This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impai... See more...

Aliases for GIPR Gene

Aliases for GIPR Gene

  • Gastric Inhibitory Polypeptide Receptor 2 3 4 5
  • Glucose-Dependent Insulinotropic Polypeptide Receptor 3 4
  • GIP-R 3 4
  • PGQTL2 3
  • GIPR 5

External Ids for GIPR Gene

Previous GeneCards Identifiers for GIPR Gene

  • GC19P046815
  • GC19P046562
  • GC19P050847
  • GC19P050863
  • GC19P046171
  • GC19P042600

Summaries for GIPR Gene

Entrez Gene Summary for GIPR Gene

  • This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]

GeneCards Summary for GIPR Gene

GIPR (Gastric Inhibitory Polypeptide Receptor) is a Protein Coding gene. Diseases associated with GIPR include Adrenal Cortical Adenoma and Adrenal Adenoma. Among its related pathways are Signaling by GPCR and Presynaptic function of Kainate receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and peptide hormone binding. An important paralog of this gene is GCGR.

UniProtKB/Swiss-Prot Summary for GIPR Gene

  • This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Gene Wiki entry for GIPR Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GIPR Gene

Genomics for GIPR Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GIPR Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GIPR on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GIPR

Top Transcription factor binding sites by QIAGEN in the GIPR gene promoter:
  • AREB6
  • c-Myc
  • CREB
  • deltaCREB
  • Max1
  • Meis-1
  • Meis-1a
  • Meis-1b
  • Pax-4a

Genomic Locations for GIPR Gene

Genomic Locations for GIPR Gene
chr19:45,668,187-45,683,722
(GRCh38/hg38)
Size:
15,536 bases
Orientation:
Plus strand
chr19:46,171,502-46,186,982
(GRCh37/hg19)
Size:
15,481 bases
Orientation:
Plus strand

Genomic View for GIPR Gene

Genes around GIPR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GIPR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GIPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GIPR Gene

Proteins for GIPR Gene

  • Protein details for GIPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48546-GIPR_HUMAN
    Recommended name:
    Gastric inhibitory polypeptide receptor
    Protein Accession:
    P48546
    Secondary Accessions:
    • B7WP14
    • B7ZKQ0
    • Q14401
    • Q16400
    • Q52M04
    • Q9UPI1

    Protein attributes for GIPR Gene

    Size:
    466 amino acids
    Molecular mass:
    53157 Da
    Quaternary structure:
    • May form homodimers and heterodimers with GLP1R.
    SequenceCaution:
    • Sequence=CAA57426.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GIPR Gene

    Alternative splice isoforms for GIPR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GIPR Gene

Post-translational modifications for GIPR Gene

  • N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation in the ER.
  • Glycosylation at Asn62 and Asn77
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for GIPR Gene

Domains & Families for GIPR Gene

Gene Families for GIPR Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for GIPR Gene

InterPro:
Blocks:
  • G-protein coupled receptors family 2 (secretin-like)
  • Gastric inhibitory polypeptide receptor precursor signature
ProtoNet:

Suggested Antigen Peptide Sequences for GIPR Gene

GenScript: Design optimal peptide antigens:
  • Glucose-dependent insulinotropic polypeptide receptor (GIPR_HUMAN)
  • GIPR protein (Q4VBP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P48546

UniProtKB/Swiss-Prot:

GIPR_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family.
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with GIPR: view

Function for GIPR Gene

Molecular function for GIPR Gene

UniProtKB/Swiss-Prot Function:
This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
GENATLAS Biochemistry:
gastric inhibitory polypeptide receptor,G protein coupled receptor superfamily,expressed in pancreatic beta cell,not involved in NIDDM,at least in a Japanese population

Phenotypes From GWAS Catalog for GIPR Gene

Gene Ontology (GO) - Molecular Function for GIPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA,TAS 7556958
GO:0004930 G protein-coupled receptor activity IEA --
GO:0005515 protein binding IPI 17715056
GO:0008528 G protein-coupled peptide receptor activity IBA 21873635
GO:0016519 gastric inhibitory peptide receptor activity IEA,IBA 21873635
genes like me logo Genes that share ontologies with GIPR: view
genes like me logo Genes that share phenotypes with GIPR: view

Animal Models for GIPR Gene

MGI Knock Outs for GIPR:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GIPR

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GIPR Gene

Localization for GIPR Gene

Subcellular locations from UniProtKB/Swiss-Prot for GIPR Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GIPR gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for GIPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GIPR: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GIPR Gene

Pathways & Interactions for GIPR Gene

genes like me logo Genes that share pathways with GIPR: view

Gene Ontology (GO) - Biological Process for GIPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002029 desensitization of G protein-coupled receptor signaling pathway IEA --
GO:0006091 generation of precursor metabolites and energy TAS 7556958
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA,TAS --
genes like me logo Genes that share ontologies with GIPR: view

No data available for SIGNOR curated interactions for GIPR Gene

Drugs & Compounds for GIPR Gene

(7) Drugs for GIPR Gene - From: PharmGKB, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Olanzapine Approved, Investigational Pharma Antagonist, Agonist, Full agonist, Inverse agonist 442
gastric inhibitory polypeptide Investigational Pharma Agonist, Full agonist 108
GIP (1-39) Pharma Highly potent insulinotropic peptide 0
GIP (human) Pharma Potent insulinotropic gut hormone 0
[Pro<sup>3</sup>]GIP Pharma Antagonist 0

(3) Additional Compounds for GIPR Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[Pro3]-GIP (Mouse)
[Pro3]-GIP (Rat)

(4) Tocris Compounds for GIPR Gene

Compound Action Cas Number
[Pro3]-GIP (Mouse) GIP receptor antagonist
[Pro3]-GIP (Rat) High affinity rat GIP receptor partial agonist
GIP (1-39) Highly potent insulinotropic peptide 725474-97-5
GIP (human) Potent insulinotropic gut hormone 100040-31-1

(2) ApexBio Compounds for GIPR Gene

Compound Action Cas Number
GIP (1-39) 725474-97-5
GIP (human) 100040-31-1
genes like me logo Genes that share compounds with GIPR: view

Drug Products

Transcripts for GIPR Gene

mRNA/cDNA for GIPR Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GIPR

Alternative Splicing Database (ASD) splice patterns (SP) for GIPR Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14
SP1: - - - -
SP2:
SP3:
SP4:

Relevant External Links for GIPR Gene

GeneLoc Exon Structure for
GIPR

Expression for GIPR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GIPR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GIPR Gene

This gene is overexpressed in Heart - Atrial Appendage (x4.2).

Protein differential expression in normal tissues from HIPED for GIPR Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GIPR Gene



Protein tissue co-expression partners for GIPR Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GIPR

SOURCE GeneReport for Unigene cluster for GIPR Gene:

Hs.658534

Evidence on tissue expression from TISSUES for GIPR Gene

  • Pancreas(4.6)
  • Intestine(4.4)
  • Stomach(2.3)
  • Nervous system(2.2)
  • Adrenal gland(2.2)
  • Liver(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with GIPR: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GIPR Gene

Orthologs for GIPR Gene

This gene was present in the common ancestor of animals.

Orthologs for GIPR Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia GIPR 30 31
  • 89.59 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GIPR 30 31
  • 88.51 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gipr 30
  • 83.68 (n)
Mouse
(Mus musculus)
Mammalia Gipr 30 17 31
  • 82.81 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia GIPR 31
  • 67 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 31
  • 46 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia GIPR 31
  • 56 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gipr 30
  • 54.91 (n)
Zebrafish
(Danio rerio)
Actinopterygii GIPR 31
  • 47 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta EG:BACR25B3.3 32
  • 28 (a)
Species where no ortholog for GIPR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GIPR Gene

ENSEMBL:
Gene Tree for GIPR (if available)
TreeFam:
Gene Tree for GIPR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GIPR: view image

Paralogs for GIPR Gene

(14) SIMAP similar genes for GIPR Gene using alignment to 4 proteins:

  • GIPR_HUMAN
  • K7EJZ3_HUMAN
  • K7EPD9_HUMAN
  • Q4VBP1_HUMAN
genes like me logo Genes that share paralogs with GIPR: view

Variants for GIPR Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GIPR Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs13306402 - p.Arg136Trp
rs1800436 - p.Ala207Val
rs1800437 - p.Glu354Gln
rs5392 - p.Leu262Val

Additional dbSNP identifiers (rs#s) for GIPR Gene

Structural Variations from Database of Genomic Variants (DGV) for GIPR Gene

Variant ID Type Subtype PubMed ID
esv3556465 CNV deletion 23714750
esv3644509 CNV gain 21293372

Variation tolerance for GIPR Gene

Residual Variation Intolerance Score: 93.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.77; 83.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GIPR Gene

Human Gene Mutation Database (HGMD)
GIPR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GIPR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GIPR Gene

Disorders for GIPR Gene

MalaCards: The human disease database

(6) MalaCards diseases for GIPR Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
adrenal cortical adenoma
  • adrenocortical adenoma
adrenal adenoma
  • adrenal cortical adenoma
conn's syndrome
  • adrenal cortical adenoma
insulinoma
  • islet cell tumor
acth-independent macronodular adrenal hyperplasia
  • aimah1
- elite association - COSMIC cancer census association via MalaCards
Search GIPR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GIPR

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with GIPR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GIPR Gene

Publications for GIPR Gene

  1. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. (PMID: 20081857) Saxena R … Watanabe RM (Nature genetics 2010) 3 23 41
  2. A follow-up study of chromosome 19q13 in multiple sclerosis susceptibility. (PMID: 19195718) Bonetti A … Tienari PJ (Journal of neuroimmunology 2009) 3 23 41
  3. Gastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groups. (PMID: 19254363) Vogel CI … Hinney A (BMC medical genetics 2009) 3 23 41
  4. Association analyses of GIP and GIPR polymorphisms with traits of the metabolic syndrome. (PMID: 17624916) Nitz I … Döring F (Molecular nutrition & food research 2007) 3 23 41
  5. Human gastric inhibitory polypeptide receptor: cloning of the gene (GIPR) and cDNA. (PMID: 8575774) Yamada Y … Seino Y (Genomics 1995) 3 4 23

Products for GIPR Gene

  • Signalway ELISA kits for GIPR
  • Signalway Proteins for GIPR

Sources for GIPR Gene