Aliases for GGPS1 Gene
External Ids for GGPS1 Gene
Previous GeneCards Identifiers for GGPS1 Gene
This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]
GeneCards Summary for GGPS1 Gene
GGPS1 (Geranylgeranyl Diphosphate Synthase 1) is a Protein Coding gene. Diseases associated with GGPS1 include Lung Cancer and Ischemic Bone Disease. Among its related pathways are Regulation of cholesterol biosynthesis by SREBP (SREBF) and Metabolism. Gene Ontology (GO) annotations related to this gene include dimethylallyltranstransferase activity and geranyltranstransferase activity. An important paralog of this gene is PDSS1.
UniProtKB/Swiss-Prot Summary for GGPS1 Gene
Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.