Aliases for GHRH Gene
External Ids for GHRH Gene
Previous HGNC Symbols for GHRH Gene
Previous GeneCards Identifiers for GHRH Gene
This gene encodes a member of the glucagon family of proteins. The encoded preproprotein is produced in the hypothalamus and cleaved to generate the mature factor, known as somatoliberin, which acts to stimulate growth hormone release from the pituitary gland. Variant receptors for somatoliberin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
GeneCards Summary for GHRH Gene
GHRH (Growth Hormone Releasing Hormone) is a Protein Coding gene. Diseases associated with GHRH include Acromegaly and Isolated Growth Hormone Deficiency, Type Ib. Among its related pathways are Signaling by GPCR and NF-KappaB Family Pathway. Gene Ontology (GO) annotations related to this gene include hormone activity and growth hormone-releasing hormone receptor binding. An important paralog of this gene is ADCYAP1.
UniProtKB/Swiss-Prot Summary for GHRH Gene
GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.