Aliases for GIT1 Gene
Aliases for GIT1 Gene
External Ids for GIT1 Gene
- HGNC: 4272
- Entrez Gene: 28964
- Ensembl: ENSG00000108262
- OMIM: 608434
- UniProtKB: Q9Y2X7
Previous GeneCards Identifiers for GIT1 Gene
- GC17M027560
- GC17M029800
- GC17M027752
- GC17M028046
- GC17M024924
- GC17M027900
- GC17M024109
Summaries for GIT1 Gene
GeneCards Summary for GIT1 Gene
GIT1 (GIT ArfGAP 1) is a Protein Coding gene. Diseases associated with GIT1 include Chromosome 17Q11.2 Deletion Syndrome, 1.4-Mb and Attention Deficit-Hyperactivity Disorder. Among its related pathways are Regulation of CDC42 activity and Developmental Biology. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is GIT2.
UniProtKB/Swiss-Prot for GIT1 Gene
-
GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve SDCCAG3 and PTPN13 (By similarity).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GIT1 Gene
Genomics for GIT1 Gene
GeneHancer (GH) Regulatory Elements for GIT1 Gene
Promoters and enhancers for GIT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around GIT1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the GIT1 gene promoter:
-
- AP-1
- c-Jun
- ATF-2
- c-Ets-1
- HEN1
- Nkx6-1
- Spz1
- PPAR-gamma1
- PPAR-gamma2
- HTF
Regulatory Element Products
Genomic Locations for GIT1 Gene
Genomic Locations for GIT1 Gene
- chr17:29,573,469-29,594,054
- (GRCh38/hg38)
- Size:
- 20,586 bases
- Orientation:
- Minus strand
- chr17:27,900,487-27,921,072
- (GRCh37/hg19)
- Size:
- 20,586 bases
- Orientation:
- Minus strand
Genomic View for GIT1 Gene
Genes around GIT1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q11.2 by Entrez Gene
- 17q11.2 by HGNC
- 17q11.2 by Ensembl
GIT1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GIT1 Gene
Proteins for GIT1 Gene
-
Protein details for GIT1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y2X7-GIT1_HUMAN
- Recommended name:
- ARF GTPase-activating protein GIT1
- Protein Accession:
- Q9Y2X7
- B4DGU9
- B4DSV3
- Q86SS0
- Q9BRJ4
Protein attributes for GIT1 Gene
- Size:
- 761 amino acids
- Molecular mass:
- 84341 Da
- Quaternary structure:
-
- Interacts with G protein-coupled receptor kinases: GRK2, PPFIA1 and PPFIA4. Interacts with ARHGEF6/alpha-PIX, with ARHGEF7/beta-PIX, with PXN/paxillin and with PTK2/FAK1 (By similarity). Component of cytoplasmic complexes, which also contain PXN, ARHGEF6 and PAK1. Interacts with TGFB1I1. Interacts with SCRIB. Interacts with SDCCAG3 (PubMed:23108400).
- SequenceCaution:
-
- Sequence=AAH48196.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for GIT1 Gene
Post-translational modifications for GIT1 Gene
- Phosphorylated on tyrosine residues by PTK2/FAK1 and SRC in growing fibroblasts. Tyrosine-phosphorylation is increased following cell spreading on fibronectin, decreased in cells arrested in mitosis and increased in the ensuing G1 phase (By similarity).
- Ubiquitination at Lys49
- Modification sites at PhosphoSitePlus
Other Protein References for GIT1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for GIT1 (GIT1)
-
Custom Antibody ServicesOriGene Antibodies for GIT1
- Novus Biologicals Antibodies for GIT1
-
Abcam antibodies for GIT1
- Invitrogen Antibodies for GIT1 (AFLGC-GIT1)
- antibodies-online: Search results for available GIT1 related products ranked by validation data
- GeneTex GIT1 Antibody for GIT1
-
Santa Cruz Biotechnology (SCBT) Antibodies for GIT1
Protein Products
-
OriGene Purified Proteins for GIT1
- Search Origene for MassSpec and Protein Over-expression Lysates for GIT1
- Origene Custom Protein Services for GIT1
- antibodies-online: Search results for available GIT1 related products ranked by validation data
- Search GeneTex for Proteins for GIT1
Assay Products
- R&D Systems ELISAs and other biochemical assays for GIT1 (GIT1)
- antibodies-online: Search results for available GIT1 related products ranked by validation data
No data available for DME Specific Peptides for GIT1 Gene
Domains & Families for GIT1 Gene
Gene Families for GIT1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for GIT1 Gene
Suggested Antigen Peptide Sequences for GIT1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y2X7UniProtKB/Swiss-Prot:
GIT1_HUMAN :- The paxillin-binding domain is masked in the full-length protein and is regulated by ARHGEF6.
- Domain:
-
- The paxillin-binding domain is masked in the full-length protein and is regulated by ARHGEF6.
Function for GIT1 Gene
Molecular function for GIT1 Gene
- UniProtKB/Swiss-Prot Function:
- GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve SDCCAG3 and PTPN13 (By similarity).
Phenotypes From GWAS Catalog for GIT1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005096 | GTPase activator activity | IEA | -- |
| GO:0005515 | protein binding | IEA,IPI | 15182672 |
| GO:0031267 | small GTPase binding | IBA | -- |
| GO:0044877 | protein-containing complex binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for GIT1 Gene
- MGI mutant phenotypes for GIT1:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for GIT1:
-
- Decreased viability ratio
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased viability in esophageal squamous lineage
- Decreased cell migration
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased NF-kappaB reporter expression
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for GIT1
-
CRISPR Products
-
OriGene CRISPR knockouts for GIT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GIT1
- genomics-online: gRNA clones - Search results for available GIT1 gene related products
- Applied Biological Materials CRISPR for GIT1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GIT1
- GenScript: Design CRISPR guide RNA sequences for GIT1
miRNA for GIT1 Gene
- miRTarBase miRNAs that target GIT1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GIT1
- Browse OriGene Inhibitory RNA Products For GIT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GIT1
- genomics-online: shRNA clones - Search results for available GIT1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for GIT1
- Addgene plasmids for GIT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GIT1
- genomics-online: cdna clones - Search results for available GIT1 gene related products
- orf clones - Search results for available GIT1 gene related products
- Applied Biological Materials Clones for GIT1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for GIT1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GIT1 Gene
Localization for GIT1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GIT1 Gene
- Cytoplasm. Note=Cycles between at least 3 distinct intracellular compartments, including focal adhesions, cytoplasmic complexes and membrane protrusions. During cell migration, when cells detach, moves from the adhesions into the cytoplasmic complexes towards the leading edge, while, when cells adhere, it is found in vinculin-containing adhesions. Recruitment to adhesions may be mediated by active tyrosine-phosphorylated paxillin.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| endosome | 1 |
- Cytosol (4)
- Focal adhesion sites (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA,IEA | -- |
| GO:0005829 | cytosol | IDA,TAS | -- |
| GO:0005925 | focal adhesion | IDA | -- |
| GO:0016020 | membrane | IBA,HDA | -- |
| GO:0043231 | intracellular membrane-bounded organelle | IBA | -- |
Pathways & Interactions for GIT1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of actin cytoskeleton | ||
| 2 | Developmental Biology |
.51
|
|
| 3 | EPH-Ephrin signaling |
.01
|
|
| 4 | Paxillin-dependent events mediated by a4b1 | ||
| 5 | Endocytosis | ||
Pathways by source for GIT1 Gene
7 BioSystems pathways for GIT1 Gene
4 Reactome pathways for GIT1 Gene
3 KEGG pathways for GIT1 Gene
2 Cell Signaling Technology pathways for GIT1 Gene
Interacting Proteins for GIT1 Gene
Selected Interacting proteins:
Q9Y2X7-GIT1_HUMAN
ENSP00000378338
for GIT1 Gene via
MINT
STRING
UniProtKB
IID
GPS-Prot Interaction Network for GIT1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway | TAS | 9826657 |
| GO:0016192 | vesicle-mediated transport | IBA | -- |
| GO:0032012 | regulation of ARF protein signal transduction | IBA | -- |
| GO:0032465 | regulation of cytokinesis | IDA | 23108400 |
| GO:0043547 | positive regulation of GTPase activity | IEA | -- |
Transcripts for GIT1 Gene
mRNA/cDNA for GIT1 Gene
- (8) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (315) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000225394 3768 bps (uc002hef.3)
- ENST00000473217 3462 bps (uc060djo.1)
- ENST00000394869 3711 bps (uc002heg.3)
- ENST00000581348 2827 bps (uc010wbg.2)
- ENST00000579937 2798 bps (uc060djp.1)
Unigene Clusters for GIT1 Gene
- G protein-coupled receptor kinase interacting ArfGAP 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for GIT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GIT1
- genomics-online: gRNA clones - Search results for available GIT1 gene related products
- Applied Biological Materials CRISPR for GIT1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GIT1
- GenScript: Design CRISPR guide RNA sequences for GIT1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GIT1
- Browse OriGene Inhibitory RNA Products For GIT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GIT1
- genomics-online: shRNA clones - Search results for available GIT1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for GIT1
- Addgene plasmids for GIT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GIT1
- genomics-online: cdna clones - Search results for available GIT1 gene related products
- orf clones - Search results for available GIT1 gene related products
- Applied Biological Materials Clones for GIT1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | · | 15c | ^ | 16 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 17a | · | 17b | · | 17c | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b | ^ | 23a | · | 23b | · | 23c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||
| SP8: | - | - | |||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||
| SP12: |
Expression for GIT1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Brain (12.0), Peripheral blood mononuclear cells (10.0), and Frontal cortex (7.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GIT1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of GIT1 Gene:
GIT1SOURCE GeneReport for Unigene cluster for GIT1 Gene:
Hs.514051Evidence on tissue expression from TISSUES for GIT1 Gene
- Nervous system(4.9)
- Lung(4.5)
- Blood(4.3)
- Liver(4.2)
- Muscle(2.2)
- Heart(2)
Primer Products
-
OriGene qPCR primer pairs for GIT1
- genomics-online: primer clones - Search results for available GIT1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GIT1 Gene
Orthologs for GIT1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GIT1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | GIT1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | GIT1 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Git1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Git1 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | GIT1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | GIT1 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | git1 34 |
|
OneToOne | |
| LOC568935 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG16728 35 |
|
|
|
| Git 34 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | F14F3.2 35 |
|
|
|
| git-1 34 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for GIT1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for GIT1 Gene
- ENSEMBL:
- Gene Tree for GIT1 (if available)
- TreeFam:
- Gene Tree for GIT1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GIT1: view image
Paralogs for GIT1 Gene
(12) SIMAP similar genes for GIT1 Gene using alignment to 11 proteins:
- GIT1_HUMAN
- E7EVC2_HUMAN
- J3QL89_HUMAN
- J3QLH1_HUMAN
- J3QQI0_HUMAN
- J3QRU8_HUMAN
- K7EIX6_HUMAN
- K7EN79_HUMAN
- L0R865_HUMAN
- Q6PIN6_HUMAN
- Q9BSI3_HUMAN
Variants for GIT1 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000175695 | -- | 29,576,336(-) | T/C | coding_sequence_variant, missense_variant | |
| rs1000196818 | -- | 29,591,122(-) | C/T | upstream_transcript_variant | |
| rs1000227959 | -- | 29,576,095(-) | G/T | coding_sequence_variant, missense_variant | |
| rs1000500862 | -- | 29,581,774(-) | C/T | coding_sequence_variant, missense_variant | |
| rs1000551274 | -- | 29,574,498(-) | G/A | 3_prime_UTR_variant |
Residual Variation Intolerance Score:
5.12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.72;
15.36% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GIT1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GIT1 Gene
Disorders for GIT1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| chromosome 17q11.2 deletion syndrome, 1.4-mb |
|
|
| attention deficit-hyperactivity disorder |
|
|
Search GIT1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GIT1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for GIT1 Gene
Publications for GIT1 Gene
- The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing. (PMID: 10896954) Premont RT … Lefkowitz RJ (The Journal of biological chemistry 2000) 2 3 4 22 58
- beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. (PMID: 9826657) Premont RT … Lefkowitz RJ (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 22 58
- Mammalian Scribble forms a tight complex with the betaPIX exchange factor. (PMID: 15182672) Audebert S … Borg JP (Current biology : CB 2004) 3 4 22 58
- GIT1 functions in a motile, multi-molecular signaling complex that regulates protrusive activity and cell migration. (PMID: 11896197) Manabe R … Horwitz AR (Journal of cell science 2002) 3 4 22 58
- The serologically defined colon cancer antigen-3 interacts with the protein tyrosine phosphatase PTPN13 and is involved in the regulation of cytokinesis. (PMID: 23108400) Hagemann N … Erdmann KS (Oncogene 2013) 3 4 58
Products for GIT1 Gene
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- Lentiviral ORF Clones
- Novus Biologicals Antibodies for GIT1
- Novus Biologicals lysates and proteins for GIT1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for GIT1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for GIT1 (AFLGC-GIT1)
- Cyagen custom Knockout/knockin (KOKI) mouse models for GIT1
- Addgene plasmids for GIT1
- antibodies-online: Search results for available GIT1 related products ranked by validation data
- antibodies-online: Search results for available GIT1 related products ranked by validation data
- antibodies-online: Search results for available GIT1 related products ranked by validation data
- GeneTex GIT1 Antibody for GIT1
- Search GeneTex for Proteins for GIT1
- Santa Cruz Biotechnology (SCBT) Antibodies for GIT1
- Search Santa Cruz Biotechnology (SCBT) for GIT1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GIT1
- Horizon Cell Lines for GIT1
- genomics-online: cdna clones - Search results for available GIT1 gene related products
- orf clones - Search results for available GIT1 gene related products
- genomics-online: gRNA clones - Search results for available GIT1 gene related products
- genomics-online: primer clones - Search results for available GIT1 gene related products
- genomics-online: shRNA clones - Search results for available GIT1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GIT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GIT1
- GeneCopoeia miRNA 3'UTR Target clone products for GIT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GIT1
Sources for GIT1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt