Aliases for GLI1 Gene
Aliases for GLI1 Gene
External Ids for GLI1 Gene
- HGNC: 4317
- Entrez Gene: 2735
- Ensembl: ENSG00000111087
- OMIM: 165220
- UniProtKB: P08151
Previous HGNC Symbols for GLI1 Gene
- GLI
Previous GeneCards Identifiers for GLI1 Gene
- GC12P056141
- GC12P057853
- GC12P054892
Summaries for GLI1 Gene
-
This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
GeneCards Summary for GLI1 Gene
GLI1 (GLI Family Zinc Finger 1) is a Protein Coding gene. Diseases associated with GLI1 include Ellis-Van Creveld Syndrome and Pallister-Hall Syndrome. Among its related pathways are ERK Signaling and G-Beta Gamma Signaling. Gene Ontology (GO) annotations related to this gene include chromatin binding and microtubule binding. An important paralog of this gene is GLI2.
UniProtKB/Swiss-Prot for GLI1 Gene
-
Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24311597, PubMed:24217340). Binds to the DNA consensus sequence 5-GACCACCCA-3 (PubMed:2105456, PubMed:8378770, PubMed:24217340). May regulate the transcription of specific genes during normal development (PubMed:19706761). May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761). Plays a role in cell proliferation and differentiation via its role in SHH signaling (Probable).
-
Isoform 2: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration.
-
The Hedgehog (Hh) signaling pathway is crucial in the development of all animals. In the embryo, it regulates morphogenesis of a variety of tissues and organs; in the adult, it controls stem cell proliferation. There are three known human Hh proteins: Shh, Dhh and Ihh.
Additional gene information for GLI1 Gene
- Monarch Initiative
- Search for GLI1 at DataMed
- Search for GLI1 at HumanCyc
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLI1 Gene
Genomics for GLI1 Gene
GeneHancer (GH) Regulatory Elements for GLI1 Gene
Promoters and enhancers for GLI1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around GLI1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the GLI1 gene promoter:
-
- p53
- NF-1
- Sp1
- STAT5A
- c-Myb
- Nkx2-5
Regulatory Element Products
Genomic Locations for GLI1 Gene
Genomic Locations for GLI1 Gene
- chr12:57,460,135-57,472,268
- (GRCh38/hg38)
- Size:
- 12,134 bases
- Orientation:
- Plus strand
- chr12:57,853,918-57,866,051
- (GRCh37/hg19)
- Size:
- 12,134 bases
- Orientation:
- Plus strand
Genomic View for GLI1 Gene
Genes around GLI1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.3 by Entrez Gene
- 12q13.3 by HGNC
- 12q13.3 by Ensembl
GLI1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GLI1 Gene
Proteins for GLI1 Gene
-
Protein details for GLI1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P08151-GLI1_HUMAN
- Recommended name:
- Zinc finger protein GLI1
- Protein Accession:
- P08151
- D0EUY3
- E9PQQ9
- F5H6H8
- Q8TDN9
Protein attributes for GLI1 Gene
- Size:
- 1106 amino acids
- Molecular mass:
- 117904 Da
- Quaternary structure:
-
- Interacts with KIF7 (By similarity). Interacts with STK36 (PubMed:10806483). Interacts with ZIC1; the interaction enhances transcription activation (PubMed:11238441). Interacts with SUFU; this inhibits transcriptional activation by GLI1 (PubMed:10806483, PubMed:24311597, PubMed:24217340, PubMed:28965847).
Three dimensional structures from OCA and Proteopedia for GLI1 Gene
Protein Expression for GLI1 Gene
Post-translational modifications for GLI1 Gene
- Phosphorylated in vitro by ULK3.
- Acetylation at Lys-518 down-regulates transcriptional activity. Deacetylated by HDAC1.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for GLI1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for GLI1 (GLI-1)
-
Custom Antibody ServicesOriGene Antibodies for GLI1
- AP05303PU-N
- AP05303SU-N
- CF803558
- CF803601
- CF803685
- CF803697
- CF803756
- CF803802
- CF803803
- CF803805
- CF803806
- CF803807
- CF803810
- CF803811
- CF803812
- CF803832
- CF803833
- CF803887
- CF803888
- CF803889
- CF803918
- CF803919
- CF803920
- CF803921
- CF803967
- CF803968
- CF803969
- CF803970
- CF804011
- CF804177
- CF804205
- TA309673
- TA309674
- TA310536
- TA328007
- TA337026
- TA803558
- TA803601
- TA803685
- TA803697
- TA803756
- TA803802
- TA803803
- TA803805
- TA803806
- TA803807
- TA803810
- TA803811
- TA803812
- TA803832
- TA803833
- TA803887
- TA803888
- TA803889
- TA803918
- TA803919
- TA803920
- TA803921
- TA803967
- TA803968
- TA803969
- TA803970
- TA804011
- TA804177
- TA804205
- UM800063
- UM800063CF
- UM870063
- Novus Biologicals Antibodies for GLI1
-
Abcam antibodies for GLI1
- Invitrogen Antibodies for GLI1 (AFLGC-GLI1)
- antibodies-online: Search results for 193 available GLI1 Antibodies ranked by validation data
- Compare Top GLI1 Antibodies
-
Recommended
- 158 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC (p) Antibodies (anti-human)
- 4 FACS Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 12 IF (p) Antibodies (anti-rat)
- 11 WB Antibodies (anti-rat)
- 43 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- GeneTex GLI1 Antibody for GLI1
-
Santa Cruz Biotechnology (SCBT) Antibodies for GLI1
- Sino Biological Antibodies for GLI1
Protein Products
-
OriGene Purified Proteins for GLI1
- Search Origene for MassSpec and Protein Over-expression Lysates for GLI1
- Origene Custom Protein Services for GLI1
- Search GeneTex for Proteins for GLI1
-
Abcam proteins for GLI1
Assay Products
No data available for DME Specific Peptides for GLI1 Gene
Domains & Families for GLI1 Gene
Gene Families for GLI1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for GLI1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for GLI1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P08151- Family:
-
- Belongs to the GLI C2H2-type zinc-finger protein family.
Function for GLI1 Gene
Molecular function for GLI1 Gene
- UniProtKB/Swiss-Prot Function:
- Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24311597, PubMed:24217340). Binds to the DNA consensus sequence 5-GACCACCCA-3 (PubMed:2105456, PubMed:8378770, PubMed:24217340). May regulate the transcription of specific genes during normal development (PubMed:19706761). May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761). Plays a role in cell proliferation and differentiation via its role in SHH signaling (Probable).
- UniProtKB/Swiss-Prot Function:
- Isoform 2: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration.
- UniProtKB/Swiss-Prot Induction:
- Isoform 1 and isoform 2 are amplified in glioblastoma cells.
Phenotypes From GWAS Catalog for GLI1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 18298960 |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS | 19274049 |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IDA | 9118802 |
Phenotypes for GLI1 Gene
- MGI mutant phenotypes for GLI1:
-
inferred from 4 alleles
- respiratory system phenotype
- limbs/digits/tail phenotype
- digestive/alimentary phenotype
- nervous system phenotype
- behavior/neurological phenotype
- no phenotypic analysis
- neoplasm
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- craniofacial phenotype
- reproductive system phenotype
- embryo phenotype
- normal phenotype
- renal/urinary system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for GLI1:
-
- Dynamic nuclei (hole, folded or small irregular)
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Increased caspase activity
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Increased transferrin (TF) endocytosis
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Models for GLI1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for GLI1
-
CRISPR Products
-
OriGene CRISPR knockouts for GLI1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GLI1
- genomics-online: gRNA clones - Search results for 88 available GLI1 gene related products
- Overview of 88 available GLI1 gene related products
- Applied Biological Materials CRISPR for GLI1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GLI1
- GenScript: Design CRISPR guide RNA sequences for GLI1
miRNA for GLI1 Gene
- miRTarBase miRNAs that target GLI1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GLI1
- Browse OriGene Inhibitory RNA Products For GLI1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GLI1
- genomics-online: shRNA clones - Search results for 88 available GLI1 gene related products
- Overview of 88 available GLI1 gene related products
Clone Products
-
OriGene ORF clones in human for GLI1
- RC201110
- RC201110L1
- RC201110L2
- RC201110L3
- RC201110L4
- RC229049
- RC229049L1
- RC229049L2
- RC229049L3
- RC229049L4
- RC230639
- RC230639L1
- RC230639L2
- RC230639L3
- RC230639L4
- RG201110
- RG229049
- RG230639
- RC201110L1V
- RC201110L2V
- RC201110L3V
- RC201110L4V
- RC229049L1V
- RC229049L2V
- RC229049L3V
- RC229049L4V
- RC230639L1V
- RC230639L2V
- RC230639L3V
- RC230639L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Addgene plasmids for GLI1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GLI1
- Applied Biological Materials Clones for GLI1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for GLI1
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GLI1 Gene
Localization for GLI1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GLI1 Gene
- Cytoplasm. Nucleus. Note=Tethered in the cytoplasm by binding to SUFU (PubMed:10806483). Activation and translocation to the nucleus is promoted by interaction with STK36 (PubMed:10806483). Phosphorylation by ULK3 may promote nuclear localization (PubMed:19878745). Translocation to the nucleus is promoted by interaction with ZIC1 (PubMed:11238441). {ECO:0000269 PubMed:10806483, ECO:0000269 PubMed:11238441, ECO:0000269 PubMed:19878745}.
- Isoform 2: Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
- Cytosol (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 10806483 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 10504446 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005929 | cilium | IEA | -- |
Pathways & Interactions for GLI1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Hedgehog Pathway |
.40
|
|
| 2 | Signaling by Hedgehog | ||
| 3 | Activation of cAMP-Dependent PKA |
.56
|
|
| 4 | G-Beta Gamma Signaling |
.44
|
|
| 5 | Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling | ||
Pathways by source for GLI1 Gene
3 BioSystems pathways for GLI1 Gene
6 Reactome pathways for GLI1 Gene
4 KEGG pathways for GLI1 Gene
1 GeneGo (Thomson Reuters) pathway for GLI1 Gene
1 Tocris pathway for GLI1 Gene
5 Qiagen pathways for GLI1 Gene
1 Cell Signaling Technology pathway for GLI1 Gene
Interacting Proteins for GLI1 Gene
Selected Interacting proteins:
P08151-GLI1_HUMAN
ENSP00000228682
for GLI1 Gene via
UniProtKB
STRING
MINT
IID
GPS-Prot Interaction Network for GLI1
SIGNOR curated interactions for GLI1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001649 | osteoblast differentiation | IDA | 12165851 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007224 | smoothened signaling pathway | TAS | 11001584 |
| GO:0007275 | multicellular organism development | IEA | -- |
Drugs & Compounds for GLI1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cyclopamine | Pharma | Hedgehog (Hh) signaling Inhibitor, Inhibitor of Hedgehog (Hh) signaling | 0 | |||
| GANT 58 | Pharma | GLI antagonist,novel and potent | 0 | |||
| GANT61 | Pharma | GLI antagonist | 0 | |||
| 20(S)-Hydroxycholesterol | Pharma | Allosteric activator of Hedgehog (Hh) signaling; induces Smo accumulation | 0 | |||
| Jervine | Pharma | Hedgehog signaling Inhibitor, Inhibitor of Hedgehog (Hh) signaling; binds directly to Smo | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(5) Tocris Compounds for GLI1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 20(S)-Hydroxycholesterol | Allosteric activator of Hedgehog (Hh) signaling; induces Smo accumulation | 516-72-3 |
| Cyclopamine | Inhibitor of Hedgehog (Hh) signaling | 4449-51-8 |
| Jervine | Inhibitor of Hedgehog (Hh) signaling; binds directly to Smo | 469-59-0 |
| SANT-1 | Inhibitor of hedgehog (Hh) signaling; antagonizes smoothened activity | 304909-07-7 |
| SANT-2 | Inhibitor of Hedgehog (Hh) signaling; antagonizes smoothened activity | 329196-48-7 |
Drug Products
Transcripts for GLI1 Gene
mRNA/cDNA for GLI1 Gene
- (5) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (45) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000532291 784 bps (uc058pvp.1)
- ENST00000228682 3613 bps (uc001snx.4)
- ENST00000528432 480 bps (uc058pvq.1)
- ENST00000530789 314 bps (uc009zpr.2)
- ENST00000528467 3196 bps (uc058pvr.1)
Unigene Clusters for GLI1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GLI1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GLI1
- genomics-online: gRNA clones - Search results for 88 available GLI1 gene related products
- Overview of 88 available GLI1 gene related products
- Applied Biological Materials CRISPR for GLI1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GLI1
- GenScript: Design CRISPR guide RNA sequences for GLI1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GLI1
- Browse OriGene Inhibitory RNA Products For GLI1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GLI1
- genomics-online: shRNA clones - Search results for 88 available GLI1 gene related products
- Overview of 88 available GLI1 gene related products
Clone Products
-
OriGene ORF clones in human for GLI1
- RC201110
- RC201110L1
- RC201110L2
- RC201110L3
- RC201110L4
- RC229049
- RC229049L1
- RC229049L2
- RC229049L3
- RC229049L4
- RC230639
- RC230639L1
- RC230639L2
- RC230639L3
- RC230639L4
- RG201110
- RG229049
- RG230639
- RC201110L1V
- RC201110L2V
- RC201110L3V
- RC201110L4V
- RC229049L1V
- RC229049L2V
- RC229049L3V
- RC229049L4V
- RC230639L1V
- RC230639L2V
- RC230639L3V
- RC230639L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Addgene plasmids for GLI1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GLI1
- Applied Biological Materials Clones for GLI1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for GLI1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Lateral Ganglionic Eminence Progenitor Cells Lateral Ganglionic Eminence
- Early Caudal Floor Plate Cells Diencephalic Floor Plate
- Early Floor Plate Cells Mesencephalic Floor Plate
- Meso-diencephalic Dopaminergic Precursor Cells Diencephalic Ventricular Zone
- Meso-diencephalic Dopaminergic Precursor Cells Mesencephalic Ventricular Zone
-
Neural Tube (Nervous System)
- Lateral Ganglionic Eminence Progenitor Cells Lateral Ganglionic Eminence
- Early Caudal Floor Plate Cells Diencephalic Floor Plate
- Early Floor Plate Cells Mesencephalic Floor Plate
- Meso-diencephalic Dopaminergic Precursor Cells Diencephalic Ventricular Zone
- Meso-diencephalic Dopaminergic Precursor Cells Mesencephalic Ventricular Zone
-
Tooth (Integumentary System)
- Dental Placode Cells Dental Placode
- Dental Papilla Cells Dental Papilla
- Dental Mesenchymal Cells Branchial Arch 1
- Inner Enamel Epithelial Cells Dental Enamel
- Stellate Reticulum Cells Dental Core
-
Cartilage (Muscoskeletal System)
- Chondrocytes Reicherts Cartilage
- Chondrocytes Nasal Capsule
- Chondrocytes Mandibular Condyle
- Chondrocytes Meckels Cartilage
- Polymorphic Progenitors Cells Temporomandibular Joint
-
Bone (Muscoskeletal System)
- Chondrocytes Mandibular Condyle
- Prechondrocytic Mesenchymal Cells Autopod
- Mandibular Condyle
- Mandibular Process
- Autopod Long Bone
-
Epithelial Cells
- Dental Placode Cells Dental Placode
- Inner Enamel Epithelial Cells Dental Enamel
- Outer Enamel Epithelial Cells Dental Enamel
-
Limb (Muscoskeletal System)
- Limb Bud Mesenchyme Cells Limb Bud
- Prechondrocytic Mesenchymal Cells Autopod
- Limb Bud
-
Hair (Integumentary System)
- Dermal Condensate Cells Dermal Papilla
- Zigzag Dermal Papilla Cells Dermal Papilla
-
Dermis (Integumentary System)
- Dermal Condensate Cells Dermal Papilla
- Zigzag Dermal Papilla Cells Dermal Papilla
-
Head Mesenchyme (Muscoskeletal System)
- Dental Mesenchymal Cells Branchial Arch 1
- Branchial Arch 1
- Glial Cells (Uncategorized)
- Spinal Cord (Nervous System)
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
-
Adipose (Muscoskeletal System)
- Stromal Vascular Preadipocyte Progenitor Cells Vascular Adipose
-
Mesoderm (Gastrulation Derivatives)
- Limb Bud Mesenchyme Cells Limb Bud
-
Testis (Reproductive System)
- Testicular Interstitial Cells Testis Interstitium
-
Neural Ectoderm (Nervous System)
- Spinal Neural Plate Cells Neural Plate
- Liver (Hepatobiliary System)
- NULL (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for GLI1 Gene
This gene is overexpressed in Nerve - Tibial (x9.7) and Cervix - Endocervix (x4.9).
This gene is overexpressed in Pancreatic juice (51.0) and Peripheral blood mononuclear cells (14.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GLI1 Gene
NURSA nuclear receptor signaling pathways regulating expression of GLI1 Gene:
GLI1SOURCE GeneReport for Unigene cluster for GLI1 Gene:
Hs.632702mRNA Expression by UniProt/SwissProt for GLI1 Gene:
P08151-GLI1_HUMAN
Tissue specificity:
Detected in testis (at protein level) (PubMed:2105456). Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract (PubMed:19878745). Isoform 1 is detected in brain, spleen, pancreas, liver, kidney and placenta; isoform 2 is not detectable in these tissues (PubMed:19706761).
Evidence on tissue expression from TISSUES for GLI1 Gene
- Muscle(4.5)
- Nervous system(2.5)
- Skin(2)
Primer Products
-
OriGene qPCR primer pairs for GLI1
-
OriGene qPCR primer pairs and template standards for GLI1
- genomics-online: primer clones - Search results for 88 available GLI1 gene related products
- Overview of 88 available GLI1 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GLI1 Gene
Orthologs for GLI1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GLI1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | GLI1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | GLI1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Gli1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Gli1 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | GLI1 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | GLI1 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | gli1 34 |
|
OneToOne | |
| -- 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | ci 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | ref-2 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for GLI1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for GLI1 Gene
- ENSEMBL:
- Gene Tree for GLI1 (if available)
- TreeFam:
- Gene Tree for GLI1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GLI1: view image
Paralogs for GLI1 Gene
(35) SIMAP similar genes for GLI1 Gene using alignment to 6 proteins:
- GLI1_HUMAN
- B1Q2M2_HUMAN
- E9PIB9_HUMAN
- E9PQQ1_HUMAN
- F5H6H8_HUMAN
- T2HQN2_HUMAN
Variants for GLI1 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs193921005 | uncertain-significance, Malignant tumor of prostate | 57,465,251(+) | G/A | coding_sequence_variant, missense_variant | |
| VAR_035557 | A breast cancer sample | p.Pro210Ala | |||
| VAR_035558 | A breast cancer sample | p.Thr514Ile | |||
| VAR_035559 | A breast cancer sample | p.Glu817Gln | |||
| rs1000032629 | -- | 57,471,809(+) | T/C | coding_sequence_variant, synonymous_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2651n54 | CNV | loss | 21841781 |
| esv2759901 | CNV | gain | 17122850 |
| nsv1143565 | CNV | deletion | 24896259 |
| nsv428283 | CNV | gain | 18775914 |
| nsv469411 | CNV | loss | 19166990 |
| nsv482992 | CNV | gain+loss | 15286789 |
| nsv559034 | CNV | loss | 21841781 |
| nsv559035 | CNV | loss | 21841781 |
| nsv8974 | CNV | gain | 18304495 |
| nsv952190 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
12.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.43;
90.94% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GLI1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLI1 Gene
Disorders for GLI1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ellis-van creveld syndrome |
|
|
| pallister-hall syndrome |
|
|
| necrobiosis lipoidica |
|
|
| basal cell carcinoma |
|
|
| granuloma annulare |
|
|
Search GLI1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GLI1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for GLI1 Gene
Publications for GLI1 Gene
- Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation. (PMID: 20081843) Canettieri G … Gulino A (Nature cell biology 2010) 3 4 22 58
- A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion. (PMID: 19706761) Lo HW … Ali-Osman F (Cancer research 2009) 3 4 22 58
- GLI1 genotypes do not predict basal cell carcinoma risk: a case control study. (PMID: 19948058) Watson A … Walterhouse DO (Molecular cancer 2009) 3 22 44 58
- Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways. (PMID: 19071955) Lees CW … Satsangi J (PLoS medicine 2008) 3 22 44 58
- Physical and functional interactions between Zic and Gli proteins. (PMID: 11238441) Koyabu Y … Mikoshiba K (The Journal of biological chemistry 2001) 3 4 22 58
Products for GLI1 Gene
- R&D Systems Antibodies for GLI1 (GLI-1)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for GLI1
- AP05303PU-N
- AP05303SU-N
- CF803558
- CF803601
- CF803685
- CF803697
- CF803756
- CF803802
- CF803803
- CF803805
- CF803806
- CF803807
- CF803810
- CF803811
- CF803812
- CF803832
- CF803833
- CF803887
- CF803888
- CF803889
- CF803918
- CF803919
- CF803920
- CF803921
- CF803967
- CF803968
- CF803969
- CF803970
- CF804011
- CF804177
- CF804205
- TA309673
- TA309674
- TA310536
- TA328007
- TA337026
- TA803558
- TA803601
- TA803685
- TA803697
- TA803756
- TA803802
- TA803803
- TA803805
- TA803806
- TA803807
- TA803810
- TA803811
- TA803812
- TA803832
- TA803833
- TA803887
- TA803888
- TA803889
- TA803918
- TA803919
- TA803920
- TA803921
- TA803967
- TA803968
- TA803969
- TA803970
- TA804011
- TA804177
- TA804205
- UM800063
- UM800063CF
- UM870063
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for GLI1
- Search Origene for MassSpec and Protein Over-expression Lysates for GLI1
- Origene Custom Protein Services for GLI1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GLI1
- Browse OriGene Inhibitory RNA Products For GLI1
- OriGene qPCR primer pairs for GLI1
- OriGene qPCR primer pairs and template standards for GLI1
- OriGene CRISPR knockouts for GLI1
- OriGene ORF clones in human for GLI1
- RC201110
- RC201110L1
- RC201110L2
- RC201110L3
- RC201110L4
- RC229049
- RC229049L1
- RC229049L2
- RC229049L3
- RC229049L4
- RC230639
- RC230639L1
- RC230639L2
- RC230639L3
- RC230639L4
- RG201110
- RG229049
- RG230639
- RC201110L1V
- RC201110L2V
- RC201110L3V
- RC201110L4V
- RC229049L1V
- RC229049L2V
- RC229049L3V
- RC229049L4V
- RC230639L1V
- RC230639L2V
- RC230639L3V
- RC230639L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For GLI1
- GenScript: Next-day shipping of latest version cDNA ORF clones for GLI1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for GLI1
- GenScript Custom Assay Services for GLI1
- GenScript Custom overexpressing Cell Line Services for GLI1
- GenScript: Design CRISPR guide RNA sequences for GLI1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for GLI1
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for GLI1
- Browse Sino Biological Assays
- Browse Antibodies
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for GLI1
- Novus Biologicals proteins and lysates for GLI1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for GLI1
- Abcam proteins for GLI1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for GLI1 (AFLGC-GLI1)
- Cyagen custom Knockout/knockin (KOKI) mouse models for GLI1
- Addgene plasmids for GLI1
- antibodies-online: Search results for 193 available GLI1 Antibodies ranked by validation data
- Compare Top GLI1 Antibodies
- Recommended
- 158 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC (p) Antibodies (anti-human)
- 4 FACS Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 12 IF (p) Antibodies (anti-rat)
- 11 WB Antibodies (anti-rat)
- 43 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- antibodies-online: Search results for 10 available GLI1 Elisa Kits ranked by validation data
- Compare Top GLI1 Elisa Kits
- antibodies-online: Search results for 10 available GLI1 Proteins ranked by validation data
- Compare Top GLI1 Proteins
- GeneTex GLI1 Antibody for GLI1
- Search GeneTex for Proteins for GLI1
- Santa Cruz Biotechnology (SCBT) Antibodies for GLI1
- Search Santa Cruz Biotechnology (SCBT) for GLI1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GLI1
- Horizon Cell Lines for GLI1
- genomics-online: cdna clones - Search results for 88 available GLI1 gene related products
- Overview of 88 available GLI1 gene related products
- orf clones - Search results for 88 available GLI1 gene related products
- Overview of 88 available GLI1 gene related products
- genomics-online: gRNA clones - Search results for 88 available GLI1 gene related products
- Overview of 88 available GLI1 gene related products
- genomics-online: primer clones - Search results for 88 available GLI1 gene related products
- Overview of 88 available GLI1 gene related products
- genomics-online: shRNA clones - Search results for 88 available GLI1 gene related products
- Overview of 88 available GLI1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GLI1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GLI1
- GeneCopoeia miRNA 3'UTR Target clone products for GLI1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GLI1
Sources for GLI1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt