Free for academic non-profit institutions. Other users need a Commercial license
Aliases for GK5 Gene
Aliases for GK5 Gene
External Ids for GK5 Gene
- HGNC: 28635
- Entrez Gene: 256356
- Ensembl: ENSG00000175066
- UniProtKB: Q6ZS86
Previous GeneCards Identifiers for GK5 Gene
- GC03M143359
- GC03M141876
- GC03M139249
Summaries for GK5 Gene
GeneCards Summary for GK5 Gene
GK5 (Glycerol Kinase 5) is a Protein Coding gene. Diseases associated with GK5 include Type 1 Diabetes Mellitus 7 and Type 1 Diabetes Mellitus 13. Among its related pathways are glycerol degradation and triacylglycerol biosynthesis. Gene Ontology (GO) annotations related to this gene include phosphotransferase activity, alcohol group as acceptor and glycerol kinase activity. An important paralog of this gene is GK.
Additional gene information for GK5 Gene
- HGNC(28635)
- Entrez Gene(256356)
- Ensembl(ENSG00000175066)
- UniProtKB(Q6ZS86)
- Open Targets Platform(ENSG00000175066)
- Search for GK5 at DataMed
- Search for GK5 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GK5 Gene
Genomics for GK5 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GK5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GK5 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GK5
- Top Transcription factor binding sites by QIAGEN in the GK5 gene promoter:
-
- ATF6
- COUP
- COUP-TF
- Egr-4
- HOXA9
- HOXA9B
- Meis-1
- Meis-1b
- MyoD
- Pax-4a
Genomic Locations for GK5 Gene
Genomic Locations for GK5 Gene
- chr3:142,157,527-142,225,592
- (GRCh38/hg38)
- Size:
- 68,066 bases
- Orientation:
- Minus strand
- chr3:141,876,369-141,944,449
- (GRCh37/hg19)
- Size:
- 68,081 bases
- Orientation:
- Minus strand
Genomic View for GK5 Gene
Genes around GK5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q23 by HGNC
- 3q23 by Entrez Gene
- 3q23 by Ensembl
GK5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GK5 Gene
Proteins for GK5 Gene
-
Protein details for GK5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6ZS86-GLPK5_HUMAN
- Recommended name:
- Putative glycerol kinase 5
- Protein Accession:
- Q6ZS86
- B2R9I2
- D3DNG2
- Q8N2A7
- Q8N5E6
Protein attributes for GK5 Gene
- Size:
- 529 amino acids
- Molecular mass:
- 59156 Da
- Quaternary structure:
- No Data Available
Protein Expression for GK5 Gene
Selected DME Specific Peptides for GK5 Gene
- Q6ZS86:
-
- AFRNKQL
- GLAVGFW
- AVKRSMNW
- FGTIDTW
- VPSFSGLQAP
- IRCHVYD
- AMFGECCF
- FHNFISWQDLR
- IFGVPIP
Post-translational modifications for GK5 Gene
Other Protein References for GK5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-GK5 (aa 1-89) polyclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for GK5
- Novus Biologicals Antibodies for GK5
- Invitrogen Antibodies for GK5 (AFLGC-GK5)
- antibodies-online: Show 14 available GK5 Antibodies ranked by validation data
-
Biorbyt antibodies for GK5
Protein Products
-
OriGene Purified Proteins for GK5
- Search Origene for MassSpec and Protein Over-expression Lysates for GK5
- Origene Custom Protein Services for GK5
- antibodies-online: Search results for available GK5 related products ranked by validation data
-
Signalway Proteins for GK5
-
Abcam proteins for GK5
Domains & Families for GK5 Gene
Gene Families for GK5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for GK5 Gene
- InterPro:
- Blocks:
-
- Carbohydrate kinase, FGGY
- ProtoNet:
Suggested Antigen Peptide Sequences for GK5 Gene
- GenScript: Design optimal peptide antigens:
-
- ATP:glycerol 3-phosphotransferase 5 (GLPK5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q6ZS86- Family:
-
- Belongs to the FGGY kinase family.
Function for GK5 Gene
Molecular function for GK5 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate; Xref=Rhea:RHEA:21644, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30616, ChEBI:CHEBI:57597, ChEBI:CHEBI:456216; EC=2.7.1.30;.
Enzyme Numbers (IUBMB) for GK5 Gene
Phenotypes From GWAS Catalog for GK5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004370 | glycerol kinase activity | IBA | 21873635 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016301 | kinase activity | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for GK5 Gene
- MGI mutant phenotypes for GK5:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for GK5:
-
- Decreased transferrin (TF) endocytosis, decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Decreased shRNA abundance
- Increased Salmonella enterica Typhimurium invasion
- Increased shRNA abundance (Z-score > 2)
- Decreased POU5F1-GFP protein expression
- Decreased HPV16-GFP infection
Animal Model Products
-
Taconic Biosciences Mouse Models for GK5
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GK5 - Select products 50% OFF >
- * GK5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GK5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GK5
-
Santa Cruz Biotechnology (SCBT) CRISPR for GK5
miRNA for GK5 Gene
- miRTarBase miRNAs that target GK5
-
- hsa-miR-340-5p (MIRT019547)
- hsa-miR-124-3p (MIRT022437)
- hsa-miR-21-5p (MIRT090589)
- hsa-miR-4279 (MIRT161216)
- hsa-miR-5571-5p (MIRT400471)
- hsa-miR-374a-5p (MIRT440567)
- mmu-miR-298-5p (MIRT602298)
- mmu-miR-1935 (MIRT602299)
- mmu-miR-709 (MIRT602300)
- mmu-miR-128-3p (MIRT604962)
- mmu-miR-804 (MIRT604963)
- mmu-miR-665-3p (MIRT604964)
- hsa-miR-6809-3p (MIRT613735)
- hsa-miR-6833-3p (MIRT613736)
- hsa-miR-4768-5p (MIRT613737)
- hsa-miR-6873-3p (MIRT613738)
- hsa-miR-4753-3p (MIRT613739)
- hsa-miR-130b-5p (MIRT613740)
- hsa-miR-7110-3p (MIRT613741)
- hsa-miR-6817-3p (MIRT613742)
- hsa-miR-3160-5p (MIRT616290)
- hsa-miR-4668-5p (MIRT623788)
- hsa-miR-145-3p (MIRT623789)
- hsa-miR-5572 (MIRT623790)
- hsa-miR-4260 (MIRT623791)
- hsa-miR-450a-2-3p (MIRT623792)
- hsa-miR-1227-5p (MIRT623793)
- hsa-miR-185-3p (MIRT623794)
- hsa-miR-4283 (MIRT623795)
- hsa-miR-4489 (MIRT623796)
- hsa-miR-3649 (MIRT623797)
- hsa-miR-6778-3p (MIRT623798)
- hsa-miR-150-5p (MIRT623799)
- hsa-miR-6787-3p (MIRT623800)
- hsa-miR-6814-5p (MIRT623801)
- hsa-miR-3691-3p (MIRT623802)
- hsa-miR-6740-5p (MIRT632883)
- hsa-miR-7703 (MIRT635270)
- hsa-miR-6720-5p (MIRT635271)
- hsa-miR-6512-3p (MIRT635272)
- hsa-miR-196a-3p (MIRT635273)
- hsa-miR-661 (MIRT635274)
- hsa-miR-4252 (MIRT635275)
- hsa-miR-6076 (MIRT635276)
- hsa-miR-6797-3p (MIRT635277)
- hsa-miR-6860 (MIRT635278)
- hsa-miR-612 (MIRT635279)
- hsa-miR-5189-5p (MIRT635280)
- hsa-miR-3187-5p (MIRT635281)
- hsa-miR-1285-3p (MIRT635282)
- hsa-miR-4793-3p (MIRT635283)
- hsa-miR-766-3p (MIRT635284)
- hsa-miR-939-3p (MIRT635285)
- hsa-miR-6849-3p (MIRT635286)
- hsa-miR-1273g-3p (MIRT635287)
- hsa-miR-6501-3p (MIRT635288)
- hsa-miR-508-5p (MIRT635289)
- hsa-miR-6084 (MIRT638645)
- hsa-miR-3194-5p (MIRT638646)
- hsa-miR-6821-3p (MIRT638647)
- hsa-miR-4454 (MIRT638648)
- hsa-miR-6790-3p (MIRT638649)
- hsa-miR-1976 (MIRT638650)
- hsa-miR-3653-5p (MIRT638651)
- hsa-miR-498 (MIRT657787)
- hsa-miR-5699-3p (MIRT657788)
- hsa-miR-4421 (MIRT657789)
- hsa-miR-6748-3p (MIRT657790)
- hsa-miR-6845-3p (MIRT657791)
- hsa-miR-4685-3p (MIRT657792)
- hsa-miR-4287 (MIRT657793)
- hsa-miR-5088-3p (MIRT657794)
- hsa-miR-1207-3p (MIRT657795)
- hsa-miR-4639-3p (MIRT657796)
- hsa-miR-3617-3p (MIRT657797)
- hsa-miR-603 (MIRT657798)
- hsa-miR-182-5p (MIRT668093)
- hsa-miR-4470 (MIRT668094)
- hsa-miR-6747-3p (MIRT668095)
- hsa-miR-6727-3p (MIRT668096)
- hsa-miR-4722-3p (MIRT668097)
- hsa-miR-890 (MIRT668098)
- hsa-miR-4449 (MIRT668099)
- hsa-miR-4284 (MIRT668100)
- hsa-miR-4772-3p (MIRT668101)
- hsa-miR-4638-5p (MIRT668102)
- hsa-miR-1307-3p (MIRT668103)
- hsa-miR-1304-3p (MIRT668104)
- hsa-miR-6741-3p (MIRT668105)
- hsa-miR-4532 (MIRT668106)
- hsa-miR-1247-3p (MIRT668107)
- hsa-miR-6890-3p (MIRT668108)
- hsa-miR-5698 (MIRT668109)
- hsa-miR-744-3p (MIRT668110)
- hsa-miR-874-3p (MIRT668111)
- hsa-miR-3157-3p (MIRT668112)
- hsa-miR-4423-5p (MIRT668113)
- hsa-miR-6501-5p (MIRT668114)
- hsa-miR-891a-3p (MIRT668115)
- hsa-miR-143-5p (MIRT668116)
- hsa-miR-4430 (MIRT668117)
- hsa-miR-3652 (MIRT668118)
- hsa-miR-122-5p (MIRT668119)
- hsa-miR-504-3p (MIRT668120)
- hsa-miR-3135b (MIRT668121)
- hsa-miR-146b-3p (MIRT668122)
- hsa-miR-6799-3p (MIRT668123)
- hsa-miR-3173-5p (MIRT668124)
- hsa-miR-7976 (MIRT668125)
- hsa-miR-6499-3p (MIRT668126)
- hsa-miR-367-5p (MIRT668127)
- hsa-miR-1915-5p (MIRT668128)
- hsa-miR-5693 (MIRT668129)
- hsa-miR-6749-3p (MIRT668130)
- hsa-miR-5089-5p (MIRT688097)
- hsa-miR-6878-3p (MIRT688098)
- hsa-miR-6807-5p (MIRT688099)
- hsa-miR-7151-3p (MIRT688100)
- hsa-miR-5095 (MIRT688101)
- hsa-miR-6744-3p (MIRT688102)
- hsa-miR-4757-5p (MIRT688103)
- hsa-miR-5589-5p (MIRT688104)
- hsa-miR-4731-5p (MIRT688105)
- hsa-miR-6506-5p (MIRT688106)
- hsa-miR-619-5p (MIRT688107)
- hsa-miR-186-3p (MIRT688108)
- hsa-miR-520h (MIRT688109)
- hsa-miR-520g-3p (MIRT688110)
- hsa-miR-6504-3p (MIRT688111)
- hsa-miR-512-3p (MIRT688112)
- hsa-miR-4438 (MIRT688113)
- hsa-miR-6818-3p (MIRT708125)
- hsa-miR-4684-5p (MIRT708126)
- hsa-miR-593-3p (MIRT708127)
- hsa-miR-6895-3p (MIRT708128)
- hsa-miR-339-5p (MIRT708129)
- hsa-miR-10b-5p (MIRT708130)
- hsa-miR-10a-5p (MIRT708131)
- hsa-miR-6732-3p (MIRT708132)
- hsa-miR-548ay-3p (MIRT708133)
- hsa-miR-548at-3p (MIRT708134)
- hsa-miR-548as-3p (MIRT708135)
- hsa-miR-548t-3p (MIRT708136)
- hsa-miR-548ap-3p (MIRT708137)
- hsa-miR-548aa (MIRT708138)
- hsa-miR-548c-3p (MIRT708139)
- hsa-miR-181c-5p (MIRT727575)
- hsa-miR-181d-5p (MIRT727576)
- hsa-miR-181b-5p (MIRT727577)
- hsa-miR-181a-5p (MIRT727578)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GK5
- Browse OriGene Inhibitory RNA Products For GK5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GK5
Clone Products
- Applied Biological Materials (abm): Clones for GK5 - Select products 50% OFF >
- * GK5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GK5
- Addgene plasmids for GK5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GK5
Cell Line Products
-
Horizon Cell Lines for GK5
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GK5 Gene
Localization for GK5 Gene
| Compartment | Confidence |
|---|---|
| mitochondrion | 3 |
| nucleus | 3 |
| cytosol | 3 |
| plasma membrane | 1 |
| extracellular | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IBA | 21873635 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for GK5 Gene
Pathways & Interactions for GK5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | triacylglycerol biosynthesis | ||
| 2 | glycerol degradation | ||
Pathways by source for GK5 Gene
2 BioSystems pathways for GK5 Gene
UniProtKB/Swiss-Prot Q6ZS86-GLPK5_HUMAN
- Pathway: Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
Interacting Proteins for GK5 Gene
GPS-Prot Interaction Network for GK5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005975 | carbohydrate metabolic process | IEA | -- |
| GO:0006071 | glycerol metabolic process | IBA | 21873635 |
| GO:0006641 | triglyceride metabolic process | IBA | 21873635 |
| GO:0016310 | phosphorylation | IBA | 21873635 |
| GO:0019563 | glycerol catabolic process | IEA | -- |
No data available for SIGNOR curated interactions for GK5 Gene
Drugs & Compounds for GK5 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
||
| glycerol 3-phosphate |
|
57-03-4 |
|
Transcripts for GK5 Gene
mRNA/cDNA for GK5 Gene
- 2 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000392993 9815 nts (view in UCSC)
- ENST00000460515 2494 nts (view in UCSC)
- ENST00000460544 744 nts (view in UCSC)
- ENST00000460630 670 nts (view in UCSC)
- ENST00000463349 520 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GK5 - Select products 50% OFF >
- * GK5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GK5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GK5
-
Santa Cruz Biotechnology (SCBT) CRISPR for GK5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GK5
- Browse OriGene Inhibitory RNA Products For GK5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GK5
Clone Products
- Applied Biological Materials (abm): Clones for GK5 - Select products 50% OFF >
- * GK5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GK5
- Addgene plasmids for GK5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GK5
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP3: |
Relevant External Links for GK5 Gene
- GeneLoc Exon Structure for
- GK5
Expression for GK5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- Mature Granulosa Cells Antral Follicle
-
Blood (Hematopoietic System)
- Natural Killer Cells Peripheral Blood
This gene is overexpressed in Fetal gut (62.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GK5 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GK5
SOURCE GeneReport for Unigene cluster for GK5 Gene:
Hs.135904Evidence on tissue expression from TISSUES for GK5 Gene
- Nervous system(4.3)
- Kidney(4.2)
- Blood(4.2)
Primer Products
-
OriGene qPCR primer pairs for GK5
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GK5 Gene
Orthologs for GK5 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GK5 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | GK5 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | GK5 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Gk5 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Gk5 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | GK5 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | GK5 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | GK5 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | GK5 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | gk5 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | gk5 30 31 |
|
OneToOne | |
| wufc06f04 30 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007581 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG1271 30 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | C55B6.1 30 31 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | GUT1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.533 30 |
|
- Species where no ortholog for GK5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for GK5 Gene
- ENSEMBL:
- Gene Tree for GK5 (if available)
- TreeFam:
- Gene Tree for GK5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GK5: view image
Paralogs for GK5 Gene
Variants for GK5 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1412e212 | CNV | gain | 25503493 |
| dgv299n21 | CNV | gain | 19592680 |
| dgv4912n100 | CNV | gain | 25217958 |
| dgv619n27 | CNV | gain | 19166990 |
| dgv8625n54 | CNV | gain | 21841781 |
| dgv8626n54 | CNV | gain | 21841781 |
| esv2751979 | CNV | gain | 17911159 |
| esv2759182 | CNV | gain | 17122850 |
| esv2763767 | CNV | gain | 21179565 |
| esv34483 | CNV | gain | 17911159 |
| esv3597995 | CNV | gain | 21293372 |
| esv3597996 | CNV | gain | 21293372 |
| esv3598001 | CNV | gain | 21293372 |
| nsv1002953 | CNV | loss | 25217958 |
| nsv1008873 | CNV | gain | 25217958 |
| nsv1011175 | CNV | gain | 25217958 |
| nsv523945 | CNV | gain | 19592680 |
Residual Variation Intolerance Score:
14.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.82;
17.26% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GK5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GK5
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GK5 Gene
Disorders for GK5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| type 1 diabetes mellitus 7 |
|
|
| type 1 diabetes mellitus 13 |
|
|
| type 1 diabetes mellitus 3 |
|
|
Search GK5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GK5
No data available for UniProtKB/Swiss-Prot and Genatlas for GK5 Gene
Publications for GK5 Gene
- Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5. (PMID: 28607088) Zhang D … Beutler B (Proceedings of the National Academy of Sciences of the United States of America 2017) 2 3
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- MicroRNA-135b exerts oncogenic activity in glioblastoma via the inhibition of glycerol kinase 5 expression. (PMID: 25936394) Yu Y … Zhang BZ (Molecular medicine reports 2015) 3
- Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3
ExternalLinks
Products for GK5 Gene
- Custom Antibody ServicesOriGene Antibodies for GK5
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for GK5
- Search Origene for MassSpec and Protein Over-expression Lysates for GK5
- Origene Custom Protein Services for GK5
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GK5
- Browse OriGene Inhibitory RNA Products For GK5
- OriGene qPCR primer pairs for GK5
- OriGene CRISPR knockouts for GK5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For GK5
- Sino Biological Human cDNA Clone for GK5
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for GK5
- Novus Biologicals proteins and lysates for GK5
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for GK5
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for GK5
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for GK5 (AFLGC-GK5)
- VectorBuilder Custom and pre-made DNA vectors for GK5 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for GK5 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for GK5 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for GK5 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for GK5
- Addgene plasmids for GK5
- antibodies-online: Show 14 available GK5 Antibodies ranked by validation data
- antibodies-online: Search results for available GK5 related products ranked by validation data
- antibodies-online: Search results for available GK5 related products ranked by validation data
- Horizon Cell Lines for GK5
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GK5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GK5
- Search GeneCopoeia for miRNA 3'UTR Target clone products for GK5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GK5
- Biorbyt antibodies for GK5
- Signalway Proteins for GK5
Sources for GK5 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB