Aliases for GK5 Gene

Aliases for GK5 Gene

  • Glycerol Kinase 5 2 3 5
  • ATP:Glycerol 3-Phosphotransferase 5 3 4
  • Glycerol Kinase 5 (Putative) 2 3
  • Putative Glycerol Kinase 5 3 4
  • Glycerokinase 5 3 4
  • EC 2.7.1.30 4 51
  • GK 5 3 4
  • MGC40579 2
  • GK5 5

External Ids for GK5 Gene

Previous GeneCards Identifiers for GK5 Gene

  • GC03M143359
  • GC03M141876
  • GC03M139249

Summaries for GK5 Gene

GeneCards Summary for GK5 Gene

GK5 (Glycerol Kinase 5) is a Protein Coding gene. Diseases associated with GK5 include Type 1 Diabetes Mellitus 7 and Type 1 Diabetes Mellitus 13. Among its related pathways are glycerol degradation and triacylglycerol biosynthesis. Gene Ontology (GO) annotations related to this gene include phosphotransferase activity, alcohol group as acceptor and glycerol kinase activity. An important paralog of this gene is GK.

Additional gene information for GK5 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GK5 Gene

Genomics for GK5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GK5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GK5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GK5

Top Transcription factor binding sites by QIAGEN in the GK5 gene promoter:
  • ATF6
  • COUP
  • COUP-TF
  • Egr-4
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • MyoD
  • Pax-4a

Genomic Locations for GK5 Gene

Genomic Locations for GK5 Gene
chr3:142,157,527-142,225,592
(GRCh38/hg38)
Size:
68,066 bases
Orientation:
Minus strand
chr3:141,876,369-141,944,449
(GRCh37/hg19)
Size:
68,081 bases
Orientation:
Minus strand

Genomic View for GK5 Gene

Genes around GK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GK5 Gene

Proteins for GK5 Gene

  • Protein details for GK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZS86-GLPK5_HUMAN
    Recommended name:
    Putative glycerol kinase 5
    Protein Accession:
    Q6ZS86
    Secondary Accessions:
    • B2R9I2
    • D3DNG2
    • Q8N2A7
    • Q8N5E6

    Protein attributes for GK5 Gene

    Size:
    529 amino acids
    Molecular mass:
    59156 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GK5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GK5 Gene

Selected DME Specific Peptides for GK5 Gene

Q6ZS86:
  • AFRNKQL
  • GLAVGFW
  • AVKRSMNW
  • FGTIDTW
  • VPSFSGLQAP
  • IRCHVYD
  • AMFGECCF
  • FHNFISWQDLR
  • IFGVPIP

Post-translational modifications for GK5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for GK5 Gene

Gene Families for GK5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for GK5 Gene

Suggested Antigen Peptide Sequences for GK5 Gene

GenScript: Design optimal peptide antigens:
  • ATP:glycerol 3-phosphotransferase 5 (GLPK5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZS86

UniProtKB/Swiss-Prot:

GLPK5_HUMAN :
  • Belongs to the FGGY kinase family.
Family:
  • Belongs to the FGGY kinase family.
genes like me logo Genes that share domains with GK5: view

Function for GK5 Gene

Molecular function for GK5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate; Xref=Rhea:RHEA:21644, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30616, ChEBI:CHEBI:57597, ChEBI:CHEBI:456216; EC=2.7.1.30;.

Enzyme Numbers (IUBMB) for GK5 Gene

Phenotypes From GWAS Catalog for GK5 Gene

Gene Ontology (GO) - Molecular Function for GK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004370 glycerol kinase activity IBA 21873635
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with GK5: view
genes like me logo Genes that share phenotypes with GK5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GK5

CRISPR Products

miRNA for GK5 Gene

miRTarBase miRNAs that target GK5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GK5

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GK5 Gene

Localization for GK5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GK5 gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 3
plasma membrane 1
extracellular 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA 21873635
genes like me logo Genes that share ontologies with GK5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for GK5 Gene

Pathways & Interactions for GK5 Gene

PathCards logo

SuperPathways for GK5 Gene

genes like me logo Genes that share pathways with GK5: view

Pathways by source for GK5 Gene

2 BioSystems pathways for GK5 Gene

UniProtKB/Swiss-Prot Q6ZS86-GLPK5_HUMAN

  • Pathway: Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.

Interacting Proteins for GK5 Gene

Gene Ontology (GO) - Biological Process for GK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006071 glycerol metabolic process IBA 21873635
GO:0006641 triglyceride metabolic process IBA 21873635
GO:0016310 phosphorylation IBA 21873635
GO:0019563 glycerol catabolic process IEA --
genes like me logo Genes that share ontologies with GK5: view

No data available for SIGNOR curated interactions for GK5 Gene

Drugs & Compounds for GK5 Gene

(2) Drugs for GK5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycerol Approved, Investigational Pharma 197
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(2) Additional Compounds for GK5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
glycerol 3-phosphate
  • (R)-Glycerol 1-phosphate
  • D-(Glycerol 1-phosphate)
  • D-Glycerol 1-phosphate
  • Glycerol-3-phosphate
  • Glycerophosphoric acid
57-03-4
genes like me logo Genes that share compounds with GK5: view

Transcripts for GK5 Gene

mRNA/cDNA for GK5 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GK5

Alternative Splicing Database (ASD) splice patterns (SP) for GK5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: - - -
SP2: - - - - - -
SP3:

Relevant External Links for GK5 Gene

GeneLoc Exon Structure for
GK5

Expression for GK5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GK5 Gene

This gene is overexpressed in Fetal gut (62.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GK5 Gene



Protein tissue co-expression partners for GK5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GK5

SOURCE GeneReport for Unigene cluster for GK5 Gene:

Hs.135904

Evidence on tissue expression from TISSUES for GK5 Gene

  • Nervous system(4.3)
  • Kidney(4.2)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with GK5: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GK5 Gene

Orthologs for GK5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GK5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GK5 30 31
  • 98.06 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GK5 30 31
  • 89.27 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GK5 30 31
  • 89.23 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Gk5 30 17 31
  • 83.61 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gk5 30
  • 83.43 (n)
Oppossum
(Monodelphis domestica)
Mammalia GK5 31
  • 83 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia GK5 31
  • 82 (a)
OneToOne
Chicken
(Gallus gallus)
Aves GK5 30 31
  • 69.78 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GK5 31
  • 67 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gk5 30
  • 66.27 (n)
Zebrafish
(Danio rerio)
Actinopterygii gk5 30 31
  • 63.78 (n)
OneToOne
wufc06f04 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007581 30
  • 48.45 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG1271 30 31
  • 47.78 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea C55B6.1 30 31
  • 49.64 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GUT1 31
  • 20 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 47 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.533 30
Species where no ortholog for GK5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GK5 Gene

ENSEMBL:
Gene Tree for GK5 (if available)
TreeFam:
Gene Tree for GK5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GK5: view image

Paralogs for GK5 Gene

Paralogs for GK5 Gene

(3) SIMAP similar genes for GK5 Gene using alignment to 4 proteins:

  • GLPK5_HUMAN
  • F8WBF0_HUMAN
  • H7C4F2_HUMAN
  • H7C5R4_HUMAN
genes like me logo Genes that share paralogs with GK5: view

Variants for GK5 Gene

Additional dbSNP identifiers (rs#s) for GK5 Gene

Structural Variations from Database of Genomic Variants (DGV) for GK5 Gene

Variant ID Type Subtype PubMed ID
dgv1412e212 CNV gain 25503493
dgv299n21 CNV gain 19592680
dgv4912n100 CNV gain 25217958
dgv619n27 CNV gain 19166990
dgv8625n54 CNV gain 21841781
dgv8626n54 CNV gain 21841781
esv2751979 CNV gain 17911159
esv2759182 CNV gain 17122850
esv2763767 CNV gain 21179565
esv34483 CNV gain 17911159
esv3597995 CNV gain 21293372
esv3597996 CNV gain 21293372
esv3598001 CNV gain 21293372
nsv1002953 CNV loss 25217958
nsv1008873 CNV gain 25217958
nsv1011175 CNV gain 25217958
nsv523945 CNV gain 19592680

Variation tolerance for GK5 Gene

Residual Variation Intolerance Score: 14.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GK5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GK5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GK5 Gene

Disorders for GK5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for GK5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
type 1 diabetes mellitus 7
  • diabetes mellitus, insulin-dependent, 7
type 1 diabetes mellitus 13
  • diabetes mellitus, insulin-dependent, 13
type 1 diabetes mellitus 3
  • diabetes mellitus, insulin-dependent, 3
- elite association - COSMIC cancer census association via MalaCards
Search GK5 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with GK5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GK5 Gene

Publications for GK5 Gene

  1. Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5. (PMID: 28607088) Zhang D … Beutler B (Proceedings of the National Academy of Sciences of the United States of America 2017) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. MicroRNA-135b exerts oncogenic activity in glioblastoma via the inhibition of glycerol kinase 5 expression. (PMID: 25936394) Yu Y … Zhang BZ (Molecular medicine reports 2015) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3

Products for GK5 Gene

  • Signalway Proteins for GK5

Sources for GK5 Gene