Aliases for GLCE Gene
External Ids for GLCE Gene
Previous GeneCards Identifiers for GLCE Gene
GeneCards Summary for GLCE Gene
GLCE (Glucuronic Acid Epimerase) is a Protein Coding gene. Diseases associated with GLCE include Spherocytosis, Type 2 and Hereditary Spherocytosis. Among its related pathways are Metabolism and heparan sulfate biosynthesis. Gene Ontology (GO) annotations related to this gene include racemase and epimerase activity, acting on carbohydrates and derivatives and UDP-glucuronate 5'-epimerase activity.
UniProtKB/Swiss-Prot Summary for GLCE Gene
Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins.