Aliases for GLG1 Gene

Aliases for GLG1 Gene

  • Golgi Glycoprotein 1 2 3 5
  • Golgi Apparatus Protein 1 2 3 4
  • Cysteine-Rich Fibroblast Growth Factor Receptor 3 4
  • Golgi Sialoglycoprotein MG-160 3 4
  • E-Selectin Ligand 1 3 4
  • CFR-1 3 4
  • ESL-1 3 4
  • MG160 3 4
  • MG-160 3
  • CFR1 4
  • ESL1 4

External Ids for GLG1 Gene

Previous GeneCards Identifiers for GLG1 Gene

  • GC16U990026
  • GC16M075446
  • GC16M074225
  • GC16M074266
  • GC16M074265
  • GC16M073044
  • GC16M074481
  • GC16M060230

Summaries for GLG1 Gene

GeneCards Summary for GLG1 Gene

GLG1 (Golgi Glycoprotein 1) is a Protein Coding gene. Diseases associated with GLG1 include Ecthyma and Pontocerebellar Hypoplasia, Type 2E. Among its related pathways are Cell surface interactions at the vascular wall and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include signaling receptor binding.

UniProtKB/Swiss-Prot Summary for GLG1 Gene

  • Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).

Gene Wiki entry for GLG1 Gene

Additional gene information for GLG1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GLG1 Gene

Genomics for GLG1 Gene

GeneHancer (GH) Regulatory Elements for GLG1 Gene

Promoters and enhancers for GLG1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GLG1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GLG1

Top Transcription factor binding sites by QIAGEN in the GLG1 gene promoter:
  • c-Ets-1
  • E47
  • GATA-1
  • GATA-2
  • GATA-3
  • p300
  • Pax-4a
  • Sox9
  • Tal-1

Genomic Locations for GLG1 Gene

Genomic Locations for GLG1 Gene
chr16:74,447,427-74,607,144
(GRCh38/hg38)
Size:
159,718 bases
Orientation:
Minus strand
chr16:74,481,325-74,641,042
(GRCh37/hg19)
Size:
159,718 bases
Orientation:
Minus strand

Genomic View for GLG1 Gene

Genes around GLG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLG1 Gene

Proteins for GLG1 Gene

  • Protein details for GLG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92896-GSLG1_HUMAN
    Recommended name:
    Golgi apparatus protein 1
    Protein Accession:
    Q92896
    Secondary Accessions:
    • B7Z8Y4
    • D3DUJ7
    • Q13221
    • Q6P9D1

    Protein attributes for GLG1 Gene

    Size:
    1179 amino acids
    Molecular mass:
    134552 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB02178.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for GLG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GLG1 Gene

Post-translational modifications for GLG1 Gene

  • Fucosylation is essential for binding to E-selectin.
  • N-glycosylated. Contains sialic acid residues.
  • Glycosylation at Asn165, Asn210, Asn581, Asn677, Thr739, and Asn786
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • GSLG1_HUMAN (1280)

No data available for DME Specific Peptides for GLG1 Gene

Domains & Families for GLG1 Gene

Gene Families for GLG1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GLG1 Gene

Suggested Antigen Peptide Sequences for GLG1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ61698, highly similar to Golgi apparatus protein 1 (B7Z8Y4_HUMAN)
  • Golgi sialoglycoprotein MG-160 (GSLG1_HUMAN)
genes like me logo Genes that share domains with GLG1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GLG1 Gene

Function for GLG1 Gene

Molecular function for GLG1 Gene

UniProtKB/Swiss-Prot Function:
Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).
GENATLAS Biochemistry:
membrane sialoglycoprotein of the Golgi apparatus,binding fibroblast growth factor and E selectin,ubiquitous

Phenotypes From GWAS Catalog for GLG1 Gene

Gene Ontology (GO) - Molecular Function for GLG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS 7531823
GO:0017134 fibroblast growth factor binding IBA,IEA 21873635
genes like me logo Genes that share ontologies with GLG1: view
genes like me logo Genes that share phenotypes with GLG1: view

Animal Models for GLG1 Gene

MGI Knock Outs for GLG1:
  • Glg1 Glg1<tm1a(KOMP)Wtsi>
  • Glg1 Glg1<tm1Brle>

Animal Model Products

miRNA for GLG1 Gene

miRTarBase miRNAs that target GLG1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GLG1 Gene

Localization for GLG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLG1 Gene

Golgi apparatus membrane; Single-pass type I membrane protein. Postsynaptic Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center. Note=Golgi medial cisternae. Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation. {ECO:0000250 UniProtKB:Q62638}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLG1 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 4
extracellular 3
cytoskeleton 2
endoplasmic reticulum 2
mitochondrion 1
peroxisome 1
nucleus 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GLG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IBA 21873635
GO:0005794 Golgi apparatus IEA,IDA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GLG1: view

Pathways & Interactions for GLG1 Gene

PathCards logo

SuperPathways for GLG1 Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.72
.66
.65
.62
.61
.60
.57
2 CREB Pathway
.68
.63
3 PAK Pathway
.56
.56
4 p70S6K Signaling
.60
.60
5 Phospholipase-C Pathway
.56
.56
genes like me logo Genes that share pathways with GLG1: view

Pathways by source for GLG1 Gene

1 KEGG pathway for GLG1 Gene
23 Qiagen pathways for GLG1 Gene
  • Actin-Based Motility by Rho Family GTPases
  • Activation of PKC through GPCR
  • Antioxidant Action of Vitamin-C
  • Apoptotic Pathways in Synovial Fibroblasts
  • Breast Cancer Regulation by Stathmin1

Gene Ontology (GO) - Biological Process for GLG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010955 negative regulation of protein processing IEA --
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA --
GO:0032330 regulation of chondrocyte differentiation IEA --
GO:0050900 leukocyte migration TAS --
GO:0060349 bone morphogenesis IEA --
genes like me logo Genes that share ontologies with GLG1: view

No data available for SIGNOR curated interactions for GLG1 Gene

Drugs & Compounds for GLG1 Gene

No Compound Related Data Available

Transcripts for GLG1 Gene

mRNA/cDNA for GLG1 Gene

3 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLG1 Gene

No ASD Table

Relevant External Links for GLG1 Gene

GeneLoc Exon Structure for
GLG1

Expression for GLG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GLG1 Gene

Protein differential expression in normal tissues from HIPED for GLG1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GLG1 Gene



Protein tissue co-expression partners for GLG1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GLG1

SOURCE GeneReport for Unigene cluster for GLG1 Gene:

Hs.109731

mRNA Expression by UniProt/SwissProt for GLG1 Gene:

Q92896-GSLG1_HUMAN
Tissue specificity: Widely expressed. Highest levels in pancreas, skeletal muscle, placenta, heart, testis and ovary. Also found in the kidney, liver, lung and brain.

Evidence on tissue expression from TISSUES for GLG1 Gene

  • Nervous system(4.9)
  • Blood(4.4)
  • Liver(4.4)
  • Adrenal gland(2.5)
  • Intestine(2.5)
  • Lung(2.5)
  • Kidney(2.2)
  • Heart(2.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with GLG1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLG1 Gene

Orthologs for GLG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GLG1 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 99 (a)
OneToMany
-- 31
  • 94 (a)
OneToMany
-- 31
  • 85 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia GLG1 31 30
  • 98.43 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GLG1 31
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GLG1 31 30
  • 90.95 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Glg1 17 31 30
  • 90.5 (n)
cow
(Bos Taurus)
Mammalia GLG1 31 30
  • 90.22 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Glg1 30
  • 87.9 (n)
chicken
(Gallus gallus)
Aves GLG1 31 30
  • 81.87 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GLG1 31
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia glg1 30
  • 75.55 (n)
Str.9135 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.7363 30
zebrafish
(Danio rerio)
Actinopterygii glg1b 31
  • 83 (a)
OneToMany
glg1a 31 30
  • 73.63 (n)
OneToMany
Dr.12007 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8564 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001320 30
  • 50.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta Glg1 31 30
  • 47.66 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_F14E5.2 30
  • 46.75 (n)
F14E5.2 31 32
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 49 (a)
OneToMany
-- 31
  • 41 (a)
OneToMany
-- 31
  • 41 (a)
OneToMany
Species where no ortholog for GLG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLG1 Gene

ENSEMBL:
Gene Tree for GLG1 (if available)
TreeFam:
Gene Tree for GLG1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GLG1: view image

Paralogs for GLG1 Gene

No data available for Paralogs for GLG1 Gene

Variants for GLG1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GLG1 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
750586 Likely Benign: not provided 74,452,127(-) G/A NONSENSE,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT
771018 Benign: not provided 74,532,160(-) G/A INTRON_VARIANT
rs538300970 Likely Benign: not specified 74,503,526(-) G/C INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for GLG1 Gene

Structural Variations from Database of Genomic Variants (DGV) for GLG1 Gene

Variant ID Type Subtype PubMed ID
dgv535e214 CNV loss 21293372
esv2660806 CNV deletion 23128226
esv2676990 CNV deletion 23128226
esv2758656 CNV gain+loss 17122850
esv2762054 CNV gain 21179565
esv32537 CNV gain 17666407
esv3406584 CNV insertion 20981092
esv3571587 CNV gain 25503493
esv3639067 CNV gain 21293372
esv3639068 CNV loss 21293372
esv3639069 CNV gain 21293372
esv3639070 CNV loss 21293372
esv3639073 CNV gain 21293372
nsv1056566 CNV loss 25217958
nsv1065964 CNV gain 25217958
nsv509632 CNV insertion 20534489
nsv833277 CNV loss 17160897
nsv833278 CNV loss 17160897
nsv833279 CNV loss 17160897
nsv984354 CNV duplication 23825009

Variation tolerance for GLG1 Gene

Residual Variation Intolerance Score: 1.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GLG1 Gene

Human Gene Mutation Database (HGMD)
GLG1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLG1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLG1 Gene

Disorders for GLG1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GLG1 Gene - From: DISEASES and Novoseek

- elite association - COSMIC cancer census association via MalaCards
Search GLG1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GLG1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GLG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GLG1 Gene

Publications for GLG1 Gene

  1. Latent transforming growth factor-beta complex in Chinese hamster ovary cells contains the multifunctional cysteine-rich fibroblast growth factor receptor, also termed E-selectin-ligand or MG-160. (PMID: 9182700) Olofsson A … Heldin CH (The Biochemical journal 1997) 3 4 23 54
  2. Cloning and sequence analysis of the human MG160, a fibroblast growth factor and E-selectin binding membrane sialoglycoprotein of the Golgi apparatus. (PMID: 8985126) Mourelatos Z … Gonatas NK (DNA and cell biology 1996) 3 4 23 54
  3. Assignment of the GLG1 gene for MGF-160, a fibroblast growth factor and E-selectin binding membrane sialoglycoprotein of the Golgi apparatus, to chromosome 16q22-q23 by fluorescence in situ hybridization. (PMID: 8530051) Mourelatos Z … Biegel JA (Genomics 1995) 2 3 23 54
  4. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z … Genest J (European journal of human genetics : EJHG 2010) 3 41 54
  5. A pilot genome-wide association study of early-onset breast cancer. (PMID: 18463975) Kibriya MG … Ahsan H (Breast cancer research and treatment 2009) 3 41 54

Products for GLG1 Gene

  • Signalway ELISA kits for GLG1
  • Signalway Proteins for GLG1

Sources for GLG1 Gene