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Aliases for GKN1 Gene

Aliases for GKN1 Gene

  • Gastrokine 1 2 3 5
  • 18 KDa Antrum Mucosa Protein 3 4
  • BRICHOS Domain Containing 1 2 3
  • AMP-18 3 4
  • AMP18 3 4
  • CA11 3 4
  • Gastrokine-1 3
  • Protein CA11 4
  • Foveolin 3
  • BRICD1 3
  • FOV 3

External Ids for GKN1 Gene

Previous GeneCards Identifiers for GKN1 Gene

  • GC02P069176
  • GC02P069114

Summaries for GKN1 Gene

Entrez Gene Summary for GKN1 Gene

  • The protein encoded by this gene is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa. [provided by RefSeq, Jul 2008]

GeneCards Summary for GKN1 Gene

GKN1 (Gastrokine 1) is a Protein Coding gene. Diseases associated with GKN1 include Gastric Cancer. Gene Ontology (GO) annotations related to this gene include growth factor activity. An important paralog of this gene is GKN3P.

UniProtKB/Swiss-Prot for GKN1 Gene

  • Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.

Gene Wiki entry for GKN1 Gene

Additional gene information for GKN1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GKN1 Gene

Genomics for GKN1 Gene

GeneHancer (GH) Regulatory Elements for GKN1 Gene

Promoters and enhancers for GKN1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J068974 Promoter 0.7 EPDnew 650.7 +0.0 44 0.1 SCRT2 MAFK GKN1 ANTXR1
GH02J068935 Promoter/Enhancer 0.7 EPDnew ENCODE 650.3 -37.7 -37662 1.8 GKN1 ANTXR1 LINC01888 GKN2 GKN3P
GH02J069011 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 10.2 +39.2 39151 3.7 SIN3A DMAP1 ZNF48 FOS RXRA REST ZNF518A KAT8 GMEB1 MXD3 ANTXR1 RNU6-1216P RNA5SP96 GKN2 GKN1 MIR3126
GH02J069080 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 9.5 +107.9 107850 4.2 FOXA2 MLX ARID4B SLC30A9 FOS RUNX3 NFKBIZ MIER2 REST KAT8 RNA5SP96 RNU6-1216P ANTXR1 GKN1 MIR3126
GH02J069136 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10 +169.0 169033 14.1 JUN ZIC2 RFX5 ZNF766 POLR2A ZBTB48 ZSCAN5C SCRT2 ZNF143 RCOR1 ANTXR1 RNA5SP96 RNU6-1216P GKN1 PROKR1 GC02M069149 MIR3126
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GKN1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GKN1 gene promoter:
  • PPAR-gamma2
  • PPAR-gamma1
  • STAT5B
  • AML1a
  • C/EBPalpha
  • E4BP4
  • HNF-1
  • HNF-1A

Genomic Locations for GKN1 Gene

Genomic Locations for GKN1 Gene
6,408 bases
Plus strand
6,408 bases
Plus strand

Genomic View for GKN1 Gene

Genes around GKN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GKN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GKN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GKN1 Gene

Proteins for GKN1 Gene

  • Protein details for GKN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q8IUA9

    Protein attributes for GKN1 Gene

    199 amino acids
    Molecular mass:
    21999 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAN75447.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAN75449.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ89409.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GKN1 Gene

Post-translational modifications for GKN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GKN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GKN1 Gene

Domains & Families for GKN1 Gene

Gene Families for GKN1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for GKN1 Gene


Suggested Antigen Peptide Sequences for GKN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the gastrokine family.
  • Belongs to the gastrokine family.
genes like me logo Genes that share domains with GKN1: view

Function for GKN1 Gene

Molecular function for GKN1 Gene

UniProtKB/Swiss-Prot Function:
Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.

Phenotypes From GWAS Catalog for GKN1 Gene

Gene Ontology (GO) - Molecular Function for GKN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with GKN1: view
genes like me logo Genes that share phenotypes with GKN1: view

Animal Models for GKN1 Gene

MGI Knock Outs for GKN1:
  • Gkn1 Gkn1<tm1.1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for GKN1

miRNA for GKN1 Gene

miRTarBase miRNAs that target GKN1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GKN1 Gene

Localization for GKN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GKN1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GKN1 gene
Compartment Confidence
extracellular 4
plasma membrane 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for GKN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with GKN1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GKN1 Gene

Pathways & Interactions for GKN1 Gene

No Data Available

Interacting Proteins for GKN1 Gene

Gene Ontology (GO) - Biological Process for GKN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007586 digestion NAS 10835488
GO:0042127 regulation of cell proliferation IBA --
GO:0051781 positive regulation of cell division IEA --
genes like me logo Genes that share ontologies with GKN1: view

No data available for Pathways by source and SIGNOR curated interactions for GKN1 Gene

Drugs & Compounds for GKN1 Gene

No Compound Related Data Available

Transcripts for GKN1 Gene

mRNA/cDNA for GKN1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(221) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GKN1 Gene

Gastrokine 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GKN1 Gene

No ASD Table

Relevant External Links for GKN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GKN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GKN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GKN1 Gene

This gene is overexpressed in Stomach (x52.7).

Protein differential expression in normal tissues from HIPED for GKN1 Gene

This gene is overexpressed in Cardia (44.3) and Stomach (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GKN1 Gene

NURSA nuclear receptor signaling pathways regulating expression of GKN1 Gene:


SOURCE GeneReport for Unigene cluster for GKN1 Gene:


mRNA Expression by UniProt/SwissProt for GKN1 Gene:

Tissue specificity: Expressed in stomach. No expression is detected in cancer tissue or gastric cancer cell lines.

Evidence on tissue expression from TISSUES for GKN1 Gene

  • Stomach(5)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with GKN1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GKN1 Gene

Orthologs for GKN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GKN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GKN1 34 33
  • 98.99 (n)
(Bos Taurus)
Mammalia GKN1 33
  • 82.52 (n)
FOV 34
  • 70 (a)
(Canis familiaris)
Mammalia GKN1 34 33
  • 79.89 (n)
(Mus musculus)
Mammalia Gkn1 16 34 33
  • 72.16 (n)
(Rattus norvegicus)
Mammalia Gkn1 33
  • 72.01 (n)
(Monodelphis domestica)
Mammalia GKN1 34
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia GKN1 34
  • 32 (a)
(Gallus gallus)
Aves GKN1 34 33
  • 51.83 (n)
(Anolis carolinensis)
Reptilia GKN1 34
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486889 33
  • 54.72 (n)
Species where no ortholog for GKN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GKN1 Gene

Gene Tree for GKN1 (if available)
Gene Tree for GKN1 (if available)
Evolutionary constrained regions (ECRs) for GKN1: view image

Paralogs for GKN1 Gene

Paralogs for GKN1 Gene

(4) SIMAP similar genes for GKN1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GKN1: view

Variants for GKN1 Gene

Sequence variations from dbSNP and Humsavar for GKN1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
VAR_035923 A breast cancer sample p.Lys118Thr
rs1000217564 -- 68,975,341(+) G/A intron_variant
rs1000366551 -- 68,976,307(+) CTTCTT/CTT intron_variant
rs1000407325 -- 68,973,765(+) T/C upstream_transcript_variant
rs1000697969 -- 68,974,976(+) T/C intron_variant

Variation tolerance for GKN1 Gene

Residual Variation Intolerance Score: 45.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GKN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GKN1 Gene

Disorders for GKN1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GKN1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gastric cancer
  • gastric cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search GKN1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GKN1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GKN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GKN1 Gene

Publications for GKN1 Gene

  1. A novel mitogenic protein that is highly expressed in cells of the gastric antrum mucosa. (PMID: 12851218) Martin TE … Toback FG (American journal of physiology. Gastrointestinal and liver physiology 2003) 2 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. AMP-18 protects barrier function of colonic epithelial cells: role of tight junction proteins. (PMID: 15961882) Walsh-Reitz MM … Toback FG (American journal of physiology. Gastrointestinal and liver physiology 2005) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for GKN1 Gene

Sources for GKN1 Gene

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