This gene is an antisense gene of the ghrelin/obestatin prepropeptide gene. Alternatively spliced transcript variants have been identified and they may function as non-coding regulatory RNAs. [provided by RefSeq, Jan 2013] See more...

Aliases for GHRLOS Gene

Subcategory (RNA class) for GHRLOS Gene

lncRNA

Number of RNA Genes sources:

3 / 14

Aliases for GHRLOS Gene

  • Ghrelin Opposite Strand/Antisense RNA 2 3 5
  • GHRL Antisense RNA 1 (Non-Protein Coding) 2 3
  • GHRLOS 2 168
  • Ghrelin Opposite Strand/Antisense RNA (Non-Protein Coding) 2
  • Ghrelin Opposite Strand RNA (Non-Protein Coding) 2
  • Non-Protein Coding RNA 68 2
  • HSALNG0024099 167
  • NCRNA00068 3
  • GHRL-AS1 3
  • GHRLAS 3

External Ids for GHRLOS Gene

Previous GeneCards Identifiers for GHRLOS Gene

  • GC03U900879
  • GC03P010327
  • GC03P010284
  • GC03P010428
  • GC03P010674
  • GC03P010705
  • GC03P010703
  • GC03P010452
  • GC03P010478
  • GC03P010506
  • GC03P010535
  • GC03P010563
  • GC03P010591
  • GC03P010619
  • GC03P010646

Summaries for GHRLOS Gene

Entrez Gene Summary for GHRLOS Gene

  • This gene is an antisense gene of the ghrelin/obestatin prepropeptide gene. Alternatively spliced transcript variants have been identified and they may function as non-coding regulatory RNAs. [provided by RefSeq, Jan 2013]

GeneCards Summary for GHRLOS Gene

GHRLOS (Ghrelin Opposite Strand/Antisense RNA) is an RNA Gene, and is affiliated with the lncRNA class.

Gene Wiki entry for GHRLOS Gene

Rfam classification for GHRLOS Gene

  • Ghrelin opposite strand RNA conserved region

Additional gene information for GHRLOS Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for GHRLOS Gene

Genomics for GHRLOS Gene

GeneHancer (GH) Regulatory Elements for GHRLOS Gene

Promoters and enhancers for GHRLOS Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GHRLOS on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GHRLOS gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • CREB
  • deltaCREB
  • PPAR-gamma2

Genomic Locations for GHRLOS Gene

Genomic Locations for GHRLOS Gene
chr3:10,279,402-10,294,903
(GRCh38/hg38)
Size:
15,502 bases
Orientation:
Plus strand
chr3:10,327,438-10,335,133
(GRCh37/hg19)
Size:
7,696 bases
Orientation:
Plus strand

Genomic View for GHRLOS Gene

Genes around GHRLOS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GHRLOS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GHRLOS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GHRLOS Gene

Proteins for GHRLOS Gene

Post-translational modifications for GHRLOS Gene

No Post-translational modifications

No data available for DME Specific Peptides for GHRLOS Gene

Domains & Families for GHRLOS Gene

Gene Families for GHRLOS Gene

genes like me logo Genes that share domains with GHRLOS: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GHRLOS Gene

Function for GHRLOS Gene

Phenotypes From GWAS Catalog for GHRLOS Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GHRLOS Gene

Localization for GHRLOS Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GHRLOS gene
Compartment Confidence
nucleus 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for GHRLOS Gene

Pathways & Interactions for GHRLOS Gene

PathCards logo

SuperPathways for GHRLOS Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for GHRLOS Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for GHRLOS Gene

Drugs & Compounds for GHRLOS Gene

No Compound Related Data Available

Transcripts for GHRLOS Gene

mRNA/cDNA for GHRLOS Gene

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for GHRLOS Gene

No ASD Table

Relevant External Links for GHRLOS Gene

GeneLoc Exon Structure for
GHRLOS

Expression for GHRLOS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GHRLOS Gene

mRNA differential expression in normal tissues according to GTEx for GHRLOS Gene

This gene is overexpressed in Stomach (x6.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GHRLOS

genes like me logo Genes that share expression patterns with GHRLOS: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GHRLOS Gene

Orthologs for GHRLOS Gene

Evolution for GHRLOS Gene

ENSEMBL:
Gene Tree for GHRLOS (if available)
TreeFam:
Gene Tree for GHRLOS (if available)

No data available for Orthologs for GHRLOS Gene

Paralogs for GHRLOS Gene

No data available for Paralogs for GHRLOS Gene

Variants for GHRLOS Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GHRLOS Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs34911341 Risk Factor: Obesity; Metabolic syndrome, susceptibility to 10,289,835(+) C/T MISSENSE_VARIANT,INTRON_VARIANT
rs4684677 Risk Factor: Obesity 10,286,769(+) T/A MISSENSE_VARIANT
rs696217 Pathogenic, Risk Factor: Metabolic syndrome, susceptibility to; Obesity, age at onset of 10,289,773(+) G/T MISSENSE_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for GHRLOS Gene

Structural Variations from Database of Genomic Variants (DGV) for GHRLOS Gene

Variant ID Type Subtype PubMed ID
dgv762e201 CNV deletion 23290073
esv4117 OTHER complex 18987735
nsv1073204 CNV deletion 25765185
nsv1121603 CNV deletion 24896259
nsv436362 CNV deletion 17901297
nsv436869 CNV insertion 17901297
nsv460420 CNV loss 19166990
nsv508903 CNV insertion 20534489
nsv589650 CNV loss 21841781

Additional Variant Information for GHRLOS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GHRLOS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for GHRLOS Gene

Disorders for GHRLOS Gene

Additional Disease Information for GHRLOS

No disorders were found for GHRLOS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GHRLOS Gene

Publications for GHRLOS Gene

  1. Complex organisation and structure of the ghrelin antisense strand gene GHRLOS, a candidate non-coding RNA gene. (PMID: 18954468) Seim I … Chopin LK (BMC molecular biology 2008) 2 3 54
  2. Revised genomic structure of the human ghrelin gene and identification of novel exons, alternative splice variants and natural antisense transcripts. (PMID: 17727735) Seim I … Chopin LK (BMC genomics 2007) 2 3 54

Products for GHRLOS Gene

Sources for GHRLOS Gene