Aliases for GINS1 Gene
External Ids for GINS1 Gene
Previous GeneCards Identifiers for GINS1 Gene
The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1, Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]).[supplied by OMIM, Mar 2008]
GeneCards Summary for GINS1 Gene
GINS1 (GINS Complex Subunit 1) is a Protein Coding gene. Diseases associated with GINS1 include Immunodeficiency 55. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and CDK-mediated phosphorylation and removal of Cdc6.
UniProtKB/Swiss-Prot for GINS1 Gene
The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. GINS1 is essential for function.