Aliases for GLI4 Gene

Aliases for GLI4 Gene

  • GLI Family Zinc Finger 4 2 3 5
  • HKR4 2 3 4
  • Glioma-Associated Oncogene Family Zinc Finger 4 2 3
  • Krueppel-Related Zinc Finger Protein 4 3 4
  • Zinc Finger Protein GLI4 3 4
  • ZNF928 2 3
  • GLI-Kruppel Family Member GLI4 (Oncogene HKR4) 3
  • GLI-Kruppel Family Member GLI4 2
  • Protein HKR4 4
  • GLI4 5

External Ids for GLI4 Gene

Previous GeneCards Identifiers for GLI4 Gene

  • GC08P142542
  • GC08P9D0066
  • GC08P144104
  • GC08P144402
  • GC08P144420
  • GC08P144329
  • GC08P144349
  • GC08P139603

Summaries for GLI4 Gene

GeneCards Summary for GLI4 Gene

GLI4 (GLI Family Zinc Finger 4) is a Protein Coding gene. Diseases associated with GLI4 include Heart Fibrosarcoma and Parameningeal Embryonal Rhabdomyosarcoma. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is ZNF250.

Additional gene information for GLI4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GLI4 Gene

Genomics for GLI4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GLI4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GLI4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GLI4

Top Transcription factor binding sites by QIAGEN in the GLI4 gene promoter:
  • AREB6
  • Bach1
  • Bach2
  • GR
  • GR-alpha
  • GR-beta
  • NF-E2
  • NF-E2 p45
  • Olf-1
  • STAT5A

Genomic Locations for GLI4 Gene

Genomic Locations for GLI4 Gene
chr8:143,267,433-143,276,931
(GRCh38/hg38)
Size:
9,499 bases
Orientation:
Plus strand
chr8:144,349,603-144,359,101
(GRCh37/hg19)
Size:
9,499 bases
Orientation:
Plus strand

Genomic View for GLI4 Gene

Genes around GLI4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLI4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLI4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLI4 Gene

Proteins for GLI4 Gene

  • Protein details for GLI4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10075-GLI4_HUMAN
    Recommended name:
    Zinc finger protein GLI4
    Protein Accession:
    P10075
    Secondary Accessions:
    • Q96CK9

    Protein attributes for GLI4 Gene

    Size:
    376 amino acids
    Molecular mass:
    41145 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GLI4 Gene

Post-translational modifications for GLI4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GLI4 Gene

No data available for DME Specific Peptides for GLI4 Gene

Domains & Families for GLI4 Gene

Gene Families for GLI4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for GLI4 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for GLI4 Gene

GenScript: Design optimal peptide antigens:
  • Protein HKR4 (GLI4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P10075

UniProtKB/Swiss-Prot:

GLI4_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with GLI4: view

Function for GLI4 Gene

Molecular function for GLI4 Gene

GENATLAS Biochemistry:
GLI-Kruppel family member GLI4

Phenotypes From GWAS Catalog for GLI4 Gene

Gene Ontology (GO) - Molecular Function for GLI4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IBA 21873635
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with GLI4: view
genes like me logo Genes that share phenotypes with GLI4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GLI4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GLI4 Gene

Localization for GLI4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLI4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLI4 gene
Compartment Confidence
nucleus 3
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GLI4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with GLI4: view

Pathways & Interactions for GLI4 Gene

PathCards logo

SuperPathways for GLI4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GLI4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA 21873635
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with GLI4: view

No data available for Pathways by source and SIGNOR curated interactions for GLI4 Gene

Drugs & Compounds for GLI4 Gene

(2) Drugs for GLI4 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
GANT 58 Pharma GLI antagonist,novel and potent 0
GANT61 Pharma GLI antagonist 0

(2) ApexBio Compounds for GLI4 Gene

Compound Action Cas Number
GANT 58 GLI antagonist,novel and potent 64048-12-0
GANT61 GLI antagonist 500579-04-4
genes like me logo Genes that share compounds with GLI4: view

Drug Products

Transcripts for GLI4 Gene

mRNA/cDNA for GLI4 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GLI4

Alternative Splicing Database (ASD) splice patterns (SP) for GLI4 Gene

No ASD Table

Relevant External Links for GLI4 Gene

GeneLoc Exon Structure for
GLI4

Expression for GLI4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GLI4 Gene

Protein differential expression in normal tissues from HIPED for GLI4 Gene

This gene is overexpressed in Skin (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GLI4 Gene



Protein tissue co-expression partners for GLI4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GLI4

SOURCE GeneReport for Unigene cluster for GLI4 Gene:

Hs.400533

Evidence on tissue expression from TISSUES for GLI4 Gene

  • Lung(4)
genes like me logo Genes that share expression patterns with GLI4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLI4 Gene

Orthologs for GLI4 Gene

This gene was present in the common ancestor of animals.

Orthologs for GLI4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GLI4 30 31
  • 99.73 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GLI4 30 31
  • 84.31 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GLI4 30
  • 83.2 (n)
Rat
(Rattus norvegicus)
Mammalia LOC100911986 30
  • 80.08 (n)
Oppossum
(Monodelphis domestica)
Mammalia GLI4 31
  • 63 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii BX649341.4 31
  • 51 (a)
ManyToMany
si:dkey-247i3.7 31
  • 33 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea mnm-2 31
  • 23 (a)
OneToMany
Species where no ortholog for GLI4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for GLI4 Gene

ENSEMBL:
Gene Tree for GLI4 (if available)
TreeFam:
Gene Tree for GLI4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GLI4: view image

Paralogs for GLI4 Gene

Paralogs for GLI4 Gene

(491) SIMAP similar genes for GLI4 Gene using alignment to 6 proteins:

  • GLI4_HUMAN
  • E5RFY1_HUMAN
  • E5RG07_HUMAN
  • E5RGM1_HUMAN
  • E5RIX4_HUMAN
  • H0YBH2_HUMAN
genes like me logo Genes that share paralogs with GLI4: view

Variants for GLI4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GLI4 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs1056148 - p.Ala180Thr

Additional dbSNP identifiers (rs#s) for GLI4 Gene

Structural Variations from Database of Genomic Variants (DGV) for GLI4 Gene

Variant ID Type Subtype PubMed ID
dgv1237e201 CNV deletion 23290073
esv2737983 CNV deletion 23290073
esv2737986 CNV deletion 23290073
esv2737987 CNV deletion 23290073
esv2737988 CNV deletion 23290073
nsv1016726 CNV loss 25217958
nsv950010 CNV deletion 24416366

Variation tolerance for GLI4 Gene

Residual Variation Intolerance Score: 33.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.78; 89.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GLI4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLI4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLI4 Gene

Disorders for GLI4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GLI4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
heart fibrosarcoma
  • cardiac fibrosarcoma
parameningeal embryonal rhabdomyosarcoma
pleomorphic rhabdomyosarcoma
  • anaplastic rhabdomyosarcoma
- elite association - COSMIC cancer census association via MalaCards
Search GLI4 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with GLI4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GLI4 Gene

Publications for GLI4 Gene

  1. The GLI-Kruppel family of human genes. (PMID: 2850480) Ruppert JM … Vogelstein B (Molecular and cellular biology 1988) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Assignment of the gene encoding human Krüppel-related zinc finger protein 4 (GLI4) to 8q24.3 by fluorescent in situ hybridization. (PMID: 8641133) Kas K … Van de Ven WJ (Cytogenetics and cell genetics 1996) 3 23
  4. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. (PMID: 29180619) Kumar R … Vertegaal ACO (Nature communications 2017) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for GLI4 Gene

Sources for GLI4 Gene