GFY Gene (Protein Coding)

Golgi Associated Olfactory Signaling Regulator

GC19P049424
GIFtS:
21
See more...

Aliases for GFY Gene

Aliases for GFY Gene

  • Golgi Associated Olfactory Signaling Regulator 2 3 5
  • Golgi Protein In Olfactory Neurons 2 3 4
  • Goofy 2 3 4
  • Golgi-Associated Olfactory Signaling Regulator 3 4
  • Protein Goofy 3
  • GFY 5

External Ids for GFY Gene

Previous GeneCards Identifiers for GFY Gene

  • GC19P049928

Summaries for GFY Gene

GeneCards Summary for GFY Gene

GFY (Golgi Associated Olfactory Signaling Regulator) is a Protein Coding gene. Diseases associated with GFY include Hydrolethalus Syndrome 1 and External Ear Disease.

UniProtKB/Swiss-Prot Summary for GFY Gene

  • Required for proper function of the olfactory system. May be involved in establishing the acuity of olfactory sensory signaling (By similarity).

Additional gene information for GFY Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GFY Gene

Genomics for GFY Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for GFY Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19J049425 Promoter 0.9 EPDnew 600.7 -0.1 -63 0.1 ARHGAP35 ZNF512 IKZF1 MTA2 PKNOX1 MTA1 EZH2 DPF2 ZNF184 ZBTB2 GFY PTH2 lnc-SLC17A7-3 POLD1 NUP62 MED25
GH19J049422 Enhancer 0.9 ENCODE 600.7 -0.9 -850 0.2 RNF2 ARHGAP35 PRDM10 KDM1A PKNOX1 MTA1 CTCF ZNF24 EZH2 DPF2 GFY PTH2 lnc-SLC17A7-3 BCL2L12 PTOV1 SCAF1 HSALNG0126988 KASH5
GH19J049428 Enhancer 0.9 ENCODE 600.7 -1.2 -1170 0.2 CTCF PRDM10 KDM1A PKNOX1 MTA1 PATZ1 REST ZNF24 EZH2 DPF2 GFY PTH2 lnc-SLC17A7-3 HSALNG0126988 KASH5
GH19J049423 Enhancer 0.8 ENCODE 600.7 -0.7 -714 0 RNF2 ARHGAP35 ZNF24 EZH2 DPF2 MGA YBX3 ZNF184 MTA3 ZNF248 GFY PTH2 lnc-SLC17A7-3 BCL2L12 PTOV1 SCAF1 HSALNG0126988 KASH5
GH19J049424 Enhancer 0.7 ENCODE 600.7 +0.3 340 0.1 ZNF512 IKZF1 MTA2 MTA1 BRD9 DPF2 ZNF600 ZNF184 RUNX3 FOXK2 GFY PTH2 lnc-SLC17A7-3 POLD1 ALDH16A1 SNORD35A SNORD35B IRF3 BCL2L12 NUP62
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GFY on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GFY

Genomic Locations for GFY Gene

Genomic Locations for GFY Gene
chr19:49,423,749-49,429,064
(GRCh38/hg38)
Size:
5,316 bases
Orientation:
Plus strand
chr19:49,927,006-49,932,075
(GRCh37/hg19)
Size:
5,070 bases
Orientation:
Plus strand

Genomic View for GFY Gene

Genes around GFY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GFY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GFY Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GFY Gene

Proteins for GFY Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for GFY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    I3L273-GFY_HUMAN
    Recommended name:
    Golgi-associated olfactory signaling regulator
    Protein Accession:
    I3L273

    Protein attributes for GFY Gene

    Size:
    518 amino acids
    Molecular mass:
    56104 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GFY Gene

Post-translational modifications for GFY Gene

  • Glycosylation at Asn124, Asn156, Asn188, Asn220, and Asn268
  • Modification sites at PhosphoSitePlus

Other Protein References for GFY Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GFY Gene

Domains & Families for GFY Gene

Gene Families for GFY Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for GFY Gene

ProtoNet:
genes like me logo Genes that share domains with GFY: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GFY Gene

Function for GFY Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for GFY Gene

UniProtKB/Swiss-Prot Function:
Required for proper function of the olfactory system. May be involved in establishing the acuity of olfactory sensory signaling (By similarity).

Phenotypes From GWAS Catalog for GFY Gene

genes like me logo Genes that share phenotypes with GFY: view

Animal Models for GFY Gene

MGI Knock Outs for GFY:
  • Gfy Gfy<tm1Yyos>

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GFY Gene

Localization for GFY Gene

Subcellular locations from UniProtKB/Swiss-Prot for GFY Gene

Golgi apparatus membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GFY gene
Compartment Confidence
golgi apparatus 4
plasma membrane 1
cytoskeleton 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for GFY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030173 integral component of Golgi membrane ISS --
genes like me logo Genes that share ontologies with GFY: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GFY Gene

Pathways & Interactions for GFY Gene

PathCards logo

SuperPathways for GFY Gene

No Data Available

Interacting Proteins for GFY Gene

Gene Ontology (GO) - Biological Process for GFY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007608 sensory perception of smell ISS --
GO:0050896 response to stimulus IEA --
GO:0097499 protein localization to non-motile cilium IEA --
GO:1905515 non-motile cilium assembly IEA --
genes like me logo Genes that share ontologies with GFY: view

No data available for Pathways by source and SIGNOR curated interactions for GFY Gene

Drugs & Compounds for GFY Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for GFY Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for GFY Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for GFY Gene

No ASD Table

Relevant External Links for GFY Gene

GeneLoc Exon Structure for
GFY

Expression for GFY Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GFY Gene

mRNA expression in normal human tissues for GFY Gene
mRNA expression by GTEx for GFY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GFY Gene

This gene is overexpressed in Testis (x20.6), Brain - Cerebellum (x9.6), and Brain - Cerebellar Hemisphere (x9.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GFY

genes like me logo Genes that share expression patterns with GFY: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GFY Gene

Orthologs for GFY Gene

This gene was present in the common ancestor of mammals.

Orthologs for GFY Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia LOC747438 30
  • 99.36 (n)
Cow
(Bos Taurus)
 Mammalia LOC100848055 30
  • 80.18 (n)
Dog
(Canis familiaris)
 Mammalia LOC100855724 30
  • 79.48 (n)
GFY 31
  • 61 (a)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia LOC100910047 30
  • 67.99 (n)
Mouse
(Mus musculus)
 Mammalia Gfy 30 17
  • 67.74 (n)
Gm581 31
  • 55 (a)
 OneToOne
Species where no ortholog for GFY was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for GFY Gene

ENSEMBL:
Gene Tree for GFY (if available)
TreeFam:
Gene Tree for GFY (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GFY: view image

Paralogs for GFY Gene

No data available for Paralogs for GFY Gene

Variants for GFY Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Additional dbSNP identifiers (rs#s) for GFY Gene

Structural Variations from Database of Genomic Variants (DGV) for GFY Gene

Variant ID Type Subtype PubMed ID
dgv52n68 CNV loss 17160897
nsv953599 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for GFY Gene

Gene Damage Index Score: 8.93; 87.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GFY Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GFY

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GFY Gene

Disorders for GFY Gene

MalaCards: The human disease database

(4) MalaCards diseases for GFY Gene - From: DISEASES

Disorder Aliases PubMed IDs
hydrolethalus syndrome 1
  • hls1
external ear disease
  • preauricular cyst
ideomotor apraxia
  • classic apraxia
otitis externa
  • swimmer's ear
- elite association - COSMIC cancer census association via MalaCards
Search GFY in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GFY

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with GFY: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GFY Gene

Publications for GFY Gene

  1. Goofy coordinates the acuity of olfactory signaling. (PMID: 23926254) Kaneko-Goto T … Yoshihara Y (The Journal of neuroscience : the official journal of the Society for Neuroscience 2013) 2 3
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4

ExternalLinks

View latest publications for GFY gene in Mastermind

Products for GFY Gene

Sources for GFY Gene