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GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008 [PubMed 18775991]).[supplied by OMIM, Apr 2009]
GIPC1 (GIPC PDZ Domain Containing Family Member 1) is a Protein Coding gene. Diseases associated with GIPC1 include Urethral Calculus and Ovary Serous Adenocarcinoma. Among its related pathways are Syndecan-4-mediated signaling events and Neurotrophic factor-mediated Trk receptor signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and actin binding. An important paralog of this gene is GIPC2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003779 | actin binding | ISS | -- |
GO:0005102 | signaling receptor binding | IPI | 15459234 |
GO:0005515 | protein binding | IPI | 9770488 |
GO:0017022 | myosin binding | ISS | -- |
GO:0030165 | PDZ domain binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA,ISS | -- |
GO:0005829 | cytosol | ISS | -- |
GO:0005903 | brush border | IEA | -- |
GO:0005938 | cell cortex | IDA | 12857860 |
GO:0008021 | synaptic vesicle | ISS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | G-protein signaling_H-RAS regulation pathway |
G-protein signaling_H-RAS regulation pathway
-
|
|
2 | Neurotrophic factor-mediated Trk receptor signaling | ||
3 | Syndecan-4-mediated signaling events |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006605 | protein targeting | ISS | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | NAS | 9770488 |
GO:0007268 | chemical synaptic transmission | ISS | -- |
GO:0014047 | glutamate secretion | ISS | -- |
GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway | ISS | -- |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||||||||
SP8: | |||||||||||||||||||||||||||||||||||||||||
SP9: | |||||||||||||||||||||||||||||||||||||||||
SP10: | - | ||||||||||||||||||||||||||||||||||||||||
SP11: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GIPC1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | GIPC1 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GIPC1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GIPC1 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | GIPC1 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Gipc1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Gipc1 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | GIPC1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | gipc2 30 |
|
||
Str.6557 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Kermit 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | gipc1 30 31 |
|
OneToOne | |
zgc56157 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | kermit 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | gipc-2 30 31 |
|
ManyToMany | |
gipc-1 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
urethral calculus |
|
|
ovary serous adenocarcinoma |
|
|
deafness, autosomal recessive 15 |
|
|
deafness, autosomal dominant 22 |
|
|
pancreatic cancer |
|