This gene is a germ cell-specific gene that encodes proteins that interact with POG (proliferation of germ cells). Alternatively spliced transcript variants of a similar mouse gene encode at least three different proteins, namely gametogenetin protein 1a, gametogenetin protein 2, and gametogenetin protein 3, which show a perinuclear, cytoplasmic, and nucleolar localization, res... See more...

Aliases for GGN Gene

Aliases for GGN Gene

  • Gametogenetin 2 3 4 5

External Ids for GGN Gene

Previous GeneCards Identifiers for GGN Gene

  • GC19M043551
  • GC19M043566
  • GC19M038874
  • GC19M035322
  • GC19M038385
  • GC19M039019
  • GC19M039157
  • GC19M039677
  • GC19M038548
  • GC19M038547
  • GC19M038649
  • GC19M038888

Summaries for GGN Gene

Entrez Gene Summary for GGN Gene

  • This gene is a germ cell-specific gene that encodes proteins that interact with POG (proliferation of germ cells). Alternatively spliced transcript variants of a similar mouse gene encode at least three different proteins, namely gametogenetin protein 1a, gametogenetin protein 2, and gametogenetin protein 3, which show a perinuclear, cytoplasmic, and nucleolar localization, respectively. These proteins regulate the localization of POG and may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for GGN Gene

GGN (Gametogenetin) is a Protein Coding gene. Diseases associated with GGN include Adenocarcinoma In Situ and Cryptorchidism, Unilateral Or Bilateral. Gene Ontology (GO) annotations related to this gene include protein dimerization activity. An important paralog of this gene is ZNF512B.

UniProtKB/Swiss-Prot Summary for GGN Gene

Additional gene information for GGN Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GGN Gene

Genomics for GGN Gene

GeneHancer (GH) Regulatory Elements for GGN Gene

Promoters and enhancers for GGN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GGN on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GGN

Top Transcription factor binding sites by QIAGEN in the GGN gene promoter:
  • CREB
  • deltaCREB
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Nkx2-5
  • Zic3

Genomic Locations for GGN Gene

Genomic Locations for GGN Gene
chr19:38,384,267-38,388,583
(GRCh38/hg38)
Size:
4,317 bases
Orientation:
Minus strand
chr19:38,874,905-38,878,722
(GRCh37/hg19)
Size:
3,818 bases
Orientation:
Minus strand

Genomic View for GGN Gene

Genes around GGN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GGN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GGN Gene

Proteins for GGN Gene

  • Protein details for GGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UU5-GGN_HUMAN
    Recommended name:
    Gametogenetin
    Protein Accession:
    Q86UU5
    Secondary Accessions:
    • Q7RTU6
    • Q86UU4
    • Q8NAA1

    Protein attributes for GGN Gene

    Size:
    652 amino acids
    Molecular mass:
    66699 Da
    Quaternary structure:
    • Interacts with FANCL, GGNBP1 and ZNF403/GGNBP2.

    Alternative splice isoforms for GGN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GGN Gene

Post-translational modifications for GGN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GGN Gene

No data available for DME Specific Peptides for GGN Gene

Domains & Families for GGN Gene

Gene Families for GGN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GGN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GGN Gene

GenScript: Design optimal peptide antigens:
  • Gametogenetin (GGN_HUMAN)
  • Gametogenetin protein 3 (Q86UU3_HUMAN)
genes like me logo Genes that share domains with GGN: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GGN Gene

Function for GGN Gene

Molecular function for GGN Gene

UniProtKB/Swiss-Prot Function:
May be involved in spermatogenesis.

Phenotypes From GWAS Catalog for GGN Gene

Gene Ontology (GO) - Molecular Function for GGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0031625 ubiquitin protein ligase binding IBA 21873635
genes like me logo Genes that share ontologies with GGN: view
genes like me logo Genes that share phenotypes with GGN: view

Animal Models for GGN Gene

MGI Knock Outs for GGN:
  • Ggn Ggn<tm1Dpj>

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GGN Gene

Localization for GGN Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GGN gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for GGN Gene

Pathways & Interactions for GGN Gene

PathCards logo

SuperPathways for GGN Gene

No Data Available

Gene Ontology (GO) - Biological Process for GGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006302 double-strand break repair IEA --
GO:0007275 multicellular organism development IEA --
GO:0007276 gamete generation ISS,IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with GGN: view

No data available for Pathways by source and SIGNOR curated interactions for GGN Gene

Drugs & Compounds for GGN Gene

No Compound Related Data Available

Transcripts for GGN Gene

mRNA/cDNA for GGN Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GGN Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7
SP1: - - -
SP2: - -
SP3: -
SP4: - - - - - -
SP5:
SP6: -

Relevant External Links for GGN Gene

GeneLoc Exon Structure for
GGN

Expression for GGN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GGN Gene

mRNA differential expression in normal tissues according to GTEx for GGN Gene

This gene is overexpressed in Testis (x39.1).

Protein differential expression in normal tissues from HIPED for GGN Gene

This gene is overexpressed in Pancreatic juice (47.1), Adipocyte (12.7), and Testis (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GGN Gene



Protein tissue co-expression partners for GGN Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GGN

SOURCE GeneReport for Unigene cluster for GGN Gene:

Hs.447948
genes like me logo Genes that share expression patterns with GGN: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GGN Gene

Orthologs for GGN Gene

This gene was present in the common ancestor of mammals.

Orthologs for GGN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GGN 31 30
  • 97.59 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GGN 31 30
  • 82.15 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GGN 31 30
  • 79.26 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ggn 30
  • 76.87 (n)
mouse
(Mus musculus)
Mammalia Ggn 17 31 30
  • 76.11 (n)
Species where no ortholog for GGN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GGN Gene

ENSEMBL:
Gene Tree for GGN (if available)
TreeFam:
Gene Tree for GGN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GGN: view image

Paralogs for GGN Gene

Paralogs for GGN Gene

genes like me logo Genes that share paralogs with GGN: view

Variants for GGN Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GGN Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
708829 Likely Benign: not provided 38,385,791(-) C/T MISSENSE_VARIANT
710766 Benign: not provided 38,386,304(-) C/T MISSENSE_VARIANT
720415 Benign: not provided 38,387,192(-) G/A MISSENSE_VARIANT
768988 Benign: not provided 38,385,765(-) A/AGCCGGGGATGGGG INFRAME_INSERTION
769453 Benign: not provided 38,386,085(-) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for GGN Gene

Structural Variations from Database of Genomic Variants (DGV) for GGN Gene

Variant ID Type Subtype PubMed ID
nsv1064275 CNV loss 25217958
nsv470140 CNV gain 18288195
nsv833822 CNV loss 17160897
nsv833823 CNV loss 17160897
nsv953296 CNV deletion 24416366

Variation tolerance for GGN Gene

Residual Variation Intolerance Score: 78.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.27; 88.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GGN Gene

Human Gene Mutation Database (HGMD)
GGN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GGN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GGN Gene

Disorders for GGN Gene

MalaCards: The human disease database

(2) MalaCards diseases for GGN Gene - From: DISEASES

Disorder Aliases PubMed IDs
adenocarcinoma in situ
cryptorchidism, unilateral or bilateral
  • undescended testis
- elite association - COSMIC cancer census association via MalaCards
Search GGN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GGN

genes like me logo Genes that share disorders with GGN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GGN Gene

Publications for GGN Gene

  1. Mouse GGN1 and GGN3, two germ cell-specific proteins from the single gene Ggn, interact with mouse POG and play a role in spermatogenesis. (PMID: 12574169) Lu B … Bishop CE (The Journal of biological chemistry 2003) 2 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Increased expression of GGN promotes tumorigenesis in bladder cancer and is correlated with poor prognosis. (PMID: 29412153) Wang W … An R (Gene 2018) 3 54
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 54

Products for GGN Gene

Sources for GGN Gene