Aliases for GIGYF2 Gene
- GRB10 Interacting GYF Protein 2 2 3 5
- PERQ Amino Acid-Rich With GYF Domain-Containing Protein 2 3 4
- Parkinson Disease (Autosomal Recessive, Early Onset) 11 2 3
- Trinucleotide Repeat-Containing Gene 15 Protein 3 4
- PERQ Amino Acid Rich, With GYF Domain 3 2 3
- GRB10-Interacting GYF Protein 2 3 4
- TNRC15 3 4
External Ids for GIGYF2 Gene
Previous HGNC Symbols for GIGYF2 Gene
Previous GeneCards Identifiers for GIGYF2 Gene
This gene contains CAG trinucleotide repeats and encodes a protein containing several stretches of polyglutamine residues. The encoded protein may be involved in the regulation of tyrosine kinase receptor signaling. This gene is located in a chromosomal region that was genetically linked to Parkinson disease type 11, and mutations in this gene were thought to be causative for this disease. However, more recent studies in different populations have been unable to replicate this association. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
GeneCards Summary for GIGYF2 Gene
GIGYF2 (GRB10 Interacting GYF Protein 2) is a Protein Coding gene. Diseases associated with GIGYF2 include Parkinson Disease 11, Autosomal Dominant and Hereditary Late-Onset Parkinson Disease. An important paralog of this gene is GIGYF1.
UniProtKB/Swiss-Prot Summary for GIGYF2 Gene
Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931). In 4EHP-GYF2 the complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (By similarity). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153).