Aliases for GGA1 Gene
- Golgi Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 1 2 3 5
- Golgi-Localized, Gamma Ear-Containing, ARF-Binding Protein 1 3 4
- ADP-Ribosylation Factor-Binding Protein GGA1 3 4
- ADP-Ribosylation Factor Binding Protein 1 3
- Gamma-Adaptin Related Protein 1 3
- Gamma-Adaptin-Related Protein 1 4
- GGA1 5
External Ids for GGA1 Gene
Previous GeneCards Identifiers for GGA1 Gene
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for GGA1 Gene
GGA1 (Golgi Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 1) is a Protein Coding gene. Diseases associated with GGA1 include 3-Methylglutaconic Aciduria, Type Iv and 3-Methylglutaconic Aciduria, Type Vii. Among its related pathways are TBC/RABGAPs and Lysosome. An important paralog of this gene is GGA3.
UniProtKB/Swiss-Prot Summary for GGA1 Gene
Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005, PubMed:15886016). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane (By similarity). Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network (PubMed:15886016, PubMed:15615712).