This locus represents naturally occurring readthrough transcription between the neighboring GIMAP1 (GTPase, IMAP family member 1) and GIMAP5 (GTPase, IMAP family member 5) genes on chromosome 7. Alternative splicing results in multiple readthrough transcript variants, one of which encodes a fusion protein that shares sequence identity with each individual gene product. [provide... See more...

Aliases for GIMAP1-GIMAP5 Gene

Aliases for GIMAP1-GIMAP5 Gene

  • GIMAP1-GIMAP5 Readthrough 2 3 5 13
  • GIMAP1-GIMAP5 Protein 3

External Ids for GIMAP1-GIMAP5 Gene

Previous GeneCards Identifiers for GIMAP1-GIMAP5 Gene

  • GC07U903080
  • GC07P150416

Summaries for GIMAP1-GIMAP5 Gene

Entrez Gene Summary for GIMAP1-GIMAP5 Gene

  • This locus represents naturally occurring readthrough transcription between the neighboring GIMAP1 (GTPase, IMAP family member 1) and GIMAP5 (GTPase, IMAP family member 5) genes on chromosome 7. Alternative splicing results in multiple readthrough transcript variants, one of which encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Jan 2015]

GeneCards Summary for GIMAP1-GIMAP5 Gene

GIMAP1-GIMAP5 (GIMAP1-GIMAP5 Readthrough) is a Protein Coding gene. An important paralog of this gene is GIMAP5.

Additional gene information for GIMAP1-GIMAP5 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GIMAP1-GIMAP5 Gene

Genomics for GIMAP1-GIMAP5 Gene

GeneHancer (GH) Regulatory Elements for GIMAP1-GIMAP5 Gene

Promoters and enhancers for GIMAP1-GIMAP5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J150714 Promoter/Enhancer 1.5 EPDnew FANTOM5 Ensembl ENCODE 500.7 +0.9 875 5.8 CTCF POLR2A SPI1 NFE2 ELF1 RAD21 MAX TAF1 HLF ETS1 GIMAP5 GIMAP1 GIMAP1-GIMAP5 lnc-GIMAP5-2 GIMAP2 GIMAP7 GIMAP4 GIMAP6 GIMAP8 lnc-GIMAP5-1
GH07J150737 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 0.4 +22.2 22170 5.3 CTCF POLR2A HDAC2 ZNF274 FOXA2 RXRA USF1 GABPA CEBPG FOS GIMAP5 GIMAP3P GIMAP2 piR-43103-059 GIMAP1-GIMAP5
GH07J150727 Enhancer 0.8 ENCODE 0.4 +11.1 11051 0.2 EP300 NCOR1 TCF7 ZNF274 NR2F2 CEBPB MIER3 JUND SMAD4 BCL6 GIMAP5 GIMAP1-GIMAP5 piR-43103-059
GH07J150720 Promoter 0.3 EPDnew 0.7 +4.1 4138 0.1 GIMAP1 GIMAP5 lnc-GIMAP5-1 GIMAP1-GIMAP5 lnc-GIMAP5-2
GH07J150743 Promoter/Enhancer 0.5 Ensembl dbSUPER 0.3 +26.1 26144 0.2 piR-43103-059 GIMAP5 GIMAP1-GIMAP5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GIMAP1-GIMAP5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GIMAP1-GIMAP5

Genomic Locations for GIMAP1-GIMAP5 Gene

Genomic Locations for GIMAP1-GIMAP5 Gene
chr7:150,716,557-150,743,649
(GRCh38/hg38)
Size:
27,093 bases
Orientation:
Plus strand
chr7:150,413,645-150,440,737
(GRCh37/hg19)
Size:
27,093 bases
Orientation:
Plus strand

Genomic View for GIMAP1-GIMAP5 Gene

Genes around GIMAP1-GIMAP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GIMAP1-GIMAP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GIMAP1-GIMAP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GIMAP1-GIMAP5 Gene

Proteins for GIMAP1-GIMAP5 Gene

  • Protein details for GIMAP1-GIMAP5 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A087WTJ2-A0A087WTJ2_HUMAN
    Recommended name:
    GIMAP1-GIMAP5 readthrough
    Protein Accession:
    A0A087WTJ2

    Protein attributes for GIMAP1-GIMAP5 Gene

    Size:
    511 amino acids
    Molecular mass:
    57052 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GIMAP1-GIMAP5 Gene

Post-translational modifications for GIMAP1-GIMAP5 Gene

No Post-translational modifications

Other Protein References for GIMAP1-GIMAP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GIMAP1-GIMAP5 Gene

Domains & Families for GIMAP1-GIMAP5 Gene

Gene Families for GIMAP1-GIMAP5 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for GIMAP1-GIMAP5 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with GIMAP1-GIMAP5: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GIMAP1-GIMAP5 Gene

Function for GIMAP1-GIMAP5 Gene

Phenotypes From GWAS Catalog for GIMAP1-GIMAP5 Gene

genes like me logo Genes that share phenotypes with GIMAP1-GIMAP5: view

Animal Models for GIMAP1-GIMAP5 Gene

MGI Knock Outs for GIMAP1-GIMAP5:

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GIMAP1-GIMAP5 Gene

Localization for GIMAP1-GIMAP5 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GIMAP1-GIMAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GIMAP1-GIMAP5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for GIMAP1-GIMAP5 Gene

Pathways & Interactions for GIMAP1-GIMAP5 Gene

PathCards logo

SuperPathways for GIMAP1-GIMAP5 Gene

No Data Available

Interacting Proteins for GIMAP1-GIMAP5 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 17)
STRING Interaction Network
Selected Interacting proteins: ENSP00000477920 for GIMAP1-GIMAP5 Gene via STRING

GPS-Prot Interaction Network for GIMAP1-GIMAP5
;

Gene Ontology (GO) - Biological Process for GIMAP1-GIMAP5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GIMAP1-GIMAP5 Gene

Drugs & Compounds for GIMAP1-GIMAP5 Gene

No Compound Related Data Available

Transcripts for GIMAP1-GIMAP5 Gene

mRNA/cDNA for GIMAP1-GIMAP5 Gene

2 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for GIMAP1-GIMAP5 Gene

No ASD Table

Relevant External Links for GIMAP1-GIMAP5 Gene

GeneLoc Exon Structure for
GIMAP1-GIMAP5

Expression for GIMAP1-GIMAP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GIMAP1-GIMAP5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GIMAP1-GIMAP5

genes like me logo Genes that share expression patterns with GIMAP1-GIMAP5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GIMAP1-GIMAP5 Gene

Orthologs for GIMAP1-GIMAP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GIMAP1-GIMAP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GIMAP5 30
  • 99.09 (n)
dog
(Canis familiaris)
Mammalia GIMAP5 30
  • 76.07 (n)
mouse
(Mus musculus)
Mammalia Gimap3 30
  • 73.48 (n)
Gimap5 17
cow
(Bos Taurus)
Mammalia LOC511617 30
  • 72.6 (n)
rat
(Rattus norvegicus)
Mammalia Gimap5 30
  • 68.05 (n)
chicken
(Gallus gallus)
Aves GIMAP1 30
  • 58.88 (n)
Species where no ortholog for GIMAP1-GIMAP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GIMAP1-GIMAP5 Gene

ENSEMBL:
Gene Tree for GIMAP1-GIMAP5 (if available)
TreeFam:
Gene Tree for GIMAP1-GIMAP5 (if available)

Paralogs for GIMAP1-GIMAP5 Gene

Paralogs for GIMAP1-GIMAP5 Gene

genes like me logo Genes that share paralogs with GIMAP1-GIMAP5: view

Variants for GIMAP1-GIMAP5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GIMAP1-GIMAP5 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
776271 Benign: not provided 150,742,952(+) G/A SYNONYMOUS_VARIANT
780726 Benign: not provided 150,720,100(+) T/A SYNONYMOUS_VARIANT,INTRON_VARIANT
789594 Benign: not provided 150,720,269(+) T/C MISSENSE_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for GIMAP1-GIMAP5 Gene

Structural Variations from Database of Genomic Variants (DGV) for GIMAP1-GIMAP5 Gene

Variant ID Type Subtype PubMed ID
dgv1146n67 CNV loss 20364138
dgv3695n106 OTHER inversion 24896259
esv2759573 CNV loss 17122850
esv3891235 CNV loss 25118596
nsv1030109 CNV gain 25217958
nsv1034409 CNV gain 25217958
nsv1067934 OTHER inversion 25765185
nsv1151906 OTHER inversion 26484159
nsv608990 CNV gain 21841781
nsv824391 CNV gain 20364138
nsv831187 CNV loss 17160897

Additional Variant Information for GIMAP1-GIMAP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GIMAP1-GIMAP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for GIMAP1-GIMAP5 Gene

Disorders for GIMAP1-GIMAP5 Gene

Additional Disease Information for GIMAP1-GIMAP5

No disorders were found for GIMAP1-GIMAP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GIMAP1-GIMAP5 Gene

Publications for GIMAP1-GIMAP5 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 54
  2. Comparative analysis of the human gimap gene cluster encoding a novel GTPase family. (PMID: 15474311) Krücken J … Wunderlich F (Gene 2004) 3 54
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 13 54
  4. Human ortholog to mouse gene imap38 encoding an ER-localizable G-protein belongs to a gene family clustered on chromosome 7q32-36. (PMID: 11814688) Stamm O … Wunderlich F (Gene 2002) 3 54
  5. Toward a complete human genome sequence. (PMID: 9847074) Sanger Center … Genome Sequencing Center (Genome research 1998) 3 54

Products for GIMAP1-GIMAP5 Gene

Sources for GIMAP1-GIMAP5 Gene