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Aliases for GKAP1 Gene

Aliases for GKAP1 Gene

  • G Kinase Anchoring Protein 1 2 3 5
  • CGMP-Dependent Protein Kinase-Anchoring Protein Of 42 KDa 3 4
  • CGMP-Dependent Protein Kinase Anchoring Protein 42kDa 2 3
  • GKAP42 3 4
  • Protein Kinase Anchoring Protein GKAP42 3
  • G Kinase-Anchoring Protein 1 3
  • FKSG21 3

External Ids for GKAP1 Gene

Previous GeneCards Identifiers for GKAP1 Gene

  • GC09M081812
  • GC09M083583
  • GC09M085544
  • GC09M086354
  • GC09M056179

Summaries for GKAP1 Gene

Entrez Gene Summary for GKAP1 Gene

  • This gene encodes a protein that is highly similar to the mouse cGMP-dependent protein kinase anchoring protein 42kDa. The mouse protein has been found to localize with the Golgi and recruit cGMP-dependent protein kinase I alpha to the Golgi in mouse testes. It is thought to play a role in germ cell development. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for GKAP1 Gene

GKAP1 (G Kinase Anchoring Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include kinase activity.

Additional gene information for GKAP1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GKAP1 Gene

Genomics for GKAP1 Gene

GeneHancer (GH) Regulatory Elements for GKAP1 Gene

Promoters and enhancers for GKAP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I083816 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 558.3 +11.2 11240 3.8 HDGF RB1 SIN3A ZNF76 ZNF48 ZNF335 GLIS2 EGR1 ZNF366 SCRT2 GKAP1 LOC101927552 KIF27 ENSG00000231616 LOC105376114
GH09I083806 Promoter 0.5 EPDnew 550.3 +22.9 22914 0.1 GKAP1 LOC101927552 GC09M083753
GH09I083977 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 5.3 -150.5 -150541 5.5 PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B IRF4 HNRNPK RMI1 KIF27 C9orf64 LOC105376116 IDNK GKAP1 ENSG00000235298
GH09I083885 Enhancer 1 Ensembl ENCODE 7.4 -56.6 -56587 1.6 FOXA2 ZSCAN9 RARA SMARCC2 RCOR1 FOS THAP11 MIXL1 ZNF362 CEBPB KIF27 IDNK GKAP1 LOC105376335 ENSG00000231616
GH09I083620 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.4 +206.1 206098 5.3 HDGF FOXA2 ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B SP3 SP5 IDNK LOC105376114 KIF27 UBQLN1 GKAP1 GC09M083666
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GKAP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GKAP1 gene promoter:

Genomic Locations for GKAP1 Gene

Genomic Locations for GKAP1 Gene
90,096 bases
Minus strand

Genomic View for GKAP1 Gene

Genes around GKAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GKAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GKAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GKAP1 Gene

Proteins for GKAP1 Gene

  • Protein details for GKAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G kinase-anchoring protein 1
    Protein Accession:
    Secondary Accessions:
    • Q96LI0
    • Q9BYI1
    • Q9BYI2
    • Q9H225

    Protein attributes for GKAP1 Gene

    366 amino acids
    Molecular mass:
    42078 Da
    Quaternary structure:
    • Interacts with PRKG1.
    • Sequence=BAB71712.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH70734.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI16011.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW62665.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for GKAP1 Gene


neXtProt entry for GKAP1 Gene

Post-translational modifications for GKAP1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for GKAP1 Gene

Domains & Families for GKAP1 Gene

Gene Families for GKAP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GKAP1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GKAP1 family.
  • Belongs to the GKAP1 family.
genes like me logo Genes that share domains with GKAP1: view

Function for GKAP1 Gene

Phenotypes From GWAS Catalog for GKAP1 Gene

Gene Ontology (GO) - Molecular Function for GKAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016301 kinase activity IEA --
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with GKAP1: view
genes like me logo Genes that share phenotypes with GKAP1: view

miRNA for GKAP1 Gene

miRTarBase miRNAs that target GKAP1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GKAP1 Gene

Localization for GKAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GKAP1 Gene

Golgi apparatus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GKAP1 gene
Compartment Confidence
nucleus 4
golgi apparatus 4
cytosol 3
cytoskeleton 2
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Microtubule organizing center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GKAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA,ISS --
genes like me logo Genes that share ontologies with GKAP1: view

Pathways & Interactions for GKAP1 Gene

SuperPathways for GKAP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GKAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA,ISS --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with GKAP1: view

No data available for Pathways by source and SIGNOR curated interactions for GKAP1 Gene

Drugs & Compounds for GKAP1 Gene

No Compound Related Data Available

Transcripts for GKAP1 Gene

Unigene Clusters for GKAP1 Gene

G kinase anchoring protein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GKAP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - -
SP3: -
SP4: - -
SP5: -

Relevant External Links for GKAP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GKAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GKAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GKAP1 Gene

This gene is overexpressed in Testis (x11.9).

Protein differential expression in normal tissues from HIPED for GKAP1 Gene

This gene is overexpressed in Testis (61.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GKAP1 Gene

Protein tissue co-expression partners for GKAP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GKAP1 Gene:


SOURCE GeneReport for Unigene cluster for GKAP1 Gene:


Evidence on tissue expression from TISSUES for GKAP1 Gene

  • Skin(4.1)
  • Gall bladder(3.5)
  • Intestine(3)
  • Liver(2.9)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with GKAP1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GKAP1 Gene

Orthologs for GKAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GKAP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GKAP1 33 34
  • 100 (n)
(Canis familiaris)
Mammalia GKAP1 33 34
  • 94.77 (n)
(Bos Taurus)
Mammalia GKAP1 33 34
  • 93.48 (n)
(Rattus norvegicus)
Mammalia Gkap1 33
  • 85.7 (n)
(Mus musculus)
Mammalia Gkap1 33 16 34
  • 85.34 (n)
(Monodelphis domestica)
Mammalia GKAP1 34
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia GKAP1 34
  • 74 (a)
(Gallus gallus)
Aves GKAP1 34 33
  • 78.48 (n)
(Anolis carolinensis)
Reptilia GKAP1 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gkap1 33
  • 68.99 (n)
Str.10774 33
African clawed frog
(Xenopus laevis)
Amphibia gkap42-pending-prov 33
(Danio rerio)
Actinopterygii gkap1 34 33
  • 63.76 (n)
wufi16a08 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10015 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
Species where no ortholog for GKAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GKAP1 Gene

Gene Tree for GKAP1 (if available)
Gene Tree for GKAP1 (if available)

Paralogs for GKAP1 Gene

No data available for Paralogs for GKAP1 Gene

Variants for GKAP1 Gene

Sequence variations from dbSNP and Humsavar for GKAP1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000001796 -- 83,818,111(-) C/T upstream_transcript_variant
rs1000019476 -- 83,793,571(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000019521 -- 83,791,912(-) G/C intron_variant
rs1000110095 -- 83,812,978(-) TTTTTTTTT/TTTTTTTTTT genic_upstream_transcript_variant, intron_variant
rs1000131124 -- 83,755,248(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GKAP1 Gene

Variant ID Type Subtype PubMed ID
nsv982312 CNV duplication 23825009
nsv469859 CNV gain 16826518
nsv1137473 CNV deletion 24896259
esv7015 CNV loss 19470904
esv3620905 CNV loss 21293372
esv3620904 CNV gain 21293372
esv2761538 CNV gain 21179565
esv2759701 CNV gain 17122850
esv2738668 CNV deletion 23290073
esv2672912 CNV deletion 23128226

Variation tolerance for GKAP1 Gene

Residual Variation Intolerance Score: 38.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GKAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GKAP1 Gene

Disorders for GKAP1 Gene

Additional Disease Information for GKAP1

No disorders were found for GKAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GKAP1 Gene

Publications for GKAP1 Gene

  1. Delineation of the minimal commonly deleted segment and identification of candidate tumor-suppressor genes in del(9q) acute myeloid leukemia. (PMID: 16015647) Sweetser DA … Daly SB (Genes, chromosomes & cancer 2005) 3 4 58
  2. Binding and phosphorylation of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Ialpha. (PMID: 10671526) Yuasa K … Yanaka N (The Journal of biological chemistry 2000) 3 4 58
  3. An inter-species protein-protein interaction network across vast evolutionary distance. (PMID: 27107014) Zhong Q … Vidal M (Molecular systems biology 2016) 3 58
  4. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for GKAP1 Gene

Sources for GKAP1 Gene

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