Aliases for GLDC Gene
- Glycine Decarboxylase 2 3 4 5
- GCSP 2 3 4
- Glycine Dehydrogenase (Decarboxylating), Mitochondrial 3 4
- Glycine Dehydrogenase (Aminomethyl-Transferring) 3 4
- Glycine Cleavage System Protein P 2 3
- Nonketotic Hyperglycinemia 2 3
- EC 18.104.22.168 4 51
- Glycine Dehydrogenase (Decarboxylating; Glycine Decarboxylase, Glycine Cleavage System Protein P) 2
External Ids for GLDC Gene
Previous GeneCards Identifiers for GLDC Gene
Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010]
GeneCards Summary for GLDC Gene
GLDC (Glycine Decarboxylase) is a Protein Coding gene. Diseases associated with GLDC include Glycine Encephalopathy and Epilepsy, Idiopathic Generalized. Among its related pathways are Carbon metabolism and Glycine, serine and threonine metabolism. Gene Ontology (GO) annotations related to this gene include electron transfer activity and lyase activity.
UniProtKB/Swiss-Prot Summary for GLDC Gene
The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH).