Aliases for GGCT Gene
External Ids for GGCT Gene
Previous HGNC Symbols for GGCT Gene
Previous GeneCards Identifiers for GGCT Gene
The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
GeneCards Summary for GGCT Gene
GGCT (Gamma-Glutamylcyclotransferase) is a Protein Coding gene. Diseases associated with GGCT include Pancreatic Cystadenocarcinoma and Liver Angiosarcoma. Among its related pathways are Glutathione metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and gamma-glutamylcyclotransferase activity. An important paralog of this gene is ENSG00000281039.
UniProtKB/Swiss-Prot Summary for GGCT Gene
Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.