Aliases for GFRA4 Gene
External Ids for GFRA4 Gene
Previous GeneCards Identifiers for GFRA4 Gene
The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for GFRA4 Gene
GFRA4 (GDNF Family Receptor Alpha 4) is a Protein Coding gene. Diseases associated with GFRA4 include Spinocerebellar Ataxia 23 and Hirschsprung Disease 1. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include glial cell-derived neurotrophic factor receptor activity. An important paralog of this gene is GFRA2.
UniProtKB/Swiss-Prot Summary for GFRA4 Gene
Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.