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Aliases for GIPR Gene

Aliases for GIPR Gene

  • Gastric Inhibitory Polypeptide Receptor 2 3 3 5
  • Glucose-Dependent Insulinotropic Polypeptide Receptor 3 4
  • GIP-R 3 4
  • PGQTL2 3

External Ids for GIPR Gene

Previous GeneCards Identifiers for GIPR Gene

  • GC19P046815
  • GC19P046562
  • GC19P050847
  • GC19P050863
  • GC19P046171
  • GC19P042600

Summaries for GIPR Gene

Entrez Gene Summary for GIPR Gene

  • This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]

GeneCards Summary for GIPR Gene

GIPR (Gastric Inhibitory Polypeptide Receptor) is a Protein Coding gene. Diseases associated with GIPR include Adrenal Cortical Adenoma and Adrenal Adenoma. Among its related pathways are Presynaptic function of Kainate receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and peptide hormone binding. An important paralog of this gene is GCGR.

UniProtKB/Swiss-Prot for GIPR Gene

  • This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Gene Wiki entry for GIPR Gene

Additional gene information for GIPR Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GIPR Gene

Genomics for GIPR Gene

GeneHancer (GH) Regulatory Elements for GIPR Gene

Promoters and enhancers for GIPR Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J045667 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 655.5 +0.4 376 2.4 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ARNT SIN3A YBX1 ZNF2 POLR2B GIPR SNRPD2 CCDC61 DM1-AS ENSG00000259605 ENSG00000268810 CLASRP FBXO46 PPP1R13L ENSG00000269148
GH19J045645 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 5.5 -22.3 -22295 1.6 PKNOX1 SMAD1 ARNT SIN3A ZNF2 IRF4 E2F8 ZNF143 ZNF207 FOS EML2 GIPR EML2-AS1 RN7SL836P
GH19J045677 Promoter/Enhancer 1.2 Ensembl ENCODE 7.1 +9.3 9332 1.4 HDGF ELF3 CTCF PKNOX1 BACH1 SIN3A ERF ZBTB7B TEAD3 ZFHX2 SNRPD2 CCDC61 GIPR PNMA8A GC19M045670 MIR642B GC19P045665
GH19J045477 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2.6 -189.9 -189893 2.4 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A ZNF2 ZBTB7B IRF4 ERCC1 PIR58452 TRU-TCA1-1 ZNF180 CCDC61 CLASRP CD3EAP FBXO46 ENSG00000269148 IRF2BP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GIPR on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GIPR gene promoter:
  • deltaCREB
  • CREB
  • AREB6
  • Max1
  • c-Myc
  • Meis-1a
  • Meis-1
  • Meis-1b
  • Pax-4a

Genomic Locations for GIPR Gene

Genomic Locations for GIPR Gene
15,532 bases
Plus strand
15,481 bases
Plus strand

Genomic View for GIPR Gene

Genes around GIPR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GIPR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GIPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GIPR Gene

Proteins for GIPR Gene

  • Protein details for GIPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Gastric inhibitory polypeptide receptor
    Protein Accession:
    Secondary Accessions:
    • B7WP14
    • B7ZKQ0
    • Q14401
    • Q16400
    • Q52M04
    • Q9UPI1

    Protein attributes for GIPR Gene

    466 amino acids
    Molecular mass:
    53157 Da
    Quaternary structure:
    • May form homodimers and heterodimers with GLP1R.
    • Sequence=CAA57426.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GIPR Gene

    Alternative splice isoforms for GIPR Gene


neXtProt entry for GIPR Gene

Post-translational modifications for GIPR Gene

  • N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation in the ER.
  • Glycosylation at Asn77 and Asn62
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GIPR Gene

Domains & Families for GIPR Gene

Gene Families for GIPR Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for GIPR Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 2 family.
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with GIPR: view

Function for GIPR Gene

Molecular function for GIPR Gene

UniProtKB/Swiss-Prot Function:
This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
GENATLAS Biochemistry:
gastric inhibitory polypeptide receptor,G protein coupled receptor superfamily,expressed in pancreatic beta cell,not involved in NIDDM,at least in a Japanese population

Phenotypes From GWAS Catalog for GIPR Gene

Gene Ontology (GO) - Molecular Function for GIPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 obsolete signal transducer activity IEA --
GO:0004888 transmembrane signaling receptor activity IEA,TAS 7556958
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005515 protein binding IPI 17715056
GO:0016519 gastric inhibitory peptide receptor activity IEA --
genes like me logo Genes that share ontologies with GIPR: view
genes like me logo Genes that share phenotypes with GIPR: view

Animal Models for GIPR Gene

MGI Knock Outs for GIPR:

Animal Model Products

Clone Products

  • Addgene plasmids for GIPR

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GIPR Gene

Localization for GIPR Gene

Subcellular locations from UniProtKB/Swiss-Prot for GIPR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GIPR gene
Compartment Confidence
plasma membrane 5
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GIPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GIPR: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GIPR Gene

Pathways & Interactions for GIPR Gene

genes like me logo Genes that share pathways with GIPR: view

Gene Ontology (GO) - Biological Process for GIPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002029 desensitization of G-protein coupled receptor protein signaling pathway IEA --
GO:0006091 generation of precursor metabolites and energy TAS 7556958
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS --
genes like me logo Genes that share ontologies with GIPR: view

No data available for SIGNOR curated interactions for GIPR Gene

Drugs & Compounds for GIPR Gene

(7) Drugs for GIPR Gene - From: PharmGKB, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Olanzapine Approved, Investigational Pharma Antagonist, Full agonist, Agonist, Inverse agonist 408
GIP (1-39) Pharma Highly potent insulinotropic peptide 0
GIP (human) Pharma Potent insulinotropic gut hormone 0
[Pro<sup>3</sup>]GIP Pharma Antagonist 0
gastric inhibitory polypeptide Pharma Full agonist, Agonist 83

(3) Additional Compounds for GIPR Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[Pro3]-GIP (Mouse)
[Pro3]-GIP (Rat)

(4) Tocris Compounds for GIPR Gene

Compound Action Cas Number
[Pro3]-GIP (Mouse) GIP receptor antagonist
[Pro3]-GIP (Rat) High affinity rat GIP receptor partial agonist
GIP (1-39) Highly potent insulinotropic peptide 725474-97-5
GIP (human) Potent insulinotropic gut hormone 100040-31-1
genes like me logo Genes that share compounds with GIPR: view

Transcripts for GIPR Gene

Unigene Clusters for GIPR Gene

Gastric inhibitory polypeptide receptor:
Representative Sequences:

Clone Products

  • Addgene plasmids for GIPR

Alternative Splicing Database (ASD) splice patterns (SP) for GIPR Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14
SP1: - - - -

Relevant External Links for GIPR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GIPR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GIPR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GIPR Gene

This gene is overexpressed in Heart - Atrial Appendage (x4.2).

Protein differential expression in normal tissues from HIPED for GIPR Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GIPR Gene

Protein tissue co-expression partners for GIPR Gene

NURSA nuclear receptor signaling pathways regulating expression of GIPR Gene:


SOURCE GeneReport for Unigene cluster for GIPR Gene:


Evidence on tissue expression from TISSUES for GIPR Gene

  • Pancreas(4.5)
  • Intestine(4.3)
genes like me logo Genes that share expression patterns with GIPR: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GIPR Gene

Orthologs for GIPR Gene

This gene was present in the common ancestor of animals.

Orthologs for GIPR Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia GIPR 34 33
  • 89.59 (n)
(Bos Taurus)
Mammalia GIPR 34 33
  • 88.51 (n)
(Rattus norvegicus)
Mammalia Gipr 33
  • 83.68 (n)
(Mus musculus)
Mammalia Gipr 16 34 33
  • 82.81 (n)
(Monodelphis domestica)
Mammalia GIPR 34
  • 67 (a)
(Gallus gallus)
Aves -- 34
  • 46 (a)
(Anolis carolinensis)
Reptilia GIPR 34
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gipr 33
  • 54.91 (n)
(Danio rerio)
Actinopterygii GIPR 34
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta EG:BACR25B3.3 35
  • 28 (a)
Species where no ortholog for GIPR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GIPR Gene

Gene Tree for GIPR (if available)
Gene Tree for GIPR (if available)
Evolutionary constrained regions (ECRs) for GIPR: view image

Paralogs for GIPR Gene

Paralogs for GIPR Gene

(14) SIMAP similar genes for GIPR Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with GIPR: view

Variants for GIPR Gene

Sequence variations from dbSNP and Humsavar for GIPR Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000136002 -- 45,668,231(+) C/A 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000223438 -- 45,669,678(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000497732 -- 45,679,336(+) G/C/T genic_downstream_transcript_variant, intron_variant
rs1000635403 -- 45,679,695(+) C/A genic_downstream_transcript_variant, intron_variant
rs1000695076 -- 45,668,545(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GIPR Gene

Variant ID Type Subtype PubMed ID
esv3556465 CNV deletion 23714750
esv3644509 CNV gain 21293372

Variation tolerance for GIPR Gene

Residual Variation Intolerance Score: 93.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.77; 83.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GIPR Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GIPR Gene

Disorders for GIPR Gene

MalaCards: The human disease database

(3) MalaCards diseases for GIPR Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
adrenal cortical adenoma
  • adrenocortical adenoma
adrenal adenoma
  • adenoma of the adrenal gland
adrenal gland hyperfunction
  • adrenocortical hyperfunction
- elite association - COSMIC cancer census association via MalaCards
Search GIPR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GIPR

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GIPR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GIPR Gene

Publications for GIPR Gene

  1. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. (PMID: 20081857) Saxena R … Watanabe RM (Nature genetics 2010) 3 22 44 58
  2. A follow-up study of chromosome 19q13 in multiple sclerosis susceptibility. (PMID: 19195718) Bonetti A … Tienari PJ (Journal of neuroimmunology 2009) 3 22 44 58
  3. Gastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groups. (PMID: 19254363) Vogel CI … Hinney A (BMC medical genetics 2009) 3 22 44 58
  4. Association analyses of GIP and GIPR polymorphisms with traits of the metabolic syndrome. (PMID: 17624916) Nitz I … Döring F (Molecular nutrition & food research 2007) 3 22 44 58
  5. Assignment of the gastric inhibitory polypeptide receptor gene (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ hybridization. (PMID: 7490109) Stoffel M … Bell GI (Genomics 1995) 2 3 22 58

Products for GIPR Gene

Sources for GIPR Gene

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