GIMAP7 Gene (Protein Coding)

GTPase, IMAP Family Member 7

GC07P150514
GIFtS:
36
This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008] See more...

Aliases for GIMAP7 Gene

Aliases for GIMAP7 Gene

  • GTPase, IMAP Family Member 7 2 3 5
  • IAN7 2 3 4
  • Immune-Associated Nucleotide-Binding Protein 7 2 3
  • Immunity-Associated Nucleotide 7 Protein 3 4
  • GTPase IMAP Family Member 7 3 4
  • IAN-7 3 4
  • Immune Associated Nucleotide 3
  • MGC27027 2
  • GIMAP7 5
  • HIAN7 3

External Ids for GIMAP7 Gene

Previous GeneCards Identifiers for GIMAP7 Gene

  • GC07P149649
  • GC07P149842
  • GC07P150211
  • GC07P144027

Summaries for GIMAP7 Gene

Entrez Gene Summary for GIMAP7 Gene

  • This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]

GeneCards Summary for GIMAP7 Gene

GIMAP7 (GTPase, IMAP Family Member 7) is a Protein Coding gene. Diseases associated with GIMAP7 include Epileptic Encephalopathy, Early Infantile, 4. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and GTPase activity. An important paralog of this gene is GIMAP1-GIMAP5.

UniProtKB/Swiss-Prot Summary for GIMAP7 Gene

  • The dimer has GTPase activity; the active site contains residues from both subunits.

Additional gene information for GIMAP7 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GIMAP7 Gene

Genomics for GIMAP7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for GIMAP7 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH07J150512 Promoter/Enhancer 1.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 610.7 +2.0 1997 9.5 POLR2A NFE2 TBP JUN FOS TAF1 ATF2 DACH1 PKNOX1 GIMAP7 GIMAP8 GIMAP4 GIMAP2 GIMAP1 GIMAP5 GIMAP6 TMEM176B STRADBP1 lnc-GIMAP6-4
GH07J150566 Promoter/Enhancer 1.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 29 +53.5 53462 4.2 SPI1 RAD21 REST GIMAP4 GIMAP7 GIMAP5 GIMAP1 GIMAP2 GIMAP8 GIMAP6 TMEM176B MN298464
GH07J150448 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.3 -63.5 -63546 6.4 RNF2 CTCF BACH1 JUND LARP7 ZNF143 ZIC2 ZNF24 REST RAD21 GIMAP8 GIMAP7 GIMAP1 ENSG00000244151 NUB1 GIMAP6 GIMAP5 STRADBP1 ZNF767P GIMAP2
GH07J150992 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.7 +479.9 479895 4.9 SIX5 LEF1 IKZF1 JUND MTA2 ZNF143 PHF21A ZIC2 PKNOX1 ZNF24 NOS3 ENSG00000244151 NUB1 GIMAP7 GIMAP6 GIMAP4 KCNH2 GIMAP1 GIMAP2 GIMAP5
GH07J150674 Promoter/Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 18.2 +162.0 161985 3.9 ZNF316 MAFG MAFK MAX ZNF148 EMSY EIF2AP3 lnc-GIMAP6-2 GIMAP1 GIMAP7 GIMAP4 GIMAP8 STRADBP1 GIMAP2 GIMAP5 GIMAP3P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GIMAP7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GIMAP7

Top Transcription factor binding sites by QIAGEN in the GIMAP7 gene promoter:
  • C/EBPalpha
  • CHOP-10
  • ER-alpha
  • GATA-1
  • GCNF
  • GCNF-1
  • GCNF-2
  • MyoD
  • POU2F1
  • POU2F1a

Genomic Locations for GIMAP7 Gene

Genomic Locations for GIMAP7 Gene
chr7:150,514,872-150,521,073
(GRCh38/hg38)
Size:
6,202 bases
Orientation:
Plus strand
chr7:150,211,918-150,218,161
(GRCh37/hg19)
Size:
6,244 bases
Orientation:
Plus strand

Genomic View for GIMAP7 Gene

Genes around GIMAP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GIMAP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GIMAP7 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GIMAP7 Gene

Proteins for GIMAP7 Gene

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  • Protein details for GIMAP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHV1-GIMA7_HUMAN
    Recommended name:
    GTPase IMAP family member 7
    Protein Accession:
    Q8NHV1

    Protein attributes for GIMAP7 Gene

    Size:
    300 amino acids
    Molecular mass:
    34509 Da
    Quaternary structure:
    • Monomer in the presence of bound GDP and in the absence of bound nucleotide. Homodimer in the presence of bound GTP. Heterodimer with GIMAP2.

    Three dimensional structures from OCA and Proteopedia for GIMAP7 Gene

neXtProt entry for GIMAP7 Gene

Protein Expression for GIMAP7 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for GIMAP7 Gene

  • Ubiquitination at Lys16, Lys21, Lys45, Lys71, and Lys178
  • Modification sites at PhosphoSitePlus

Other Protein References for GIMAP7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GIMAP7 Gene

Domains & Families for GIMAP7 Gene

Gene Families for GIMAP7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GIMAP7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GIMAP7 Gene

GenScript: Design optimal peptide antigens:
  • Immunity-associated nucleotide 7 protein (GIMA7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NHV1

UniProtKB/Swiss-Prot:

GIMA7_HUMAN :
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
Family:
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
genes like me logo Genes that share domains with GIMAP7: view

Function for GIMAP7 Gene

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  2. CRISPR
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  6. Cell Line

Molecular function for GIMAP7 Gene

UniProtKB/Swiss-Prot Function:
The dimer has GTPase activity; the active site contains residues from both subunits.

Phenotypes From GWAS Catalog for GIMAP7 Gene

Gene Ontology (GO) - Molecular Function for GIMAP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IDA 23454188
GO:0005515 protein binding IPI 23454188
GO:0005525 GTP binding IDA 23454188
GO:0042802 identical protein binding IPI 23454188
genes like me logo Genes that share ontologies with GIMAP7: view
genes like me logo Genes that share phenotypes with GIMAP7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GIMAP7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GIMAP7 Gene

Localization for GIMAP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GIMAP7 Gene

Lipid droplet. Cytoplasm. Endoplasmic reticulum. Golgi apparatus. Note=Colocalizes with GIMAP2 on the surface of cytoplasmic lipid droplets.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GIMAP7 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 3
golgi apparatus 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GIMAP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005811 lipid droplet IEA,IDA 23454188
GO:0005829 cytosol IBA,IDA --
genes like me logo Genes that share ontologies with GIMAP7: view

Pathways & Interactions for GIMAP7 Gene

PathCards logo

SuperPathways for GIMAP7 Gene

No Data Available

Interacting Proteins for GIMAP7 Gene

STRING Interaction Network Preview (showing top 3 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: Q8NHV1-GIMA7_HUMAN ENSP00000315474 for GIMAP7 Gene via UniProtKB STRING IID

GPS-Prot Interaction Network for GIMAP7

Gene Ontology (GO) - Biological Process for GIMAP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046039 GTP metabolic process IDA 23454188
genes like me logo Genes that share ontologies with GIMAP7: view

No data available for Pathways by source and SIGNOR curated interactions for GIMAP7 Gene

Drugs & Compounds for GIMAP7 Gene

Products:

  1. Drug

(1) Drugs for GIMAP7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for GIMAP7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N1-acetylspermine
  • N'-acetylspermine
  • N'-monoacetylspermine
  • N(1)-Acetylspermine
  • N-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)-acetamide
  • N-Acetylspermine
 25593-72-0
genes like me logo Genes that share compounds with GIMAP7: view

Transcripts for GIMAP7 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for GIMAP7 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GIMAP7

Alternative Splicing Database (ASD) splice patterns (SP) for GIMAP7 Gene

No ASD Table

Relevant External Links for GIMAP7 Gene

GeneLoc Exon Structure for
GIMAP7

Expression for GIMAP7 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GIMAP7 Gene

mRNA expression in normal human tissues for GIMAP7 Gene
mRNA expression by BioGPS for GIMAP7 GenemRNA expression by GTEx for GIMAP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GIMAP7 Gene

This gene is overexpressed in Spleen (x5.2) and Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for GIMAP7 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (32.5) and Lymph node (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GIMAP7 Gene



Protein tissue co-expression partners for GIMAP7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GIMAP7

SOURCE GeneReport for Unigene cluster for GIMAP7 Gene:

Hs.647074

mRNA Expression by UniProt/SwissProt for GIMAP7 Gene:

Q8NHV1-GIMA7_HUMAN
Tissue specificity: Most abundantly expressed in spleen, lymph nodes, and fetal kidney, but also present in the heart and the small intestine. Lower expression levels are found in lung, kidney, liver, and thyroid, salivary, and mammary glands. Also detected in the thymus (PubMed:15474311). Detected in T-cells (PubMed:23454188).

Evidence on tissue expression from TISSUES for GIMAP7 Gene

  • Spleen(3)
  • Lymph node(2.6)
  • Heart(2.4)
  • Blood(2.4)
  • Muscle(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with GIMAP7: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GIMAP7 Gene

Orthologs for GIMAP7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GIMAP7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia GIMAP7 30 31
  • 99.44 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia GIMAP7 30 31 31 31
  • 74.23 (n)
 OneToMany
-- 31
  • 65 (a)
 OneToMany
Dog
(Canis familiaris)
 Mammalia GIMAP7 31
  • 72 (a)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Gimap7 30 17 31
  • 70.24 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Gimap7 30
  • 69.43 (n)
Oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 48 (a)
 OneToMany
-- 31
  • 43 (a)
 OneToMany
Chicken
(Gallus gallus)
 Aves -- 31
  • 36 (a)
 ManyToMany
-- 31
  • 36 (a)
 ManyToMany
-- 31
  • 14 (a)
 ManyToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 42 (a)
 ManyToMany
-- 31
  • 36 (a)
 ManyToMany
-- 31
  • 33 (a)
 ManyToMany
-- 31
  • 24 (a)
 ManyToMany
-- 31
  • 12 (a)
 ManyToMany
Zebrafish
(Danio rerio)
 Actinopterygii CU550714.1 31
  • 38 (a)
 ManyToMany
si:ch211-254c8.3 31
  • 37 (a)
 ManyToMany
CR933791.1 31
  • 35 (a)
 ManyToMany
CR450842.1 31
  • 34 (a)
 ManyToMany
BX323987.1 31
  • 32 (a)
 ManyToMany
CR933791.3 31
  • 31 (a)
 ManyToMany
si:dkeyp-67a8.4 31 31
  • 30 (a)
 ManyToMany
zgc:172131 31
  • 29 (a)
 ManyToMany
BX322792.2 31
  • 29 (a)
 ManyToMany
CU695221.1 31
  • 29 (a)
 ManyToMany
zgc:152753 31
  • 27 (a)
 ManyToMany
BX005442.2 31
  • 26 (a)
 ManyToMany
zgc:101806 31
  • 25 (a)
 ManyToMany
si:ch211-280c16.1 31
  • 23 (a)
 ManyToMany
zgc:165583 31
  • 21 (a)
 ManyToMany
BX322792.1 31
  • 18 (a)
 ManyToMany
zgc:195075 31
  • 18 (a)
 ManyToMany
BX004816.3 31
  • 17 (a)
 ManyToMany
BX004857.2 31
  • 17 (a)
 ManyToMany
si:ch73-308m11.1 31
  • 17 (a)
 ManyToMany
zgc:172090 31
  • 17 (a)
 ManyToMany
CABZ01029902.1 31
  • 16 (a)
 ManyToMany
si:dkey-30g5.1 31
  • 15 (a)
 ManyToMany
si:ch1073-185p12.2 31
  • 13 (a)
 ManyToMany
BX321875.5 31 31
  • 12 (a)
 ManyToMany
Species where no ortholog for GIMAP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GIMAP7 Gene

ENSEMBL:
Gene Tree for GIMAP7 (if available)
TreeFam:
Gene Tree for GIMAP7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GIMAP7: view image

Paralogs for GIMAP7 Gene

Paralogs for GIMAP7 Gene

(6) SIMAP similar genes for GIMAP7 Gene using alignment to 1 proteins:

  • GIMA7_HUMAN
genes like me logo Genes that share paralogs with GIMAP7: view

Variants for GIMAP7 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GIMAP7 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs3735080 - p.Arg83Cys

Additional dbSNP identifiers (rs#s) for GIMAP7 Gene

Structural Variations from Database of Genomic Variants (DGV) for GIMAP7 Gene

Variant ID Type Subtype PubMed ID
dgv3695n106 OTHER inversion 24896259
nsv1015582 CNV gain 25217958
nsv1031309 CNV loss 25217958
nsv1034409 CNV gain 25217958
nsv1067934 OTHER inversion 25765185
nsv1151906 OTHER inversion 26484159
nsv608990 CNV gain 21841781

Variation tolerance for GIMAP7 Gene

Residual Variation Intolerance Score: 55.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.85; 79.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GIMAP7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GIMAP7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GIMAP7 Gene

Disorders for GIMAP7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GIMAP7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
epileptic encephalopathy, early infantile, 4
  • eiee4
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GIMAP7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with GIMAP7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GIMAP7 Gene

Publications for GIMAP7 Gene

  1. Comparative analysis of the human gimap gene cluster encoding a novel GTPase family. (PMID: 15474311) Krücken J … Wunderlich F (Gene 2004) 2 3 4
  2. Structural insights into the mechanism of GTPase activation in the GIMAP family. (PMID: 23454188) Schwefel D … Daumke O (Structure (London, England : 1993) 2013) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

ExternalLinks

View latest publications for GIMAP7 gene in Mastermind

Products for GIMAP7 Gene

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