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Aliases for GFRAL Gene

Aliases for GFRAL Gene

  • GDNF Family Receptor Alpha Like 2 3 5
  • C6orf144 3 4
  • Chromosome 6 Open Reading Frame 144 2
  • GDNF Family Receptor Alpha-Like 3
  • BA360D14.1 3
  • IVFI9356 3
  • UNQ9356 3
  • GRAL 3

External Ids for GFRAL Gene

Previous HGNC Symbols for GFRAL Gene

  • C6orf144

Previous GeneCards Identifiers for GFRAL Gene

  • GC06P055192
  • GC06P055027

Summaries for GFRAL Gene

GeneCards Summary for GFRAL Gene

GFRAL (GDNF Family Receptor Alpha Like) is a Protein Coding gene.

Additional gene information for GFRAL Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GFRAL Gene

Genomics for GFRAL Gene

GeneHancer (GH) Regulatory Elements for GFRAL Gene

Promoters and enhancers for GFRAL Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I055628 Enhancer 0.2 FANTOM5 23.4 +300.8 300795 0 GC06P055627 GC06P055628 GC06P055629 GC06P055630 GC06P055631 GC06P055632 GC06P055633 GC06P055634 GC06P055635 GC06P055636
GH06I054980 Enhancer 0.7 FANTOM5 ENCODE 3.4 -346.2 -346234 1.8 YY2 BCL6B ZSCAN4 FOXP2 ENSG00000224984 ENSG00000261116 GFRAL GC06P055030
GH06I055363 Enhancer 0.2 FANTOM5 7.3 +35.8 35775 0 GFRAL HMGCLL1 GC06M055404
GH06I055276 Enhancer 0.6 ENCODE 0.2 -50.5 -50521 0.2 SCRT1 CTCF ZNF654 RAD21 SCRT2 SMC3 ZNF143 BCL6 HCRTR2 GFRAL GC06M055192
GH06I055277 Enhancer 0.5 ENCODE 0.2 -50.0 -49985 0.8 SCRT1 CTCF ZNF654 SCRT2 ZNF143 BCL6 RAD21 HCRTR2 FAM83B GFRAL GC06M055192
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GFRAL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GFRAL gene promoter:

Genomic Locations for GFRAL Gene

Genomic Locations for GFRAL Gene
75,025 bases
Plus strand

Genomic View for GFRAL Gene

Genes around GFRAL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GFRAL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GFRAL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GFRAL Gene

Proteins for GFRAL Gene

  • Protein details for GFRAL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GDNF family receptor alpha-like
    Protein Accession:
    Secondary Accessions:
    • Q5VTF6

    Protein attributes for GFRAL Gene

    394 amino acids
    Molecular mass:
    44518 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for GFRAL Gene

neXtProt entry for GFRAL Gene

Post-translational modifications for GFRAL Gene

  • Glycosylation at posLast=2323, posLast=5050, posLast=6262, posLast=6767, posLast=103103, and posLast=116116

Other Protein References for GFRAL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GFRAL Gene

Domains & Families for GFRAL Gene

Gene Families for GFRAL Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for GFRAL Gene


Suggested Antigen Peptide Sequences for GFRAL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GDNFR family.
  • Belongs to the GDNFR family.
genes like me logo Genes that share domains with GFRAL: view

Function for GFRAL Gene

Phenotypes From GWAS Catalog for GFRAL Gene

Gene Ontology (GO) - Molecular Function for GFRAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
genes like me logo Genes that share ontologies with GFRAL: view

Phenotypes for GFRAL Gene

genes like me logo Genes that share phenotypes with GFRAL: view

Animal Model Products

  • Taconic Biosciences Mouse Models for GFRAL

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GFRAL Gene

Localization for GFRAL Gene

Subcellular locations from UniProtKB/Swiss-Prot for GFRAL Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GFRAL gene
Compartment Confidence
plasma membrane 3
extracellular 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GFRAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GFRAL: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GFRAL Gene

Pathways & Interactions for GFRAL Gene

SuperPathways for GFRAL Gene

No Data Available

Interacting Proteins for GFRAL Gene

Selected Interacting proteins: Q6UXV0-GFRAL_HUMAN for GFRAL Gene via IID

Gene Ontology (GO) - Biological Process for GFRAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031098 stress-activated protein kinase signaling cascade IEA --
GO:0043524 negative regulation of neuron apoptotic process IEA --
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA --
genes like me logo Genes that share ontologies with GFRAL: view

No data available for Pathways by source and SIGNOR curated interactions for GFRAL Gene

Drugs & Compounds for GFRAL Gene

No Compound Related Data Available

Transcripts for GFRAL Gene

mRNA/cDNA for GFRAL Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GFRAL Gene

No ASD Table

Relevant External Links for GFRAL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GFRAL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GFRAL Gene

mRNA differential expression in normal tissues according to GTEx for GFRAL Gene

This gene is overexpressed in Adipose - Subcutaneous (x14.8), Testis (x6.1), Breast - Mammary Tissue (x5.7), and Brain - Cerebellar Hemisphere (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of GFRAL Gene:


SOURCE GeneReport for Unigene cluster for GFRAL Gene:

genes like me logo Genes that share expression patterns with GFRAL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GFRAL Gene

Orthologs for GFRAL Gene

This gene was present in the common ancestor of chordates.

Orthologs for GFRAL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GFRAL 33 34
  • 99.41 (n)
(Canis familiaris)
Mammalia GFRAL 33 34
  • 88.18 (n)
(Bos Taurus)
Mammalia GFRAL 33 34
  • 83.02 (n)
(Mus musculus)
Mammalia Gfral 33 16 34
  • 81.17 (n)
(Rattus norvegicus)
Mammalia Gfral 33
  • 79.98 (n)
(Monodelphis domestica)
Mammalia GFRAL 34
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia GFRAL 34
  • 58 (a)
(Gallus gallus)
Aves GFRAL 33 34
  • 61.33 (n)
(Anolis carolinensis)
Reptilia GFRAL 34
  • 42 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gfral 33
  • 54.06 (n)
(Danio rerio)
Actinopterygii GFRAL 34
  • 21 (a)
Species where no ortholog for GFRAL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GFRAL Gene

Gene Tree for GFRAL (if available)
Gene Tree for GFRAL (if available)

Paralogs for GFRAL Gene

No data available for Paralogs for GFRAL Gene

Variants for GFRAL Gene

Sequence variations from dbSNP and Humsavar for GFRAL Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
VAR_036234 A breast cancer sample p.Asp195His
rs1000011174 -- 55,340,718(+) G/C intron_variant
rs1000039854 -- 55,361,615(+) T/A intron_variant
rs1000059498 -- 55,392,943(+) G/T intron_variant
rs1000118749 -- 55,372,464(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GFRAL Gene

Variant ID Type Subtype PubMed ID
dgv5964n100 CNV gain 25217958
dgv5965n100 CNV gain 25217958
esv3539766 CNV deletion 23714750
esv3571074 CNV loss 25503493
esv3609065 CNV loss 21293372
nsv1034037 CNV gain 25217958
nsv1153415 CNV duplication 26484159
nsv462948 CNV gain 19166990
nsv470819 CNV gain 18288195
nsv5311 CNV deletion 18451855
nsv603162 CNV loss 21841781
nsv603163 CNV gain 21841781

Variation tolerance for GFRAL Gene

Residual Variation Intolerance Score: 75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.86; 89.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GFRAL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GFRAL Gene

Disorders for GFRAL Gene

Additional Disease Information for GFRAL

No disorders were found for GFRAL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GFRAL Gene

Publications for GFRAL Gene

  1. GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates. (PMID: 28846097) Mullican SE … Rangwala SM (Nature medicine 2017) 2 3 58
  2. The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL. (PMID: 28846098) Emmerson PJ … Wu X (Nature medicine 2017) 2 3 58
  3. GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand. (PMID: 28846099) Yang L … Jørgensen SB (Nature medicine 2017) 2 3 58
  4. Identification, expression and functional characterization of the GRAL gene. (PMID: 16086688) Li Z … Zhou J (Journal of neurochemistry 2005) 2 3 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for GFRAL Gene

Sources for GFRAL Gene

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