The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1 (GINS1; MIM 610608), Psf2, and Psf3 (GINS3; MIM 610610). The formation of this complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2... See more...

Aliases for GINS2 Gene

Aliases for GINS2 Gene

  • GINS Complex Subunit 2 2 3 4 5
  • DNA Replication Complex GINS Protein PSF2 3 4
  • GINS Complex Subunit 2 (Psf2 Homolog) 2 3
  • PSF2 3 4
  • HSPC037 3
  • Pfs2 3

External Ids for GINS2 Gene

Previous GeneCards Identifiers for GINS2 Gene

  • GC16M084269
  • GC16M085709
  • GC16M071453

Summaries for GINS2 Gene

Entrez Gene Summary for GINS2 Gene

  • The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1 (GINS1; MIM 610608), Psf2, and Psf3 (GINS3; MIM 610610). The formation of this complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008]

GeneCards Summary for GINS2 Gene

GINS2 (GINS Complex Subunit 2) is a Protein Coding gene. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include 3'-5' DNA helicase activity.

UniProtKB/Swiss-Prot Summary for GINS2 Gene

  • The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.

Gene Wiki entry for GINS2 Gene

Additional gene information for GINS2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GINS2 Gene

Genomics for GINS2 Gene

GeneHancer (GH) Regulatory Elements for GINS2 Gene

Promoters and enhancers for GINS2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J085687 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 765.8 +1.4 1435 2.7 E2F8 SP1 ZBTB6 RBPJ POLR2A FOS CREB1 NFYC ELF1 L3MBTL2 GINS2 MTHFSD ENSG00000270184 RNU1-103P RN7SL381P ZDHHC7 EMC8 piR-35775 lnc-C16orf74-1
GH16J085690 Promoter 0.5 Ensembl 756.8 -0.4 -428 0.2 VEZF1 NFXL1 GINS2 C16orf74 ENSG00000275393 lnc-C16orf74-1
GH16J085630 Enhancer 1 Ensembl ENCODE dbSUPER 19.1 +54.7 54672 10.4 MNT NFIB MYC HDGF GLIS2 CREB1 ZIC2 PKNOX1 ZBTB33 ZNF143 GINS2 USP10 FOXL1 ZDHHC7 RF00017-2178 lnc-COX4I1-5 RN7SL381P HQ292136 GSE1
GH16J085732 Enhancer 1 ENCODE CraniofacialAtlas 18.5 -43.2 -43157 5.7 CREB1 MYC HLF L3MBTL2 MAX SP1 ELF3 CEBPG CREM TRIM24 RF00017-2179 GINS2 COX4I1 EMC8 ZDHHC7 MIR1910 lnc-C16orf74-1 C16orf74
GH16J085393 Enhancer 1.6 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11 +294.2 294172 5 L3MBTL2 RAD21 ZNF121 MNT NFIB ZKSCAN8 CTCF NKRF SP7 PRDM1 GSE1 GINS2 lnc-GINS2-3 lnc-FAM92B-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GINS2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GINS2 gene promoter:
  • AREB6
  • COMP1
  • E47
  • FAC1
  • HNF-1
  • HNF-1A
  • POU3F2
  • Tal-1
  • Tal-1beta
  • ZID

Genomic Locations for GINS2 Gene

Genomic Locations for GINS2 Gene
chr16:85,676,198-85,690,073
(GRCh38/hg38)
Size:
13,876 bases
Orientation:
Minus strand
chr16:85,709,804-85,723,679
(GRCh37/hg19)
Size:
13,876 bases
Orientation:
Minus strand

Genomic View for GINS2 Gene

Genes around GINS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GINS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GINS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GINS2 Gene

Proteins for GINS2 Gene

  • Protein details for GINS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y248-PSF2_HUMAN
    Recommended name:
    DNA replication complex GINS protein PSF2
    Protein Accession:
    Q9Y248
    Secondary Accessions:
    • D3DUM5
    • Q6IAG9

    Protein attributes for GINS2 Gene

    Size:
    185 amino acids
    Molecular mass:
    21428 Da
    Quaternary structure:
    • Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS3. GINS complex interacts with DNA primase in vitro.

    Three dimensional structures from OCA and Proteopedia for GINS2 Gene

neXtProt entry for GINS2 Gene

Post-translational modifications for GINS2 Gene

  • Ubiquitination at Lys73, Lys80, and Lys118
  • Modification sites at PhosphoSitePlus

Other Protein References for GINS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GINS2 Gene

Domains & Families for GINS2 Gene

Gene Families for GINS2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GINS2 Gene

Suggested Antigen Peptide Sequences for GINS2 Gene

GenScript: Design optimal peptide antigens:
  • GINS complex subunit 2 (PSF2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y248

UniProtKB/Swiss-Prot:

PSF2_HUMAN :
  • Belongs to the GINS2/PSF2 family.
Family:
  • Belongs to the GINS2/PSF2 family.
genes like me logo Genes that share domains with GINS2: view

Function for GINS2 Gene

Molecular function for GINS2 Gene

UniProtKB/Swiss-Prot Function:
The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.

Phenotypes From GWAS Catalog for GINS2 Gene

Gene Ontology (GO) - Molecular Function for GINS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0043138 contributes_to 3'-5' DNA helicase activity IBA 21873635
genes like me logo Genes that share ontologies with GINS2: view
genes like me logo Genes that share phenotypes with GINS2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GINS2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GINS2 Gene

Localization for GINS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GINS2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GINS2 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GINS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000811 GINS complex IBA 21873635
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0031298 replication fork protection complex IBA 21873635
genes like me logo Genes that share ontologies with GINS2: view

Pathways & Interactions for GINS2 Gene

genes like me logo Genes that share pathways with GINS2: view

Pathways by source for GINS2 Gene

Gene Ontology (GO) - Biological Process for GINS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000727 double-strand break repair via break-induced replication IBA 21873635
GO:0006260 DNA replication IEA --
GO:0006271 DNA strand elongation involved in DNA replication TAS --
GO:0032508 DNA duplex unwinding IEA --
genes like me logo Genes that share ontologies with GINS2: view

No data available for SIGNOR curated interactions for GINS2 Gene

Drugs & Compounds for GINS2 Gene

No Compound Related Data Available

Transcripts for GINS2 Gene

mRNA/cDNA for GINS2 Gene

(1) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(330) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GINS2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GINS2 Gene

No ASD Table

Relevant External Links for GINS2 Gene

GeneLoc Exon Structure for
GINS2
ECgene alternative splicing isoforms for
GINS2

Expression for GINS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GINS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GINS2 Gene

This gene is overexpressed in Testis (x5.2).

Protein differential expression in normal tissues from HIPED for GINS2 Gene

This gene is overexpressed in Fetal heart (25.7), Lymph node (22.7), and Fetal Brain (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GINS2 Gene



Protein tissue co-expression partners for GINS2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GINS2 Gene:

GINS2

SOURCE GeneReport for Unigene cluster for GINS2 Gene:

Hs.433180

Evidence on tissue expression from TISSUES for GINS2 Gene

  • Nervous system(4.3)
  • Blood(4.2)
  • Lymph node(4.1)
  • Spleen(4)
genes like me logo Genes that share expression patterns with GINS2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GINS2 Gene

Orthologs for GINS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GINS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GINS2 33 32
  • 98.92 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GINS2 33
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GINS2 33
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GINS2 33 32
  • 89.19 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GINS2 33 32
  • 87.75 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gins2 32
  • 85.77 (n)
mouse
(Mus musculus)
Mammalia Gins2 17 33 32
  • 83.96 (n)
chicken
(Gallus gallus)
Aves GINS2 33 32
  • 78.74 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GINS2 33
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gins2 32
  • 75.68 (n)
Str.7608 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.3786 32
zebrafish
(Danio rerio)
Actinopterygii gins2 33 32
  • 68.5 (n)
OneToOne
Dr.15045 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1858 32
fruit fly
(Drosophila melanogaster)
Insecta Psf2 33 32
  • 56.02 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012743 32
  • 52.25 (n)
worm
(Caenorhabditis elegans)
Secernentea F31C3.5 32
  • 48.93 (n)
psf-2 33
  • 36 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR121W 32
  • 49.69 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D06501g 32
  • 48.45 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PSF2 35 33 32
  • 44.79 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PSF2 32
  • 50.82 (n)
rice
(Oryza sativa)
Liliopsida Os01g0248600 32
  • 52.03 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 53 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU06322 32
  • 50.1 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes psf2 32
  • 48.15 (n)
Species where no ortholog for GINS2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GINS2 Gene

ENSEMBL:
Gene Tree for GINS2 (if available)
TreeFam:
Gene Tree for GINS2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GINS2: view image

Paralogs for GINS2 Gene

Pseudogenes.org Pseudogenes for GINS2 Gene

genes like me logo Genes that share paralogs with GINS2: view

No data available for Paralogs for GINS2 Gene

Variants for GINS2 Gene

Sequence variations from dbSNP and Humsavar for GINS2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000350220 -- 85,676,179(-) A/G downstream_transcript_variant
rs1000378640 -- 85,685,660(-) G/C/T intron_variant
rs1000783555 -- 85,682,563(-) A/G intron_variant
rs1000810133 -- 85,686,563(-) C/G intron_variant
rs1000849249 -- 85,681,885(-) A/C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GINS2 Gene

Variant ID Type Subtype PubMed ID
esv4262 OTHER complex 18987735
nsv483044 CNV gain 15286789
nsv573517 CNV loss 21841781

Variation tolerance for GINS2 Gene

Residual Variation Intolerance Score: 50.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GINS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GINS2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GINS2 Gene

Disorders for GINS2 Gene

Additional Disease Information for GINS2

No disorders were found for GINS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GINS2 Gene

Publications for GINS2 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 56
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 56
  3. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PMID: 17525332) Matsuoka S … Elledge SJ (Science (New York, N.Y.) 2007) 3 4 56
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56

Products for GINS2 Gene

Sources for GINS2 Gene