Aliases for GLA Gene
External Ids for GLA Gene
Previous GeneCards Identifiers for GLA Gene
This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties. [provided by RefSeq, Jul 2008]
GeneCards Summary for GLA Gene
GLA (Galactosidase Alpha) is a Protein Coding gene. Diseases associated with GLA include Fabry Disease and Hypertrophic Cardiomyopathy. Among its related pathways are Sphingolipid metabolism and Lysosome. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and hydrolase activity. An important paralog of this gene is NAGA.
UniProtKB/Swiss-Prot Summary for GLA Gene
Catalyzes the hydrolysis of glycosphingolipids and participates to their degradation in the lysosome.