Free for academic non-profit institutions. Other users need a Commercial license
GK5 (Glycerol Kinase 5) is a Protein Coding gene. Diseases associated with GK5 include Type 1 Diabetes Mellitus 7 and Type 1 Diabetes Mellitus 13. Among its related pathways are glycerol degradation and triacylglycerol biosynthesis. Gene Ontology (GO) annotations related to this gene include phosphotransferase activity, alcohol group as acceptor and glycerol kinase activity. An important paralog of this gene is GK.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0004370 | glycerol kinase activity | IBA | 21873635 |
GO:0005524 | ATP binding | IEA | -- |
GO:0016301 | kinase activity | IEA | -- |
GO:0016740 | transferase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005739 | mitochondrion | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | triacylglycerol biosynthesis | ||
2 | glycerol degradation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005975 | carbohydrate metabolic process | IEA | -- |
GO:0006071 | glycerol metabolic process | IBA | 21873635 |
GO:0006641 | triglyceride metabolic process | IBA | 21873635 |
GO:0016310 | phosphorylation | IBA | 21873635 |
GO:0019563 | glycerol catabolic process | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
||
glycerol 3-phosphate |
|
57-03-4 |
|
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
SP3: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GK5 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GK5 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GK5 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Gk5 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Gk5 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | GK5 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | GK5 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | GK5 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | GK5 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | gk5 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | gk5 30 31 |
|
OneToOne | |
wufc06f04 30 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007581 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG1271 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | C55B6.1 30 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | GUT1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.533 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1412e212 | CNV | gain | 25503493 |
dgv299n21 | CNV | gain | 19592680 |
dgv4912n100 | CNV | gain | 25217958 |
dgv619n27 | CNV | gain | 19166990 |
dgv8625n54 | CNV | gain | 21841781 |
dgv8626n54 | CNV | gain | 21841781 |
esv2751979 | CNV | gain | 17911159 |
esv2759182 | CNV | gain | 17122850 |
esv2763767 | CNV | gain | 21179565 |
esv34483 | CNV | gain | 17911159 |
esv3597995 | CNV | gain | 21293372 |
esv3597996 | CNV | gain | 21293372 |
esv3598001 | CNV | gain | 21293372 |
nsv1002953 | CNV | loss | 25217958 |
nsv1008873 | CNV | gain | 25217958 |
nsv1011175 | CNV | gain | 25217958 |
nsv523945 | CNV | gain | 19592680 |
Disorder | Aliases | PubMed IDs |
---|---|---|
type 1 diabetes mellitus 7 |
|
|
type 1 diabetes mellitus 13 |
|
|
type 1 diabetes mellitus 3 |
|
|