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Aliases for GLI4 Gene

Aliases for GLI4 Gene

  • GLI Family Zinc Finger 4 2 3 5
  • Glioma-Associated Oncogene Family Zinc Finger 4 2 3
  • Krueppel-Related Zinc Finger Protein 4 3 4
  • HKR4 3 4
  • GLI-Kruppel Family Member GLI4 (Oncogene HKR4) 3
  • GLI-Kruppel Family Member GLI4 2
  • Zinc Finger Protein GLI4 3
  • Protein HKR4 4
  • ZNF928 3

External Ids for GLI4 Gene

Previous GeneCards Identifiers for GLI4 Gene

  • GC08P142542
  • GC08P9D0066
  • GC08P144104
  • GC08P144402
  • GC08P144420
  • GC08P144329
  • GC08P144349
  • GC08P139603

Summaries for GLI4 Gene

GeneCards Summary for GLI4 Gene

GLI4 (GLI Family Zinc Finger 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is ZNF34.

Additional gene information for GLI4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLI4 Gene

Genomics for GLI4 Gene

GeneHancer (GH) Regulatory Elements for GLI4 Gene

Promoters and enhancers for GLI4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J143275 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 653.1 +11.6 11641 6.5 HDGF PKNOX1 CLOCK SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 GLI4 MINCR ZNF623 GPAA1 PARP10 SHARPIN ENSG00000255050 ZNF707 ZFP41 EEF1D
GH08J143266 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.0 30 2.4 ATF1 ARID4B SIN3A DMAP1 ZNF48 ETS1 GLIS2 E2F8 ELK1 ZNF207 GLI4 MINCR ENSG00000264668
GH08J142725 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.8 -540.2 -540204 3.2 PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 THEM6 ENSG00000253806 LOC100288181 LY6K JRK ZNF623 ENSG00000255050 ZC3H3 GLI4 ZNF696
GH08J144101 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.8 +836.5 836478 4 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 SP3 NFYC SHARPIN MAF1 ZNF623 ZNF7 ZNF16 ZNF251 ZNF250 ZNF517 CPSF1 ZNF696
GH08J143634 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.1 +368.7 368680 2.9 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B ZNF623 LOC105375798 VPS28 CPSF1 ZNF707 LRRC14 ADCK5 SLC52A2 NAPRT GPAA1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GLI4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GLI4 gene promoter:
  • Bach1
  • AREB6
  • Bach2
  • Olf-1
  • GR-beta
  • GR-alpha
  • GR
  • NF-E2 p45
  • NF-E2
  • STAT5A

Genomic Locations for GLI4 Gene

Genomic Locations for GLI4 Gene
9,499 bases
Plus strand
9,499 bases
Plus strand

Genomic View for GLI4 Gene

Genes around GLI4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLI4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLI4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLI4 Gene

Proteins for GLI4 Gene

  • Protein details for GLI4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein GLI4
    Protein Accession:
    Secondary Accessions:
    • Q96CK9

    Protein attributes for GLI4 Gene

    376 amino acids
    Molecular mass:
    41145 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GLI4 Gene

Post-translational modifications for GLI4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GLI4 Gene

No data available for DME Specific Peptides for GLI4 Gene

Domains & Families for GLI4 Gene

Gene Families for GLI4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for GLI4 Gene

Suggested Antigen Peptide Sequences for GLI4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with GLI4: view

Function for GLI4 Gene

Molecular function for GLI4 Gene

GENATLAS Biochemistry:
GLI-Kruppel family member GLI4

Phenotypes From GWAS Catalog for GLI4 Gene

Gene Ontology (GO) - Molecular Function for GLI4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
genes like me logo Genes that share ontologies with GLI4: view
genes like me logo Genes that share phenotypes with GLI4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GLI4 Gene

Localization for GLI4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLI4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLI4 gene
Compartment Confidence
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GLI4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with GLI4: view

Pathways & Interactions for GLI4 Gene

No Data Available

Interacting Proteins for GLI4 Gene

Gene Ontology (GO) - Biological Process for GLI4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with GLI4: view

No data available for Pathways by source and SIGNOR curated interactions for GLI4 Gene

Drugs & Compounds for GLI4 Gene

(2) Drugs for GLI4 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
GANT 58 Pharma GLI antagonist,novel and potent 0
GANT61 Pharma GLI antagonist 0

(2) ApexBio Compounds for GLI4 Gene

Compound Action Cas Number
GANT 58 GLI antagonist,novel and potent 64048-12-0
GANT61 GLI antagonist 500579-04-4
genes like me logo Genes that share compounds with GLI4: view

Drug Products

Transcripts for GLI4 Gene

mRNA/cDNA for GLI4 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(184) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GLI4 Gene

GLI family zinc finger 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLI4 Gene

No ASD Table

Relevant External Links for GLI4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GLI4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GLI4 Gene

Protein differential expression in normal tissues from HIPED for GLI4 Gene

This gene is overexpressed in Skin (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GLI4 Gene

Protein tissue co-expression partners for GLI4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GLI4 Gene:


SOURCE GeneReport for Unigene cluster for GLI4 Gene:


Evidence on tissue expression from TISSUES for GLI4 Gene

  • Lung(4)
genes like me logo Genes that share expression patterns with GLI4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLI4 Gene

Orthologs for GLI4 Gene

This gene was present in the common ancestor of animals.

Orthologs for GLI4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GLI4 34 33
  • 99.73 (n)
(Canis familiaris)
Mammalia GLI4 34 33
  • 84.31 (n)
(Bos Taurus)
Mammalia GLI4 33
  • 83.2 (n)
(Rattus norvegicus)
Mammalia LOC100911986 33
  • 80.08 (n)
(Monodelphis domestica)
Mammalia GLI4 34
  • 63 (a)
(Danio rerio)
Actinopterygii BX649341.4 34
  • 51 (a)
si:dkey-247i3.7 34
  • 33 (a)
(Caenorhabditis elegans)
Secernentea mnm-2 34
  • 23 (a)
Species where no ortholog for GLI4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GLI4 Gene

Gene Tree for GLI4 (if available)
Gene Tree for GLI4 (if available)
Evolutionary constrained regions (ECRs) for GLI4: view image

Paralogs for GLI4 Gene

(491) SIMAP similar genes for GLI4 Gene using alignment to 6 proteins:

  • E5RG07_HUMAN
genes like me logo Genes that share paralogs with GLI4: view

Variants for GLI4 Gene

Sequence variations from dbSNP and Humsavar for GLI4 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000024007 -- 143,270,497(+) C/T intron_variant
rs1000074700 -- 143,270,318(+) G/A intron_variant
rs1000759240 -- 143,271,707(+) C/T intron_variant
rs1000929052 -- 143,265,806(+) A/C upstream_transcript_variant
rs1001333794 -- 143,272,703(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GLI4 Gene

Variant ID Type Subtype PubMed ID
dgv1237e201 CNV deletion 23290073
esv2737983 CNV deletion 23290073
esv2737986 CNV deletion 23290073
esv2737987 CNV deletion 23290073
esv2737988 CNV deletion 23290073
nsv1016726 CNV loss 25217958
nsv950010 CNV deletion 24416366

Variation tolerance for GLI4 Gene

Residual Variation Intolerance Score: 33.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.78; 89.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GLI4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLI4 Gene

Disorders for GLI4 Gene

Additional Disease Information for GLI4

No disorders were found for GLI4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLI4 Gene

Publications for GLI4 Gene

  1. The GLI-Kruppel family of human genes. (PMID: 2850480) Ruppert JM … Vogelstein B (Molecular and cellular biology 1988) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Assignment of the gene encoding human Krüppel-related zinc finger protein 4 (GLI4) to 8q24.3 by fluorescent in situ hybridization. (PMID: 8641133) Kas K … Van de Ven WJ (Cytogenetics and cell genetics 1996) 3 22 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes. (PMID: 25544563) Davis ZH … Glaunsinger BA (Molecular cell 2015) 3 58

Products for GLI4 Gene

Sources for GLI4 Gene

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