Aliases for GGT6 Gene
External Ids for GGT6 Gene
Previous GeneCards Identifiers for GGT6 Gene
GGT6 belongs to the gamma-glutamyltransferase (GGT; EC 184.108.40.206) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]
GeneCards Summary for GGT6 Gene
GGT6 (Gamma-Glutamyltransferase 6) is a Protein Coding gene. Diseases associated with GGT6 include Bladder Sarcoma and Blood Group Incompatibility. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include obsolete gamma-glutamyltransferase activity and glutathione hydrolase activity. An important paralog of this gene is GGT7.
UniProtKB/Swiss-Prot Summary for GGT6 Gene
Cleaves glutathione conjugates.