potential role in sperm-oocyte binding. (PMID: 20219979) Gibbs GM … O'Bryan MK (Endocrinology 2010) 2 3 54
  2. Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster. (PMID: 16714093) Ren C … Thompson TC (Genomics 2006) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 54
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 54

Products for GLIPR1L1 Gene

Sources for GLIPR1L1 Gene