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Gamma-glutamyltransferase-1 (GGT1; MIM 612346) is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. Autocatalytic cleavage of the GGT1 precursor polypeptide produces a heavy chain and a light chain that associate with each other to form the functional enzyme. Light chain-only GGTs, such as GGTLC3, contain a region corresponding to the GGT1 light chain, but they lack the membrane-anchoring heavy chain region (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]
GGTLC3 (Gamma-Glutamyltransferase Light Chain Family Member 3) is a Protein Coding gene. Diseases associated with GGTLC3 include Bile Duct Rhabdomyosarcoma and Cataract 34, Multiple Types. Gene Ontology (GO) annotations related to this gene include obsolete gamma-glutamyltransferase activity. An important paralog of this gene is GGT2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH22J018515 | Enhancer | 0.2 | Ensembl | 0.7 | +2.2 | 2207 | 0.7 | piR-48049-050 GGTLC3 FAM247B |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003674 | molecular_function | ND | -- |
GO:0036374 | glutathione hydrolase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0070062 | extracellular exosome | HDA | 23533145 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006508 | proteolysis | IEA | -- |
GO:0006751 | glutathione catabolic process | IEA | -- |
GO:0008150 | biological_process | ND | -- |
GO:1901750 | leukotriene D4 biosynthetic process | ISS | -- |
Disorder | Aliases | PubMed IDs |
---|---|---|
bile duct rhabdomyosarcoma |
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cataract 34, multiple types |
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cataract 4, multiple types |
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gallbladder papillary carcinoma |
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common bile duct disease |
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