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Aliases for GLIPR1 Gene

Aliases for GLIPR1 Gene

  • GLI Pathogenesis Related 1 2 3 5
  • GLI Pathogenesis-Related 1 (Glioma) 2 3
  • Protein RTVP-1 3 4
  • GliPR 1 3 4
  • GLIPR 3 4
  • RTVP1 3 4
  • Related To Testis-Specific, Vespid, And Pathogenesis Proteins 1 3
  • Testes-Specific Vespid And Pathogenesis Protein 1 3
  • Glioma Pathogenesis-Related Protein 1 3
  • CRISP7 3

External Ids for GLIPR1 Gene

Previous GeneCards Identifiers for GLIPR1 Gene

  • GC12P075800
  • GC12P075591
  • GC12P074160
  • GC12P072924

Summaries for GLIPR1 Gene

Entrez Gene Summary for GLIPR1 Gene

  • This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for GLIPR1 Gene

GLIPR1 (GLI Pathogenesis Related 1) is a Protein Coding gene. Diseases associated with GLIPR1 include Glioma and Glioblastoma Multiforme. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). An important paralog of this gene is GLIPR1L2.

Gene Wiki entry for GLIPR1 Gene

Additional gene information for GLIPR1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLIPR1 Gene

Genomics for GLIPR1 Gene

GeneHancer (GH) Regulatory Elements for GLIPR1 Gene

Promoters and enhancers for GLIPR1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J075477 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 655.7 +1.1 1082 7.5 HDGF ATF1 RB1 ZSCAN4 SIN3A BMI1 ZBTB40 RAD21 YY1 ZNF366 GLIPR1 GLIPR1L2 KRR1 GLIPR1L1 CAPS2 ENSG00000257497
GH12J075508 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.2 +30.0 30042 4.9 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B ZNF766 KRR1 ENSG00000257497 GLIPR1L2 GLIPR1L1 GLIPR1 CAPS2 PHLDA1 KCNC2
GH12J075388 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.3 -90.2 -90199 3.9 HDGF PKNOX1 SIN3A ZNF2 ZBTB7B YY1 ZNF207 ZNF143 FOS ZNF263 GLIPR1L2 CAPS2 KRR1 GLIPR1 GLIPR1L1
GH12J075456 Enhancer 0.9 Ensembl ENCODE dbSUPER 12.2 -23.1 -23130 1.6 GATA3 ZNF26 ZNF444 GTF2A2 KLF13 SETDB1 GLIPR1L2 GLIPR1 KRR1
GH12J075974 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5 +498.4 498438 10.2 HDGF PKNOX1 FOXA2 ARNT MLX ARID4B NEUROD1 SIN3A DMAP1 IRF4 ENSG00000258077 PHLDA1 NAP1L1 ENSG00000251893 GLIPR1 LOC100289143
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GLIPR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GLIPR1 gene promoter:
  • p53
  • HFH-3
  • FOXI1
  • TBP
  • IRF-1
  • AP-4
  • NCX
  • C/EBPalpha

Genomic Locations for GLIPR1 Gene

Genomic Locations for GLIPR1 Gene
23,174 bases
Plus strand
23,174 bases
Plus strand

Genomic View for GLIPR1 Gene

Genes around GLIPR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLIPR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLIPR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLIPR1 Gene

Proteins for GLIPR1 Gene

  • Protein details for GLIPR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glioma pathogenesis-related protein 1
    Protein Accession:
    Secondary Accessions:
    • A7YET6
    • F8VUC2
    • Q15409
    • Q969K2

    Protein attributes for GLIPR1 Gene

    266 amino acids
    Molecular mass:
    30366 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAA82731.3; Type=Frameshift; Positions=3; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GLIPR1 Gene

    Alternative splice isoforms for GLIPR1 Gene


neXtProt entry for GLIPR1 Gene

Post-translational modifications for GLIPR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GLIPR1 Gene

Antibody Products

  • Abcam antibodies for GLIPR1
  • Santa Cruz Biotechnology (SCBT) Antibodies for GLIPR1

No data available for DME Specific Peptides for GLIPR1 Gene

Domains & Families for GLIPR1 Gene

Gene Families for GLIPR1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for GLIPR1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CRISP family.
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with GLIPR1: view

Function for GLIPR1 Gene

genes like me logo Genes that share phenotypes with GLIPR1: view

Animal Models for GLIPR1 Gene

MGI Knock Outs for GLIPR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for GLIPR1

CRISPR Products

miRNA for GLIPR1 Gene

miRTarBase miRNAs that target GLIPR1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GLIPR1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GLIPR1 Gene

Localization for GLIPR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLIPR1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLIPR1 gene
Compartment Confidence
plasma membrane 5
extracellular 4
lysosome 4
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GLIPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GLIPR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GLIPR1 Gene

Pathways & Interactions for GLIPR1 Gene

genes like me logo Genes that share pathways with GLIPR1: view

Interacting Proteins for GLIPR1 Gene

Gene Ontology (GO) - Biological Process for GLIPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019216 regulation of lipid metabolic process TAS --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with GLIPR1: view

No data available for SIGNOR curated interactions for GLIPR1 Gene

Drugs & Compounds for GLIPR1 Gene

(1) Drugs for GLIPR1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
SOT-107 Investigational Pharma Target 0
genes like me logo Genes that share compounds with GLIPR1: view

Transcripts for GLIPR1 Gene

mRNA/cDNA for GLIPR1 Gene

Unigene Clusters for GLIPR1 Gene

GLI pathogenesis-related 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GLIPR1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLIPR1 Gene

No ASD Table

Relevant External Links for GLIPR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GLIPR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GLIPR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GLIPR1 Gene

This gene is overexpressed in Whole Blood (x13.5) and Artery - Aorta (x5.6).

Protein differential expression in normal tissues from HIPED for GLIPR1 Gene

This gene is overexpressed in Monocytes (45.0) and NK cells (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GLIPR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of GLIPR1 Gene:


SOURCE GeneReport for Unigene cluster for GLIPR1 Gene:


mRNA Expression by UniProt/SwissProt for GLIPR1 Gene:

Tissue specificity: According to PubMed:8973356, it is ubiquitously expressed with high levels in lung and kidney and low levels in heart and liver. Highly expressed in cell lines derived from nervous system tumors arising from glia, low or absent in non-glial-derived nervous system tumor cell lines. Also found in fetal kidney. According to PubMed:7607567 it is expressed only in brain tumor glioblastoma multiforme/astrocytoma and not in other nervous system tumors or normal fetal or adult tissues.

Evidence on tissue expression from TISSUES for GLIPR1 Gene

  • Kidney(4.3)
  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with GLIPR1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLIPR1 Gene

Orthologs for GLIPR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GLIPR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GLIPR1 34 33
  • 99.5 (n)
(Bos Taurus)
Mammalia GLIPR1 34 33
  • 83.33 (n)
(Mus musculus)
Mammalia Glipr1 16 34 33
  • 78.82 (n)
(Canis familiaris)
Mammalia GLIPR1 34 33
  • 76.93 (n)
(Rattus norvegicus)
Mammalia Glipr1 33
  • 75.83 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 63 (a)
-- 34
  • 49 (a)
(Monodelphis domestica)
Mammalia GLIPR1 34
  • 56 (a)
(Gallus gallus)
Aves GLIPR1 33
  • 66.51 (n)
-- 34
  • 49 (a)
  • 48 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 46 (a)
-- 34
  • 45 (a)
(Danio rerio)
Actinopterygii LOC101886846 33
  • 54.51 (n)
(Caenorhabditis elegans)
Secernentea scl-5 34
  • 30 (a)
scl-7 34
  • 29 (a)
scl-2 34
  • 29 (a)
scl-15 34
  • 29 (a)
scl-14 34
  • 28 (a)
scl-1 34
  • 28 (a)
scl-20 34
  • 28 (a)
scl-3 34
  • 28 (a)
scl-12 34
  • 27 (a)
scl-6 34
  • 26 (a)
scl-8 34
  • 26 (a)
scl-11 34
  • 26 (a)
scl-13 34
  • 26 (a)
scl-10 34
  • 25 (a)
scl-21 34
  • 25 (a)
scl-9 34
  • 23 (a)
scl-19 34
  • 22 (a)
scl-18 34
  • 22 (a)
scl-17 34
  • 21 (a)
Species where no ortholog for GLIPR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GLIPR1 Gene

Gene Tree for GLIPR1 (if available)
Gene Tree for GLIPR1 (if available)
Evolutionary constrained regions (ECRs) for GLIPR1: view image

Paralogs for GLIPR1 Gene

(7) SIMAP similar genes for GLIPR1 Gene using alignment to 4 proteins:

  • B4E3S5_HUMAN
genes like me logo Genes that share paralogs with GLIPR1: view

Variants for GLIPR1 Gene

Sequence variations from dbSNP and Humsavar for GLIPR1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000012607 -- 75,482,323(+) A/G intron_variant
rs1000111362 -- 75,485,019(+) T/C intron_variant
rs1000353184 -- 75,478,749(+) G/A upstream_transcript_variant
rs1000394527 -- 75,485,380(+) T/C intron_variant
rs1000708245 -- 75,500,375(+) TCAATA/TCAATATCAATA 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for GLIPR1 Gene

Variant ID Type Subtype PubMed ID
esv3373789 CNV insertion 20981092
nsv826439 CNV gain 20364138

Variation tolerance for GLIPR1 Gene

Residual Variation Intolerance Score: 71.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GLIPR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLIPR1 Gene

Disorders for GLIPR1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GLIPR1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
glioblastoma multiforme
  • adult glioblastoma multiforme
nervous system cancer
  • malignant neoplasm of nervous system
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GLIPR1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GLIPR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GLIPR1 Gene

Publications for GLIPR1 Gene

  1. RTVP-1, a novel human gene with sequence similarity to genes of diverse species, is expressed in tumor cell lines of glial but not neuronal origin. (PMID: 8973356) Rich T … Israel MA (Gene 1996) 2 3 4 22 58
  2. The human glioma pathogenesis-related protein is structurally related to plant pathogenesis-related proteins and its gene is expressed specifically in brain tumors. (PMID: 7607567) Murphy EV … Biggs J (Gene 1995) 2 3 4 22 58
  3. Structure comparison of human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein P14a indicates a functional link between the human immune system and a plant defense system. (PMID: 9482873) Szyperski T … Wüthrich K (Proceedings of the National Academy of Sciences of the United States of America 1998) 3 4 22 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. [Methylation and expression of glioma pathogenesis-related protein 1 gene in acute myeloid leukemia]. (PMID: 19483285) Liang T … Xiao Z (Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 2009) 3 22 58

Products for GLIPR1 Gene

Sources for GLIPR1 Gene

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