Aliases for GJA9 Gene
External Ids for GJA9 Gene
Previous HGNC Symbols for GJA9 Gene
Previous GeneCards Identifiers for GJA9 Gene
Connexins, such as GJA9, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM, Mar 2008]
GeneCards Summary for GJA9 Gene
GJA9 (Gap Junction Protein Alpha 9) is a Protein Coding gene. Diseases associated with GJA9 include Deafness, Autosomal Dominant 66. Among its related pathways are Gap junction trafficking and Vesicle-mediated transport. An important paralog of this gene is GJA10.
UniProtKB/Swiss-Prot Summary for GJA9 Gene
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Gap channels (gap junctions) are specialized cell-cell contacts that provide direct intracellular communication. They allow passive diffusion of molecules up to 1 kDa, including nutrients, metabolites (glucose), ions (K+, Ca2+) and second messengers (IP3, cAMP).