This gene is the ortholog of the mouse gametogenetin-binding protein 1 gene. In human, the open reading frame is disrupted by a nonsense mutation after 8-aa; consequently, this gene is currently considered to be a unitary pseudogene in human even though it is functional in other mammals. [provided by RefSeq, Aug 2009] See more...

Aliases for GGNBP1 Gene

Aliases for GGNBP1 Gene

  • Gametogenetin Binding Protein 1 (Pseudogene) 2 3 5
  • Putative Gametogenetin-Binding Protein 1 4
  • Gametogenetin Binding Protein 1 2

External Ids for GGNBP1 Gene

Previous GeneCards Identifiers for GGNBP1 Gene

  • GC06U900709
  • GC06P033660
  • GC06P033551
  • GC06P033295
  • GC06P033543
  • GC06P033545

Summaries for GGNBP1 Gene

Entrez Gene Summary for GGNBP1 Gene

  • This gene is the ortholog of the mouse gametogenetin-binding protein 1 gene. In human, the open reading frame is disrupted by a nonsense mutation after 8-aa; consequently, this gene is currently considered to be a unitary pseudogene in human even though it is functional in other mammals. [provided by RefSeq, Aug 2009]

GeneCards Summary for GGNBP1 Gene

GGNBP1 (Gametogenetin Binding Protein 1 (Pseudogene)) is a Pseudogene.

UniProtKB/Swiss-Prot Summary for GGNBP1 Gene

Additional gene information for GGNBP1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GGNBP1 Gene

Genomics for GGNBP1 Gene

GeneHancer (GH) Regulatory Elements for GGNBP1 Gene

Promoters and enhancers for GGNBP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GGNBP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GGNBP1 gene promoter:
  • HSF1 (long)
  • HSF1short
  • p53
  • Pax-5
  • Sp1
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT5B

Genomic Locations for GGNBP1 Gene

Genomic Locations for GGNBP1 Gene
chr6:33,540,046-33,589,026
(GRCh38/hg38)
Size:
48,981 bases
Orientation:
Plus strand
chr6:33,551,476-33,556,803
(GRCh37/hg19)
Size:
5,328 bases
Orientation:
Plus strand

Genomic View for GGNBP1 Gene

Genes around GGNBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GGNBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GGNBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GGNBP1 Gene

Proteins for GGNBP1 Gene

  • Protein details for GGNBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5YKI7-GGNB1_HUMAN
    Recommended name:
    Putative gametogenetin-binding protein 1
    Protein Accession:
    Q5YKI7
    Secondary Accessions:
    • Q5YKI8

    Protein attributes for GGNBP1 Gene

    Size:
    109 amino acids
    Molecular mass:
    12309 Da
    Quaternary structure:
    • Interacts with GGN.

    Alternative splice isoforms for GGNBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GGNBP1 Gene

Post-translational modifications for GGNBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GGNBP1 Gene

Domains & Families for GGNBP1 Gene

Protein Domains for GGNBP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GGNBP1 Gene

GenScript: Design optimal peptide antigens:
  • Putative gametogenetin-binding protein 1 (GGNB1_HUMAN)
genes like me logo Genes that share domains with GGNBP1: view

No data available for Gene Families , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GGNBP1 Gene

Function for GGNBP1 Gene

Molecular function for GGNBP1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in spermatogenesis.

Phenotypes From GWAS Catalog for GGNBP1 Gene

Phenotypes for GGNBP1 Gene

GenomeRNAi human phenotypes for GGNBP1:
genes like me logo Genes that share phenotypes with GGNBP1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GGNBP1 Gene

Localization for GGNBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GGNBP1 Gene

Cytoplasm. Membrane; Peripheral membrane protein. Golgi apparatus.

Gene Ontology (GO) - Cellular Components for GGNBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GGNBP1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for GGNBP1 Gene

Pathways & Interactions for GGNBP1 Gene

PathCards logo

SuperPathways for GGNBP1 Gene

No Data Available

Interacting Proteins for GGNBP1 Gene

Selected Interacting proteins: Q5YKI7-GGNB1_HUMAN for GGNBP1 Gene via IID

Symbol External ID(s) Details
EIF2AK4
GGN
;

Gene Ontology (GO) - Biological Process for GGNBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000266 mitochondrial fission IEA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with GGNBP1: view

No data available for Pathways by source and SIGNOR curated interactions for GGNBP1 Gene

Drugs & Compounds for GGNBP1 Gene

No Compound Related Data Available

Transcripts for GGNBP1 Gene

mRNA/cDNA for GGNBP1 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GGNBP1 Gene

No ASD Table

Relevant External Links for GGNBP1 Gene

GeneLoc Exon Structure for
GGNBP1

Expression for GGNBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GGNBP1 Gene

mRNA differential expression in normal tissues according to GTEx for GGNBP1 Gene

This gene is overexpressed in Testis (x24.9) and Brain - Anterior cingulate cortex (BA24) (x7.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GGNBP1

SOURCE GeneReport for Unigene cluster for GGNBP1 Gene:

Hs.582973
genes like me logo Genes that share expression patterns with GGNBP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GGNBP1 Gene

Orthologs for GGNBP1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for GGNBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GGNBP1 31
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GGNBP1 31
  • 75 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GGNBP1 31
  • 20 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GGNBP1 31
  • 15 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ggnbp1 31
  • 15 (a)
OneToOne
Species where no ortholog for GGNBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GGNBP1 Gene

ENSEMBL:
Gene Tree for GGNBP1 (if available)
TreeFam:
Gene Tree for GGNBP1 (if available)

Paralogs for GGNBP1 Gene

No data available for Paralogs for GGNBP1 Gene

Variants for GGNBP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for GGNBP1 Gene

Variant ID Type Subtype PubMed ID
dgv85n68 CNV loss 17160897
esv3608630 CNV gain 21293372
nsv602833 CNV loss 21841781

Variation tolerance for GGNBP1 Gene

Gene Damage Index Score: 0.80; 16.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GGNBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GGNBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Additional dbSNP identifiers (rs#s) for GGNBP1 Gene

Disorders for GGNBP1 Gene

Additional Disease Information for GGNBP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GGNBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GGNBP1 Gene

Publications for GGNBP1 Gene

  1. Identification and characterization of a novel testicular germ cell-specific gene Ggnbp1. (PMID: 15625700) Zhou Y … Lu B (Molecular reproduction and development 2005) 3 4 23 54
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54
  3. Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are potential interaction partners of testicular germ cell-specific protein GGN1. (PMID: 15642376) Zhang J … Lu B (FEBS letters 2005) 2 3 54
  4. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud PJ … BRIGHT Consortium (American journal of human genetics 2009) 3 54
  5. Germ-cell specific protein gametogenetin protein 2 (GGN2), expression in the testis, and association with intracellular membrane. (PMID: 15892049) Zhao Q … Lu B (Molecular reproduction and development 2005) 3 54

Products for GGNBP1 Gene

Sources for GGNBP1 Gene