GGTLC3 Gene (Protein Coding)

Gamma-Glutamyltransferase Light Chain Family Member 3

GC22M018516
GIFtS:
20
Gamma-glutamyltransferase-1 (GGT1; MIM 612346) is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. Autocatalytic cleavage of the GGT1 precursor polypeptide produces a heavy chain and a light chain that associate with each other to form the functional enzyme. Li... See more...

Aliases for GGTLC3 Gene

Aliases for GGTLC3 Gene

  • Gamma-Glutamyltransferase Light Chain Family Member 3 2 3 5
  • Putative Gamma-Glutamyltransferase Light Chain 3 3 4
  • Putative Glutathione Hydrolase Light Chain 3 3 4
  • Gamma-Glutamyltransferase Light Chain 3 2 3
  • EC 2.3.2.2 51
  • GGTLC3 5
  • GGT 3

External Ids for GGTLC3 Gene

Previous GeneCards Identifiers for GGTLC3 Gene

  • GC22M018747
  • GC22M020366

Summaries for GGTLC3 Gene

Entrez Gene Summary for GGTLC3 Gene

  • Gamma-glutamyltransferase-1 (GGT1; MIM 612346) is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. Autocatalytic cleavage of the GGT1 precursor polypeptide produces a heavy chain and a light chain that associate with each other to form the functional enzyme. Light chain-only GGTs, such as GGTLC3, contain a region corresponding to the GGT1 light chain, but they lack the membrane-anchoring heavy chain region (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]

GeneCards Summary for GGTLC3 Gene

GGTLC3 (Gamma-Glutamyltransferase Light Chain Family Member 3) is a Protein Coding gene. Diseases associated with GGTLC3 include Bile Duct Rhabdomyosarcoma and Cataract 34, Multiple Types. Gene Ontology (GO) annotations related to this gene include obsolete gamma-glutamyltransferase activity. An important paralog of this gene is GGT2.

Additional gene information for GGTLC3 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GGTLC3 Gene

Genomics for GGTLC3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for GGTLC3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH22J018515 Enhancer 0.2 Ensembl 0.7 +2.2 2207 0.7 piR-48049-050 GGTLC3 FAM247B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GGTLC3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GGTLC3

Genomic Locations for GGTLC3 Gene

Genomic Locations for GGTLC3 Gene
chr22:18,516,335-18,518,165
(GRCh38/hg38)
Size:
1,831 bases
Orientation:
Minus strand
chr22:20,366,205-20,368,028
(GRCh37/hg19)
Size:
1,824 bases
Orientation:
Minus strand

Genomic View for GGTLC3 Gene

Genes around GGTLC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GGTLC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GGTLC3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GGTLC3 Gene

Proteins for GGTLC3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for GGTLC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B5MD39-GGTL3_HUMAN
    Recommended name:
    Putative glutathione hydrolase light chain 3
    Protein Accession:
    B5MD39
    Secondary Accessions:
    • A6NEA2

    Protein attributes for GGTLC3 Gene

    Size:
    225 amino acids
    Molecular mass:
    24102 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Corresponds to the light chain of other gamma-glutamyltransferase family members. Has no catalytic activity.

neXtProt entry for GGTLC3 Gene

Protein Expression for GGTLC3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for GGTLC3 Gene

B5MD39:
  • PSPANFI
  • PEFYTPDD
  • VVQAIVRT
  • ATSTINLYFGSKV
  • DDGGTAHLS

Post-translational modifications for GGTLC3 Gene

No Post-translational modifications

Other Protein References for GGTLC3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GGTLC3 Gene

Gene Families for GGTLC3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GGTLC3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GGTLC3 Gene

GenScript: Design optimal peptide antigens:
  • Putative gamma-glutamyltransferase light chain 3 (GGTL3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

B5MD39

UniProtKB/Swiss-Prot:

GGTL3_HUMAN :
  • Belongs to the gamma-glutamyltransferase family.
Family:
  • Belongs to the gamma-glutamyltransferase family.
genes like me logo Genes that share domains with GGTLC3: view

Function for GGTLC3 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Enzyme Numbers (IUBMB) for GGTLC3 Gene

Gene Ontology (GO) - Molecular Function for GGTLC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0036374 glutathione hydrolase activity IEA --
genes like me logo Genes that share ontologies with GGTLC3: view

No data available for Molecular function , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GGTLC3 Gene

Localization for GGTLC3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GGTLC3 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 3
mitochondrion 3
nucleus 3
cytosol 3
peroxisome 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for GGTLC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with GGTLC3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for GGTLC3 Gene

Pathways & Interactions for GGTLC3 Gene

PathCards logo

SuperPathways for GGTLC3 Gene

No Data Available

Interacting Proteins for GGTLC3 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 20)
STRING Interaction Network
Selected Interacting proteins: ENSP00000477856 B5MD39-GGTL3_HUMAN for GGTLC3 Gene via STRING IID

GPS-Prot Interaction Network for GGTLC3

Gene Ontology (GO) - Biological Process for GGTLC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006751 glutathione catabolic process IEA --
GO:0008150 biological_process ND --
GO:1901750 leukotriene D4 biosynthetic process ISS --
genes like me logo Genes that share ontologies with GGTLC3: view

No data available for Pathways by source and SIGNOR curated interactions for GGTLC3 Gene

Drugs & Compounds for GGTLC3 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for GGTLC3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for GGTLC3 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for GGTLC3 Gene

No ASD Table

Relevant External Links for GGTLC3 Gene

GeneLoc Exon Structure for
GGTLC3

Expression for GGTLC3 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GGTLC3 Gene

mRNA expression in normal human tissues for GGTLC3 Gene
mRNA expression by GTEx for GGTLC3 Gene

mRNA differential expression in normal tissues according to GTEx for GGTLC3 Gene

This gene is overexpressed in Kidney - Cortex (x19.4), Thyroid (x7.8), and Lung (x5.5).

Protein differential expression in normal tissues from HIPED for GGTLC3 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GGTLC3 Gene



Protein tissue co-expression partners for GGTLC3 Gene

- Elite partner

Evidence on tissue expression from TISSUES for GGTLC3 Gene

  • Liver(3.4)
  • Blood(3.3)
  • Kidney(2.9)
  • Skin(2.9)
  • Nervous system(2.8)
  • Intestine(2.7)
  • Muscle(2.7)
  • Heart(2.7)
  • Urine(2.7)
  • Spleen(2.5)
  • Lung(2.5)
  • Bone(2.4)
  • Pancreas(2.4)
  • Lymph node(2.3)
  • Stomach(2.3)
  • Gall bladder(2.3)
  • Bone marrow(2.3)
  • Thyroid gland(2.3)
  • Eye(2.1)
genes like me logo Genes that share expression patterns with GGTLC3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GGTLC3 Gene

Orthologs for GGTLC3 Gene

Evolution for GGTLC3 Gene

ENSEMBL:
Gene Tree for GGTLC3 (if available)
TreeFam:
Gene Tree for GGTLC3 (if available)

No data available for Orthologs for GGTLC3 Gene

Paralogs for GGTLC3 Gene

Paralogs for GGTLC3 Gene

(7) SIMAP similar genes for GGTLC3 Gene using alignment to 2 proteins:

  • GGTL3_HUMAN
  • J3KR28_HUMAN
genes like me logo Genes that share paralogs with GGTLC3: view

Variants for GGTLC3 Gene

Additional dbSNP identifiers (rs#s) for GGTLC3 Gene

Variation tolerance for GGTLC3 Gene

Gene Damage Index Score: 0.83; 17.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GGTLC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GGTLC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for GGTLC3 Gene

Disorders for GGTLC3 Gene

MalaCards: The human disease database

(47) MalaCards diseases for GGTLC3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bile duct rhabdomyosarcoma
  • rhabdomyosarcoma of the bile duct
cataract 34, multiple types
  • ctrct34
cataract 4, multiple types
  • ctrct4
gallbladder papillary carcinoma
  • papillary carcinoma of the gallbladder
common bile duct disease
  • common bile duct diseases
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GGTLC3

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with GGTLC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GGTLC3 Gene

Publications for GGTLC3 Gene

  1. The human gamma-glutamyltransferase gene family. (PMID: 18357469) Heisterkamp N … Sneddon TP (Human genetics 2008) 2 3 4
  2. Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer. (PMID: 30945288) Liu H … Yang C (The Journal of pathology 2019) 3
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S … Drake RR (Proteomics 2013) 3
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 4
  5. Expression of multiple gamma-glutamyltransferase genes in man. (PMID: 7906515) Courtay C … Groffen J (The Biochemical journal 1994) 3

ExternalLinks

View latest publications for GGTLC3 gene in Mastermind

Products for GGTLC3 Gene

Sources for GGTLC3 Gene