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Aliases for GIN1 Gene

Aliases for GIN1 Gene

  • Gypsy Retrotransposon Integrase 1 2 3 5
  • Ty3/Gypsy Integrase 1 2 3 4
  • Zinc Finger H2C2 Domain-Containing Protein 3 4
  • ZH2C2 3 4
  • GIN-1 3 4
  • TGIN1 3 4
  • Gypsy Retrotransposon Integrase-Like Protein 1 3
  • Zinc Finger, H2C2 Domain Containing 2
  • Gypsy Integrase 1 2

External Ids for GIN1 Gene

Previous HGNC Symbols for GIN1 Gene

  • ZH2C2

Previous GeneCards Identifiers for GIN1 Gene

  • GC05M102453
  • GC05M097602
  • GC05M102421

Summaries for GIN1 Gene

GeneCards Summary for GIN1 Gene

GIN1 (Gypsy Retrotransposon Integrase 1) is a Protein Coding gene. Diseases associated with GIN1 include Parametritis and Osmotic Diarrhea. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

Additional gene information for GIN1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GIN1 Gene

Genomics for GIN1 Gene

GeneHancer (GH) Regulatory Elements for GIN1 Gene

Promoters and enhancers for GIN1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I103117 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.4 407 4.6 MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D PPIP5K2 GIN1 GC05P103117
GH05I103224 Enhancer 0.9 Ensembl ENCODE 10.7 -104.5 -104493 0.5 CTCF PKNOX1 RB1 RAD21 SMC3 ZNF143 RFX1 ZNF654 L3MBTL2 BHLHE40 PPIP5K2 ENSG00000248203 GIN1 GC05P103227
GH05I102778 Enhancer 0.8 ENCODE dbSUPER 10.5 +341.4 341448 0.9 JUN JUNB BMI1 BATF PRDM6 JUND POLR2A FOS ZNF24 IKZF2 PAM PPIP5K2 GIN1 EIF3KP1
GH05I103449 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 4.6 -331.6 -331569 3.5 SMARCE1 MEIS2 STAT1 FOXA1 GATA3 ZNF766 JUND POLR2A CUX1 ENSG00000248203 GIN1 C5orf30 ENSG00000250567 PDZPH1P
GH05I102771 Enhancer 0.4 Ensembl 10.5 +348.2 348168 1.2 MAX MYC NR2F2 PAM GIN1 PPIP5K2 EIF3KP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GIN1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GIN1 gene promoter:

Genomic Locations for GIN1 Gene

Genomic Locations for GIN1 Gene
chr5:103,086,000-103,120,169
(GRCh38/hg38)
Size:
34,170 bases
Orientation:
Minus strand
chr5:102,421,704-102,455,855
(GRCh37/hg19)

Genomic View for GIN1 Gene

Genes around GIN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GIN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GIN1 Gene

Proteins for GIN1 Gene

  • Protein details for GIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXP7-GIN1_HUMAN
    Recommended name:
    Gypsy retrotransposon integrase-like protein 1
    Protein Accession:
    Q9NXP7
    Secondary Accessions:
    • B2RXF7
    • B4DIV4
    • Q6AI03
    • Q96BR2

    Protein attributes for GIN1 Gene

    Size:
    522 amino acids
    Molecular mass:
    59842 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA90963.1; Type=Frameshift; Positions=375; Evidence={ECO:0000305}; Sequence=CAH10511.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for GIN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GIN1 Gene

Post-translational modifications for GIN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GIN1 Gene

No data available for DME Specific Peptides for GIN1 Gene

Domains & Families for GIN1 Gene

Gene Families for GIN1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GIN1 Gene

Suggested Antigen Peptide Sequences for GIN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GIN1: view

No data available for UniProtKB/Swiss-Prot for GIN1 Gene

Function for GIN1 Gene

Phenotypes From GWAS Catalog for GIN1 Gene

Gene Ontology (GO) - Molecular Function for GIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with GIN1: view
genes like me logo Genes that share phenotypes with GIN1: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GIN1 Gene

Localization for GIN1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GIN1 gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GIN1 Gene

Pathways & Interactions for GIN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015074 DNA integration IEA --
genes like me logo Genes that share ontologies with GIN1: view

No data available for Pathways by source and SIGNOR curated interactions for GIN1 Gene

Drugs & Compounds for GIN1 Gene

(7) Drugs for GIN1 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atazanavir Approved, Investigational Pharma HIV protease inhibitor,highly potent 0
BMS-707035 Pharma HIV-I integrase inhibitor,potent and specific 0
Elvitegravir (GS-9137) Pharma HIV-1 integrase inhibitor,potent 0
Fluorouracil (Adrucil) Pharma Antitumor agent;inhibitor of thymidylate synthase 0
GSK744 (S/GSK1265744) Pharma HIV integrase inhibitor, oral active and long-acting 0

(7) ApexBio Compounds for GIN1 Gene

Compound Action Cas Number
Atazanavir HIV protease inhibitor,highly potent 198904-31-3
BMS-707035 HIV-I integrase inhibitor,potent and specific 729607-74-3
Elvitegravir (GS-9137) HIV-1 integrase inhibitor,potent 697761-98-1
Fluorouracil (Adrucil) Antitumor agent;inhibitor of thymidylate synthase 51-21-8
GSK744 (S/GSK1265744) HIV integrase inhibitor, oral active and long-acting 1051375-10-0
MK-2048 Integrase inhibitor for HIV-1,second generation 869901-69-9
Raltegravir (MK-0518) HIV-1 integrase inhibitor 518048-05-0
genes like me logo Genes that share compounds with GIN1: view

Drug Products

Transcripts for GIN1 Gene

Unigene Clusters for GIN1 Gene

Gypsy retrotransposon integrase 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GIN1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: -
SP2:
SP3: - - - -
SP4:

Relevant External Links for GIN1 Gene

GeneLoc Exon Structure for
GIN1
ECgene alternative splicing isoforms for
GIN1

Expression for GIN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GIN1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GIN1 Gene



Protein tissue co-expression partners for GIN1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GIN1 Gene:

GIN1

SOURCE GeneReport for Unigene cluster for GIN1 Gene:

Hs.24088

mRNA Expression by UniProt/SwissProt for GIN1 Gene:

Q9NXP7-GIN1_HUMAN
Tissue specificity: Widely expressed. Also found in tumors originating from parathyroid gland, colon, stomach, bladder, uterus and prostate.

Evidence on tissue expression from TISSUES for GIN1 Gene

  • Kidney(4.2)
  • Intestine(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with GIN1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GIN1 Gene

Orthologs for GIN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GIN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GIN1 33 34
  • 99.81 (n)
dog
(Canis familiaris)
Mammalia GIN1 33 34
  • 92.66 (n)
cow
(Bos Taurus)
Mammalia GIN1 33 34
  • 89.04 (n)
mouse
(Mus musculus)
Mammalia Gin1 33 16 34
  • 85.01 (n)
rat
(Rattus norvegicus)
Mammalia Gin1 33
  • 82.24 (n)
oppossum
(Monodelphis domestica)
Mammalia GIN1 34
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GIN1 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves GIN1 33 34
  • 71.3 (n)
lizard
(Anolis carolinensis)
Reptilia GIN1 34
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii GIN1 34
  • 21 (a)
OneToOne
Species where no ortholog for GIN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GIN1 Gene

ENSEMBL:
Gene Tree for GIN1 (if available)
TreeFam:
Gene Tree for GIN1 (if available)

Paralogs for GIN1 Gene

No data available for Paralogs for GIN1 Gene

Variants for GIN1 Gene

Sequence variations from dbSNP and Humsavar for GIN1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000354781 -- 103,091,242(-) T/C intron_variant
rs1000366570 -- 103,097,180(-) T/C intron_variant
rs1000574460 -- 103,115,767(-) A/C intron_variant
rs1000707441 -- 103,110,206(-) A/G intron_variant
rs1000861992 -- 103,086,067(-) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GIN1 Gene

Variant ID Type Subtype PubMed ID
nsv1029894 CNV gain 25217958
nsv830430 CNV gain 17160897

Variation tolerance for GIN1 Gene

Residual Variation Intolerance Score: 34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.52; 55.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GIN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GIN1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GIN1 Gene

Disorders for GIN1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GIN1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
parametritis
  • pelvic cellulitis
osmotic diarrhea
- elite association - COSMIC cancer census association via MalaCards
Search GIN1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GIN1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GIN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GIN1 Gene

Publications for GIN1 Gene

  1. A mammalian gene evolved from the integrase domain of an LTR retrotransposon. (PMID: 11470852) Lloréns C … Marín I (Molecular biology and evolution 2001) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP. (PMID: 25925205) Bhattacharya S … Ghosh MK (Cellular oncology (Dordrecht) 2015) 3 58
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58
  5. Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African Americans. (PMID: 21120996) Hughes LB … Bridges SL (Arthritis and rheumatism 2010) 44 58

Products for GIN1 Gene

Sources for GIN1 Gene

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