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Aliases for GLCE Gene

Aliases for GLCE Gene

  • Glucuronic Acid Epimerase 2 3 5
  • Heparosan-N-Sulfate-Glucuronate 5-Epimerase 3 4
  • UDP-Glucuronic Acid Epimerase 2 3
  • Heparan Sulfate C5-Epimerase 3 4
  • D-Glucuronyl C5-Epimerase 2 3
  • Heparan Sulfate Epimerase 2 3
  • Heparin/Heparan Sulfate-Glucuronic Acid C5-Epimerase 3
  • Heparin/Heparan Sulfate:Glucuronic Acid C5-Epimerase 4
  • Glucuronyl C5-Epimerase 3
  • EC 5.1.3.17 4
  • KIAA0836 4
  • HSEPI 3
  • Hsepi 4

External Ids for GLCE Gene

Previous GeneCards Identifiers for GLCE Gene

  • GC15P065389
  • GC15P062646
  • GC15P067127
  • GC15P067168
  • GC15P067240
  • GC15P069452
  • GC15P046285
  • GC15P069162
  • GC15P069306

Summaries for GLCE Gene

GeneCards Summary for GLCE Gene

GLCE (Glucuronic Acid Epimerase) is a Protein Coding gene. Among its related pathways are heparan sulfate biosynthesis and Metabolism. Gene Ontology (GO) annotations related to this gene include racemase and epimerase activity, acting on carbohydrates and derivatives and UDP-glucuronate 5-epimerase activity.

UniProtKB/Swiss-Prot for GLCE Gene

  • Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins.

Gene Wiki entry for GLCE Gene

Additional gene information for GLCE Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GLCE Gene

Genomics for GLCE Gene

GeneHancer (GH) Regulatory Elements for GLCE Gene

Promoters and enhancers for GLCE Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J069159 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 652.5 +0.3 327 2.7 HDGF FOXA2 PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B GLCE LOC100421574 PAQR5
GH15J069164 Enhancer 0.8 ENCODE 0.7 +4.8 4751 0.8 HDAC1 PKNOX1 ZNF133 MZF1 ZNF366 SCRT2 ATF7 ZNF362 ZNF398 ZEB2 PAQR5 LOC100421574 GLCE GC15P069323
GH15J069142 Enhancer 1.1 ENCODE dbSUPER 0.4 -16.7 -16655 2.1 PKNOX1 ARNT FEZF1 ZNF2 ZNF121 ZNF213 KLF7 YY2 ZNF662 TSHZ1 ENSG00000259265 TLE3 PAQR5 GC15M069102 GLCE
GH15J069153 Enhancer 1 Ensembl ENCODE dbSUPER 0.4 -5.9 -5882 1.6 ZNF146 ZNF680 JUN ZNF133 ZFHX2 JUND GLIS1 MYC EGR2 PAQR5 GLCE GC15M069102
GH15J069141 Enhancer 0.8 ENCODE dbSUPER 0.4 -19.0 -19023 0.2 CTCF ZBTB8A RAD21 JUND SMC3 PRDM10 HNF4A FOSL2 SP7 GC15M069102 GLCE
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GLCE on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GLCE gene promoter:
  • Pax-5
  • Egr-4
  • FOXJ2 (long isoform)
  • FOXJ2
  • POU2F1a
  • POU2F1
  • POU2F1b
  • POU2F1c

Genomic Locations for GLCE Gene

Genomic Locations for GLCE Gene
chr15:69,160,560-69,272,217
(GRCh38/hg38)
Size:
111,658 bases
Orientation:
Plus strand
chr15:69,452,923-69,564,556
(GRCh37/hg19)
Size:
111,634 bases
Orientation:
Plus strand

Genomic View for GLCE Gene

Genes around GLCE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GLCE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GLCE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GLCE Gene

Proteins for GLCE Gene

  • Protein details for GLCE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94923-GLCE_HUMAN
    Recommended name:
    D-glucuronyl C5-epimerase
    Protein Accession:
    O94923
    Secondary Accessions:
    • Q6GUQ2

    Protein attributes for GLCE Gene

    Size:
    617 amino acids
    Molecular mass:
    70101 Da
    Quaternary structure:
    • Homodimer. Interacts with HS2ST1.

neXtProt entry for GLCE Gene

Post-translational modifications for GLCE Gene

  • Glycosylation at Asn225, Ser59, and Ser44
  • Ubiquitination at isoforms=98
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GLCE Gene

Domains & Families for GLCE Gene

Gene Families for GLCE Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for GLCE Gene

Suggested Antigen Peptide Sequences for GLCE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94923

UniProtKB/Swiss-Prot:

GLCE_HUMAN :
  • Belongs to the D-glucuronyl C5-epimerase family.
Family:
  • Belongs to the D-glucuronyl C5-epimerase family.
genes like me logo Genes that share domains with GLCE: view

Function for GLCE Gene

Molecular function for GLCE Gene

UniProtKB/Swiss-Prot Function:
Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins.
UniProtKB/Swiss-Prot CatalyticActivity:
Epimerization of D-glucuronate in heparosan-N-sulfate to L-iduronate.

Enzyme Numbers (IUBMB) for GLCE Gene

Phenotypes From GWAS Catalog for GLCE Gene

Gene Ontology (GO) - Molecular Function for GLCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016853 isomerase activity IEA --
GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives ISS --
GO:0047464 heparosan-N-sulfate-glucuronate 5-epimerase activity IMP 20118238
GO:0050379 UDP-glucuronate 5-epimerase activity IDA --
genes like me logo Genes that share ontologies with GLCE: view
genes like me logo Genes that share phenotypes with GLCE: view

Animal Models for GLCE Gene

MGI Knock Outs for GLCE:
  • Glce Glce<tm1Jpli>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GLCE

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GLCE Gene

Localization for GLCE Gene

Subcellular locations from UniProtKB/Swiss-Prot for GLCE Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GLCE gene
Compartment Confidence
golgi apparatus 5
extracellular 2
mitochondrion 2
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GLCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GLCE: view

Pathways & Interactions for GLCE Gene

genes like me logo Genes that share pathways with GLCE: view

UniProtKB/Swiss-Prot O94923-GLCE_HUMAN

  • Pathway: Glycan metabolism; heparan sulfate biosynthesis.
  • Pathway: Glycan metabolism; heparin biosynthesis.

Interacting Proteins for GLCE Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000261858%0d%0a9606.ENSP00000377836%0d%0a9606.ENSP00000254351%0d%0a9606.ENSP00000366246%0d%0a9606.ENSP00000359864%0d%0a9606.ENSP00000368678%0d%0a
Selected Interacting proteins: ENSP00000261858 O94923-GLCE_HUMAN for GLCE Gene via STRING IID

Gene Ontology (GO) - Biological Process for GLCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006024 glycosaminoglycan biosynthetic process IEA --
GO:0015012 heparan sulfate proteoglycan biosynthetic process ISS --
GO:0030210 heparin biosynthetic process ISS --
genes like me logo Genes that share ontologies with GLCE: view

No data available for SIGNOR curated interactions for GLCE Gene

Drugs & Compounds for GLCE Gene

(5) Drugs for GLCE Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for GLCE Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
D-Glucurono-6,3-lactone
  • D-Glucurone
  • D-Glucuronic acid
  • D-Glucuronic acid lactone
  • D-glucurono-3,6-Lactone
  • D-Glucuronolactone
32449-92-6
genes like me logo Genes that share compounds with GLCE: view

Transcripts for GLCE Gene

Unigene Clusters for GLCE Gene

Glucuronic acid epimerase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GLCE

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GLCE Gene

No ASD Table

Relevant External Links for GLCE Gene

GeneLoc Exon Structure for
GLCE
ECgene alternative splicing isoforms for
GLCE

Expression for GLCE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GLCE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GLCE Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x7.1) and Brain - Cerebellum (x6.5).

Protein differential expression in normal tissues from HIPED for GLCE Gene

This gene is overexpressed in Peripheral blood mononuclear cells (29.7), Pancreatic juice (17.5), and Placenta (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GLCE Gene



Protein tissue co-expression partners for GLCE Gene

NURSA nuclear receptor signaling pathways regulating expression of GLCE Gene:

GLCE

SOURCE GeneReport for Unigene cluster for GLCE Gene:

Hs.183006

Evidence on tissue expression from TISSUES for GLCE Gene

  • Nervous system(4.4)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with GLCE: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GLCE Gene

Orthologs for GLCE Gene

This gene was present in the common ancestor of animals.

Orthologs for GLCE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLCE 34 33
  • 99.89 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GLCE 34 33
  • 93.94 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GLCE 34 33
  • 93.83 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Glce 16 34 33
  • 91.46 (n)
rat
(Rattus norvegicus)
Mammalia Glce 33
  • 91.46 (n)
oppossum
(Monodelphis domestica)
Mammalia GLCE 34
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GLCE 34
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves GLCE 34 33
  • 75 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GLCE 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia glce 33
  • 70.68 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32770 33
zebrafish
(Danio rerio)
Actinopterygii glcea 34
  • 71 (a)
OneToMany
glceb 34 33
  • 69.17 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005699 33
  • 54.1 (n)
fruit fly
(Drosophila melanogaster)
Insecta Hsepi 34 33
  • 53.06 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hse-5 34 33
  • 49.4 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2697 34
  • 47 (a)
OneToOne
Species where no ortholog for GLCE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GLCE Gene

ENSEMBL:
Gene Tree for GLCE (if available)
TreeFam:
Gene Tree for GLCE (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GLCE: view image

Paralogs for GLCE Gene

No data available for Paralogs for GLCE Gene

Variants for GLCE Gene

Sequence variations from dbSNP and Humsavar for GLCE Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000024908 -- 69,235,385(+) G/A intron_variant
rs1000113057 -- 69,262,838(+) A/G intron_variant
rs1000114948 -- 69,182,523(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000130373 -- 69,227,643(+) G/A intron_variant
rs1000133632 -- 69,243,085(+) G/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GLCE Gene

Variant ID Type Subtype PubMed ID
dgv306e201 CNV deletion 23290073
dgv4584n54 CNV gain 21841781
esv2264721 CNV deletion 18987734
esv23604 CNV gain 19812545
esv2476720 CNV deletion 19546169
esv2741191 CNV deletion 23290073
esv2749821 CNV deletion 23290073
esv2749822 CNV deletion 23290073
esv2749824 CNV deletion 23290073
esv3636821 CNV gain 21293372
esv989223 OTHER inversion 20482838
nsv1039652 CNV loss 25217958
nsv1113722 CNV deletion 24896259
nsv1122979 CNV deletion 24896259
nsv517185 CNV gain+loss 19592680
nsv569811 CNV gain 21841781

Variation tolerance for GLCE Gene

Residual Variation Intolerance Score: 19.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 41.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GLCE Gene

Human Gene Mutation Database (HGMD)
GLCE
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GLCE

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GLCE Gene

Disorders for GLCE Gene

Additional Disease Information for GLCE

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GLCE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GLCE Gene

Publications for GLCE Gene

  1. The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the beta-catenin-TCF4 pathway. (PMID: 15853773) Ghiselli G … Agrawal A (The Biochemical journal 2005) 2 3 22 58
  2. Uncovering biphasic catalytic mode of C5-epimerase in heparan sulfate biosynthesis. (PMID: 22528493) Sheng J … Liu J (The Journal of biological chemistry 2012) 3 4 58
  3. Using engineered 2-O-sulfotransferase to determine the activity of heparan sulfate C5-epimerase and its mutants. (PMID: 20118238) Li K … Liu J (The Journal of biological chemistry 2010) 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Decreased expression of human D-glucuronyl C5-epimerase in breast cancer. (PMID: 17985344) Grigorieva E … Sidorov SV (International journal of cancer 2008) 3 22 58

Products for GLCE Gene

Sources for GLCE Gene

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