Aliases for GINS1 Gene
External Ids for GINS1 Gene
Previous GeneCards Identifiers for GINS1 Gene
The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1, Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]).[supplied by OMIM, Mar 2008]
GeneCards Summary for GINS1 Gene
GINS1 (GINS Complex Subunit 1) is a Protein Coding gene. Diseases associated with GINS1 include Immunodeficiency 55 and Neutropenia. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and CDK-mediated phosphorylation and removal of Cdc6.
UniProtKB/Swiss-Prot Summary for GINS1 Gene
Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.