Aliases for GIPC1 Gene
Aliases for GIPC1 Gene
- GIPC PDZ Domain Containing Family Member 1 2 3 5
- Regulator Of G-Protein Signalling 19 Interacting Protein 1 2 3
- GAIP C-Terminus-Interacting Protein 3 4
- RGS-GAIP-Interacting Protein 3 4
- RGS19-Interacting Protein 1 3 4
- Tax Interaction Protein 2 3 4
- SYNECTIN 3 4
- RGS19IP1 3 4
- C19orf3 3 4
- TIP-2 3 4
- GIPC 3 4
- GIPC PDZ Domain Containing Family, Member 1 2
External Ids for GIPC1 Gene
- HGNC: 1226
- Entrez Gene: 10755
- Ensembl: ENSG00000123159
- OMIM: 605072
- UniProtKB: O14908
Previous HGNC Symbols for GIPC1 Gene
- C19orf3
- RGS19IP1
Previous GeneCards Identifiers for GIPC1 Gene
- GC19M014592
- GC19M014158
- GC19M014593
- GC19M014596
- GC19M014600
Summaries for GIPC1 Gene
-
GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008 [PubMed 18775991]).[supplied by OMIM, Apr 2009]
GeneCards Summary for GIPC1 Gene
GIPC1 (GIPC PDZ Domain Containing Family Member 1) is a Protein Coding gene. Diseases associated with GIPC1 include Cholesterol Embolism and Intracranial Embolism. Among its related pathways are Syndecan-4-mediated signaling events and Neurotrophic factor-mediated Trk receptor signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and actin binding. An important paralog of this gene is GIPC2.
UniProtKB/Swiss-Prot for GIPC1 Gene
-
May be involved in G protein-linked signaling.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GIPC1 Gene
Genomics for GIPC1 Gene
GeneHancer (GH) Regulatory Elements for GIPC1 Gene
Promoters and enhancers for GIPC1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around GIPC1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for GIPC1 Gene
Genomic Locations for GIPC1 Gene
- chr19:14,477,759-14,496,149
- (GRCh38/hg38)
- Size:
- 18,391 bases
- Orientation:
- Minus strand
- chr19:14,588,571-14,606,944
- (GRCh37/hg19)
Genomic View for GIPC1 Gene
Genes around GIPC1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.12 by Ensembl
- 19p13.12 by Entrez Gene
- 19p13.12 by HGNC
GIPC1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GIPC1 Gene
Proteins for GIPC1 Gene
-
Protein details for GIPC1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O14908-GIPC1_HUMAN
- Recommended name:
- PDZ domain-containing protein GIPC1
- Protein Accession:
- O14908
- A8K4I3
- A8MZG3
- Q9BTC9
Protein attributes for GIPC1 Gene
- Size:
- 333 amino acids
- Molecular mass:
- 36049 Da
- Quaternary structure:
-
- Interacts with GLUT1 (C-terminus), ACTN1, KIF1B, MYO6, PLEKHG5, SDC4/syndecan-4 and SEMA4C/semaphorin-4C (By similarity). Interacts with RGS19 C-terminus. Interacts with HTLV-I Tax through the PDZ domain.
Protein Expression for GIPC1 Gene
Post-translational modifications for GIPC1 Gene
Other Protein References for GIPC1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for GIPC1
- Novus Biologicals Antibodies for GIPC1
-
Abcam antibodies for GIPC1
- Invitrogen Antibodies for GIPC1
- GeneTex GIPC1 antibody for GIPC1
-
Santa Cruz Biotechnology (SCBT) Antibodies for GIPC1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for GIPC1
- Origene Custom Protein Services for GIPC1
- ProSpec Recombinant Proteins for GIPC1
- Search GeneTex for Proteins for GIPC1
-
Abcam proteins for GIPC1
Assay Products
No data available for DME Specific Peptides for GIPC1 Gene
Domains & Families for GIPC1 Gene
Gene Families for GIPC1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for GIPC1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for GIPC1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O14908- Family:
-
- Belongs to the GIPC family.
Function for GIPC1 Gene
Molecular function for GIPC1 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in G protein-linked signaling.
Phenotypes From GWAS Catalog for GIPC1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003779 | actin binding | ISS | -- |
| GO:0005102 | receptor binding | IPI | 15459234 |
| GO:0005515 | protein binding | IPI | 9770488 |
| GO:0017022 | myosin binding | ISS | -- |
| GO:0030165 | PDZ domain binding | IEA | -- |
Phenotypes for GIPC1 Gene
- MGI mutant phenotypes for GIPC1:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for GIPC1:
Animal Models for GIPC1 Gene
- MGI Knock Outs for GIPC1:
-
- Gipc1 tm1Mvc
Animal Model Products
-
Taconic Biosciences Mouse Models for GIPC1
- Cyagen custom Knockout/knockin (KOKI) mouse models for GIPC1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for GIPC1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GIPC1 gene
- Search ViGene Biosciences for GIPC1
CRISPR Products
-
OriGene CRISPR knockouts for GIPC1
- genomics-online: gRNA clones - Search results for 128 available GIPC1 gene related products
- Overview of 128 available GIPC1 gene related products
- Applied Biological Materials CRISPR for GIPC1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GIPC1
- GenScript: Design CRISPR guide RNA sequences for GIPC1
miRNA for GIPC1 Gene
- miRTarBase miRNAs that target GIPC1
-
- hsa-mir-18a-3p (MIRT040897)
- hsa-mir-1976 (MIRT614981)
- hsa-mir-4469 (MIRT614982)
- hsa-mir-6893-3p (MIRT614983)
- hsa-mir-370-3p (MIRT614984)
- hsa-mir-660-3p (MIRT614985)
- hsa-mir-4667-3p (MIRT614986)
- hsa-mir-1470 (MIRT614987)
- hsa-mir-1263 (MIRT736680)
- hsa-mir-128-1-5p (MIRT736974)
- hsa-mir-128-2-5p (MIRT736993)
- hsa-mir-1292-5p (MIRT737133)
- hsa-mir-1321 (MIRT737330)
- hsa-mir-149-3p (MIRT737731)
- hsa-mir-204-3p (MIRT738822)
- hsa-mir-3144-5p (MIRT740213)
- hsa-mir-4270 (MIRT743564)
- hsa-mir-4441 (MIRT744531)
- hsa-mir-4463 (MIRT744874)
- hsa-mir-4471 (MIRT744951)
- hsa-mir-4494 (MIRT745327)
- hsa-mir-4646-5p (MIRT746431)
- hsa-mir-4707-5p (MIRT747356)
- hsa-mir-4728-5p (MIRT747827)
- hsa-mir-4739 (MIRT748048)
- hsa-mir-4756-5p (MIRT748420)
- hsa-mir-5579-5p (MIRT750919)
- hsa-mir-6753-5p (MIRT754675)
- hsa-mir-6754-5p (MIRT754706)
- hsa-mir-6781-5p (MIRT755679)
- hsa-mir-6785-5p (MIRT755822)
- hsa-mir-6883-5p (MIRT758407)
- hsa-mir-7113-5p (MIRT759108)
- hsa-mir-8059 (MIRT760034)
- hsa-mir-105-5p (MIRT761092)
- hsa-mir-1254 (MIRT761639)
- hsa-mir-1273f (MIRT761892)
- hsa-mir-1273h-5p (MIRT762042)
- hsa-mir-1343-5p (MIRT762575)
- hsa-mir-185-5p (MIRT763175)
- hsa-mir-187-3p (MIRT763210)
- hsa-mir-194-5p (MIRT763468)
- hsa-mir-27a-3p (MIRT764321)
- hsa-mir-27b-3p (MIRT764327)
- hsa-mir-2861 (MIRT764344)
- hsa-mir-30b-3p (MIRT764580)
- hsa-mir-3116 (MIRT764755)
- hsa-mir-3150a-3p (MIRT765024)
- hsa-mir-3175 (MIRT765237)
- hsa-mir-3202 (MIRT765520)
- hsa-mir-3689a-3p (MIRT766808)
- hsa-mir-3689b-3p (MIRT766896)
- hsa-mir-3689c (MIRT766984)
- hsa-mir-3689d (MIRT767067)
- hsa-mir-377-5p (MIRT767398)
- hsa-mir-4306 (MIRT768516)
- hsa-mir-4428 (MIRT768891)
- hsa-mir-4438 (MIRT769129)
- hsa-mir-4533 (MIRT770097)
- hsa-mir-4636 (MIRT770511)
- hsa-mir-4644 (MIRT770563)
- hsa-mir-4706 (MIRT771359)
- hsa-mir-4749-5p (MIRT771927)
- hsa-mir-4771 (MIRT772196)
- hsa-mir-491-5p (MIRT772757)
- hsa-mir-513a-5p (MIRT773388)
- hsa-mir-6086 (MIRT775529)
- hsa-mir-6133 (MIRT775912)
- hsa-mir-6134 (MIRT775940)
- hsa-mir-658 (MIRT777340)
- hsa-mir-6763-5p (MIRT778484)
- hsa-mir-6774-3p (MIRT778726)
- hsa-mir-6779-5p (MIRT778885)
- hsa-mir-6780a-5p (MIRT778976)
- hsa-mir-6799-5p (MIRT779411)
- hsa-mir-6825-5p (MIRT779891)
- hsa-mir-6851-5p (MIRT780404)
- hsa-mir-6871-5p (MIRT780701)
- hsa-mir-7106-5p (MIRT781341)
- hsa-mir-744-5p (MIRT781729)
- hsa-mir-765 (MIRT781820)
- hsa-mir-7853-5p (MIRT782248)
- hsa-mir-922 (MIRT782646)
- hsa-mir-92a-2-5p (MIRT782660)
- hsa-mir-939-5p (MIRT782855)
miRNA Products
- Search ViGene Biosciences for GIPC1
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GIPC1
- Browse OriGene Inhibitory RNA Products For GIPC1
- genomics-online: shRNA clones - Search results for 128 available GIPC1 gene related products
- Overview of 128 available GIPC1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for GIPC1 gene
Clone Products
-
OriGene ORF clones in human for GIPC1
- RC216466L1V
- RC216466L2V
- RC224373L1V
- RC224373L2V
- RC216637L1V
- RC216637L2V
- RC201175L1V
- RC201175L2V
- RC224484L1V
- RC224484L2V
- RC216466
- RC216466L1
- RC216466L2
- RG216466
- RC224373
- RC224373L1
- RC224373L2
- RG224373
- RC216637
- RC216637L1
- RC216637L2
- RG216637
- RC201175
- RC201175L1
- RC201175L2
- RG201175
- RC224484
- RC224484L1
- RC224484L2
- RG224484
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GIPC1
- VectorBuilder custom plasmid, inducible vectors for GIPC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GIPC1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for GIPC1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for GIPC1
-
ViGene Biosciences adenoviral particle packaged cDNA for GIPC1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GIPC1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GIPC1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GIPC1 Gene
Localization for GIPC1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GIPC1 Gene
- Cytoplasm. Membrane; Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| endosome | 2 |
- Cell Junctions (2)
- Nucleus (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,ISS | -- |
| GO:0005829 | cytosol | ISS | -- |
| GO:0005903 | brush border | IEA | -- |
| GO:0005938 | cell cortex | IDA | 12857860 |
| GO:0008021 | synaptic vesicle | ISS | -- |
Pathways & Interactions for GIPC1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | G-protein signaling_H-RAS regulation pathway | ||
| 2 | Neurotrophic factor-mediated Trk receptor signaling | ||
| 3 | Syndecan-4-mediated signaling events | ||
Pathways by source for GIPC1 Gene
2 BioSystems pathways for GIPC1 Gene
1 GeneGo (Thomson Reuters) pathway for GIPC1 Gene
Interacting Proteins for GIPC1 Gene
Selected Interacting proteins:
O14908-GIPC1_HUMAN
ENSP00000340698
for GIPC1 Gene via
MINT
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006605 | protein targeting | ISS | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | NAS | 9770488 |
| GO:0007268 | chemical synaptic transmission | ISS | -- |
| GO:0014047 | glutamate secretion | ISS | -- |
| GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway | ISS | -- |
No data available for SIGNOR curated interactions for GIPC1 Gene
Transcripts for GIPC1 Gene
mRNA/cDNA for GIPC1 Gene
- (8) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (454) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GIPC1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GIPC1
- genomics-online: gRNA clones - Search results for 128 available GIPC1 gene related products
- Overview of 128 available GIPC1 gene related products
- Applied Biological Materials CRISPR for GIPC1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GIPC1
- GenScript: Design CRISPR guide RNA sequences for GIPC1
miRNA Products
- Search ViGene Biosciences for GIPC1
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GIPC1
- Browse OriGene Inhibitory RNA Products For GIPC1
- genomics-online: shRNA clones - Search results for 128 available GIPC1 gene related products
- Overview of 128 available GIPC1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for GIPC1 gene
Clone Products
-
OriGene ORF clones in human for GIPC1
- RC216466L1V
- RC216466L2V
- RC224373L1V
- RC224373L2V
- RC216637L1V
- RC216637L2V
- RC201175L1V
- RC201175L2V
- RC224484L1V
- RC224484L2V
- RC216466
- RC216466L1
- RC216466L2
- RG216466
- RC224373
- RC224373L1
- RC224373L2
- RG224373
- RC216637
- RC216637L1
- RC216637L2
- RG216637
- RC201175
- RC201175L1
- RC201175L2
- RG201175
- RC224484
- RC224484L1
- RC224484L2
- RG224484
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GIPC1
- VectorBuilder custom plasmid, inducible vectors for GIPC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GIPC1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for GIPC1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||
| SP10: | - | ||||||||||||||||||||||||||||||||||||||||
| SP11: |
Expression for GIPC1 Gene
mRNA differential expression in normal tissues according to GTEx for GIPC1 Gene
This gene is overexpressed in Esophagus - Mucosa (x4.8).
This gene is overexpressed in Cervix (44.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GIPC1 Gene
NURSA nuclear receptor signaling pathways regulating expression of GIPC1 Gene:
GIPC1SOURCE GeneReport for Unigene cluster for GIPC1 Gene:
Hs.655012mRNA Expression by UniProt/SwissProt for GIPC1 Gene:
O14908-GIPC1_HUMAN
Tissue specificity:
Widely expressed.
Evidence on tissue expression from TISSUES for GIPC1 Gene
- Nervous system(4.5)
- Lung(4.3)
- Muscle(4.3)
- Liver(4.2)
- Skin(2.7)
- Pancreas(2.2)
- Heart(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for GIPC1
-
OriGene qPCR primer pairs for GIPC1
- genomics-online: primer clones - Search results for 128 available GIPC1 gene related products
- Overview of 128 available GIPC1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for GIPC1 Gene
Orthologs for GIPC1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GIPC1 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | GIPC1 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | GIPC1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | GIPC1 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | GIPC1 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Gipc1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Gipc1 33 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | GIPC1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | gipc2 33 |
|
||
| Str.6557 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Kermit 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | gipc1 33 34 |
|
||
| zgc56157 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | kermit 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | gipc-2 33 34 |
|
||
| gipc-1 34 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for GIPC1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for GIPC1 Gene
(2) SIMAP similar genes for GIPC1 Gene using alignment to 6 proteins:
Variants for GIPC1 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000023088 | -- | 14,489,110(-) | G/A | intron_variant | |
| rs1000125562 | -- | 14,493,991(-) | G/A | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000152196 | -- | 14,494,621(-) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000183841 | -- | 14,494,814(-) | G/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000233985 | -- | 14,489,977(-) | TCT/T | intron_variant |
Residual Variation Intolerance Score:
14.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.05;
68.73% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GIPC1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GIPC1 Gene
Disorders for GIPC1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cholesterol embolism |
|
|
| intracranial embolism |
|
|
Search GIPC1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GIPC1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for GIPC1 Gene
Publications for GIPC1 Gene
- The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins. (PMID: 9482110) Rousset R … Jalinot P (Oncogene 1998) 2 3 4 58
- GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP. (PMID: 9770488) De Vries L … Farquhar MG (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- Overexpression of myosin VI in prostate cancer cells enhances PSA and VEGF secretion, but has no effect on endocytosis. (PMID: 19855435) Puri C … Buss F (Oncogene 2010) 3 22 58
- An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking. (PMID: 19016655) Wieman HL … Rathmell JC (The Biochemical journal 2009) 3 22 58
Products for GIPC1 Gene
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- Taconic Biosciences Mouse Models for GIPC1
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- Mammalian expression: PiggyBac
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 83 available GIPC1 Antibodies ranked by validation data
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- GeneTex GIPC1 antibody for GIPC1
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- ViGene Biosciences adenoviral particle packaged cDNA for GIPC1 gene
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- genomics-online: cdna clones - Search results for 128 available GIPC1 gene related products
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Sources for GIPC1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
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- (7) GeneLoc
- (8) Gene Wiki
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- (23) PharmGKB
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- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
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- (39) Pseudogene
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- (42) GenAtlas
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- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
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- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
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- (84) Vector BioLabs
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- (92) COMPARTMENTS
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