Aliases for GIT1 Gene
External Ids for GIT1 Gene
Previous GeneCards Identifiers for GIT1 Gene
GeneCards Summary for GIT1 Gene
GIT1 (GIT ArfGAP 1) is a Protein Coding gene. Diseases associated with GIT1 include Blind Loop Syndrome and Pneumatosis Cystoides Intestinalis. Among its related pathways are Regulation of CDC42 activity and Adhesion. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is GIT2.
UniProtKB/Swiss-Prot Summary for GIT1 Gene
GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve ENTR1 and PTPN13 (By similarity).