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Aliases for GID8 Gene

Aliases for GID8 Gene

  • GID Complex Subunit 8 Homolog 2 3 5
  • Two Hybrid Associated Protein No. 1 With RanBPM 2 3
  • Two Hybrid-Associated Protein 1 With RanBPM 3 4
  • C20orf11 3 4
  • TWA1 3 4
  • GID Complex Subunit 8 Homolog (S. Cerevisiae) 2
  • Glucose-Induced Degradation Protein 8 Homolog 3
  • Chromosome 20 Open Reading Frame 11 2
  • GID Complex Subunit 8 2
  • Protein C20orf11 3

External Ids for GID8 Gene

Previous HGNC Symbols for GID8 Gene

  • C20orf11

Previous GeneCards Identifiers for GID8 Gene

  • GC20P061570

Summaries for GID8 Gene

GeneCards Summary for GID8 Gene

GID8 (GID Complex Subunit 8 Homolog) is a Protein Coding gene.

Additional gene information for GID8 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GID8 Gene

Genomics for GID8 Gene

GeneHancer (GH) Regulatory Elements for GID8 Gene

Promoters and enhancers for GID8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I062935 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 556.3 -0.3 -336 4.7 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 DIDO1 GID8 GMEB2 RPS21 SLC17A9 FNDC11 MRGBP LAMA5 ENSG00000226332 RTEL1
GH20I063625 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 27.2 +689.7 689726 4.8 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC GMEB2 GC20P063629 MHENCR DIDO1 CICP4 MRGBP GID8 RTEL1 MIR647 UCKL1
GH20I062922 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.3 -11.6 -11624 8.5 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 E2F8 ZNF207 DIDO1 GMEB2 TAF4 GID8 MRGBP RTEL1 SLC17A9 COL9A3 ENSG00000273759 ARF4P2
GH20I062300 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 -634.3 -634299 5.7 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SP3 ADRM1 DIDO1 TAF4 MRGBP ENSG00000226332 RPS21 LAMA5 GID8 LAMA5-AS1 CABLES2
GH20I063863 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.4 +926.8 926783 3.6 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 ENSG00000268858 TPD52L2 DIDO1 GMEB2 PRPF6 CICP4 MIR647 UCKL1 ENSG00000237371 DNAJC5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GID8 on UCSC Golden Path with GeneCards custom track

Genomic Locations for GID8 Gene

Genomic Locations for GID8 Gene
10,387 bases
Plus strand

Genomic View for GID8 Gene

Genes around GID8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GID8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GID8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GID8 Gene

Proteins for GID8 Gene

  • Protein details for GID8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glucose-induced degradation protein 8 homolog
    Protein Accession:
    Secondary Accessions:
    • E1P5I3
    • Q8N5M5

    Protein attributes for GID8 Gene

    228 amino acids
    Molecular mass:
    26749 Da
    Quaternary structure:
    • Interacts with RANBP9. Part of a complex consisting of RANBP9, MKLN1 and GID8.

neXtProt entry for GID8 Gene

Post-translational modifications for GID8 Gene

  • Ubiquitination at posLast=171171 and isoforms=197
  • Modification sites at PhosphoSitePlus

Other Protein References for GID8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GID8 Gene

Domains & Families for GID8 Gene

Gene Families for GID8 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for GID8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GID8 family.
  • Belongs to the GID8 family.
genes like me logo Genes that share domains with GID8: view

Function for GID8 Gene

Phenotypes From GWAS Catalog for GID8 Gene

Gene Ontology (GO) - Molecular Function for GID8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27173435
genes like me logo Genes that share ontologies with GID8: view

Phenotypes for GID8 Gene

genes like me logo Genes that share phenotypes with GID8: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GID8 Gene

Localization for GID8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GID8 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GID8 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GID8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with GID8: view

Pathways & Interactions for GID8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GID8 Gene


No data available for Pathways by source and SIGNOR curated interactions for GID8 Gene

Drugs & Compounds for GID8 Gene

No Compound Related Data Available

Transcripts for GID8 Gene

mRNA/cDNA for GID8 Gene

Unigene Clusters for GID8 Gene

GID complex subunit 8 homolog (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GID8 Gene

No ASD Table

Relevant External Links for GID8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GID8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GID8 Gene

Protein differential expression in normal tissues from HIPED for GID8 Gene

This gene is overexpressed in Cervix (21.5), Urine (7.5), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GID8 Gene

Protein tissue co-expression partners for GID8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GID8 Gene:


SOURCE GeneReport for Unigene cluster for GID8 Gene:


Evidence on tissue expression from TISSUES for GID8 Gene

  • Muscle(4.2)
  • Nervous system(3.8)
  • Lung(2)
genes like me logo Genes that share expression patterns with GID8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GID8 Gene

Orthologs for GID8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GID8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GID8 34 33
  • 99.71 (n)
(Monodelphis domestica)
Mammalia GID8 34
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia GID8 34
  • 98 (a)
(Canis familiaris)
Mammalia GID8 34 33
  • 90.2 (n)
(Bos Taurus)
Mammalia GID8 34 33
  • 89.62 (n)
(Mus musculus)
Mammalia Gid8 16 34 33
  • 89.47 (n)
(Rattus norvegicus)
Mammalia Gid8 33
  • 88.89 (n)
(Gallus gallus)
Aves GID8 34
  • 97 (a)
C20H20ORF11 33
  • 84.21 (n)
(Anolis carolinensis)
Reptilia GID8 34
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gid8 33
  • 80.7 (n)
Str.9059 33
(Danio rerio)
Actinopterygii gid8a 34
  • 83 (a)
gid8b 34 33
  • 79.82 (n)
-- 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1136 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000951 33
  • 62.7 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6617 33 34
  • 62.05 (n)
CG18467 34
  • 37 (a)
(Caenorhabditis elegans)
Secernentea tag-304 34
  • 13 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G61150 33
  • 55.61 (n)
(Oryza sativa)
Liliopsida Os03g0235100 33
  • 56 (n)
(Triticum aestivum)
Liliopsida Ta.28704 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5728 34
  • 61 (a)
Species where no ortholog for GID8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for GID8 Gene

Gene Tree for GID8 (if available)
Gene Tree for GID8 (if available)

Paralogs for GID8 Gene

No data available for Paralogs for GID8 Gene

Variants for GID8 Gene

Sequence variations from dbSNP and Humsavar for GID8 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000085881 -- 62,937,224(+) G/C upstream_transcript_variant
rs1000150377 -- 62,938,526(+) G/A intron_variant
rs1000222345 -- 62,945,378(+) A/C/G/T 3_prime_UTR_variant
rs1000257014 -- 62,942,751(+) A/G intron_variant
rs1000300119 -- 62,942,087(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GID8 Gene

Variant ID Type Subtype PubMed ID
nsv459069 CNV gain 19166990
nsv470559 CNV loss 18288195
nsv586532 CNV gain 21841781
nsv9825 CNV gain 18304495

Variation tolerance for GID8 Gene

Residual Variation Intolerance Score: 26.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GID8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GID8 Gene

Disorders for GID8 Gene

Additional Disease Information for GID8

No disorders were found for GID8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GID8 Gene

Publications for GID8 Gene

  1. A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM. (PMID: 12559565) Umeda M … Nishimoto T (Gene 2003) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for GID8 Gene

Sources for GID8 Gene

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