Aliases for GINS4 Gene
External Ids for GINS4 Gene
Previous GeneCards Identifiers for GINS4 Gene
The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1; MIM 610608), Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008]
GeneCards Summary for GINS4 Gene
GINS4 (GINS Complex Subunit 4) is a Protein Coding gene. Diseases associated with GINS4 include Nk Cell Deficiency. Among its related pathways are Cell Cycle, Mitotic and Telomere C-strand (Lagging Strand) Synthesis. Gene Ontology (GO) annotations related to this gene include 3'-5' DNA helicase activity.
UniProtKB/Swiss-Prot Summary for GINS4 Gene
The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA.