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Aliases for GLG1 Gene

Aliases for GLG1 Gene

  • Golgi Glycoprotein 1 2 3 5
  • Cysteine-Rich Fibroblast Growth Factor Receptor 3 4
  • Golgi Sialoglycoprotein MG-160 3 4
  • Golgi Apparatus Protein 1 2 3
  • E-Selectin Ligand 1 3 4
  • CFR-1 3 4
  • ESL-1 3 4
  • MG160 3 4
  • MG-160 3
  • CFR1 4
  • ESL1 4

External Ids for GLG1 Gene

Previous GeneCards Identifiers for GLG1 Gene

  • GC16U990026
  • GC16M075446
  • GC16M074225
  • GC16M074266
  • GC16M074265
  • GC16M073044
  • GC16M074481
  • GC16M060230

Summaries for GLG1 Gene

GeneCards Summary for GLG1 Gene

GLG1 (Golgi Glycoprotein 1) is a Protein Coding gene. Diseases associated with GLG1 include Muscular Dystrophy-Dystroglycanopathy , Type B, 5 and Amyotrophic Lateral Sclerosis 1. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PAK Pathway. Gene Ontology (GO) annotations related to this gene include signaling receptor binding.

UniProtKB/Swiss-Prot for GLG1 Gene

  • Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).

Gene Wiki entry for GLG1 Gene

Additional gene information for GLG1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLG1 Gene

Genomics for GLG1 Gene

GeneHancer (GH) Regulatory Elements for GLG1 Gene

Promoters and enhancers for GLG1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J074605 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 -0.2 -214 4.3 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 GLG1 RFWD3 ENSG00000259972 RPL21P118 ENSG00000260884 ENSG00000214331 WDR59 CLEC18B HSPE1P7
GH16J075432 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20 -826.6 -826610 2.5 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 CFDP1 ENSG00000274220 ENSG00000261783 RFWD3 ADAT1 GLG1 KARS TMEM231 ENSG00000261717
GH16J074562 Enhancer 1.1 Ensembl ENCODE 27.6 +43.4 43370 1.8 HDGF ATF1 PKNOX1 ARNT TCF12 FOS ATF7 REST ZNF592 MEF2D GLG1 RFWD3 RNU6-237P GC16P074552
GH16J074577 Enhancer 1.1 Ensembl ENCODE 26.7 +28.8 28816 1.6 FEZF1 GTF3C2 ZNF213 ATF7 FOS KLF13 SP3 YY2 JUNB REST RFWD3 ENSG00000260884 GLG1 RPL21P118 ENSG00000259972 WDR59 ENSG00000214331 ENSG00000261079 NPIPB15 ENSG00000261783
GH16J074997 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.7 -395.0 -395021 8.5 PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNRF1 WDR59 ENSG00000214331 ENSG00000261783 ENSG00000259972 ENSG00000207525 RFWD3 ENSG00000260884 RPL21P118 TMEM231
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GLG1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GLG1 gene promoter:
  • p300
  • GATA-3
  • GATA-2
  • GATA-1
  • Sox9
  • Tal-1
  • E47
  • c-Ets-1
  • Pax-4a

Genomic Locations for GLG1 Gene

Genomic Locations for GLG1 Gene
159,718 bases
Minus strand
159,718 bases
Minus strand

Genomic View for GLG1 Gene

Genes around GLG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLG1 Gene

Proteins for GLG1 Gene

  • Protein details for GLG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Golgi apparatus protein 1
    Protein Accession:
    Secondary Accessions:
    • B7Z8Y4
    • D3DUJ7
    • Q13221
    • Q6P9D1

    Protein attributes for GLG1 Gene

    1179 amino acids
    Molecular mass:
    134552 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB02178.1; Type=Frameshift; Positions=27, 35; Evidence={ECO:0000305};

    Alternative splice isoforms for GLG1 Gene


neXtProt entry for GLG1 Gene

Post-translational modifications for GLG1 Gene

  • Fucosylation is essential for binding to E-selectin.
  • N-glycosylated. Contains sialic acid residues (By similarity).
  • Glycosylation at Asn786, Thr739, Asn677, isoforms=2, 3581, isoforms=2, 3210, and isoforms=2, 3165
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GLG1 Gene

Domains & Families for GLG1 Gene

Gene Families for GLG1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for GLG1 Gene

Suggested Antigen Peptide Sequences for GLG1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GLG1: view

No data available for UniProtKB/Swiss-Prot for GLG1 Gene

Function for GLG1 Gene

Molecular function for GLG1 Gene

UniProtKB/Swiss-Prot Function:
Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).
GENATLAS Biochemistry:
membrane sialoglycoprotein of the Golgi apparatus,binding fibroblast growth factor and E selectin,ubiquitous

Phenotypes From GWAS Catalog for GLG1 Gene

Gene Ontology (GO) - Molecular Function for GLG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS 7531823
GO:0005515 protein binding IEA --
GO:0017134 fibroblast growth factor binding IBA --
genes like me logo Genes that share ontologies with GLG1: view
genes like me logo Genes that share phenotypes with GLG1: view

Animal Models for GLG1 Gene

MGI Knock Outs for GLG1:
  • Glg1 Glg1<tm1a(KOMP)Wtsi>
  • Glg1 Glg1<tm1Brle>

Animal Model Products

miRNA for GLG1 Gene

miRTarBase miRNAs that target GLG1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GLG1 Gene

Localization for GLG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLG1 Gene

Golgi apparatus membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLG1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
golgi apparatus 5
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GLG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IBA --
GO:0005794 Golgi apparatus IDA,IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GLG1: view

Pathways & Interactions for GLG1 Gene

genes like me logo Genes that share pathways with GLG1: view

Gene Ontology (GO) - Biological Process for GLG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010955 negative regulation of protein processing IEA --
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA --
GO:0032330 regulation of chondrocyte differentiation IEA --
GO:0050900 leukocyte migration TAS --
GO:0060349 bone morphogenesis IEA --
genes like me logo Genes that share ontologies with GLG1: view

No data available for SIGNOR curated interactions for GLG1 Gene

Drugs & Compounds for GLG1 Gene

No Compound Related Data Available

Transcripts for GLG1 Gene

mRNA/cDNA for GLG1 Gene

Unigene Clusters for GLG1 Gene

Golgi glycoprotein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLG1 Gene

No ASD Table

Relevant External Links for GLG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GLG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GLG1 Gene

Protein differential expression in normal tissues from HIPED for GLG1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GLG1 Gene

Protein tissue co-expression partners for GLG1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GLG1 Gene:


SOURCE GeneReport for Unigene cluster for GLG1 Gene:


mRNA Expression by UniProt/SwissProt for GLG1 Gene:

Tissue specificity: Widely expressed. Highest levels in pancreas, skeletal muscle, placenta, heart, testis and ovary. Also found in the kidney, liver, lung and brain.

Evidence on tissue expression from TISSUES for GLG1 Gene

  • Nervous system(4.9)
  • Blood(4.4)
  • Liver(4.4)
  • Adrenal gland(2.5)
  • Intestine(2.5)
  • Lung(2.5)
  • Kidney(2.2)
  • Heart(2.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with GLG1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLG1 Gene

Orthologs for GLG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GLG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 99 (a)
-- 34
  • 94 (a)
-- 34
  • 85 (a)
(Pan troglodytes)
Mammalia GLG1 34 33
  • 98.43 (n)
(Monodelphis domestica)
Mammalia GLG1 34
  • 96 (a)
(Canis familiaris)
Mammalia GLG1 34 33
  • 90.95 (n)
(Mus musculus)
Mammalia Glg1 16 34 33
  • 90.5 (n)
(Bos Taurus)
Mammalia GLG1 34 33
  • 90.22 (n)
(Rattus norvegicus)
Mammalia Glg1 33
  • 87.9 (n)
(Gallus gallus)
Aves GLG1 34 33
  • 81.87 (n)
(Anolis carolinensis)
Reptilia GLG1 34
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia glg1 33
  • 75.55 (n)
Str.9135 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7363 33
(Danio rerio)
Actinopterygii glg1b 34
  • 83 (a)
glg1a 34 33
  • 73.63 (n)
Dr.12007 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8564 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001320 33
  • 50.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta Glg1 34 33
  • 47.66 (n)
(Caenorhabditis elegans)
Secernentea CELE_F14E5.2 33
  • 46.75 (n)
F14E5.2 34 35
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 49 (a)
-- 34
  • 41 (a)
-- 34
  • 41 (a)
Species where no ortholog for GLG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLG1 Gene

Gene Tree for GLG1 (if available)
Gene Tree for GLG1 (if available)
Evolutionary constrained regions (ECRs) for GLG1: view image

Paralogs for GLG1 Gene

No data available for Paralogs for GLG1 Gene

Variants for GLG1 Gene

Sequence variations from dbSNP and Humsavar for GLG1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000005265 -- 74,463,153(-) G/A intron_variant
rs1000008857 -- 74,582,795(-) G/C intron_variant
rs1000017853 -- 74,560,538(-) T/C intron_variant
rs1000038585 -- 74,483,518(-) A/G intron_variant
rs1000041766 -- 74,529,457(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GLG1 Gene

Variant ID Type Subtype PubMed ID
dgv535e214 CNV loss 21293372
esv2660806 CNV deletion 23128226
esv2676990 CNV deletion 23128226
esv2758656 CNV gain+loss 17122850
esv2762054 CNV gain 21179565
esv32537 CNV gain 17666407
esv3406584 CNV insertion 20981092
esv3571587 CNV gain 25503493
esv3639067 CNV gain 21293372
esv3639068 CNV loss 21293372
esv3639069 CNV gain 21293372
esv3639070 CNV loss 21293372
esv3639073 CNV gain 21293372
nsv1056566 CNV loss 25217958
nsv1065964 CNV gain 25217958
nsv509632 CNV insertion 20534489
nsv833277 CNV loss 17160897
nsv833278 CNV loss 17160897
nsv833279 CNV loss 17160897
nsv984354 CNV duplication 23825009

Variation tolerance for GLG1 Gene

Residual Variation Intolerance Score: 1.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GLG1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLG1 Gene

Disorders for GLG1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GLG1 Gene - From: HGMD, DISEASES, and Novoseek

- elite association - COSMIC cancer census association via MalaCards
Search GLG1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GLG1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GLG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GLG1 Gene

Publications for GLG1 Gene

  1. Latent transforming growth factor-beta complex in Chinese hamster ovary cells contains the multifunctional cysteine-rich fibroblast growth factor receptor, also termed E-selectin-ligand or MG-160. (PMID: 9182700) Olofsson A … Heldin CH (The Biochemical journal 1997) 3 4 22 58
  2. Cloning and sequence analysis of the human MG160, a fibroblast growth factor and E-selectin binding membrane sialoglycoprotein of the Golgi apparatus. (PMID: 8985126) Mourelatos Z … Gonatas NK (DNA and cell biology 1996) 3 4 22 58
  3. Assignment of the GLG1 gene for MGF-160, a fibroblast growth factor and E-selectin binding membrane sialoglycoprotein of the Golgi apparatus, to chromosome 16q22-q23 by fluorescence in situ hybridization. (PMID: 8530051) Mourelatos Z … Biegel JA (Genomics 1995) 2 3 22 58
  4. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z … Genest J (European journal of human genetics : EJHG 2010) 3 44 58
  5. Expression of E-selectin ligand-1 (CFR/ESL-1) on hepatic stellate cells: implications for leukocyte extravasation and liver metastasis. (PMID: 19148508) Antoine M … Kiefer P (Oncology reports 2009) 3 22 58

Products for GLG1 Gene

Sources for GLG1 Gene

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