This gene encodes a member of the GTPases of immunity-associated proteins (GIMAP) family. GIMAP proteins contain GTP-binding and coiled-coil motifs, and may play roles in the regulation of cell survival. Decreased expression of this gene may play a role in non-small cell lung cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for thi... See more...

Aliases for GIMAP6 Gene

Aliases for GIMAP6 Gene

  • GTPase, IMAP Family Member 6 2 3 5
  • IAN6 2 3 4
  • Immune-Associated Nucleotide-Binding Protein 6 2 3
  • GTPase IMAP Family Member 6 3 4
  • IAN-2 3 4
  • IAN-6 3 4
  • IAN2 3 4
  • Immunity-Associated Nucleotide 2 Protein 4
  • Immunity-Associated Nucleotide 6 Protein 4
  • Immune Associated Nucleotide 2 3
  • Immune Associated Nucleotide 6 3
  • FLJ22690 2
  • GIMAP6 5
  • HIAN2 4
  • HIAN6 4

External Ids for GIMAP6 Gene

Previous GeneCards Identifiers for GIMAP6 Gene

  • GC07U901512
  • GC07M149761
  • GC07M149953
  • GC07M150322
  • GC07M144134

Summaries for GIMAP6 Gene

Entrez Gene Summary for GIMAP6 Gene

  • This gene encodes a member of the GTPases of immunity-associated proteins (GIMAP) family. GIMAP proteins contain GTP-binding and coiled-coil motifs, and may play roles in the regulation of cell survival. Decreased expression of this gene may play a role in non-small cell lung cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is found in a cluster with seven additional GIMAP genes on the long arm of chromosome 7. [provided by RefSeq, Sep 2011]

GeneCards Summary for GIMAP6 Gene

GIMAP6 (GTPase, IMAP Family Member 6) is a Protein Coding gene. Diseases associated with GIMAP6 include Lymphopenia and Lung Cancer. Gene Ontology (GO) annotations related to this gene include GTP binding. An important paralog of this gene is GIMAP1.

Additional gene information for GIMAP6 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GIMAP6 Gene

Genomics for GIMAP6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GIMAP6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J150628 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 605.9 +0.9 904 6.5 CREB1 IKZF2 POLR2A YY1 MNT EED YBX1 SIN3A ELK1 RELB GIMAP6 NUB1 ENSG00000244151 NOS3 GIMAP2 GIMAP4 GIMAP7 GIMAP1 GIMAP8 LOC100288724
GH07J150448 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.4 +181.3 181322 6.4 RNF2 CTCF BACH1 JUND LARP7 ZNF143 ZIC2 ZNF24 REST RAD21 GIMAP8 GIMAP7 GIMAP1 ENSG00000244151 NUB1 GIMAP6 GIMAP5 STRADBP1 ZNF767P GIMAP2
GH07J150992 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.5 -362.1 -362119 4.9 SIX5 LEF1 IKZF1 JUND MTA2 ZNF143 PHF21A ZIC2 PKNOX1 ZNF24 NOS3 ENSG00000244151 NUB1 GIMAP7 GIMAP6 GIMAP4 KCNH2 GIMAP1 GIMAP2 GIMAP5
GH07J150662 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 15.8 -34.5 -34520 8.5 SP1 BACH1 STAT3 RELA IKZF2 POLR2A TRIM22 PKNOX1 EED CEBPB GIMAP1 GIMAP4 GIMAP6 GIMAP2 GIMAP8 GIMAP5 GIMAP7 GIMAP3P ACTR3C EIF2AP3
GH07J150566 Promoter/Enhancer 1.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 +64.3 64314 4.2 SPI1 RAD21 REST GIMAP4 GIMAP7 GIMAP5 GIMAP1 GIMAP2 GIMAP8 GIMAP6 TMEM176B MN298464
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GIMAP6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GIMAP6

Top Transcription factor binding sites by QIAGEN in the GIMAP6 gene promoter:
  • AML1a
  • Elk-1
  • IRF-2
  • RORalpha2
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for GIMAP6 Gene

Genomic Locations for GIMAP6 Gene
chr7:150,625,375-150,632,648
(GRCh38/hg38)
Size:
7,274 bases
Orientation:
Minus strand
chr7:150,322,463-150,329,680
(GRCh37/hg19)
Size:
7,218 bases
Orientation:
Minus strand

Genomic View for GIMAP6 Gene

Genes around GIMAP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GIMAP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GIMAP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GIMAP6 Gene

Proteins for GIMAP6 Gene

  • Protein details for GIMAP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P9H5-GIMA6_HUMAN
    Recommended name:
    GTPase IMAP family member 6
    Protein Accession:
    Q6P9H5
    Secondary Accessions:
    • C9J7B6
    • D3DWZ4
    • Q5ZPR6
    • Q9H612

    Protein attributes for GIMAP6 Gene

    Size:
    292 amino acids
    Molecular mass:
    32949 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GIMAP6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GIMAP6 Gene

Post-translational modifications for GIMAP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GIMAP6 Gene

No data available for DME Specific Peptides for GIMAP6 Gene

Domains & Families for GIMAP6 Gene

Gene Families for GIMAP6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GIMAP6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GIMAP6 Gene

GenScript: Design optimal peptide antigens:
  • Immunity-associated nucleotide 6 protein (GIMA6_HUMAN)
  • FLJ00102 protein (Q8TES8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6P9H5

UniProtKB/Swiss-Prot:

GIMA6_HUMAN :
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
Family:
  • Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
genes like me logo Genes that share domains with GIMAP6: view

Function for GIMAP6 Gene

Phenotypes From GWAS Catalog for GIMAP6 Gene

Gene Ontology (GO) - Molecular Function for GIMAP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with GIMAP6: view
genes like me logo Genes that share phenotypes with GIMAP6: view

Animal Models for GIMAP6 Gene

MGI Knock Outs for GIMAP6:
  • Gimap6 Gimap6<tm1a(KOMP)Wtsi>
  • Gimap6 Gimap6<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GIMAP6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GIMAP6 Gene

Localization for GIMAP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GIMAP6 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GIMAP6 gene
Compartment Confidence
cytosol 5
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GIMAP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IBA,IDA 23454188
genes like me logo Genes that share ontologies with GIMAP6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GIMAP6 Gene

Pathways & Interactions for GIMAP6 Gene

PathCards logo

SuperPathways for GIMAP6 Gene

No Data Available

Interacting Proteins for GIMAP6 Gene

STRING Interaction Network Preview (showing top 3 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000479580 Q6P9H5-GIMA6_HUMAN for GIMAP6 Gene via STRING IID

Gene Ontology (GO) - Biological Process for GIMAP6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GIMAP6 Gene

Drugs & Compounds for GIMAP6 Gene

(1) Drugs for GIMAP6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for GIMAP6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N1-acetylspermine
  • N'-acetylspermine
  • N'-monoacetylspermine
  • N(1)-Acetylspermine
  • N-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)-acetamide
  • N-Acetylspermine
25593-72-0
genes like me logo Genes that share compounds with GIMAP6: view

Transcripts for GIMAP6 Gene

mRNA/cDNA for GIMAP6 Gene

4 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GIMAP6

Alternative Splicing Database (ASD) splice patterns (SP) for GIMAP6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b
SP1: -
SP2:
SP3:

Relevant External Links for GIMAP6 Gene

GeneLoc Exon Structure for
GIMAP6

Expression for GIMAP6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GIMAP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GIMAP6 Gene

This gene is overexpressed in Whole Blood (x5.3) and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for GIMAP6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (29.9), Liver, secretome (21.3), and Lymph node (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GIMAP6 Gene



Protein tissue co-expression partners for GIMAP6 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GIMAP6

SOURCE GeneReport for Unigene cluster for GIMAP6 Gene:

Hs.647105

mRNA Expression by UniProt/SwissProt for GIMAP6 Gene:

Q6P9H5-GIMA6_HUMAN
Tissue specificity: Highly expressed in spleen, lymph nodes, lung and placenta. Expressed at moderate level in thymus, kidney, heart and digestive tract. Weakly expressed in other lymphoid tissues. Detected in T-cells.

Evidence on tissue expression from TISSUES for GIMAP6 Gene

  • Intestine(4.3)
  • Spleen(2.3)
  • Nervous system(2.3)
  • Lymph node(2.2)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with GIMAP6: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GIMAP6 Gene

Orthologs for GIMAP6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GIMAP6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GIMAP6 30 31
  • 99.77 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gimap6 30
  • 73.8 (n)
Mouse
(Mus musculus)
Mammalia Gimap6 30 17 31
  • 72.34 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GIMAP6 30
  • 67.37 (n)
Dog
(Canis familiaris)
Mammalia GIMAP6 31
  • 44 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia GIMAP6 31
  • 38 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 31
  • 39 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 45 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii GIMAP6 31
  • 14 (a)
OneToMany
Species where no ortholog for GIMAP6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GIMAP6 Gene

ENSEMBL:
Gene Tree for GIMAP6 (if available)
TreeFam:
Gene Tree for GIMAP6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GIMAP6: view image

Paralogs for GIMAP6 Gene

Paralogs for GIMAP6 Gene

(6) SIMAP similar genes for GIMAP6 Gene using alignment to 2 proteins:

  • GIMA6_HUMAN
  • Q8TES8_HUMAN
genes like me logo Genes that share paralogs with GIMAP6: view

Variants for GIMAP6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GIMAP6 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
714358 Benign: not provided 150,627,830(-) G/T SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT
716359 Benign: not provided 150,628,405(-) C/T MISSENSE_VARIANT,INTRON_VARIANT
776269 Benign: not provided 150,627,888(-) T/C MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT
776270 Benign: not provided 150,628,290(-) T/C SPLICE_ACCEPTOR_VARIANT,MISSENSE_VARIANT
rs11974345 - p.Gly170Asp

Additional dbSNP identifiers (rs#s) for GIMAP6 Gene

Structural Variations from Database of Genomic Variants (DGV) for GIMAP6 Gene

Variant ID Type Subtype PubMed ID
dgv3695n106 OTHER inversion 24896259
esv2759573 CNV loss 17122850
esv2762711 CNV loss 21179565
esv3891235 CNV loss 25118596
nsv1030109 CNV gain 25217958
nsv1034409 CNV gain 25217958
nsv1067934 OTHER inversion 25765185
nsv1151906 OTHER inversion 26484159
nsv608990 CNV gain 21841781
nsv831187 CNV loss 17160897

Variation tolerance for GIMAP6 Gene

Residual Variation Intolerance Score: 97.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.05; 84.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GIMAP6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GIMAP6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GIMAP6 Gene

Disorders for GIMAP6 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GIMAP6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lymphopenia
  • lymphocytopenia
lung cancer
  • adenocarcinoma of lung
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GIMAP6

genes like me logo Genes that share disorders with GIMAP6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GIMAP6 Gene

Publications for GIMAP6 Gene

  1. Comparative analysis of the human gimap gene cluster encoding a novel GTPase family. (PMID: 15474311) Krücken J … Wunderlich F (Gene 2004) 2 3 4
  2. Structural insights into the mechanism of GTPase activation in the GIMAP family. (PMID: 23454188) Schwefel D … Daumke O (Structure (London, England : 1993) 2013) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. Human immune associated nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells. (PMID: 11964296) Cambot M … Roméo PH (Blood 2002) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for GIMAP6 Gene

Sources for GIMAP6 Gene