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GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008 [PubMed 18775991]).[supplied by OMIM, Apr 2009] See more...
Aliases for GIPC1 Gene
Aliases for GIPC1 Gene
- GIPC PDZ Domain Containing Family Member 1 2 3 5
- TIP-2 2 3 4
- GIPC 2 3 4
- Regulator Of G-Protein Signalling 19 Interacting Protein 1 2 3
- PDZ Domain-Containing Protein GIPC1 3 4
- GAIP C-Terminus-Interacting Protein 3 4
- RGS-GAIP-Interacting Protein 3 4
- RGS19-Interacting Protein 1 3 4
- Tax Interaction Protein 2 3 4
- GLUT1CBP 2 3
- RGS19IP1 3 4
- SYNECTIN 2 3
External Ids for GIPC1 Gene
- HGNC: 1226
- Entrez Gene: 10755
- Ensembl: ENSG00000123159
- OMIM: 605072
- UniProtKB: O14908
Previous HGNC Symbols for GIPC1 Gene
- C19orf3
- RGS19IP1
Previous GeneCards Identifiers for GIPC1 Gene
- GC19M014592
- GC19M014158
- GC19M014593
- GC19M014596
- GC19M014600
Summaries for GIPC1 Gene
-
GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008 [PubMed 18775991]).[supplied by OMIM, Apr 2009]
GeneCards Summary for GIPC1 Gene
GIPC1 (GIPC PDZ Domain Containing Family Member 1) is a Protein Coding gene. Diseases associated with GIPC1 include Urethral Calculus and Ovary Serous Adenocarcinoma. Among its related pathways are Syndecan-4-mediated signaling events and Neurotrophic factor-mediated Trk receptor signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and actin binding. An important paralog of this gene is GIPC2.
UniProtKB/Swiss-Prot Summary for GIPC1 Gene
-
May be involved in G protein-linked signaling.
Additional gene information for GIPC1 Gene
- HGNC(1226)
- Entrez Gene(10755)
- Ensembl(ENSG00000123159)
- OMIM(605072)
- UniProtKB(O14908)
- Open Targets Platform(ENSG00000123159)
- Search for GIPC1 at DataMed
- Search for GIPC1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GIPC1 Gene
Genomics for GIPC1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GIPC1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GIPC1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GIPC1
- Top Transcription factor binding sites by QIAGEN in the GIPC1 gene promoter:
-
- aMEF-2
- C/EBPalpha
- Elk-1
- HOXA9
- HOXA9B
- MEF-2
- MEF-2A
- Meis-1
- Meis-1b
- YY1
Genomic Locations for GIPC1 Gene
Genomic Locations for GIPC1 Gene
- chr19:14,477,759-14,496,149
- (GRCh38/hg38)
- Size:
- 18,391 bases
- Orientation:
- Minus strand
- chr19:14,588,571-14,606,944
- (GRCh37/hg19)
- Size:
- 18,374 bases
- Orientation:
- Minus strand
Genomic View for GIPC1 Gene
Genes around GIPC1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.12 by HGNC
- 19p13.12 by Entrez Gene
- 19p13.12 by Ensembl
GIPC1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GIPC1 Gene
Proteins for GIPC1 Gene
-
Protein details for GIPC1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O14908-GIPC1_HUMAN
- Recommended name:
- PDZ domain-containing protein GIPC1
- Protein Accession:
- O14908
- A8K4I3
- A8MZG3
- Q9BTC9
Protein attributes for GIPC1 Gene
- Size:
- 333 amino acids
- Molecular mass:
- 36049 Da
- Quaternary structure:
-
- Interacts with GLUT1 (C-terminus), ACTN1, KIF1B, MYO6, PLEKHG5, SDC4/syndecan-4 and SEMA4C/semaphorin-4C (By similarity). Interacts with RGS19 C-terminus. Interacts with HTLV-I Tax through the PDZ domain.
Protein Expression for GIPC1 Gene
Post-translational modifications for GIPC1 Gene
Other Protein References for GIPC1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-GIPC1 monoclonal antibody
- Creative Biolabs Recombinant Anti-human GIPC1 Antibody scFv Fragment and Recombinant Anti-human GIPC1 Antibody
- Novus Biologicals Antibodies for GIPC1
-
Abcam antibodies for GIPC1
- Invitrogen Antibodies for GIPC1 (AFLGC-GIPC1)
-
Boster Bio Antibodies for GIPC1
-
Santa Cruz Biotechnology (SCBT) Antibodies for GIPC1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for GIPC1
- Origene Custom Protein Services for GIPC1
- ProSpec Recombinant Proteins for GIPC1
-
Abcam proteins for GIPC1
No data available for DME Specific Peptides for GIPC1 Gene
Domains & Families for GIPC1 Gene
Gene Families for GIPC1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for GIPC1 Gene
Suggested Antigen Peptide Sequences for GIPC1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ76166, highly similar to Homo sapiens GIPC PDZ domain containing family, member 1 (GIPC1), transcript variant 2, mRNA (A8K4I3_HUMAN)
- Tax interaction protein 2 (GIPC1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O14908- Family:
-
- Belongs to the GIPC family.
Function for GIPC1 Gene
Molecular function for GIPC1 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in G protein-linked signaling.
Phenotypes From GWAS Catalog for GIPC1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003779 | actin binding | ISS | -- |
| GO:0005102 | signaling receptor binding | IPI | 15459234 |
| GO:0005515 | protein binding | IPI | 9770488 |
| GO:0017022 | myosin binding | ISS | -- |
| GO:0030165 | PDZ domain binding | IEA | -- |
Phenotypes for GIPC1 Gene
- MGI mutant phenotypes for GIPC1:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for GIPC1:
-
- Decreased hepcidin::fluc mRNA expression
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Increased gamma-H2AX phosphorylation
- Decreased G3BP1 protein expression and assembly in stress granules after arsenite stimulation
- Decreased viability in esophageal squamous lineage; decreased viability in pancreas lineage
Animal Models for GIPC1 Gene
- MGI Knock Outs for GIPC1:
-
- Gipc1 Gipc1<tm1Mvc>
Animal Model Products
-
Taconic Biosciences Mouse Models for GIPC1
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GIPC1 - Select products 50% OFF >
- * GIPC1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GIPC1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GIPC1
-
Santa Cruz Biotechnology (SCBT) CRISPR for GIPC1
miRNA for GIPC1 Gene
- miRTarBase miRNAs that target GIPC1
-
- hsa-miR-18a-3p (MIRT040897)
- mmu-miR-363-5p (MIRT605741)
- mmu-miR-804 (MIRT605742)
- mmu-miR-1195 (MIRT605743)
- mmu-miR-5135 (MIRT605744)
- mmu-miR-3089-5p (MIRT605745)
- hsa-miR-1976 (MIRT614981)
- hsa-miR-4469 (MIRT614982)
- hsa-miR-6893-3p (MIRT614983)
- hsa-miR-370-3p (MIRT614984)
- hsa-miR-660-3p (MIRT614985)
- hsa-miR-4667-3p (MIRT614986)
- hsa-miR-1470 (MIRT614987)
- hsa-miR-1263 (MIRT736680)
- hsa-miR-128-1-5p (MIRT736974)
- hsa-miR-128-2-5p (MIRT736993)
- hsa-miR-1292-5p (MIRT737133)
- hsa-miR-1321 (MIRT737330)
- hsa-miR-149-3p (MIRT737731)
- hsa-miR-204-3p (MIRT738822)
- hsa-miR-3144-5p (MIRT740213)
- hsa-miR-4270 (MIRT743564)
- hsa-miR-4441 (MIRT744531)
- hsa-miR-4463 (MIRT744874)
- hsa-miR-4471 (MIRT744951)
- hsa-miR-4494 (MIRT745327)
- hsa-miR-4646-5p (MIRT746431)
- hsa-miR-4707-5p (MIRT747356)
- hsa-miR-4728-5p (MIRT747827)
- hsa-miR-4739 (MIRT748048)
- hsa-miR-4756-5p (MIRT748420)
- hsa-miR-5579-5p (MIRT750919)
- hsa-miR-6753-5p (MIRT754675)
- hsa-miR-6754-5p (MIRT754706)
- hsa-miR-6781-5p (MIRT755679)
- hsa-miR-6785-5p (MIRT755822)
- hsa-miR-6883-5p (MIRT758407)
- hsa-miR-7113-5p (MIRT759108)
- hsa-miR-8059 (MIRT760034)
- hsa-miR-105-5p (MIRT761092)
- hsa-miR-1254 (MIRT761639)
- hsa-miR-1273f (MIRT761892)
- hsa-miR-1273h-5p (MIRT762042)
- hsa-miR-1343-5p (MIRT762575)
- hsa-miR-185-5p (MIRT763175)
- hsa-miR-187-3p (MIRT763210)
- hsa-miR-194-5p (MIRT763468)
- hsa-miR-27a-3p (MIRT764321)
- hsa-miR-27b-3p (MIRT764327)
- hsa-miR-2861 (MIRT764344)
- hsa-miR-30b-3p (MIRT764580)
- hsa-miR-3116 (MIRT764755)
- hsa-miR-3150a-3p (MIRT765024)
- hsa-miR-3175 (MIRT765237)
- hsa-miR-3202 (MIRT765520)
- hsa-miR-3689a-3p (MIRT766808)
- hsa-miR-3689b-3p (MIRT766896)
- hsa-miR-3689c (MIRT766984)
- hsa-miR-3689d (MIRT767067)
- hsa-miR-377-5p (MIRT767398)
- hsa-miR-4306 (MIRT768516)
- hsa-miR-4428 (MIRT768891)
- hsa-miR-4438 (MIRT769129)
- hsa-miR-4533 (MIRT770097)
- hsa-miR-4636 (MIRT770511)
- hsa-miR-4644 (MIRT770563)
- hsa-miR-4706 (MIRT771359)
- hsa-miR-4749-5p (MIRT771927)
- hsa-miR-4771 (MIRT772196)
- hsa-miR-491-5p (MIRT772757)
- hsa-miR-513a-5p (MIRT773388)
- hsa-miR-6086 (MIRT775529)
- hsa-miR-6133 (MIRT775912)
- hsa-miR-6134 (MIRT775940)
- hsa-miR-658 (MIRT777340)
- hsa-miR-6763-5p (MIRT778484)
- hsa-miR-6774-3p (MIRT778726)
- hsa-miR-6779-5p (MIRT778885)
- hsa-miR-6780a-5p (MIRT778976)
- hsa-miR-6799-5p (MIRT779411)
- hsa-miR-6825-5p (MIRT779891)
- hsa-miR-6851-5p (MIRT780404)
- hsa-miR-6871-5p (MIRT780701)
- hsa-miR-7106-5p (MIRT781341)
- hsa-miR-744-5p (MIRT781729)
- hsa-miR-765 (MIRT781820)
- hsa-miR-7853-5p (MIRT782248)
- hsa-miR-922 (MIRT782646)
- hsa-miR-92a-2-5p (MIRT782660)
- hsa-miR-939-5p (MIRT782855)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GIPC1
- Browse OriGene Inhibitory RNA Products For GIPC1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GIPC1
Clone Products
- Applied Biological Materials (abm): Clones for GIPC1 - Select products 50% OFF >
- * GIPC1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG204910
- MR204910
- MR204910L3
- MR204910L4
- RC201175
- RC201175L1
- RC201175L2
- RC201175L3
- RC201175L4
- RC216466
- RC216466L3
- RC216466L4
- RC216637
- RC216637L3
- RC216637L4
- RC224373
- RC224373L3
- RC224373L4
- RC224484
- RC224484L3
- RC224484L4
- RG201175
- RG216466
- RG216637
- RG224373
- RG224484
- RR202420
- RR202420L3
- RR202420L4
- MR204910L3V
- MR204910L4V
- RC201175L1V
- RC201175L2V
- RC201175L3V
- RC201175L4V
- RC216466L3V
- RC216466L4V
- RC216637L3V
- RC216637L4V
- RC224373L3V
- RC224373L4V
- RC224484L3V
- RC224484L4V
- RR202420L3V
- RR202420L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GIPC1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GIPC1
Cell Line Products
-
Horizon Cell Lines for GIPC1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GIPC1 Gene
Localization for GIPC1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GIPC1 Gene
- Cytoplasm. Membrane. Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| extracellular | 4 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
- Cell Junctions (2)
- Nucleoplasm (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,ISS | -- |
| GO:0005829 | cytosol | ISS | -- |
| GO:0005903 | brush border | IEA | -- |
| GO:0005938 | cell cortex | IDA | 12857860 |
| GO:0008021 | synaptic vesicle | ISS | -- |
Pathways & Interactions for GIPC1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | G-protein signaling_H-RAS regulation pathway |
G-protein signaling_H-RAS regulation pathway
-
|
|
| 2 | Neurotrophic factor-mediated Trk receptor signaling | ||
| 3 | Syndecan-4-mediated signaling events | ||
Pathways by source for GIPC1 Gene
2 BioSystems pathways for GIPC1 Gene
1 GeneGo (Thomson Reuters) pathway for GIPC1 Gene
- G-protein signaling_H-RAS regulation pathway
Interacting Proteins for GIPC1 Gene
Selected Interacting proteins:
O14908-GIPC1_HUMAN
ENSP00000376753
for GIPC1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for GIPC1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006605 | protein targeting | ISS | -- |
| GO:0007186 | G protein-coupled receptor signaling pathway | NAS | 9770488 |
| GO:0007268 | chemical synaptic transmission | ISS | -- |
| GO:0014047 | glutamate secretion | ISS | -- |
| GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway | ISS | -- |
No data available for SIGNOR curated interactions for GIPC1 Gene
Transcripts for GIPC1 Gene
mRNA/cDNA for GIPC1 Gene
- 6 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000345425 1782 nts (view in UCSC)
- ENST00000393028 1483 nts (view in UCSC)
- ENST00000393033 1921 nts (view in UCSC)
- ENST00000585606 2071 nts (view in UCSC)
- ENST00000586027 1386 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GIPC1 - Select products 50% OFF >
- * GIPC1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GIPC1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GIPC1
-
Santa Cruz Biotechnology (SCBT) CRISPR for GIPC1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GIPC1
- Browse OriGene Inhibitory RNA Products For GIPC1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GIPC1
Clone Products
- Applied Biological Materials (abm): Clones for GIPC1 - Select products 50% OFF >
- * GIPC1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG204910
- MR204910
- MR204910L3
- MR204910L4
- RC201175
- RC201175L1
- RC201175L2
- RC201175L3
- RC201175L4
- RC216466
- RC216466L3
- RC216466L4
- RC216637
- RC216637L3
- RC216637L4
- RC224373
- RC224373L3
- RC224373L4
- RC224484
- RC224484L3
- RC224484L4
- RG201175
- RG216466
- RG216637
- RG224373
- RG224484
- RR202420
- RR202420L3
- RR202420L4
- MR204910L3V
- MR204910L4V
- RC201175L1V
- RC201175L2V
- RC201175L3V
- RC201175L4V
- RC216466L3V
- RC216466L4V
- RC216637L3V
- RC216637L4V
- RC224373L3V
- RC224373L4V
- RC224484L3V
- RC224484L4V
- RR202420L3V
- RR202420L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GIPC1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GIPC1
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||
| SP10: | - | ||||||||||||||||||||||||||||||||||||||||
| SP11: |
Relevant External Links for GIPC1 Gene
- GeneLoc Exon Structure for
- GIPC1
Expression for GIPC1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for GIPC1 Gene
This gene is overexpressed in Esophagus - Mucosa (x4.8).
This gene is overexpressed in Cervix (44.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GIPC1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GIPC1
SOURCE GeneReport for Unigene cluster for GIPC1 Gene:
Hs.655012mRNA Expression by UniProt/SwissProt for GIPC1 Gene:
O14908-GIPC1_HUMAN
Tissue specificity:
Widely expressed.
Evidence on tissue expression from TISSUES for GIPC1 Gene
- Nervous system(4.7)
- Muscle(4.5)
- Lung(4.4)
- Liver(4.4)
- Skin(3.5)
- Pancreas(2.9)
- Kidney(2.6)
- Heart(2.6)
- Eye(2.6)
- Intestine(2.4)
- Blood(2.1)
- Stomach(2.1)
- Adrenal gland(2)
Primer Products
-
OriGene qPCR primer pairs for GIPC1
-
OriGene qPCR primer pairs and template standards for GIPC1
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GIPC1 Gene
Orthologs for GIPC1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GIPC1 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | GIPC1 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | GIPC1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | GIPC1 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | GIPC1 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Gipc1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Gipc1 30 |
|
||
| Lizard (Anolis carolinensis) |
Reptilia | GIPC1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | gipc2 30 |
|
||
| Str.6557 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Kermit 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | gipc1 30 31 |
|
OneToOne | |
| zgc56157 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | kermit 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | gipc-2 30 31 |
|
ManyToMany | |
| gipc-1 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for GIPC1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for GIPC1 Gene
- ENSEMBL:
- Gene Tree for GIPC1 (if available)
- TreeFam:
- Gene Tree for GIPC1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GIPC1: view image
Paralogs for GIPC1 Gene
Variants for GIPC1 Gene
Residual Variation Intolerance Score:
14.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.05;
68.73% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GIPC1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GIPC1 Gene
Disorders for GIPC1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| urethral calculus |
|
|
| ovary serous adenocarcinoma |
|
|
| deafness, autosomal recessive 15 |
|
|
| deafness, autosomal dominant 22 |
|
|
| pancreatic cancer |
|
Search GIPC1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GIPC1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for GIPC1 Gene
Publications for GIPC1 Gene
- The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins. (PMID: 9482110) Rousset R … Jalinot P (Oncogene 1998) 2 3 4
- GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP. (PMID: 9770488) De Vries L … Farquhar MG (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4
- Overexpression of myosin VI in prostate cancer cells enhances PSA and VEGF secretion, but has no effect on endocytosis. (PMID: 19855435) Puri C … Buss F (Oncogene 2010) 3 23
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
- An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking. (PMID: 19016655) Wieman HL … Rathmell JC (The Biochemical journal 2009) 3 23
ExternalLinks
Products for GIPC1 Gene
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- antibodies-online: Show 37 available GIPC1 Antibodies ranked by validation data
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Sources for GIPC1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB