Aliases for GGTLC3 Gene
External Ids for GGTLC3 Gene
Previous GeneCards Identifiers for GGTLC3 Gene
Gamma-glutamyltransferase-1 (GGT1; MIM 612346) is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. Autocatalytic cleavage of the GGT1 precursor polypeptide produces a heavy chain and a light chain that associate with each other to form the functional enzyme. Light chain-only GGTs, such as GGTLC3, contain a region corresponding to the GGT1 light chain, but they lack the membrane-anchoring heavy chain region (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]
GeneCards Summary for GGTLC3 Gene
GGTLC3 (Gamma-Glutamyltransferase Light Chain Family Member 3) is a Protein Coding gene. Diseases associated with GGTLC3 include Contractural Arachnodactyly, Congenital and Cataract 4, Multiple Types. Gene Ontology (GO) annotations related to this gene include obsolete gamma-glutamyltransferase activity. An important paralog of this gene is GGT2.